OAZ2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ2
Entrez Gene ID	427481
Full Name	ornithine decarboxylase antizyme 2
General protein information	Preferred Names ornithine decarboxylase antizyme 2 Names ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001142862.3	NP_001136334.1	ornithine decarboxylase antizyme 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Oaz2	NP_035082.1
Canis lupus familiaris (dog)	OAZ2	XP_005638755.1
Bos taurus (cattle)	OAZ2	NP_001166047.1
Rattus norvegicus (Norway rat)	Oaz2	NP_001103369.1
Homo sapiens (human)	OAZ2	NP_002528.1
Pan troglodytes (chimpanzee)	OAZ2	XP_001158081.2
	OAZ2	NP_001128381.1
Gallus gallus (chicken)	OAZ2	NP_001136334.1
Xenopus tropicalis (tropical clawed frog)	oaz2	NP_001106583.2

Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Gene expression profiling of chicken primordial germ cell ESTs.
Han JY, Park TS, Kim JN, Kim MA, Lim D, Lim JM, Kim H
BMC genomics7220(2006 Aug)

An expressed sequence tag analysis of the chicken reproductive tract transcriptome.
Froman DP, Kirby JD, Rhoads DD
Poultry science85(8)1438-41(2006 Aug)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

A second mammalian antizyme: conservation of programmed ribosomal frameshifting.
Ivanov IP, Gesteland RF, Atkins JF
Genomics52(2)119-29(1998 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa86405	NM_001142862.3 Latest version!	Gallus gallus ornithine decarboxylase antizyme 2 (OAZ2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ2 ( NM_001142862.3 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001136334.1 Gallus gallus ornithine decarboxylase antizyme 2 (OAZ2), mRNA.

Price & Availability↑

CloneID	OGa86405
Clone ID Related Accession (Same CDS sequence)	NM_001142862.3
Accession Version	NM_001142862.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	ornithine decarboxylase antizyme 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR416898.1, BU135163.1, BU112284.1 and BU342545.1. On Feb 23, 2016 this sequence version replaced NM_001142862.2. ##Evidence-Data-START## Transcript exon combination :: DR418943.1, DR415771.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TAGTATTTTA CCTTTGAGTA ACTGTCCCCA GCTGCAGTGC 
TGCAGGCACA TCGTTCCGGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG TAGCAGGGAT CCTTCTCTTT CAGCTCTGAT TTATAAGGAT 
GAGAAGATCA CTGTTAGCCA AGATGTCCCA GTGCATGAAG GGAAGCCTCA TGTTGTCCAC 
TTCCAGTACA AGGTCACAGA GGTGAAGACC TCCTCCTGGG ATGCAGTGCT TTCAAATCAG 
AGCCTCTTTG TGGAAATCCC TGATGGGTTA TTAGCTGATG GAAGCAAAGA AGGGTTATCA 
GCACTGCTGG AATTTGCTGA AGAAAAAATG AAAGTCAACT ATGTCTTTAT TTGCTTCAGA 
AAAAGCAGAG AAGATAGAGC ACCGCTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATC 
GTGAGGCCTG GTCACCCCTC TGTCCCGTCG CGGCCAGATG TGATGTTCAT GGTGTACCCC 
TTGGATCAGA ACTCTTCCTC TGATGAAGAA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136334.1
CDS	join(67..162,164..640)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGSRDPSLSALIYKDEKITVSQDVPVHEGKPHVVHFQYKVTEVKTSSWDAVLSNQSLFVEIPDGLLADGSKEGLSALLEFAEEKMKVNYVFICFRKSREDRAPLLKTFSFLGFEIVRPGHPSVPSRPDVMFMVYPLDQNSSSDEE

Target ORF information:

RefSeq Version	NM_001142862.3
Organism	Gallus gallus(chicken)
Definition	Gallus gallus ornithine decarboxylase antizyme 2 (OAZ2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142862.3

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATTTTA CCTTTGAGTA ACTGTCCCCA GCTGCAGTGC 
TGCAGGCACA TCGTTCCGGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG TAGCAGGGAT CCTTCTCTTT CAGCTCTGAT TTATAAGGAT 
GAGAAGATCA CTGTTAGCCA AGATGTCCCA GTGCATGAAG GGAAGCCTCA TGTTGTCCAC 
TTCCAGTACA AGGTCACAGA GGTGAAGACC TCCTCCTGGG ATGCAGTGCT TTCAAATCAG 
AGCCTCTTTG TGGAAATCCC TGATGGGTTA TTAGCTGATG GAAGCAAAGA AGGGTTATCA 
GCACTGCTGG AATTTGCTGA AGAAAAAATG AAAGTCAACT ATGTCTTTAT TTGCTTCAGA 
AAAAGCAGAG AAGATAGAGC ACCGCTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATC 
GTGAGGCCTG GTCACCCCTC TGTCCCGTCG CGGCCAGATG TGATGTTCAT GGTGTACCCC 
TTGGATCAGA ACTCTTCCTC TGATGAAGAA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Gene expression profiling of chicken primordial germ cell ESTs.
BMC genomics7220(2006 Aug)
Han JY,Park TS,Kim JN,Kim MA,Lim D,Lim JM,Kim H

An expressed sequence tag analysis of the chicken reproductive tract transcriptome.
Poultry science85(8)1438-41(2006 Aug)
Froman DP,Kirby JD,Rhoads DD

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

A second mammalian antizyme: conservation of programmed ribosomal frameshifting.
Genomics52(2)119-29(1998 Sep)
Ivanov IP,Gesteland RF,Atkins JF

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OAZ2 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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