Madd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Madd
Entrez Gene ID	94193
Full Name	MAP-kinase activating death domain
General protein information	Preferred Names MAP-kinase activating death domain Names MAP kinase-activating death domain protein Rab3 GDP/GTP exchange protein madd rab3 GDP/GTP exchange factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q24
Summary	GDP/GTP exchange protein (GEP) for Rab3 subfamily small G proteins; may play a role in intracellular vesicle trafficking [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053585.1	NP_446037.1	MAP kinase-activating death domain protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MADD	NP_001180007.1
Rattus norvegicus (Norway rat)	Madd	NP_446037.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000630	XP_311160.5
Caenorhabditis elegans (roundworm)	aex-3	NP_741710.1
Xenopus tropicalis (tropical clawed frog)	madd	NP_001072717.1
Mus musculus (house mouse)	Madd	NP_001171191.1
Danio rerio (zebrafish)	madd	XP_005169012.1
	MADD	XP_001107689.1
Homo sapiens (human)	MADD	NP_003673.3
Pan troglodytes (chimpanzee)	MADD	XP_003951918.1
Canis lupus familiaris (dog)	MADD	XP_005631300.1
Gallus gallus (chicken)	MADD	XP_004941623.1
Drosophila melanogaster (fruit fly)	rab3-GEF	NP_001096983.2

Gene Ontology
Bibliography

Related articles in PubMed

MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
Imai A, Ishida M, Fukuda M, Nashida T, Shimomura H
Archives of biochemistry and biophysics536(1)31-7(2013 Aug)

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA
The Journal of cell biology191(2)367-81(2010 Oct)

KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.
Niwa S, Tanaka Y, Hirokawa N
Nature cell biology10(11)1269-79(2008 Nov)

Purification and properties of Rab3 GEP (DENN/MADD).
Sakisaka T, Takai Y
Methods in enzymology403254-61(2005)

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons.
Del Villar K, Miller CA
Proceedings of the National Academy of Sciences of the United States of America101(12)4210-5(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings indicated that Madd functions as a guanine nucleotide exchange factor for Rab27 in parotid acinar cells and regulates isoproterenol-stimulated amylase release.
Title: MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.

The following Madd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Madd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09974	NM_053585.1 Latest version!	Rattus norvegicus MAP-kinase activating death domain (Madd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Madd ( NM_053585.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446037.1 Rattus norvegicus MAP-kinase activating death domain (Madd), mRNA.

Price & Availability↑

CloneID	ORa09974
Clone ID Related Accession (Same CDS sequence)	NM_053585.1
Accession Version	NM_053585.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4809bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	MAP kinase-activating death domain protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U72995.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U72995.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGTGCAAA AGAAGTTCTG CCCTCGGTTA CTTGACTATC TAGTGATCGT AGGGGCCAGG 
CATCCAAGCA GTGACAGTGT GGCTCAGACT CCTGAACTTC TGCGGAGGTA CCCACTAGAG 
GACCACCCGG AGTTTCCCCT GCCCCCAGAT GTGGTGTTCT TCTGCCAGCC AGAGGGATGT 
CTGAGCGTGC GGCAACGGCG CATGAGCCTC CGAGATGATA CCTCTTTTGT CTTCACCCTA 
ACCGATAAGG ACACTGGAGT CACCCGTTAT GGCATCTGTG TCAACTTCTA CCGTTCCTTT 
CAAAAGCGAA TGCCAAAGGA AAAGGCGGAA GGCGGAGCAG GACCCCGTGG GAAGGAAGGA 
GCTCATGCCC CCTGTGCCTC AGAAGAGGCC GCCACCGAGA GCTCAGAGAG TGGCTCAACC 
TTGCAGCCTC CTAGTGCTGA CTCCACTCCT GACGTAAACC AGTCTCCTCG GGGCAAACGT 
AGGGCAAAAG CAGGCAACCG CTCCCGAAAC AGTACCCTGA CATCCCTGTG TGTGCTTAGC 
CACTACCCTT TCTTCTCTAC CTTCAGAGAG TGTCTGTATA CTCTCAAACG TCTGGTAGAC 
TGCTGTAGTG AACGGCTCCT AGGCAAGAAA CCGGGCATCC CTCGAGGTGT ACAAAGGGAC 
ACCATGTGGC GAATCTTTAC TGGATCACTG CTAGTGGAGG AGAAGTCCAG TGCCCTTCTG 
CATGACCTTC GAGAGATCGA GGCCTGGATC TATCGGTTGC TACGCTCCCC GGTGCCTGTC 
TCTGGGCAGA AGCGAGTGGA CATTGAGGTC CTACCCCAGG AAGTGCAGCA GGCCCTGACA 
TTTGCTCTTC CAGATCCATC CCGGTTCACC CTAGTAGATT TCCCTCTTCA CCTTCCCTTG 
GAACTTCTGG GTGTAGATGC TTGTCTTCAG GTGCTAACCT GCATCCTGTT GGAGCACAAG 
GTGGTGCTAC AGTCTCGAGA CTACAACGCA CTCTCCATGT CTGTGATGGC GTTTGTGGCA 
ATGATCTACC CCCTGGAGTA CATGTTCCCT GTCATCCCGC TGCTTCCCAC CTGCATGGCT 
TCGGCAGAGC AGCTACTCTT GGCTCCAACC CCATATATCA TTGGAGTCCC TGCCAGCTTT 
TTCCTCTATA AGCTAGACTT CAAAATGCCT GATGACGTGT GGCTGGTGGA TCTGGACAGC 
AACAGGGTGA TTGCCCCCAC CAATGCAGAA GTGCTACCCA TCCTGCCAGA ACCGGAATCA 
TTAGAGCTGA AAAAACACTT AAAGCAGGCT CTAGCCAGCA TGAGTCTCAA CACCCAGCCC 
ATTCTTAATC TGGAGAAATT CCATGAGGGC CAGGAGACAC CACTTCTCTT GGGAAGGTTT 
TCTAATGACC TTCAGTCTAC ACCTTCCACT GAATTCAACC CACTCATTTA TGGCAATGAT 
GTAGATTCAG TCGATGTTGC AACGAGAGTG GCCATGGTTC GTTTCTTCAA CTCTGCTAAC 
GTGCTGCAGG GCTTTCAGAT GCACACACGT ACCCTGCGAC TCTTCCCCCG GCCCGTGGTT 
GCCTTCCAAG CTGGCTCCTT TCTGGCCTCA CGCCCCCGGC AGACCCCCTT TGCTGAGAAA 
CTGGCCAGGA CTCAAGCCGT GGAGTACTTT GGAGAATGGA TCCTGAACCC TTCTAACTAT 
GCCTTCCAGC GGATTCACAA CAATACGTTT GATCCAGCCC TCATTGGTGA CAAGCCTAAG 
TGGTACGCTC ACCAGCTGCA GCCCATTCAC TATCGAGTCT ATGACAGCAA TTCTCAGCTG 
GCTGAGGCCC TGAGTGTGCC ACCGGAGCGT GATTCTGAGT CTGACCCCAC TGATGACAGT 
GGCAGTGACA GCATGGACTA TGATGACTCA AGCTCTTCTT ACTCCTCCCT GGGGGACTTC 
GTCAGTGAAA TGATGAAGTG TGACATCAAT GGCGACACTC CCAATGTGGA TCCTCTGACG 
CATGCGGCCC TGGGAGACGC CAGTGAAGTG GAGATTGATG AGCTGCAGCC CCAGAAGGAG 
GGAGAGGAGC CTGGCCCAGA CAGTGAGAAC TCTCAGGAGA ACCTTCCCCT GCGCTCCAGC 
TCCAGCACCA CTGCCAGCAG TAGCCCTAGC ACCATCGTCC ACGGCGCCCA CTCTGAACCT 
GCTGATTCTA CAGAGGTGGG AGATAAGGCA GCAACAGGCA TCTCCAAGCC CCTCCCTCCT 
GTGCCTCCCA GCATTTGCAA ATCTACTGTG GACAGGAGAC AGACAGAGAC TGGAGAGGGG 
TCAGTGTGCC AGCGAACCTA CGACCATCCA TATTTTGAGC CCCAATATGG CTCCCCCGCT 
GAGGAAGATG ATGACGAGCA GGGAGAGAGC TACACGCCCC GGTTCAGCCA ACATGCCAGT 
GGCAGTCGGG CTCAAAAGCT GCTGCGGCCC AACAGCTTGA AGCTGGCCAG TGACTCAGAC 
GCAGAGTCAG ACTCCCGAGC AAGCTCTCCC AACTCCACCG TCTCTAACAA CAGCACCGAG 
GGCTTCGGGG GCATCATGTC TTTTGCTAGC AGCCTGTATC GGAACCATAG TACAAGCTTC 
AGCCTTTCAA ACCTCACACT GCCCACCAAA GGTGCCCGAG AGAAGACTAC ACCATTCCCC 
AGCCTGAAAG GAAACAGGAG GGCCTTAGTG GACCAGAAAT CATCTGTCAT TAAACACAGC 
CCAACTGTGA AAAGAGAACC TCCATCACCG CAGGGCCGGT CCAGCAATTC TAGCGAGAAC 
CAACAGTTCC TGAAGGAGGT GGTCCACAGT GTGCTGGATG GCCAGGGAGT CGGCTGGCTC 
AACATGAAAA AGGTGCGCCG GCTGCTGGAG AGTGAGCAGC TCCGAGTCTT TGTACTGAGC 
AAGCTGAGTC GTGCAGTGCA GTCAGAGGAT GATGCCCGAC AGGATGTCAT CCAGGATGTG 
GAGATCAGTC GGAAGGTGTA CAAGGGAATG CTAGACCTCC TCAAGTGCAC AGTCCTCAGC 
CTCGAGCAGT CCTATGCCCA TGCTGGTCTG GGTGGCATGG CCAGCATCTT TGGGCTTTTG 
GAGATTGCCC AGACCCATTA CTATAGTAAA GAACCAGACA AACGCAAGAG AAGTCCAACA 
GAGAATGTAA ATACCCCAGT TGGCAAGGAT CCTGGTCTGG CTGGGCGGGG GGACCCAAAG 
GCAATGGCTC AGCTAAGGGT CCCTCAGCTG GGTCCTCGGG CACCAAGTGC TACAGGAAGG 
GGTCCTAAAG AACTGGACAC CAGAAGTTTA AAGGAAGAGA ATTTTGTAGC GTCTGTGGGA 
CCAGAGGTCA TCAAGCCTGT CTTTGACCTG GGTGAGACTG AGGAGAAAAA GTCCCAGATC 
AGCGCAGACA GTGGTGTGAG CCTGGCATCT GCTTCCCAGA GGACTGATCA AGACTCTGTC 
ATCGGTGTGA GTCCAGCTGT TATGATCCGA AGCTCAAGTC AGGATTCTGA AGTGAGTAAC 
AGTTCAGGAG AGACCCTCGG AGCAGACAGT GACCTGAGCA GCAATGCAGG TGATGGGCCA 
GGAGGCGAAG GCAGTGCCCA CTTGGCAAGT TCTCGGGCTA CTCTGTCTGA CAGTGAAATT 
GAAACCAATT CTGCTACAAG CACCATCTTT GGTAAAGCCC ATAGCTTGAA GCCAAAGGAG 
AAGCCGGCTA GTAGTCCAGT TCGCTCTTCC GAAGATGTAA GCCAGCGAGT CTATCTCTAT 
GAGGGACTAC TAGGAAGGGA CAAAGGATCC ATGTGGGACC AGTTAGAGGA TGCTGCTATG 
GAGACCTTTT CTATAAGCAA AGAGCGGTCT ACTTTATGGG ACCAAATGCA GTTCTGGGAA 
GATGCGTTCC TAGATGCTGT GATGTTGGAA AGAGAAGGAA TGGGTATGGA CCAGGGCCCT 
CAGGAAATGA TCGACAGGTA CCTGTCCCTA GGAGAGCATG ACCGGAAGCG CCTGGAGGAT 
GATGAAGATC GCTTACTGGC CACACTCTTA CACAACCTCA TATCCTATAT GCTCCTGATG 
AAGGTGAACA AGAACGACAT CAGGAAGAAA GTACGGCGCC TAATGGGAAA GTCCCACGTT 
GGGCTGGTGT ACAGTCAACA AATCAATGAG GTGCTCGATC AGCTGACCAA CCTGAATGGG 
CGTGATCTCT CCATCCGATC CAGTGGCAGC AGGCACATGA AGAAGCAGAC GTTCGTTGTG 
CACGCAGGGA CGGACACAAA TGGAGATATC TTTTTCATGG AAGTGTGTGA CGACTGTGTG 
GTCTTACGTA GTAACATCGG GACAGTGTAC GAGCGCTGGT GGTATGAGAA GCTTATCAAC 
ATGACCTACT GTCCCAAGAC CAAGGTCCTG TGCTTATGGC GTAGAAATGG CTCTGAGACG 
CAGCTCAACA AGTTCTATAC CAAGAAGTGT CGGGAGCTGT ACTACTGTGT GAAGGACAGC 
ATGGAGCGTG CGGCTGCCCG GCAACAAAGC ATCAAACCCG GGCCTGAACT AGGTGGTGAG 
TTCCCTGTGC AGGACATGAA GACTGGAGAG GGCGGCTTGC TTCAGGTCAC CCTGGAAGGG 
ATCAATCTCA AGTTCATGCA TAACCAGGTT TTCATAGAGC TGAATCACAT TAAAAAGTGC 
AATACAGTTC GAGGCGTCTT TGTCCTGGAA GAATTTGTTC CTGAAATTAA AGAAGTGGTG 
AGCCACAAGT ACAAGACTCC AATGGCCCAC GAGATCTGCT ATTCTGTGTT GTGTCTCTTC 
TCGTATGTGG CCGCAGTTCG TAGCAGTGAA GAAGACCTCC GAACCCCACC TCGGCCTGTC 
TCTAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446037.1
CDS	192..5000
Translation	MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKAEGGAGPRGKEGAHAPCASEEAATESSESGSTLQPPSADSTPDVNQSPRGKRRAKAGNRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKPGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEVQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQETPLLLGRFSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSESDPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGEEPGPDSENSQENLPLRSSSSTTASSSPSTIVHGAHSEPADSTEVGDKAATGISKPLPPVPPSICKSTVDRRQTETGEGSVCQRTYDHPYFEPQYGSPAEEDDDEQGESYTPRFSQHASGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKTTPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLSRAVQSEDDARQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGRGPKELDTRSLKEENFVASVGPEVIKPVFDLGETEEKKSQISADSGVSLASASQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSTIFGKAHSLKPKEKPASSPVRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHVGLVYSQQINEVLDQLTNLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVRSSEEDLRTPPRPVSS

Target ORF information:

RefSeq Version	NM_053585.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAP-kinase activating death domain (Madd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053585.1

ORF Insert Sequence:

ATGGTGCAAA AGAAGTTCTG CCCTCGGTTA CTTGACTATC TAGTGATCGT AGGGGCCAGG 
CATCCAAGCA GTGACAGTGT GGCTCAGACT CCTGAACTTC TGCGGAGGTA CCCACTAGAG 
GACCACCCGG AGTTTCCCCT GCCCCCAGAT GTGGTGTTCT TCTGCCAGCC AGAGGGATGT 
CTGAGCGTGC GGCAACGGCG CATGAGCCTC CGAGATGATA CCTCTTTTGT CTTCACCCTA 
ACCGATAAGG ACACTGGAGT CACCCGTTAT GGCATCTGTG TCAACTTCTA CCGTTCCTTT 
CAAAAGCGAA TGCCAAAGGA AAAGGCGGAA GGCGGAGCAG GACCCCGTGG GAAGGAAGGA 
GCTCATGCCC CCTGTGCCTC AGAAGAGGCC GCCACCGAGA GCTCAGAGAG TGGCTCAACC 
TTGCAGCCTC CTAGTGCTGA CTCCACTCCT GACGTAAACC AGTCTCCTCG GGGCAAACGT 
AGGGCAAAAG CAGGCAACCG CTCCCGAAAC AGTACCCTGA CATCCCTGTG TGTGCTTAGC 
CACTACCCTT TCTTCTCTAC CTTCAGAGAG TGTCTGTATA CTCTCAAACG TCTGGTAGAC 
TGCTGTAGTG AACGGCTCCT AGGCAAGAAA CCGGGCATCC CTCGAGGTGT ACAAAGGGAC 
ACCATGTGGC GAATCTTTAC TGGATCACTG CTAGTGGAGG AGAAGTCCAG TGCCCTTCTG 
CATGACCTTC GAGAGATCGA GGCCTGGATC TATCGGTTGC TACGCTCCCC GGTGCCTGTC 
TCTGGGCAGA AGCGAGTGGA CATTGAGGTC CTACCCCAGG AAGTGCAGCA GGCCCTGACA 
TTTGCTCTTC CAGATCCATC CCGGTTCACC CTAGTAGATT TCCCTCTTCA CCTTCCCTTG 
GAACTTCTGG GTGTAGATGC TTGTCTTCAG GTGCTAACCT GCATCCTGTT GGAGCACAAG 
GTGGTGCTAC AGTCTCGAGA CTACAACGCA CTCTCCATGT CTGTGATGGC GTTTGTGGCA 
ATGATCTACC CCCTGGAGTA CATGTTCCCT GTCATCCCGC TGCTTCCCAC CTGCATGGCT 
TCGGCAGAGC AGCTACTCTT GGCTCCAACC CCATATATCA TTGGAGTCCC TGCCAGCTTT 
TTCCTCTATA AGCTAGACTT CAAAATGCCT GATGACGTGT GGCTGGTGGA TCTGGACAGC 
AACAGGGTGA TTGCCCCCAC CAATGCAGAA GTGCTACCCA TCCTGCCAGA ACCGGAATCA 
TTAGAGCTGA AAAAACACTT AAAGCAGGCT CTAGCCAGCA TGAGTCTCAA CACCCAGCCC 
ATTCTTAATC TGGAGAAATT CCATGAGGGC CAGGAGACAC CACTTCTCTT GGGAAGGTTT 
TCTAATGACC TTCAGTCTAC ACCTTCCACT GAATTCAACC CACTCATTTA TGGCAATGAT 
GTAGATTCAG TCGATGTTGC AACGAGAGTG GCCATGGTTC GTTTCTTCAA CTCTGCTAAC 
GTGCTGCAGG GCTTTCAGAT GCACACACGT ACCCTGCGAC TCTTCCCCCG GCCCGTGGTT 
GCCTTCCAAG CTGGCTCCTT TCTGGCCTCA CGCCCCCGGC AGACCCCCTT TGCTGAGAAA 
CTGGCCAGGA CTCAAGCCGT GGAGTACTTT GGAGAATGGA TCCTGAACCC TTCTAACTAT 
GCCTTCCAGC GGATTCACAA CAATACGTTT GATCCAGCCC TCATTGGTGA CAAGCCTAAG 
TGGTACGCTC ACCAGCTGCA GCCCATTCAC TATCGAGTCT ATGACAGCAA TTCTCAGCTG 
GCTGAGGCCC TGAGTGTGCC ACCGGAGCGT GATTCTGAGT CTGACCCCAC TGATGACAGT 
GGCAGTGACA GCATGGACTA TGATGACTCA AGCTCTTCTT ACTCCTCCCT GGGGGACTTC 
GTCAGTGAAA TGATGAAGTG TGACATCAAT GGCGACACTC CCAATGTGGA TCCTCTGACG 
CATGCGGCCC TGGGAGACGC CAGTGAAGTG GAGATTGATG AGCTGCAGCC CCAGAAGGAG 
GGAGAGGAGC CTGGCCCAGA CAGTGAGAAC TCTCAGGAGA ACCTTCCCCT GCGCTCCAGC 
TCCAGCACCA CTGCCAGCAG TAGCCCTAGC ACCATCGTCC ACGGCGCCCA CTCTGAACCT 
GCTGATTCTA CAGAGGTGGG AGATAAGGCA GCAACAGGCA TCTCCAAGCC CCTCCCTCCT 
GTGCCTCCCA GCATTTGCAA ATCTACTGTG GACAGGAGAC AGACAGAGAC TGGAGAGGGG 
TCAGTGTGCC AGCGAACCTA CGACCATCCA TATTTTGAGC CCCAATATGG CTCCCCCGCT 
GAGGAAGATG ATGACGAGCA GGGAGAGAGC TACACGCCCC GGTTCAGCCA ACATGCCAGT 
GGCAGTCGGG CTCAAAAGCT GCTGCGGCCC AACAGCTTGA AGCTGGCCAG TGACTCAGAC 
GCAGAGTCAG ACTCCCGAGC AAGCTCTCCC AACTCCACCG TCTCTAACAA CAGCACCGAG 
GGCTTCGGGG GCATCATGTC TTTTGCTAGC AGCCTGTATC GGAACCATAG TACAAGCTTC 
AGCCTTTCAA ACCTCACACT GCCCACCAAA GGTGCCCGAG AGAAGACTAC ACCATTCCCC 
AGCCTGAAAG GAAACAGGAG GGCCTTAGTG GACCAGAAAT CATCTGTCAT TAAACACAGC 
CCAACTGTGA AAAGAGAACC TCCATCACCG CAGGGCCGGT CCAGCAATTC TAGCGAGAAC 
CAACAGTTCC TGAAGGAGGT GGTCCACAGT GTGCTGGATG GCCAGGGAGT CGGCTGGCTC 
AACATGAAAA AGGTGCGCCG GCTGCTGGAG AGTGAGCAGC TCCGAGTCTT TGTACTGAGC 
AAGCTGAGTC GTGCAGTGCA GTCAGAGGAT GATGCCCGAC AGGATGTCAT CCAGGATGTG 
GAGATCAGTC GGAAGGTGTA CAAGGGAATG CTAGACCTCC TCAAGTGCAC AGTCCTCAGC 
CTCGAGCAGT CCTATGCCCA TGCTGGTCTG GGTGGCATGG CCAGCATCTT TGGGCTTTTG 
GAGATTGCCC AGACCCATTA CTATAGTAAA GAACCAGACA AACGCAAGAG AAGTCCAACA 
GAGAATGTAA ATACCCCAGT TGGCAAGGAT CCTGGTCTGG CTGGGCGGGG GGACCCAAAG 
GCAATGGCTC AGCTAAGGGT CCCTCAGCTG GGTCCTCGGG CACCAAGTGC TACAGGAAGG 
GGTCCTAAAG AACTGGACAC CAGAAGTTTA AAGGAAGAGA ATTTTGTAGC GTCTGTGGGA 
CCAGAGGTCA TCAAGCCTGT CTTTGACCTG GGTGAGACTG AGGAGAAAAA GTCCCAGATC 
AGCGCAGACA GTGGTGTGAG CCTGGCATCT GCTTCCCAGA GGACTGATCA AGACTCTGTC 
ATCGGTGTGA GTCCAGCTGT TATGATCCGA AGCTCAAGTC AGGATTCTGA AGTGAGTAAC 
AGTTCAGGAG AGACCCTCGG AGCAGACAGT GACCTGAGCA GCAATGCAGG TGATGGGCCA 
GGAGGCGAAG GCAGTGCCCA CTTGGCAAGT TCTCGGGCTA CTCTGTCTGA CAGTGAAATT 
GAAACCAATT CTGCTACAAG CACCATCTTT GGTAAAGCCC ATAGCTTGAA GCCAAAGGAG 
AAGCCGGCTA GTAGTCCAGT TCGCTCTTCC GAAGATGTAA GCCAGCGAGT CTATCTCTAT 
GAGGGACTAC TAGGAAGGGA CAAAGGATCC ATGTGGGACC AGTTAGAGGA TGCTGCTATG 
GAGACCTTTT CTATAAGCAA AGAGCGGTCT ACTTTATGGG ACCAAATGCA GTTCTGGGAA 
GATGCGTTCC TAGATGCTGT GATGTTGGAA AGAGAAGGAA TGGGTATGGA CCAGGGCCCT 
CAGGAAATGA TCGACAGGTA CCTGTCCCTA GGAGAGCATG ACCGGAAGCG CCTGGAGGAT 
GATGAAGATC GCTTACTGGC CACACTCTTA CACAACCTCA TATCCTATAT GCTCCTGATG 
AAGGTGAACA AGAACGACAT CAGGAAGAAA GTACGGCGCC TAATGGGAAA GTCCCACGTT 
GGGCTGGTGT ACAGTCAACA AATCAATGAG GTGCTCGATC AGCTGACCAA CCTGAATGGG 
CGTGATCTCT CCATCCGATC CAGTGGCAGC AGGCACATGA AGAAGCAGAC GTTCGTTGTG 
CACGCAGGGA CGGACACAAA TGGAGATATC TTTTTCATGG AAGTGTGTGA CGACTGTGTG 
GTCTTACGTA GTAACATCGG GACAGTGTAC GAGCGCTGGT GGTATGAGAA GCTTATCAAC 
ATGACCTACT GTCCCAAGAC CAAGGTCCTG TGCTTATGGC GTAGAAATGG CTCTGAGACG 
CAGCTCAACA AGTTCTATAC CAAGAAGTGT CGGGAGCTGT ACTACTGTGT GAAGGACAGC 
ATGGAGCGTG CGGCTGCCCG GCAACAAAGC ATCAAACCCG GGCCTGAACT AGGTGGTGAG 
TTCCCTGTGC AGGACATGAA GACTGGAGAG GGCGGCTTGC TTCAGGTCAC CCTGGAAGGG 
ATCAATCTCA AGTTCATGCA TAACCAGGTT TTCATAGAGC TGAATCACAT TAAAAAGTGC 
AATACAGTTC GAGGCGTCTT TGTCCTGGAA GAATTTGTTC CTGAAATTAA AGAAGTGGTG 
AGCCACAAGT ACAAGACTCC AATGGCCCAC GAGATCTGCT ATTCTGTGTT GTGTCTCTTC 
TCGTATGTGG CCGCAGTTCG TAGCAGTGAA GAAGACCTCC GAACCCCACC TCGGCCTGTC 
TCTAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
Archives of biochemistry and biophysics536(1)31-7(2013 Aug)
Imai A,Ishida M,Fukuda M,Nashida T,Shimomura H

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
The Journal of cell biology191(2)367-81(2010 Oct)
Yoshimura S,Gerondopoulos A,Linford A,Rigden DJ,Barr FA

KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.
Nature cell biology10(11)1269-79(2008 Nov)
Niwa S,Tanaka Y,Hirokawa N

Purification and properties of Rab3 GEP (DENN/MADD).
Methods in enzymology403254-61(2005)
Sakisaka T,Takai Y

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America101(12)4210-5(2004 Mar)
Del Villar K,Miller CA

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Madd cDNA ORF clone, Rattus norvegicus(Norway rat)

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