OAZ2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ2
Entrez Gene ID	4947
Full Name	ornithine decarboxylase antizyme 2
Synonyms	AZ2
General protein information	Preferred Names ornithine decarboxylase antizyme 2 Names ornithine decarboxylase antizyme 2 ODC-Az 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.31
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014].
Disorder MIM:	604152

mRNA and Protein(s)

mRNA	Protein	Name
NM_002537.3	NP_002528.1	ornithine decarboxylase antizyme 2 isoform 1
NM_001301302.1	NP_001288231.1	ornithine decarboxylase antizyme 2 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Oaz2	NP_035082.1
Canis lupus familiaris (dog)	OAZ2	XP_005638755.1
Bos taurus (cattle)	OAZ2	NP_001166047.1
Rattus norvegicus (Norway rat)	Oaz2	NP_001103369.1
Homo sapiens (human)	OAZ2	NP_002528.1
Pan troglodytes (chimpanzee)	OAZ2	XP_001158081.2
	OAZ2	NP_001128381.1
Gallus gallus (chicken)	OAZ2	NP_001136334.1
Xenopus tropicalis (tropical clawed frog)	oaz2	NP_001106583.2

Gene Ontology
Bibliography

Related articles in PubMed

Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.
Gross JA, Fiori LM, Labont? B, Lopez JP, Turecki G
Journal of psychiatric research47(4)513-9(2013 Apr)

Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.
Fiori LM, Gross JA, Turecki G
The international journal of neuropsychopharmacology15(8)1161-6(2012 Sep)

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.
Geerts D, Koster J, Albert D, Koomoa DL, Feith DJ, Pegg AE, Volckmann R, Caron H, Versteeg R, Bachmann AS
International journal of cancer126(9)2012-24(2010 May)

Subcellular localization and phosphorylation of antizyme 2.
Murai N, Shimizu A, Murakami Y, Matsufuji S
Journal of cellular biochemistry108(4)1012-21(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 2 in suicide completers with a history of mood disorders.
Title: Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.

This study demomistrated that H3K4me3 modification plays an important role in up regulation of OAZ2 in prefrontal cortex.
Title: Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.

elevated ODC and low OAZ2 mRNA expression levels correlate with several unfavorable genetic and clinical features in neuroblastoma.
Title: The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.

The protein product is generated using polyamine-regulated programmed ribosomal frameshifting.
Title: A second mammalian antizyme: conservation of programmed ribosomal frameshifting.

The following OAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu100969	NM_002537.3 Latest version!	Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu100970	NM_001301302.1 Latest version!	Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ2 ( NM_002537.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002528.1 Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu100969
Clone ID Related Accession (Same CDS sequence)	NM_002537.3
Accession Version	NM_002537.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	ornithine decarboxylase antizyme 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA210449.1, BC035493.2 and BG059726.1. On Jul 31, 2014 this sequence version replaced NM_002537.2. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660807.178414.1, SRR1660803.240986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAATGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCTTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGCCGAG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTACGTCCAG GCCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTCAT GGTTTATCCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002528.1
CDS	join(234..329,331..804)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_002537.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002537.3

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAATGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCTTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGCCGAG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTACGTCCAG GCCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTCAT GGTTTATCCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OAZ2 ( NM_001301302.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288231.1 Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100970
Clone ID Related Accession (Same CDS sequence)	NM_001301302.1
Accession Version	NM_001301302.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	ornithine decarboxylase antizyme 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA210449.1, BI597670.1, BC035493.2 and BG059726.1. Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.332900.1, SRR1660807.154697.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TATTTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCAGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTCTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TGACCCAGGA CCTCCCTGTG AATGATGGAA AACCTCACAT CGTCCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTCTCT TCTTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATCCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTGTTAGCA 
CTGCTAGAGT TTGCTGAAGA GAAGATGAAA GTGAACTATG TCTTCATCTG CTTCAGGAAG 
GGCCGAGAAG ACAGAGCTCC ACTCCTGAAG ACCTTCAGCT TCTTGGGCTT TGAGATTGTA 
CGTCCAGGCC ATCCCTGTGT CCCCTCTCGG CCAGATGTGA TGTTCATGGT TTATCCCCTG 
GACCAGAACT TGTCCGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288231.1
CDS	join(234..326,328..801)
Translation	MINTQDSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001301302.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301302.1

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TATTTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCAGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTCTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TGACCCAGGA CCTCCCTGTG AATGATGGAA AACCTCACAT CGTCCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTCTCT TCTTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATCCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTGTTAGCA 
CTGCTAGAGT TTGCTGAAGA GAAGATGAAA GTGAACTATG TCTTCATCTG CTTCAGGAAG 
GGCCGAGAAG ACAGAGCTCC ACTCCTGAAG ACCTTCAGCT TCTTGGGCTT TGAGATTGTA 
CGTCCAGGCC ATCCCTGTGT CCCCTCTCGG CCAGATGTGA TGTTCATGGT TTATCCCCTG 
GACCAGAACT TGTCCGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.
Journal of psychiatric research47(4)513-9(2013 Apr)
Gross JA,Fiori LM,Labont? B,Lopez JP,Turecki G

Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.
The international journal of neuropsychopharmacology15(8)1161-6(2012 Sep)
Fiori LM,Gross JA,Turecki G

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.
International journal of cancer126(9)2012-24(2010 May)
Geerts D,Koster J,Albert D,Koomoa DL,Feith DJ,Pegg AE,Volckmann R,Caron H,Versteeg R,Bachmann AS

Subcellular localization and phosphorylation of antizyme 2.
Journal of cellular biochemistry108(4)1012-21(2009 Nov)
Murai N,Shimizu A,Murakami Y,Matsufuji S

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OAZ2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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