GenScript TurboCHO™プラットフォーム

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専門的なフォーマットデザイン

AIによるコドンの最適化

最適化されたプラスミド用量

製造プロセスの最適化

独自のTurboCHO™細胞株

多段階の精製ストラテジー

製造情報

二重特異性抗体 (bsAb) のフォーマットは非対称型、対称型、フラグメントに分類することができます。特定の治療目標、標的抗原、期待する薬物動態や薬力学的特性に応じてbsAbのフォーマットを選択する必要があります。それぞれのフォーマットには技術面、製造面、臨床応用面において独自の利点と注意点があります。

下記の抗体情報リストをクリックすると、70以上の異なるフォーマットの製造知見をご覧いただけます。各フォーマットの製造難易度をスコア化し、推奨精製ステップと予想収量を示しました。

1 CrossMab^CH1-CL

製造難易度 bsAbの発現量と精製難易度に基づき、GenScriptが1-5までのスコアを定義しました。 (スコア1が、最も製造が困難となります。)	2
推奨精製ステップ	2 steps
典型的な収量 低：<50mg /L 中: 50 – 200mg/L 高：>200mg/L	High

• 非対称型二重特異性抗体

  非対称型フォーマットは別個の2つの抗原結合ドメインが特徴で、それぞれの抗原に対して異なる特異性や親和性、機能を持つように設計することができます。これらの抗体は多様な抗原を柔軟に標的とすることができ、特定の生物学的パスウェイやシグナル伝達機構を調節する目的で使用することができます。

  1 CrossMab^CH1-CL

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  2 scFv/BiTE-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  3 Fab/scFv-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  4 Fab-Fc/scFv-Fc-scFv

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  5 scFab/BiTE-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  6 Heterodimeric IgG(KiH assembly)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  7 Duobody (FAE)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  8 Heterodimeric IgG(Common LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  9 Heterodimeric scFv-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  10 Heterodimeric scFab-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  11 Heterodimeric IgG-protein

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  12 Fab/Diabody-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  13 Fab-Fc/scFv-VHH-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  14 Fab/VHH-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  15 CrossMab^VH-VL

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  16 Fab-IgG (CrossMab^VH-VL)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  17 IgG-Fab (CrossMab^CH1-CL)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  18 BiTE-Fc (KiH)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  19 Fab/BiTE-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  20 scFv-Fab/scFv-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  21 Fab-Fc-scFv/scFv-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	3 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  22 Heterodimeric VHH-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  23 Heterodimeric IgG-VHH (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  24 Heterodimeric IgG

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  25 Fab/scFab-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  26 DART-Fc (KiH)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  27 Fab/protein-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  28 Heterodimeric IgG-protein complex

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  29 Heterodimeric VHH-IgG (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  30 Fab-Fc-scFv/VHH-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  31 Fab/VHH2-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

• 対称型二重特異性抗体

  非対称型フォーマットは同一の2つの抗原結合ドメインと、1つのFc領域で設計されています。このフォーマットは製造難易度と安定性に優れます。このフォーマットにはFc領域が含まれており、抗体依存性細胞傷害作用 (ADCC) や補体依存性細胞傷害作用 (CDC) を媒介する薬物動態やエフェクター機能を促進することができます。

  1 scFv-IgG (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  2 scFv-IgG (LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  3 Diabody-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  4 VHH-Fc-VHH

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  5 Multiple VHH-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  6 IgG-VHH (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  7 IgG-scFv (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  8 IgG-scFv (LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  9 scFv-Fc-scFv

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  10 DVD-Ig

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  11 VHH-IgG (HC+LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  12 Fab-scFv-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  13 IgG-scFv (HC+LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  14 IgG-BiTE (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  15 BiTE-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  16 VHH-IgG (LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  17 BiTE-scFc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  18 scFv-IgG (HC+LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  19 scDb-Fc

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  20 VHH-IgG (HC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  21 IgG-VHH (LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  22 IgG-VHH (HC+LC)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  23 Protein-IgG

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

• 二重特異性抗体フラグメント

  フラグメントフォーマットは2つの異なるものクローナル抗体フラグメント (scFvやFab) を組み合わせて構築されます。サイズが小さくなる場合が多く、組織への透過性が向上して薬物動態的特性を改善することができます。また、技術面や製造面も比較的容易な傾向にあります。

  1 Fab-VHHn

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  2 Multiple VHH

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	High

  3 Fab-VHH

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  4 scFv-Fab

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  5 Fab-scFv

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  6 scFv-VHH-scFv

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  7 Fab-Fab

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	4
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Moderate

  8 scDb (sc-Diabody)

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  9 TandAb

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  10 BiTE

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	2 steps
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  11 scFv2-Fab

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	3
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  12 Fab-scFv2

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	2
  Recommend purification step(s)	1 step
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L	Low

  13 Diabody

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  14 VHH-Protein

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  15 Fab-Protein

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  16 BiTE-Protein

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

  17 scFv-Fab-Fab

  

  Manufacturability Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript (e.g. score 1 represents the most difficult)	Data to be collected
  Recommend purification step(s)
  Typical yield Low: <50mg /L Moderate: 50 – 200mg/L High: >200mg/L

• 上記の各抗体は、記載されている各抗体は、GenScriptのTurboCHO™抗体発現プラットフォームを用いて製造に成功したものです。
• 個別の純度情報、ウェスタンブロット結果、精製法についてはJapanmarket＠genscript.comにお問い合わせください。

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TurboCHO™ Stable Cell Pool & Cell Line

ECACCにライセンス供与を受けた、目的タンパク質を高発現するCHO-K1細胞

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