Dio2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dio2
Entrez Gene ID	13371
Full Name	deiodinase, iodothyronine, type II
Synonyms	5DII,AI324267,DIOII
General protein information	Preferred Names deiodinase, iodothyronine, type II Names type II iodothyronine deiodinase iodothyronine type II deiodinase type 2 DI type-II 5' deiodinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 D3
Summary	The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is highly expressed in brain, placenta and mammary gland. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. Knockout studies in mice suggest that this gene may play an important role in brown adipose tissue lipogenesis, auditory function, and bone formation. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010050.2	NP_034180.1	type II iodothyronine deiodinase
NM_010050.3	NP_034180.1	type II iodothyronine deiodinase
NM_010050.4	NP_034180.2	type II iodothyronine deiodinase

Pathways from BioSystems

Homologies

Homo sapiens (human)	DIO2	NP_001007024.1
Bos taurus (cattle)	DIO2	NP_001010992.1
Danio rerio (zebrafish)	dio2	NP_997954.2
Xenopus tropicalis (tropical clawed frog)	dio2	NP_001184161.2
Pan troglodytes (chimpanzee)	DIO2	NP_001116109.1
Canis lupus familiaris (dog)	DIO2	NP_001116117.1
	DIO2	NP_001152766.1
Mus musculus (house mouse)	Dio2	NP_034180.1
Rattus norvegicus (Norway rat)	Dio2	NP_113908.3
Gallus gallus (chicken)	DIO2	NP_989445.2

Gene Ontology
Bibliography

Related articles in PubMed

Deletion of the Thyroid Hormone-Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase.
Ng L, Liu H, St Germain DL, Hernandez A, Forrest D
Endocrinology158(6)1999-2010(2017 Jun)

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
Lu J, Xu Q, Ji M, Guo X, Xu X, Fargo DC, Li X
EMBO reports18(5)841-857(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dio3-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2-/- mice, cone function was largely normal but deletion of Dio2 in Dio3-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.
Title: Deletion of the Thyroid Hormone-Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase.

mice with astrocyte-specific Dio2 inactivation (Astro-D2KO) have normal serum T3 but exhibit anxiety-depression-like behavior as found in open field and elevated plus maze studies and when tested for depression using the tail-suspension and the forced-swimming tests
Title: Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.

The consistent association between Calr and Dio2 expression suggests that enhanced expression of these two genes facilitate detrimental effects on cartilage integrity.
Title: Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Title: Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.

Data show that type 2 deiodinase (Dio2) inactivation in skeletal myocytes preserves T3 thyroid hormone content and only mildly disrupts thyroid hormone signaling.
Title: Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.

The following Dio2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dio2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18906	NM_010050.3 Latest version!	Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu84346	NM_010050.4 Latest version!	Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu18906	NM_010050.2	Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dio2 ( NM_010050.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034180.1 Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.

Price & Availability↑

CloneID	OMu18906
Clone ID Related Accession (Same CDS sequence)	NM_010050.2 , NM_010050.3
Accession Version	NM_010050.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Mus musculus(House mouse)
Product	type II iodothyronine deiodinase
Comment

ATGGGACTCC TCAGCGTAGA CTTGCTGATC ACCCTGCAGA TCCTGCCAGT CTTTTTCTCC 
AACTGCCTCT TCCTGGCGCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGCGTTGCTT 
CTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGAGGCGCA TGCTGACCTC AGAAGGGCTG 
CGCTGTGTCT GGAACAGCTT CCTCCTAGAT GCCTACAAAC AGGTTAAACT GGGTGAAGAT 
GCTCCCAATT CCAGTGTGGT GCACGTCTCC AATCCTGAAT CAGGTAACAA TTATGCCTCG 
GAGAAGACCG CTGATGGGGC CGAATGCCAC CTTCTTGACT TTGCCAGTGC AGAGCGCCCA 
CTGGTGGTCA ACTTTGGTTC AGCCACCTGA CCACCTTTCA CTAGGCAACT GCCAGCCTTC 
CGCCAGCTGG TGGAAGAGTT CTCCTCGGTG GCTGACTTCC TGTTGGTATA CATTGATGAG 
GCTCACCCTT CGGATGGCTG GGCAGTGCCT GGGGACTCCT CTCTGTCTTT TGAGGTTAAG 
AAGCACCGGA ACCAAGAGGA CCGATGTGCA GCAGCTCACC AGCTCCTGGA GCGTTTCTCC 
TTGCCGCCCC AGTGTCAAGT TGTGGCTGAC CGCATGGACA ATAATGCCAA CGTAGCTTAC 
GGGGTAGCCT TTGAACGTGT GTGCATCGTG CAGAGACGGA AAATTGCTTA CTTAGGAGGG 
AAGGGCCCCT TCAGCTATAA CCTACAAGAA GTCCGAAGTT GGCTGGAGAA GAATTTCAGC 
AAGAGATGAA TTCTAGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034180.1
Translation	MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRILD

Target ORF information:

RefSeq Version	NM_010050.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010050.2

ORF Insert Sequence:

ATGGGACTCC TCAGCGTAGA CTTGCTGATC ACCCTGCAGA TCCTGCCAGT CTTTTTCTCC 
AACTGCCTCT TCCTGGCGCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGCGTTGCTT 
CTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGAGGCGCA TGCTGACCTC AGAAGGGCTG 
CGCTGTGTCT GGAACAGCTT CCTCCTAGAT GCCTACAAAC AGGTTAAACT GGGTGAAGAT 
GCTCCCAATT CCAGTGTGGT GCACGTCTCC AATCCTGAAT CAGGTAACAA TTATGCCTCG 
GAGAAGACCG CTGATGGGGC CGAATGCCAC CTTCTTGACT TTGCCAGTGC AGAGCGCCCA 
CTGGTGGTCA ACTTTGGTTC AGCCACCTGA CCACCTTTCA CTAGGCAACT GCCAGCCTTC 
CGCCAGCTGG TGGAAGAGTT CTCCTCGGTG GCTGACTTCC TGTTGGTATA CATTGATGAG 
GCTCACCCTT CGGATGGCTG GGCAGTGCCT GGGGACTCCT CTCTGTCTTT TGAGGTTAAG 
AAGCACCGGA ACCAAGAGGA CCGATGTGCA GCAGCTCACC AGCTCCTGGA GCGTTTCTCC 
TTGCCGCCCC AGTGTCAAGT TGTGGCTGAC CGCATGGACA ATAATGCCAA CGTAGCTTAC 
GGGGTAGCCT TTGAACGTGT GTGCATCGTG CAGAGACGGA AAATTGCTTA CTTAGGAGGG 
AAGGGCCCCT TCAGCTATAA CCTACAAGAA GTCCGAAGTT GGCTGGAGAA GAATTTCAGC 
AAGAGATGAA TTCTAGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dio2 ( NM_010050.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034180.1 Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.

Price & Availability↑

CloneID	OMu18906
Clone ID Related Accession (Same CDS sequence)	NM_010050.2 , NM_010050.3
Accession Version	NM_010050.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-09
Organism	Mus musculus(house mouse)
Product	type II iodothyronine deiodinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT573100.6, BY328738.1, AF177197.1, AK045607.1, CO425270.1, CJ055557.1, CO042302.1 and BQ033571.1. On May 11, 2016 this sequence version replaced NM_010050.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF096875.1, SRR1660811.237479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9927339 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGACTCC TCAGCGTAGA CTTGCTGATC ACCCTGCAGA TCCTGCCAGT CTTTTTCTCC 
AACTGCCTCT TCCTGGCGCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGCGTTGCTT 
CTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGAGGCGCA TGCTGACCTC AGAAGGGCTG 
CGCTGTGTCT GGAACAGCTT CCTCCTAGAT GCCTACAAAC AGGTTAAACT GGGTGAAGAT 
GCTCCCAATT CCAGTGTGGT GCACGTCTCC AATCCTGAAT CAGGTAACAA TTATGCCTCG 
GAGAAGACCG CTGATGGGGC CGAATGCCAC CTTCTTGACT TTGCCAGTGC AGAGCGCCCA 
CTGGTGGTCA ACTTTGGTTC AGCCACCTGA CCACCTTTCA CTAGGCAACT GCCAGCCTTC 
CGCCAGCTGG TGGAAGAGTT CTCCTCGGTG GCTGACTTCC TGTTGGTATA CATTGATGAG 
GCTCACCCTT CGGATGGCTG GGCAGTGCCT GGGGACTCCT CTCTGTCTTT TGAGGTTAAG 
AAGCACCGGA ACCAAGAGGA CCGATGTGCA GCAGCTCACC AGCTCCTGGA GCGTTTCTCC 
TTGCCGCCCC AGTGTCAAGT TGTGGCTGAC CGCATGGACA ATAATGCCAA CGTAGCTTAC 
GGGGTAGCCT TTGAACGTGT GTGCATCGTG CAGAGACGGA AAATTGCTTA CTTAGGAGGG 
AAGGGCCCCT TCAGCTATAA CCTACAAGAA GTCCGAAGTT GGCTGGAGAA GAATTTCAGC 
AAGAGATGAA TTCTAGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034180.1
CDS	754..1554
Translation	MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRILD

Target ORF information:

RefSeq Version	NM_010050.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010050.3

ORF Insert Sequence:

ATGGGACTCC TCAGCGTAGA CTTGCTGATC ACCCTGCAGA TCCTGCCAGT CTTTTTCTCC 
AACTGCCTCT TCCTGGCGCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGCGTTGCTT 
CTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGAGGCGCA TGCTGACCTC AGAAGGGCTG 
CGCTGTGTCT GGAACAGCTT CCTCCTAGAT GCCTACAAAC AGGTTAAACT GGGTGAAGAT 
GCTCCCAATT CCAGTGTGGT GCACGTCTCC AATCCTGAAT CAGGTAACAA TTATGCCTCG 
GAGAAGACCG CTGATGGGGC CGAATGCCAC CTTCTTGACT TTGCCAGTGC AGAGCGCCCA 
CTGGTGGTCA ACTTTGGTTC AGCCACCTGA CCACCTTTCA CTAGGCAACT GCCAGCCTTC 
CGCCAGCTGG TGGAAGAGTT CTCCTCGGTG GCTGACTTCC TGTTGGTATA CATTGATGAG 
GCTCACCCTT CGGATGGCTG GGCAGTGCCT GGGGACTCCT CTCTGTCTTT TGAGGTTAAG 
AAGCACCGGA ACCAAGAGGA CCGATGTGCA GCAGCTCACC AGCTCCTGGA GCGTTTCTCC 
TTGCCGCCCC AGTGTCAAGT TGTGGCTGAC CGCATGGACA ATAATGCCAA CGTAGCTTAC 
GGGGTAGCCT TTGAACGTGT GTGCATCGTG CAGAGACGGA AAATTGCTTA CTTAGGAGGG 
AAGGGCCCCT TCAGCTATAA CCTACAAGAA GTCCGAAGTT GGCTGGAGAA GAATTTCAGC 
AAGAGATGAA TTCTAGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dio2 ( NM_010050.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034180.2 Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.

Price & Availability↑

CloneID	OMu84346
Clone ID Related Accession (Same CDS sequence)	NM_010050.4
Accession Version	NM_010050.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	type II iodothyronine deiodinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT573100.6, AK045607.1, AK032038.1 and BQ033571.1. On Oct 10, 2018 this sequence version replaced NM_010050.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF096875.1, SRR1660815.138267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9927339 ##RefSeq-Attributes-END##

ATGGGACTCC TCAGCGTAGA CTTGCTGATC ACCCTGCAGA TCCTGCCAGT CTTTTTCTCC 
AACTGCCTCT TCCTGGCGCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGCGTTGCTT 
CTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGAGGCGCA TGCTGACCTC AGAAGGGCTG 
CGCTGTGTCT GGAACAGCTT CCTCCTAGAT GCCTACAAAC AGGTTAAACT GGGTGAAGAT 
GCTCCCAATT CCAGTGTGGT GCACGTCTCC AATCCTGAAT CAGGTAACAA TTATGCCTCG 
GAGAAGACCG CTGATGGGGC CGAATGCCAC CTTCTTGACT TTGCCAGTGC AGAGCGCCCA 
CTGGTGGTCA ACTTTGGTTC AGCCACCTGA CCACCTTTCA CTAGGCAACT GCCAGCCTTC 
CGCCAGCTGG TGGAAGAGTT CTCCTCGGTG GCTGACTTCC TGTTGGTATA CATTGATGAG 
GCTCACCCTT CGGATGGCTG GGCAGTGCCT GGGGACTCCT CTCTGTCTTT TGAGGTTAAG 
AAGCACCGGA ACCAAGAGGA CCGATGTGCA GCAGCTCACC AGCTCCTGGA GCGTTTCTCC 
TTGCCGCCCC AGTGTCAAGT TGTGGCTGAC CGCATGGACA ATAATGCCAA CGTAGCTTAC 
GGGGTAGCCT TTGAACGTGT GTGCATCGTG CAGAGACGGA AAATTGCTTA CTTAGGAGGG 
AAGGGCCCCT TCAGCTATAA CCTACAAGAA GTCCGAAGTT GGCTGGAGAA GAATTTCAGC 
AAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034180.2
CDS	755..1543
Translation	MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSAT*PPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKR

Target ORF information:

RefSeq Version	NM_010050.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus deiodinase, iodothyronine, type II (Dio2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010050.4

ORF Insert Sequence:

ATGGGACTCC TCAGCGTAGA CTTGCTGATC ACCCTGCAGA TCCTGCCAGT CTTTTTCTCC 
AACTGCCTCT TCCTGGCGCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGCGTTGCTT 
CTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGAGGCGCA TGCTGACCTC AGAAGGGCTG 
CGCTGTGTCT GGAACAGCTT CCTCCTAGAT GCCTACAAAC AGGTTAAACT GGGTGAAGAT 
GCTCCCAATT CCAGTGTGGT GCACGTCTCC AATCCTGAAT CAGGTAACAA TTATGCCTCG 
GAGAAGACCG CTGATGGGGC CGAATGCCAC CTTCTTGACT TTGCCAGTGC AGAGCGCCCA 
CTGGTGGTCA ACTTTGGTTC AGCCACCTGA CCACCTTTCA CTAGGCAACT GCCAGCCTTC 
CGCCAGCTGG TGGAAGAGTT CTCCTCGGTG GCTGACTTCC TGTTGGTATA CATTGATGAG 
GCTCACCCTT CGGATGGCTG GGCAGTGCCT GGGGACTCCT CTCTGTCTTT TGAGGTTAAG 
AAGCACCGGA ACCAAGAGGA CCGATGTGCA GCAGCTCACC AGCTCCTGGA GCGTTTCTCC 
TTGCCGCCCC AGTGTCAAGT TGTGGCTGAC CGCATGGACA ATAATGCCAA CGTAGCTTAC 
GGGGTAGCCT TTGAACGTGT GTGCATCGTG CAGAGACGGA AAATTGCTTA CTTAGGAGGG 
AAGGGCCCCT TCAGCTATAA CCTACAAGAA GTCCGAAGTT GGCTGGAGAA GAATTTCAGC 
AAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deletion of the Thyroid Hormone-Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase.
Endocrinology158(6)1999-2010(2017 Jun)
Ng L,Liu H,St Germain DL,Hernandez A,Forrest D

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
EMBO reports18(5)841-857(2017 May)
Lu J,Xu Q,Ji M,Guo X,Xu X,Fargo DC,Li X

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Dio2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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