oaz2 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	oaz2
Entrez Gene ID	100127795
Full Name	ornithine decarboxylase antizyme 2
General protein information	Preferred Names ornithine decarboxylase antizyme 2 Names ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Xenopus tropicalis(tropical clawed frog)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001113112.2	NP_001106583.3	ornithine decarboxylase antizyme 2 isoform 1
NM_001301325.1	NP_001288254.1	ornithine decarboxylase antizyme 2 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Oaz2	NP_035082.1
Canis lupus familiaris (dog)	OAZ2	XP_005638755.1
Bos taurus (cattle)	OAZ2	NP_001166047.1
Rattus norvegicus (Norway rat)	Oaz2	NP_001103369.1
Homo sapiens (human)	OAZ2	NP_002528.1
Pan troglodytes (chimpanzee)	OAZ2	XP_001158081.2
	OAZ2	NP_001128381.1
Gallus gallus (chicken)	OAZ2	NP_001136334.1
Xenopus tropicalis (tropical clawed frog)	oaz2	NP_001106583.2

Gene Ontology
Bibliography

Related articles in PubMed

Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis.
Fierro AC, Thuret R, Coen L, Perron M, Demeneix BA, Wegnez M, Gyapay G, Weissenbach J, Wincker P, Mazabraud A, Pollet N
BMC genomics8118(2007 May)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following oaz2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the oaz2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OXa47196	NM_001113112.2 Latest version!	Xenopus tropicalis ornithine decarboxylase antizyme 2 (oaz2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00
OXa47197	NM_001301325.1 Latest version!	Xenopus tropicalis ornithine decarboxylase antizyme 2 (oaz2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

oaz2 ( NM_001113112.2 ) cDNA ORF clone, Xenopus tropicalis(tropical clawed frog) -> NP_001106583.3 Xenopus tropicalis ornithine decarboxylase antizyme 2 (oaz2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OXa47196
Clone ID Related Accession (Same CDS sequence)	NM_001113112.2
Accession Version	NM_001113112.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Xenopus tropicalis(tropical clawed frog)
Product	ornithine decarboxylase antizyme 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN090581.1, BC135959.1 and DN009108.1. On Aug 2, 2014 this sequence version replaced NM_001113112.1. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC135959.1, DT432717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00861986, SAMN00861988 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAGAGC CGCAGGACAG TAGTATTTTG CCTTTGAGTA GCAGTCAACA GCTCCATTGC 
TGCAGGCACC TTATTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTTGAAG 
ATCCCCGGTG GGCGAGGGGA CAGCAGGGAT CCTGCGCTCC CAGCAGTGAT CTACAAGGAC 
GAGAAGCTCA CGGTTTCTCA AGATATCCCA GTGAACAATG GGAAGCCCCA TCTCGTCCAC 
TTCCAGTACA AGGTCACTGA GGTGAAAGTA TCCTCATGGA ATGCCATGCG GTCGAACCAG 
AGCCTTTTTG TGGAAATTCC TGAGGGCATG CTGGCTGATG GGAGCAAAGA GGGGTTGCTG 
GCTCTGTTGG AATTTGCCGA GGAGAAGATG GAAATGAGCT ATGTCTTTAT TTGCTTCAGA 
AAGAGTCGGG AGGACAGAGG TTCTCTGTTG AAGACCTTCA GCTTTCTAGG CTTTGAGATC 
GTACGTCCTG GTCACCCGTG TGTTCCTGCT CGCCCAGATG TCATGTTCAT GGTGTACACT 
TTAGACCAGA GTTCTTCAGA TGAAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106583.3
CDS	join(282..377,379..852)
Translation	MIEPQDSSILPLSSSQQLHCCRHLIPGPLWCSDAPHPLLKIPGGRGDSRDPALPAVIYKDEKLTVSQDIPVNNGKPHLVHFQYKVTEVKVSSWNAMRSNQSLFVEIPEGMLADGSKEGLLALLEFAEEKMEMSYVFICFRKSREDRGSLLKTFSFLGFEIVRPGHPCVPARPDVMFMVYTLDQSSSDEE

Target ORF information:

RefSeq Version	NM_001113112.2
Organism	Xenopus tropicalis(tropical clawed frog)
Definition	Xenopus tropicalis ornithine decarboxylase antizyme 2 (oaz2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113112.2

ORF Insert Sequence:

ATGATAGAGC CGCAGGACAG TAGTATTTTG CCTTTGAGTA GCAGTCAACA GCTCCATTGC 
TGCAGGCACC TTATTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTTGAAG 
ATCCCCGGTG GGCGAGGGGA CAGCAGGGAT CCTGCGCTCC CAGCAGTGAT CTACAAGGAC 
GAGAAGCTCA CGGTTTCTCA AGATATCCCA GTGAACAATG GGAAGCCCCA TCTCGTCCAC 
TTCCAGTACA AGGTCACTGA GGTGAAAGTA TCCTCATGGA ATGCCATGCG GTCGAACCAG 
AGCCTTTTTG TGGAAATTCC TGAGGGCATG CTGGCTGATG GGAGCAAAGA GGGGTTGCTG 
GCTCTGTTGG AATTTGCCGA GGAGAAGATG GAAATGAGCT ATGTCTTTAT TTGCTTCAGA 
AAGAGTCGGG AGGACAGAGG TTCTCTGTTG AAGACCTTCA GCTTTCTAGG CTTTGAGATC 
GTACGTCCTG GTCACCCGTG TGTTCCTGCT CGCCCAGATG TCATGTTCAT GGTGTACACT 
TTAGACCAGA GTTCTTCAGA TGAAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

oaz2 ( NM_001301325.1 ) cDNA ORF clone, Xenopus tropicalis(tropical clawed frog) -> NP_001288254.1 Xenopus tropicalis ornithine decarboxylase antizyme 2 (oaz2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OXa47197
Clone ID Related Accession (Same CDS sequence)	NM_001301325.1
Accession Version	NM_001301325.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Xenopus tropicalis(tropical clawed frog)
Product	ornithine decarboxylase antizyme 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN090581.1, BC135959.1, EL851728.1 and DN009108.1. Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: EL851728.1, CN100151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00861997, SAMN00862015 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAGAGC CGCAGGACAG TATTTTGCCT TTGAGTAGCA GTCAACAGCT CCATTGCTGC 
AGGCACCTTA TTCCAGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTTGAAGATC 
CCCGGTGGGC GAGGGGACAG CAGGGATCCT GCGCTCCCAG CAGTGATCTA CAAGGACGAG 
AAGCTCACGG TTTCTCAAGA TATCCCAGTG AACAATGGGA AGCCCCATCT CGTCCACTTC 
CAGTACAAGG TCACTGAGGT GAAAGTATCC TCATGGAATG CCATGCGGTC GAACCAGAGC 
CTTTTTGTGG AAATTCCTGA GGGCATGCTG GCTGATGGGA GCAAAGAGGG GTTGCTGGCT 
CTGTTGGAAT TTGCCGAGGA GAAGATGGAA ATGAGCTATG TCTTTATTTG CTTCAGAAAG 
AGTCGGGAGG ACAGAGGTTC TCTGTTGAAG ACCTTCAGCT TTCTAGGCTT TGAGATCGTA 
CGTCCTGGTC ACCCGTGTGT TCCTGCTCGC CCAGATGTCA TGTTCATGGT GTACACTTTA 
GACCAGAGTT CTTCAGATGA AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288254.1
CDS	join(282..374,376..849)
Translation	MIEPQDSILPLSSSQQLHCCRHLIPGPLWCSDAPHPLLKIPGGRGDSRDPALPAVIYKDEKLTVSQDIPVNNGKPHLVHFQYKVTEVKVSSWNAMRSNQSLFVEIPEGMLADGSKEGLLALLEFAEEKMEMSYVFICFRKSREDRGSLLKTFSFLGFEIVRPGHPCVPARPDVMFMVYTLDQSSSDEE

Target ORF information:

RefSeq Version	NM_001301325.1
Organism	Xenopus tropicalis(tropical clawed frog)
Definition	Xenopus tropicalis ornithine decarboxylase antizyme 2 (oaz2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301325.1

ORF Insert Sequence:

ATGATAGAGC CGCAGGACAG TATTTTGCCT TTGAGTAGCA GTCAACAGCT CCATTGCTGC 
AGGCACCTTA TTCCAGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTTGAAGATC 
CCCGGTGGGC GAGGGGACAG CAGGGATCCT GCGCTCCCAG CAGTGATCTA CAAGGACGAG 
AAGCTCACGG TTTCTCAAGA TATCCCAGTG AACAATGGGA AGCCCCATCT CGTCCACTTC 
CAGTACAAGG TCACTGAGGT GAAAGTATCC TCATGGAATG CCATGCGGTC GAACCAGAGC 
CTTTTTGTGG AAATTCCTGA GGGCATGCTG GCTGATGGGA GCAAAGAGGG GTTGCTGGCT 
CTGTTGGAAT TTGCCGAGGA GAAGATGGAA ATGAGCTATG TCTTTATTTG CTTCAGAAAG 
AGTCGGGAGG ACAGAGGTTC TCTGTTGAAG ACCTTCAGCT TTCTAGGCTT TGAGATCGTA 
CGTCCTGGTC ACCCGTGTGT TCCTGCTCGC CCAGATGTCA TGTTCATGGT GTACACTTTA 
GACCAGAGTT CTTCAGATGA AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis.
BMC genomics8118(2007 May)
Fierro AC,Thuret R,Coen L,Perron M,Demeneix BA,Wegnez M,Gyapay G,Weissenbach J,Wincker P,Mazabraud A,Pollet N

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P

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oaz2 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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