Oaz2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oaz2
Entrez Gene ID	501454
Full Name	ornithine decarboxylase antizyme 2
Synonyms	RGD1562933
General protein information	Preferred Names ornithine decarboxylase antizyme 2 Names ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301297.1	NP_001288226.1	ornithine decarboxylase antizyme 2 isoform 2
NM_001109899.2	NP_001103369.1	ornithine decarboxylase antizyme 2 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Oaz2	NP_035082.1
Canis lupus familiaris (dog)	OAZ2	XP_005638755.1
Bos taurus (cattle)	OAZ2	NP_001166047.1
Rattus norvegicus (Norway rat)	Oaz2	NP_001103369.1
Homo sapiens (human)	OAZ2	NP_002528.1
Pan troglodytes (chimpanzee)	OAZ2	XP_001158081.2
	OAZ2	NP_001128381.1
Gallus gallus (chicken)	OAZ2	NP_001136334.1
Xenopus tropicalis (tropical clawed frog)	oaz2	NP_001106583.2

Gene Ontology
Bibliography

Related articles in PubMed

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2.
Ramos-Molina B, Lambertos A, Lopez-Contreras AJ, Kasprzak JM, Czerwoniec A, Bujnicki JM, Cremades A, Pe?afiel R
FEBS open bio4510-21(2014)

Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer.
Olsen RR, Zetter BR
Molecular cancer research : MCR9(10)1285-93(2011 Oct)

Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes.
L?pez-Contreras AJ, S?nchez-Laorden BL, Ramos-Molina B, de la Morena ME, Cremades A, Pe?afiel R
Journal of cellular biochemistry107(4)732-40(2009 Jul)

Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells.
L?pez-Contreras AJ, Ramos-Molina B, Cremades A, Pe?afiel R
The Journal of biological chemistry283(30)20761-9(2008 Jul)

Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.
Kanerva K, M?kitie LT, Pelander A, Heiskala M, Andersson LC
The Biochemical journal409(1)187-92(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Oaz2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oaz2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa63251	NM_001109899.2 Latest version!	Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa63252	NM_001301297.1 Latest version!	Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oaz2 ( NM_001109899.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103369.1 Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa63251
Clone ID Related Accession (Same CDS sequence)	NM_001109899.2
Accession Version	NM_001109899.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	ornithine decarboxylase antizyme 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FQ211793.1, FQ134463.1 and BQ195681.1. On Aug 1, 2014 this sequence version replaced NM_001109899.1. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: FQ211793.1, FQ214772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTAACCCA GGATCTCCCC GTGAGCGATG GAAAACCTCA CATTGTGCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTG TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTATTA 
GCACTGCTAG AGTTTGCTGA GGAGAAGATG AAAGTGAACT ACGTCTTCAT CTGCTTCAGG 
AAGGGCCGGG AAGACAGAGC TCCACTCCTG AAGACGTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GTCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTTAT GGTTTACCCC 
CTGGACCAGA ACTTGTCTGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103369.1
CDS	join(168..263,265..738)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVSDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001109899.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109899.2

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTAACCCA GGATCTCCCC GTGAGCGATG GAAAACCTCA CATTGTGCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTG TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTATTA 
GCACTGCTAG AGTTTGCTGA GGAGAAGATG AAAGTGAACT ACGTCTTCAT CTGCTTCAGG 
AAGGGCCGGG AAGACAGAGC TCCACTCCTG AAGACGTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GTCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTTAT GGTTTACCCC 
CTGGACCAGA ACTTGTCTGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Oaz2 ( NM_001301297.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001288226.1 Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa63252
Clone ID Related Accession (Same CDS sequence)	NM_001301297.1
Accession Version	NM_001301297.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	ornithine decarboxylase antizyme 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FQ211793.1, FQ134463.1 and BQ195681.1. Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: CK473319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TATTTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCAGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTCTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TAACCCAGGA TCTCCCCGTG AGCGATGGAA AACCTCACAT TGTGCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTGTCT TCCTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATCCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTATTAGCA 
CTGCTAGAGT TTGCTGAGGA GAAGATGAAA GTGAACTACG TCTTCATCTG CTTCAGGAAG 
GGCCGGGAAG ACAGAGCTCC ACTCCTGAAG ACGTTCAGCT TCTTGGGCTT TGAGATTGTG 
CGTCCAGGTC ATCCCTGTGT CCCCTCTCGG CCAGATGTGA TGTTTATGGT TTACCCCCTG 
GACCAGAACT TGTCTGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288226.1
CDS	join(168..260,262..735)
Translation	MINTQDSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVSDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001301297.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301297.1

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TATTTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCAGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTCTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TAACCCAGGA TCTCCCCGTG AGCGATGGAA AACCTCACAT TGTGCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTGTCT TCCTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATCCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTATTAGCA 
CTGCTAGAGT TTGCTGAGGA GAAGATGAAA GTGAACTACG TCTTCATCTG CTTCAGGAAG 
GGCCGGGAAG ACAGAGCTCC ACTCCTGAAG ACGTTCAGCT TCTTGGGCTT TGAGATTGTG 
CGTCCAGGTC ATCCCTGTGT CCCCTCTCGG CCAGATGTGA TGTTTATGGT TTACCCCCTG 
GACCAGAACT TGTCTGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2.
FEBS open bio4510-21(2014)
Ramos-Molina B,Lambertos A,Lopez-Contreras AJ,Kasprzak JM,Czerwoniec A,Bujnicki JM,Cremades A,Pe?afiel R

Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer.
Molecular cancer research : MCR9(10)1285-93(2011 Oct)
Olsen RR,Zetter BR

Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes.
Journal of cellular biochemistry107(4)732-40(2009 Jul)
L?pez-Contreras AJ,S?nchez-Laorden BL,Ramos-Molina B,de la Morena ME,Cremades A,Pe?afiel R

Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells.
The Journal of biological chemistry283(30)20761-9(2008 Jul)
L?pez-Contreras AJ,Ramos-Molina B,Cremades A,Pe?afiel R

Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.
The Biochemical journal409(1)187-92(2008 Jan)
Kanerva K,M?kitie LT,Pelander A,Heiskala M,Andersson LC

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Oaz2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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