OAZ2 cDNA ORF clone, Pan troglodytes(chimpanzee)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ2
Entrez Gene ID	747719
Full Name	ornithine decarboxylase antizyme 2
General protein information	Preferred Names ornithine decarboxylase antizyme 2 Names ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Pan troglodytes(chimpanzee)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001289918.1	NP_001276847.1	ornithine decarboxylase antizyme 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Oaz2	NP_035082.1
Canis lupus familiaris (dog)	OAZ2	XP_005638755.1
Bos taurus (cattle)	OAZ2	NP_001166047.1
Rattus norvegicus (Norway rat)	Oaz2	NP_001103369.1
Homo sapiens (human)	OAZ2	NP_002528.1
Pan troglodytes (chimpanzee)	OAZ2	XP_001158081.2
	OAZ2	NP_001128381.1
Gallus gallus (chicken)	OAZ2	NP_001136334.1
Xenopus tropicalis (tropical clawed frog)	oaz2	NP_001106583.2

Gene Ontology
Bibliography

Related articles in PubMed

Major chimpanzee-specific structural changes in sperm development-associated genes.
Kim RN, Kim DW, Choi SH, Chae SH, Nam SH, Kim DW, Kim A, Kang A, Park KH, Lee YS, Hirai M, Suzuki Y, Sugano S, Hashimoto K, Kim DS, Park HS
Functional & integrative genomics11(3)507-17(2011 Sep)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OPc91383	NM_001289918.1 Latest version!	Pan troglodytes ornithine decarboxylase antizyme 2 (OAZ2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ2 ( NM_001289918.1 ) cDNA ORF clone, Pan troglodytes(chimpanzee) -> NP_001276847.1 Pan troglodytes ornithine decarboxylase antizyme 2 (OAZ2), mRNA.

Price & Availability↑

CloneID	OPc91383
Clone ID Related Accession (Same CDS sequence)	NM_001289918.1
Accession Version	NM_001289918.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-03-08
Organism	Pan troglodytes(chimpanzee)
Product	ornithine decarboxylase antizyme 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK305933.1 and GABC01020507.1. ##Evidence-Data-START## Transcript exon combination :: AK305933.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01120800, SAMN01120804 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTGAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAATGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCTTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGTCGAG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTACGTCCAG GCCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTCAT GGTTTATCCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276847.1
CDS	join(168..263,265..738)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001289918.1
Organism	Pan troglodytes(chimpanzee)
Definition	Pan troglodytes ornithine decarboxylase antizyme 2 (OAZ2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289918.1

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTGAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAATGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCTTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGTCGAG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTACGTCCAG GCCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTCAT GGTTTATCCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Major chimpanzee-specific structural changes in sperm development-associated genes.
Functional & integrative genomics11(3)507-17(2011 Sep)
Kim RN,Kim DW,Choi SH,Chae SH,Nam SH,Kim DW,Kim A,Kang A,Park KH,Lee YS,Hirai M,Suzuki Y,Sugano S,Hashimoto K,Kim DS,Park HS

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

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OAZ2 cDNA ORF clone, Pan troglodytes(chimpanzee)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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