OAZ2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ2
Entrez Gene ID	524677
Full Name	ornithine decarboxylase antizyme 2
General protein information	Preferred Names ornithine decarboxylase antizyme 2 Names ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301322.1	NP_001288251.1	ornithine decarboxylase antizyme 2 isoform 2
NM_001172576.2	NP_001166047.1	ornithine decarboxylase antizyme 2 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Oaz2	NP_035082.1
Canis lupus familiaris (dog)	OAZ2	XP_005638755.1
Bos taurus (cattle)	OAZ2	NP_001166047.1
Rattus norvegicus (Norway rat)	Oaz2	NP_001103369.1
Homo sapiens (human)	OAZ2	NP_002528.1
Pan troglodytes (chimpanzee)	OAZ2	XP_001158081.2
	OAZ2	NP_001128381.1
Gallus gallus (chicken)	OAZ2	NP_001136334.1
Xenopus tropicalis (tropical clawed frog)	oaz2	NP_001106583.2

Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

A second generation radiation hybrid map to aid the assembly of the bovine genome sequence.
Jann OC, Aerts J, Jones M, Hastings N, Law A, McKay S, Marques E, Prasad A, Yu J, Moore SS, Floriot S, Mah? MF, Eggen A, Silveri L, Negrini R, Milanesi E, Ajmone-Marsan P, Valentini A, Marchitelli C, Savarese MC, Janitz M, Herwig R, Hennig S, Gorni C, Connor EE, Sonstegard TS, Smith T, Dr?gem?ller C, Williams JL
BMC genomics7283(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa134030	NM_001172576.2 Latest version!	Bos taurus ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00
OBa134031	NM_001301322.1 Latest version!	Bos taurus ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ2 ( NM_001172576.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001166047.1 Bos taurus ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OBa134030
Clone ID Related Accession (Same CDS sequence)	NM_001172576.2
Accession Version	NM_001172576.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Bos taurus(cattle)
Product	ornithine decarboxylase antizyme 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EE350146.1, BC149484.1, BC149845.1, DN531747.1 and CB461552.1. On Aug 2, 2014 this sequence version replaced NM_001172576.1. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: EE350146.1, CR552515.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCGGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAATGATG GAAAGCCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATTCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ACGTCTTCAT CTGCTTCAGG 
AAGGGCCGGG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GCCATCCCTG TGTCCCCTCT CGACCAGATG TGATGTTCAT GGTTTACCCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166047.1
CDS	join(206..301,303..776)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001172576.2
Organism	Bos taurus(cattle)
Definition	Bos taurus ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172576.2

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCGGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAATGATG GAAAGCCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATTCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ACGTCTTCAT CTGCTTCAGG 
AAGGGCCGGG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GCCATCCCTG TGTCCCCTCT CGACCAGATG TGATGTTCAT GGTTTACCCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OAZ2 ( NM_001301322.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001288251.1 Bos taurus ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OBa134031
Clone ID Related Accession (Same CDS sequence)	NM_001301322.1
Accession Version	NM_001301322.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Bos taurus(cattle)
Product	ornithine decarboxylase antizyme 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EE350146.1, CO887362.1, BC149845.1, DN531747.1 and CB461552.1. Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: CO887362.1, EH164842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145415 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TATTTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCGGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTCTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TGACCCAGGA CCTCCCTGTG AATGATGGAA AGCCTCACAT CGTCCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTCTCT TCCTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATTCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTGTTAGCA 
CTGCTAGAGT TTGCTGAAGA GAAGATGAAA GTGAACTACG TCTTCATCTG CTTCAGGAAG 
GGCCGGGAAG ACAGAGCTCC ACTCCTGAAG ACCTTCAGCT TCTTGGGCTT TGAGATTGTG 
CGTCCAGGCC ATCCCTGTGT CCCCTCTCGA CCAGATGTGA TGTTCATGGT TTACCCCCTG 
GACCAGAACT TGTCCGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288251.1
CDS	join(206..298,300..773)
Translation	MINTQDSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001301322.1
Organism	Bos taurus(cattle)
Definition	Bos taurus ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301322.1

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TATTTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCGGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTCTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TGACCCAGGA CCTCCCTGTG AATGATGGAA AGCCTCACAT CGTCCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTCTCT TCCTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATTCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTGTTAGCA 
CTGCTAGAGT TTGCTGAAGA GAAGATGAAA GTGAACTACG TCTTCATCTG CTTCAGGAAG 
GGCCGGGAAG ACAGAGCTCC ACTCCTGAAG ACCTTCAGCT TCTTGGGCTT TGAGATTGTG 
CGTCCAGGCC ATCCCTGTGT CCCCTCTCGA CCAGATGTGA TGTTCATGGT TTACCCCCTG 
GACCAGAACT TGTCCGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

A second generation radiation hybrid map to aid the assembly of the bovine genome sequence.
BMC genomics7283(2006 Nov)
Jann OC,Aerts J,Jones M,Hastings N,Law A,McKay S,Marques E,Prasad A,Yu J,Moore SS,Floriot S,Mah? MF,Eggen A,Silveri L,Negrini R,Milanesi E,Ajmone-Marsan P,Valentini A,Marchitelli C,Savarese MC,Janitz M,Herwig R,Hennig S,Gorni C,Connor EE,Sonstegard TS,Smith T,Dr?gem?ller C,Williams JL

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OAZ2 cDNA ORF clone, Bos taurus(cattle)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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