DIO2 gene cDNA ORF clone, Homo sapiens(human)

mRNA	Protein	Name
NM_001007023.3	NP_001007024.1	type II iodothyronine deiodinase isoform b
NM_001324462.2	NP_001311391.2	type II iodothyronine deiodinase isoform b
NM_000793.6	NP_000784.3	type II iodothyronine deiodinase isoform b
NM_001242502.2	NP_001229431.1	type II iodothyronine deiodinase isoform c
NM_013989.5	NP_054644.1	type II iodothyronine deiodinase isoform a
NM_001007023.4	NP_001007024.1	type II iodothyronine deiodinase isoform b
NM_001366496.1	NP_001353425.1	type II iodothyronine deiodinase isoform b
NM_001242503.2	NP_001229432.1	type II iodothyronine deiodinase isoform d
NM_000793.5	NP_000784.2	type II iodothyronine deiodinase isoform a
NM_013989.4	NP_054644.1	type II iodothyronine deiodinase isoform a
NM_001324462.1	NP_001311391.1	type II iodothyronine deiodinase isoform a

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23599	NM_001007023.4 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23664	NM_000793.5 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23664	NM_013989.5 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23664	NM_001324462.1 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23281	NM_001242503.2 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu24084	NM_001242502.2 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu107684	NM_001324462.2 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107684	NM_000793.6 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107684	NM_001366496.1 Latest version!	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu23599	NM_001007023.3	Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23664	NM_013989.4	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

DIO2 ( NM_001007023.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007024.1 Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu23599
Clone ID Related Accession (Same CDS sequence)	NM_001007023.3 , NM_001007023.4
Accession Version	NM_001007023.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Homo sapiens(Human)
Product	type II iodothyronine deiodinase isoform b
Comment

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGCTAAATTG TCCTCCATCA 
GGTTTTAGCA AAGATGGACA CATTTTATGA CTAGTATATG AAGCTTATAA AAGCAGACTA 
CTGGTCTACT CACATTTGGA TTTATGGATG GTGAAATTGG GTGAGGATGC CCCCAATTCC 
AGTGTGGTGC ATGTCTCCAG TACAGAAGGA GGTGACAACA GTGGCAATGG TACCCAGGAG 
AAGATAGCTG AGGGAGCCAC ATGCCACCTT CTTGACTTTG CCAGCCCTGA GCGCCCACTA 
GTGGTCAACT TTGGCTCAGC CACTTGACCT CCTTTCACGA GCCAGCTGCC AGCCTTCCGC 
AAACTGGTGG AAGAGTTCTC CTCAGTGGCT GACTTCCTGC TGGTCTACAT TGATGAGGCT 
CATCCATCAG ATGGCTGGGC GATACCGGGG GACTCCTCTT TGTCTTTTGA GGTGAAGAAG 
CACCAGAACC AGGAAGATCG ATGTGCAGCA GCCCAGCAGC TTCTGGAGCG TTTCTCCTTG 
CCGCCCCAGT GCCGAGTTGT GGCTGACCGC ATGGACAATA ACGCCAACAT AGCTTACGGG 
GTAGCCTTTG AACGTGTGTG CATTGTGCAG AGACAGAAAA TTGCTTATCT GGGAGGAAAG 
GGCCCCTTCT CCTACAACCT TCAAGAAGTC CGGCATTGGC TGGAGAAGAA TTTCAGCAAG 
AGATGAAAGA AAACTAGATT AGCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007024.1
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQLNCPPSGFSKDGHILLVYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKR*KKTRLAG

Target ORF information:

RefSeq Version	NM_001007023.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007023.3

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGCTAAATTG TCCTCCATCA 
GGTTTTAGCA AAGATGGACA CATTTTATGA CTAGTATATG AAGCTTATAA AAGCAGACTA 
CTGGTCTACT CACATTTGGA TTTATGGATG GTGAAATTGG GTGAGGATGC CCCCAATTCC 
AGTGTGGTGC ATGTCTCCAG TACAGAAGGA GGTGACAACA GTGGCAATGG TACCCAGGAG 
AAGATAGCTG AGGGAGCCAC ATGCCACCTT CTTGACTTTG CCAGCCCTGA GCGCCCACTA 
GTGGTCAACT TTGGCTCAGC CACTTGACCT CCTTTCACGA GCCAGCTGCC AGCCTTCCGC 
AAACTGGTGG AAGAGTTCTC CTCAGTGGCT GACTTCCTGC TGGTCTACAT TGATGAGGCT 
CATCCATCAG ATGGCTGGGC GATACCGGGG GACTCCTCTT TGTCTTTTGA GGTGAAGAAG 
CACCAGAACC AGGAAGATCG ATGTGCAGCA GCCCAGCAGC TTCTGGAGCG TTTCTCCTTG 
CCGCCCCAGT GCCGAGTTGT GGCTGACCGC ATGGACAATA ACGCCAACAT AGCTTACGGG 
GTAGCCTTTG AACGTGTGTG CATTGTGCAG AGACAGAAAA TTGCTTATCT GGGAGGAAAG 
GGCCCCTTCT CCTACAACCT TCAAGAAGTC CGGCATTGGC TGGAGAAGAA TTTCAGCAAG 
AGATGAAAGA AAACTAGATT AGCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_001007023.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007024.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu23599
Clone ID Related Accession (Same CDS sequence)	NM_001007023.3 , NM_001007023.4
Accession Version	NM_001007023.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF093774.1, AB041843.1, BC136514.1, BG055336.1 and AI248279.1. On May 6, 2016 this sequence version replaced NM_001007023.3. Transcript Variant: This variant (3, also known as hDII-b) includes a novel in-frame coding exon compared to variant 1. The resulting isoform (b) is longer, containing an internal protein segment not found in isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.40526.1, SRR1660805.102787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGCTAAATTG TCCTCCATCA 
GGTTTTAGCA AAGATGGACA CATTTTATGA CTAGTATATG AAGCTTATAA AAGCAGACTA 
CTGGTCTACT CACATTTGGA TTTATGGATG GTGAAATTGG GTGAGGATGC CCCCAATTCC 
AGTGTGGTGC ATGTCTCCAG TACAGAAGGA GGTGACAACA GTGGCAATGG TACCCAGGAG 
AAGATAGCTG AGGGAGCCAC ATGCCACCTT CTTGACTTTG CCAGCCCTGA GCGCCCACTA 
GTGGTCAACT TTGGCTCAGC CACTTGACCT CCTTTCACGA GCCAGCTGCC AGCCTTCCGC 
AAACTGGTGG AAGAGTTCTC CTCAGTGGCT GACTTCCTGC TGGTCTACAT TGATGAGGCT 
CATCCATCAG ATGGCTGGGC GATACCGGGG GACTCCTCTT TGTCTTTTGA GGTGAAGAAG 
CACCAGAACC AGGAAGATCG ATGTGCAGCA GCCCAGCAGC TTCTGGAGCG TTTCTCCTTG 
CCGCCCCAGT GCCGAGTTGT GGCTGACCGC ATGGACAATA ACGCCAACAT AGCTTACGGG 
GTAGCCTTTG AACGTGTGTG CATTGTGCAG AGACAGAAAA TTGCTTATCT GGGAGGAAAG 
GGCCCCTTCT CCTACAACCT TCAAGAAGTC CGGCATTGGC TGGAGAAGAA TTTCAGCAAG 
AGATGAAAGA AAACTAGATT AGCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007024.1
CDS	156..1085
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQLNCPPSGFSKDGHILLVYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKR*KKTRLAG

Target ORF information:

RefSeq Version	NM_001007023.4
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007023.4

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGCTAAATTG TCCTCCATCA 
GGTTTTAGCA AAGATGGACA CATTTTATGA CTAGTATATG AAGCTTATAA AAGCAGACTA 
CTGGTCTACT CACATTTGGA TTTATGGATG GTGAAATTGG GTGAGGATGC CCCCAATTCC 
AGTGTGGTGC ATGTCTCCAG TACAGAAGGA GGTGACAACA GTGGCAATGG TACCCAGGAG 
AAGATAGCTG AGGGAGCCAC ATGCCACCTT CTTGACTTTG CCAGCCCTGA GCGCCCACTA 
GTGGTCAACT TTGGCTCAGC CACTTGACCT CCTTTCACGA GCCAGCTGCC AGCCTTCCGC 
AAACTGGTGG AAGAGTTCTC CTCAGTGGCT GACTTCCTGC TGGTCTACAT TGATGAGGCT 
CATCCATCAG ATGGCTGGGC GATACCGGGG GACTCCTCTT TGTCTTTTGA GGTGAAGAAG 
CACCAGAACC AGGAAGATCG ATGTGCAGCA GCCCAGCAGC TTCTGGAGCG TTTCTCCTTG 
CCGCCCCAGT GCCGAGTTGT GGCTGACCGC ATGGACAATA ACGCCAACAT AGCTTACGGG 
GTAGCCTTTG AACGTGTGTG CATTGTGCAG AGACAGAAAA TTGCTTATCT GGGAGGAAAG 
GGCCCCTTCT CCTACAACCT TCAAGAAGTC CGGCATTGGC TGGAGAAGAA TTTCAGCAAG 
AGATGAAAGA AAACTAGATT AGCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_013989.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_054644.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23664
Clone ID Related Accession (Same CDS sequence)	NM_013989.5 , NM_000793.5 , NM_013989.4 , NM_001324462.1
Accession Version	NM_013989.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF093774.1, BC136514.1 and AC007372.4. On Oct 7, 2018 this sequence version replaced NM_013989.4. Transcript Variant: This variant (1, also known as hDII-a) represents the predominant transcript and encodes two isoforms resulting from the use of alternative in-frame translation termination codons. The shorter isoform (b) with one Sec residue results from translation termination at the second UGA codon, while the longer isoform (a) with two Sec residues results from translation termination at an in-frame downstream UAA stop codon. This RefSeq represents the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.248181.1, SRR1660805.88700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913, 10403186 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054644.1
CDS	33..854
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRKKTRLAG

Target ORF information:

RefSeq Version	NM_013989.5
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013989.5

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_000793.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000784.2 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23664
Clone ID Related Accession (Same CDS sequence)	NM_013989.5 , NM_000793.5 , NM_013989.4 , NM_001324462.1
Accession Version	NM_000793.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292210.1, BC136514.1, AC007372.4 and AI248279.1. On Jun 10, 2011 this sequence version replaced NM_000793.4. Transcript Variant: This variant (2) contains two novel 5' non-coding exons; thus, differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000784.2
CDS	387..1208
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRKKTRLAG

Target ORF information:

RefSeq Version	NM_000793.5
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000793.5

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_013989.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054644.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.

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CloneID	OHu23664
Clone ID Related Accession (Same CDS sequence)	NM_013989.5 , NM_000793.5 , NM_013989.4 , NM_001324462.1
Accession Version	NM_013989.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF093774.1, BC136514.1, AC007372.4 and AI248279.1. On Jun 10, 2011 this sequence version replaced NM_013989.3. Transcript Variant: This variant (1, also known as hDII-a) represents the predominant transcript and encodes isoform a. Variants 1, 2, and 6 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF093774.1, SRR1803613.248181.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054644.1
CDS	156..977
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRKKTRLAG

Target ORF information:

RefSeq Version	NM_013989.4
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013989.4

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_001324462.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001311391.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 6, mRNA.

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CloneID	OHu23664
Clone ID Related Accession (Same CDS sequence)	NM_013989.5 , NM_000793.5 , NM_013989.4 , NM_001324462.1
Accession Version	NM_001324462.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007372.4, CD701270.1, JK546617.1, AF093774.1, BC136514.1, BG055336.1 and AI248279.1. Transcript Variant: This variant (6) contains a novel 5' non-coding exon; thus, differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JK546617.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001311391.1
CDS	403..1224
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRKKTRLAG

Target ORF information:

RefSeq Version	NM_001324462.1
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001324462.1

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGAAA GAAAACTAGA TTAGCTGGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_001242503.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229432.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 5, mRNA.

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CloneID	OHu23281
Clone ID Related Accession (Same CDS sequence)	NM_001242503.2
Accession Version	NM_001242503.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF093774.1, AK311603.1, AB041844.1, BC136514.1, BG055336.1 and AI248279.1. On May 6, 2016 this sequence version replaced NM_001242503.1. Transcript Variant: This variant (5) includes a novel exon in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (d) is shorter with a distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK311603.1, DB068020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGACTGACAG TGTTGTACTT 
ACTCTAAATT TCCCAAGGCA AATTAGTCTG TGTTTTGGAA AGAATTCTGC AGCTGAACTA 
TACATTGTTT CTAAGAAGGA GAAGGTGCCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229432.1
CDS	156..488
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQTDSVVLTLNFPRQISLCFGKNSAAELYIVSKKEKVP

Target ORF information:

RefSeq Version	NM_001242503.2
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242503.2

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGACTGACAG TGTTGTACTT 
ACTCTAAATT TCCCAAGGCA AATTAGTCTG TGTTTTGGAA AGAATTCTGC AGCTGAACTA 
TACATTGTTT CTAAGAAGGA GAAGGTGCCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_001242502.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229431.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu24084
Clone ID Related Accession (Same CDS sequence)	NM_001242502.2
Accession Version	NM_001242502.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF093774.1, AB041844.1, BC136514.1, BG055336.1 and AI248279.1. On May 6, 2016 this sequence version replaced NM_001242502.1. Transcript Variant: This variant (4, also known as hDII-c) includes two novel exons in the coding region, with the latter causing a frameshift compared to variant 1. The resulting isoform (c) is shorter with a distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB041844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGCTAAATTG TCCTCCATCA 
GGTTTTAGCA AAGATGGACA CATTTTATGA CTAGTATATG AAGCTTATAA AAGCAGACTA 
CTGGTCTACT CACATTTGGA TTTATGGATG ACTGACAGTG TTGTACTTAC TCTAAATTTC 
CCAAGGCAAA TTAGTCTGTG TTTTGGAAAG AATTCTGCAG CTGAACTATA CATTGTTTCT 
AAGAAGGAGA AGGTGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229431.1
CDS	156..596
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQLNCPPSGFSKDGHIL*LVYEAYKSRLLVYSHLDLWMTDSVVLTLNFPRQISLCFGKNSAAELYIVSKKEKVP

Target ORF information:

RefSeq Version	NM_001242502.2
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242502.2

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGCTAAATTG TCCTCCATCA 
GGTTTTAGCA AAGATGGACA CATTTTATGA CTAGTATATG AAGCTTATAA AAGCAGACTA 
CTGGTCTACT CACATTTGGA TTTATGGATG ACTGACAGTG TTGTACTTAC TCTAAATTTC 
CCAAGGCAAA TTAGTCTGTG TTTTGGAAAG AATTCTGCAG CTGAACTATA CATTGTTTCT 
AAGAAGGAGA AGGTGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_001324462.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001311391.2 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu107684
Clone ID Related Accession (Same CDS sequence)	NM_001324462.2 , NM_000793.6 , NM_001366496.1
Accession Version	NM_001324462.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD701270.1, JK546617.1, AF093774.1, BC136514.1 and AC007372.4. On Oct 5, 2018 this sequence version replaced NM_001324462.1. Transcript Variant: This variant (3) uses a different promoter and contains a novel 5' non-coding exon; thus, has a longer 5' UTR compared to variant 1. Variants 1 (NM_001366496.1), 2 and 3 represent the same one-Sec containing isoform (b), considered to be the canonical form. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1803613.248181.1, SRR1660805.88700.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913, 10403186 ##RefSeq-Attributes-END##

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001311391.2
CDS	399..1196
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSAT*PPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKR

Target ORF information:

RefSeq Version	NM_001324462.2
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001324462.2

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_000793.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000784.3 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 2, mRNA.

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CloneID	OHu107684
Clone ID Related Accession (Same CDS sequence)	NM_001324462.2 , NM_000793.6 , NM_001366496.1
Accession Version	NM_000793.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007372.4, AK292210.1, AF093774.1 and BC136514.1. On Oct 5, 2018 this sequence version replaced NM_000793.5. Transcript Variant: This variant (2) uses a different promoter and contains two novel 5' non-coding exons; thus, has a longer 5' UTR compared to the variant 1. Variants 1 (NM_001366496.1), 2 and 3 represent the same one-Sec containing isoform (b), considered to be the canonical form. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913, 10403186 ##RefSeq-Attributes-END##

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000784.3
CDS	390..1187
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSAT*PPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKR

Target ORF information:

RefSeq Version	NM_000793.6
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000793.6

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIO2 ( NM_001366496.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001353425.1 Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.

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CloneID	OHu107684
Clone ID Related Accession (Same CDS sequence)	NM_001324462.2 , NM_000793.6 , NM_001366496.1
Accession Version	NM_001366496.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	type II iodothyronine deiodinase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF093774.1, BC136514.1 and AC007372.4. Transcript Variant: This variant (1, also known as hDII-a) represents the predominant transcript and encodes two isoforms resulting from the use of alternative in-frame translation termination codons. The shorter isoform (b) with one Sec residue results from translation termination at the second UGA codon, while the longer isoform (a) with two Sec residues results from translation termination at an in-frame downstream UAA stop codon. This RefSeq represents the shorter isoform (b), which is considered the canonical form as the protein extension past the second UGA codon is not conserved in orthologs from other vertebrate species. Variants 2 and 3 also represent isoform b. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.248181.1, SRR1660805.88700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 9837913, 10403186 ##RefSeq-Attributes-END##

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001353425.1
CDS	33..830
Translation	MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSAT*PPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKR

Target ORF information:

RefSeq Version	NM_001366496.1
Organism	Homo sapiens(human)
Definition	Homo sapiens iodothyronine deiodinase 2 (DIO2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001366496.1

ORF Insert Sequence:

ATGGGCATCC TCAGCGTAGA CTTGCTGATC ACACTGCAAA TTCTGCCAGT TTTTTTCTCC 
AACTGCCTCT TCCTGGCTCT CTATGACTCG GTCATTCTGC TCAAGCACGT GGTGCTGCTG 
TTGAGCCGCT CCAAGTCCAC TCGCGGAGAG TGGCGGCGCA TGCTGACCTC AGAGGGACTG 
CGCTGCGTCT GGAAGAGCTT CCTCCTCGAT GCCTACAAAC AGGTGAAATT GGGTGAGGAT 
GCCCCCAATT CCAGTGTGGT GCATGTCTCC AGTACAGAAG GAGGTGACAA CAGTGGCAAT 
GGTACCCAGG AGAAGATAGC TGAGGGAGCC ACATGCCACC TTCTTGACTT TGCCAGCCCT 
GAGCGCCCAC TAGTGGTCAA CTTTGGCTCA GCCACTTGAC CTCCTTTCAC GAGCCAGCTG 
CCAGCCTTCC GCAAACTGGT GGAAGAGTTC TCCTCAGTGG CTGACTTCCT GCTGGTCTAC 
ATTGATGAGG CTCATCCATC AGATGGCTGG GCGATACCGG GGGACTCCTC TTTGTCTTTT 
GAGGTGAAGA AGCACCAGAA CCAGGAAGAT CGATGTGCAG CAGCCCAGCA GCTTCTGGAG 
CGTTTCTCCT TGCCGCCCCA GTGCCGAGTT GTGGCTGACC GCATGGACAA TAACGCCAAC 
ATAGCTTACG GGGTAGCCTT TGAACGTGTG TGCATTGTGC AGAGACAGAA AATTGCTTAT 
CTGGGAGGAA AGGGCCCCTT CTCCTACAAC CTTCAAGAAG TCCGGCATTG GCTGGAGAAG 
AATTTCAGCA AGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gene Symbol	DIO2
Entrez Gene ID	1734
Full Name	iodothyronine deiodinase 2
Synonyms	5DII,D2,DIOII,SelY,TXDI2
General protein information	Preferred Names iodothyronine deiodinase 2 Names type II iodothyronine deiodinase deiodinase, iodothyronine type II deiodinase-2 deiodonase-2 thyroxine deiodinase, type II type 2 DI type 2 iodothyronine deiodinase type-II 5'-deiodinase type-II 5'deiodinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q31.1
Summary	The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2016].
Disorder MIM:	601413

Homo sapiens (human)	DIO2	NP_001007024.1
Bos taurus (cattle)	DIO2	NP_001010992.1
Danio rerio (zebrafish)	dio2	NP_997954.2
Xenopus tropicalis (tropical clawed frog)	dio2	NP_001184161.2
Pan troglodytes (chimpanzee)	DIO2	NP_001116109.1
Canis lupus familiaris (dog)	DIO2	NP_001116117.1
	DIO2	NP_001152766.1
Mus musculus (house mouse)	Dio2	NP_034180.1
Rattus norvegicus (Norway rat)	Dio2	NP_113908.3
Gallus gallus (chicken)	DIO2	NP_989445.2

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

DIO2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

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