概要

イディオタイプは、抗体の可変領域に存在する抗原決定基です。抗イディオタイプ抗体は通常、抗体医薬のような他の抗体のイディオタイプに結合できます。そのため、抗イディオタイプ抗体は、抗体医薬レベルを測定するための薬物動態(PK)解析の目的で、前臨床での評価に使用されます。抗イディオタイプ抗体は抗薬物抗体(ADA)と大変類似しているため、抗イディオタイプ抗体は免疫原性アッセイのポジティプコントロールとしても用いられます。

GenScriptはバイオシミラー領域におけるお客様の研究を加速、支援するため、ブロックバスター医薬品に対する、既成品の抗イディオタイプ抗体を幅広く開発しました。

ベネフィット

100点以上の製品ラインナップ

28種類のモノクローナル抗体医薬品に対応

Ready-to-useの抗イディオタイプ(ID)抗体ペア

PK研究用の、様々な事前検証済み抗ID抗体ペア

高感度なMonoRab™ モノクローナル抗体

ピコモルレベルのイムノアッセイに最適

製品概要

Anti-Adalimumab/Humira (Target‎: ‎TNF alpha)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01954-40 Anti-Adalimumab Antibody (15C7), mAb, Mouse 0.258 ELISA, PK study A01954-40 (C) - A01955-40 (D)
A01954-40 (C) - A01956-40 (D)
 
A01955-40 Anti-Adalimumab Antibody (3C2), mAb, Mouse Non-inhibitory ELISA, PK study
 
A01956-40 Anti-Adalimumab Antibody (3C2) [Biotin], mAb, Mouse - ELISA, PK study
 
A01921-40 MonoRab™ Anti-Adalimumab Antibody (4E12), mAb, Rabbit 0.175 ELISA, PK study A01921-40 (C) - A01922-40 (D)
 
A01922-40 MonoRab™ Anti-Adalimumab Antibody (134D5), mAb, Rabbit 0.353 ELISA, PK study
 
A01923-40 MonoRab™ Anti-Adalimumab Antibody (196F3), mAb, Rabbit Non-inhibitory ELISA, PK study -
 
A01886-40 Anti-Adalimumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Atezolizumab/Tecentriq (Target‎: ‎PD-L1)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01948-40 Anti-Atezolizumab Antibody (10G9), mAb, Mouse 0.118 ELISA, PK study A01948-40 (C) - A01949-40 (D)
A01948-40 (C) - A01950-40 (D)
 
A01949-40 Anti-Atezolizumab Antibody (6B12), mAb, Mouse Non-inhibitory ELISA, PK study
 
A01950-40 Anti-Atezolizumab Antibody (6B12) [Biotin], mAb, Mouse - ELISA, PK study
 
A01984-40 MonoRab™ Anti-Atezolizumab Antibody (55D8) mAb, Rabbit 0.391 ELISA, PK study A01984-40 (C) - A01985-40 (D)
A01984-40 (C) - A01986-40 (D)
 
A01985-40 MonoRab™ Anti-Atezolizumab Antibody (43H11), mAb, Rabbit 0.847 ELISA, PK study
 
A01986-40 MonoRab™ Anti-Atezolizumab Antibody (43H11)[Biotin], mAb, Rabbit - ELISA, PK study
 

Anti-Avelumab/Bavencio (Target: ‎PD-L1)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02121-40 Anti-Avelumab Antibody (12H7), mAb, Mouse 0.748 ELISA, PK study A02121-40 (C) - A02120-40 (D)
 
A02120-40 Anti-Avelumab Antibody (12G9), mAb, Mouse 0.741 ELISA, PK study
 

Anti-Bevacizumab/Avastin (Target: VEGF-A)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01975-40 Anti-Bevacizumab Antibody (4H1), mAb, Mouse Non-inhibitory ELISA, PK study A01975-40 (C) - A01976-40 (D)
A01975-40 (C) - A01977-40 (D)
 
A01976-40 Anti-Bevacizumab Antibody (6C3), mAb, Mouse 0.157 ELISA, PK study
 
A01977-40 Anti-Bevacizumab Antibody (6C3)[Biotin], mAb, Mouse - ELISA, PK study
 
A02185-40 Anti-Bevacizumab Antibody (11C1), mAb, Mouse Non-inhibitory ELISA, PK study A02185-40 (C) - A01962-40 (D)
A02185-40 (C) - A01896-40 (D)
 
A01895-40 MonoRab™ Anti-Bevacizumab Antibody (30E1), mAb, Rabbit Non-inhibitory ELISA, PK study A01895-40 (C) - A01962-40 (D)
A01895-40 (C) - A01896-40 (D)
 
A01962-40 MonoRab™ Anti-Bevacizumab Antibody (46E3), mAb, Rabbit 0.046 ELISA, PK study
 
A01896-40 MonoRab™ Anti-Bevacizumab Antibody (46E3)[Biotin], mAb, Rabbit - ELISA, PK study
 
A01887-40 Anti-Bevacizumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Cetuximab/Erbitux (Target: EGF Receptor)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01939-40 Anti-Cetuximab Antibody (20H1), mAb, Mouse Non-inhibitory ELISA, PK study A01939-40 (C) - A01938-40 (D) 
 
A01938-40 Anti-Cetuximab Antibody (18D5), mAb, Mouse 0.2073 ELISA, PK study
 
A01991-40 MonoRab™ Anti-Cetuximab Antibody (69H10), mAb, Rabbit 0.039 ELISA, PK study A01991-40 (C) - A01992-40 (D)
 
A01992-40 MonoRab™ Anti-Cetuximab Antibody (90G3), mAb, Rabbit 0.015 ELISA, PK study
 

Anti-Daratumumab/Darzalex (Target: CD38)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01996-40 Anti-Daratumumab Antibody (11F2), mAb, Mouse Non-inhibitory ELISA, PK study A01996-40 (C) - A01997-40 (D)
 
A01997-40 Anti-Daratumumab Antibody (6A3), mAb, Mouse 0.582 ELISA, PK study
 
A01998-40 Anti-Daratumumab Antibody (9A6), mAb, Mouse 0.118 ELISA, PK study -
 
A02009-40 MonoRab™ Anti-Daratumumab(139B10), mAb, Rabbit 0.017 ELISA, PK study -
 

Anti-Denosumab/Prolia (Target: RANK Ligand)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02101-40 Anti-Denosumab Antibody (2H7), mAb, Mouse Non-inhibitory ELISA, PK study A02101-40 (C) - A02102-40 (D)
 
A02102-40 Anti-Denosumab Antibody (9A10), mAb, Mouse 0.893 ELISA, PK study
 

Anti-Dupilumab/Dupixent (Target: IL-4Rα)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02098-40 Anti-Dupilumab Antibody (6C9), mAb, Mouse 0.185 ELISA, PK study A02098-40 (C) - A02097-40 (D)
 
A02097-40 Anti-Dupilumab Antibody (2D5), mAb, Mouse 0.174 ELISA, PK study
 

Anti-Durvalumab/Imfinzi (Target: CD274)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02031-40 Anti-Durvalumab Antibody (15D6), mAb, Mouse 1.37 ELISA, PK study -
 

Anti-Eculizumab/Soliris (Target: ‎Complement protein C5)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02115-40 Anti-Eculizumab Antibody (4F6), mAb, Mouse Non-inhibitory ELISA, PK study A02115-40 (C) - A02116-40 (D)
 
A02116-40  Anti-Eculizumab Antibody(13F5), mAb, Mouse 1.053 ELISA, PK study
 

Anti-Etanercept/Enbrel (Target: ‎TNF alpha)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02114-40 Anti-Etanercept Antibody (4H5), mAb, Mouse 0.467 ELISA, PK study A02114-40 (C) - A02113-40 (D)
 
A02113-40 Anti-Etanercept Antibody (4H1), mAb, Mouse Non-inhibitory ELISA, PK study
 

Anti-Golimumab/Simponi (Target: ‎TNF alpha)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02093-40 Anti-Golimumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Infliximab/Remicade (Target: TNF alpha)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02040-40 Anti-Infliximab Antibody (27A4) , mAb, Mouse Non-inhibitory ELISA, PK study A02040-40 (C) - A02041-40 (D)
 
A02041-40 Anti-Infliximab Antibody (23H5) , mAb, Mouse Non-inhibitory ELISA, PK study
 
A02061-40 Anti-Infliximab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Ipilimumab/Yervoy (Target: CTLA-4)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01859-40 Anti-Ipilimumab Antibody(26B6H7D9), mAb, Mouse Non-inhibitory ELISA, PK study A01859-40 (C) - A01961-40 (D)
A01859-40 (C) - A01858-40 (D)
 
A01961-40 Anti-Ipilimumab Antibody (4H6), mAb, Mouse Non-inhibitory ELISA, PK study
 
A01858-40 Anti-Ipilimumab Antibody (4H6)[Biotin], mAb, Mouse - ELISA, PK study
 

Anti-Nivolumab/Opdivo (Target‎: ‎PD-1)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01847-40 Anti-Nivolumab Antibody(8G6G3D8), mAb, Mouse Non-inhibitory ELISA, PK study A01847-40 (C) - A01965-40 (D)
A01847-40 (C) - A01848-40 (D)
 
A01965-40 Anti-Nivolumab Antibody (6G5), mAb, Mouse Non-inhibitory ELISA, PK study
 
A01848-40 Anti-Nivolumab Antibody(6G5)[Biotin], mAb, Mouse - ELISA, PK study
 
A01987-40 MonoRab™ Anti-Nivolumab Antibody (33H4), mAb, Rabbit 0.484 ELISA, PK study A01987-40 (C) - A01988-40 (D)
A01987-40 (C) - A01989-40 (D)
 
A01988-40 MonoRab™ Anti-Nivolumab Antibody (40F11), mAb, Rabbit 0.171 ELISA, PK study
 
A01989-40 MonoRab™ Anti-Nivolumab Antibody (40F11)[Biotin], mAb, Rabbit - ELISA, PK study
 
A01990-40 MonoRab™ Anti-Nivolumab Antibody (47F6), mAb, Rabbit 0.104 ELISA, PK study -
 
A01931-40 Anti-Nivolumab Antibody, pAb, Rabbit - ELISA,
Immunogenicity assay
-
 

Anti-Obinutuzumab/Gazyva (Target: CD20)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01945-40 Anti-Obinutuzumab Antibody (18H8), mAb, Mouse Non-inhibitory ELISA, PK study A01945-40 (C) - A01946-40 (D)
A01945-40 (C) - A01947-40 (D)
 
A01946-40 Anti-Obinutuzumab Antibody (16B7), mAb, Mouse Non-inhibitory ELISA, PK study
 
A01947-40 Anti-Obinutuzumab Antibody (16B7) [Biotin], mAb, Mouse - ELISA, PK study
 
A01966-40 MonoRab™ Anti-Obinutuzumab Antibody (8G12), mAb, Rabbit Non-inhibitory ELISA, PK study A01966-40 (C) - A01967-40 (D)
A01966-40 (C) - A01968-40 (D)
 
A01967-40 MonoRab™ Anti-Obinutuzumab Antibody (169F10), mAb, Rabbit Non-inhibitory ELISA, PK study
 
A01968-40 MonoRab™ Anti-Obinutuzumab Antibody (169F10) [Biotin], mAb, Rabbit - ELISA, PK study
 
A01933-40 Anti-Obinutuzumab Antibody, pAb, Rabbit - ELISA,
Immunogenicity assay
-
 

Anti-Omalizumab/Xolair (Target: Human IgE)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02095-40 Anti-Omalizumab Antibody (10G3), mAb, Mouse Non-inhibitory ELISA, PK study A02095-40 (C) - A02094-40 (D)
 
A02094-40 Anti-Omalizumab Antibody (15B12), mAb, Mouse Non-inhibitory ELISA, PK study
 
A02096-40 Anti-Omalizumab Antibody (7G11), mAb, Mouse 0.37 ELISA, PK study -
 

Anti-Palivizumab/Synagis (Target: RSV F)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02112-40 Anti-Palivizumab Antibody (7B3), mAb, Mouse 0.821 ELISA, PK study A02112-40 (C) - A02111-40 (D)
 
A02111-40 Anti-Palivizumab Antibody (2F12), mAb, Mouse Non-inhibitory ELISA, PK study
 
A02064-40 Anti-Palivizumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Panitumumab/Vectibix (Target‎: EGF Receptor)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02100-40 Anti-Panitumumab Antibody (9G12), mAb, Mouse Non-inhibitory ELISA, PK study A02100-40 (C) - A02099-40 (D)
 
A02099-40 Anti-Panitumumab Antibody (2E7), mAb, Mouse 0.567 ELISA, PK study
 
A02063-40 Anti-Panitumumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Pembrolizumab/Keytruda (Target: PD-1)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01844-40 Anti-Pembrolizumab Antibody(1D6E10), mAb, Mouse Non-inhibitory ELISA, PK study -
 
A01845-40 Anti-Pembrolizumab Antibody(10E12C6)[Biotin], mAb, Mouse - ELISA, PK study -
 
A02008-40 MonoRab™ Anti-Pembrolizumab Antibody (94B9), mAb, Rabbit 0.580 ELISA, PK study A02008-40 (C) - A02007-40 (D)
 
A02007-40 MonoRab™ Anti-Pembrolizumab Antibody (47E5), mAb, Rabbit 0.009 ELISA, PK study
 
A01960-40 MonoRab™ Anti-Pembrolizumab Antibody (90G12), mAb, Rabbit  0.38 ELISA, PK study -
 
A01853-40 MonoRab™ Anti-Pembrolizumab Antibody(90G12)[Biotin], mAb, Rabbit - ELISA, PK study -
 
A01846-40 Anti-Pembrolizumab Antibody, pAb, Rabbit - ELISA,Immunogenicity assay -
 

Anti-Pertuzumab/Perjeta (Target: ‎HER2)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02150-40 Anti-Pertuzumab Antibody (1A3), mAb, Mouse 0.387 ELISA, PK study A02150-40 (C) - A02151-40 (D)
 
A02151-40 Anti-Pertuzumab Antibody (11H4), mAb, Mouse 0.711 ELISA, PK study
 

Anti-Ranibizumab/Lucentis (Target: VEGF-A)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02035-40 Anti-Ranibizumab Antibody (6C3), mAb, Mouse 0.848 ELISA, PK study A02035-40 (C) - A02036-40 (D)
 
A02036-40 Anti-Ranibizumab Antibody (10D12), mAb, Mouse Non-inhibitory ELISA, PK study
 
A02037-40 Anti-Ranibizumab Antibody, pAb, Rabbit - ELISA,
Immunogenicity assay
-
 

Anti-Rituximab/Rituxan (Target‎: ‎CD20)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01969-40 Anti-Rituximab Antibody (6C1), mAb, Mouse Non-inhibitory ELISA, PK study A01969-40 (C) - A01970-40 (D)
A01969-40 (C) - A01971-40 (D)
 
A01970-40 Anti-Rituximab Antibody (17B6), mAb, Mouse Non-inhibitory ELISA, PK study
 
A01971-40 Anti-Rituximab Antibody (17B6)[Biotin], mAb, Mouse - ELISA, PK study
 
A01942-40 MonoRab™ Anti-Rituximab Antibody (137C6), mAb, Rabbit Non-inhibitory ELISA, PK study A01942-40 (C) - A01943-40 (D)
A01942-40 (C) - A01944-40 (D)
 
A01943-40 MonoRab™ Anti-Rituximab Antibody (194D7), mAb, Rabbit Non-inhibitory ELISA, PK study
 
A01944-40 MonoRab™ Anti-Rituximab Antibody (194D7)[Biotin], mAb, Rabbit - ELISA, PK study
 
A01918-40 Anti-Rituximab Antibody, pAb, Rabbit - ELISA,
Immunogenicity assay
-
 

Anti-Sarilumab/Kevzara (Target: IL-6 Receptor)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02042-40 Anti-Sarilumab Antibody (26B10) , mAb, Mouse 0.062 ELISA, PK study A02042-40 (C) - A02043-40 (D)
 
A02043-40 Anti-Sarilumab Antibody (23H12) , mAb, Mouse 0.056 ELISA, PK study
 
A02044-40 Anti-Sarilumab Antibody (20F5), mAb, Mouse Non-inhibitory ELISA, PK study -
 
A02122-40 Anti-Sarilumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Secukinumab/Cosentyx (Target: ‎IL-17A)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02152-40 Anti-Secukinumab Antibody (22G7), mAb, Mouse 1.923 ELISA, PK study A02152-40 (C) - A02153-40 (D)
 
A02153-40 Anti-Secukinumab Antibody (23E11), mAb, Mouse 0.654 ELISA, PK study
 

Anti-Tocilizumab/Actemra (Target: IL-6 Receptor)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A01978-40 Anti-Tocilizumab Antibody (14B10), mAb, Mouse Non-inhibitory ELISA, PK study A01978-40 (C) - A01979-40 (D)
A01978-40 (C) - A01980-40 (D)
 
A01979-40 Anti-Tocilizumab Antibody (6C10), mAb, Mouse 0.656 ELISA, PK study
 
A01980-40 Anti-Tocilizumab Antibody (6C10)[Biotin], mAb, Mouse - ELISA, PK study
 
A01932-40 Anti-Tocilizumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

Anti-Trastuzumab/Herceptin (Target: HER2)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02032-40 Anti-Trastuzumab Antibody (11C4), mAb, Mouse - ELISA, PK study A02032-40 (C) - A02033-40 (D)
 
A02033-40 Anti-Trastuzumab Antibody (15H2), mAb, Mouse - ELISA, PK study
 

Anti-Ustekinumab/Stelara (Target: IL-12 & ‎IL-23)

Cat. No. Product Name Inhibitory IC50 (μg/ml) Recommend Applications Recommended Pairs (Capture-Detection) Order
A02118-40 Anti-Ustekinumab Antibody (9A5), mAb, Mouse Non-inhibitory ELISA, PK study A02118-40 (C) - A02117-40 (D)
 
A02117-40 Anti-Ustekinumab Antibody (5F9), mAb, Mouse Non-inhibitory ELISA, PK study
 
A02119-40 Anti-Ustekinumab Antibody (11E3), mAb, Mouse 0.5 ELISA, PK study -
 
A02123-40 Anti-Ustekinumab Antibody, pAb, Rabbit - ELISA, Immunogenicity assay -
 

アプリケーション

リソース

抗イディオタイプ抗体
抗イディオタイプ抗体

バイオシミラーのPKおよび免疫原性研究をサポート

無料ダウンロード

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