Slc5a3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc5a3
Entrez Gene ID	53881
Full Name	solute carrier family 5 (inositol transporters), member 3
Synonyms	AA623876,BF642829,Smit1
General protein information	Preferred Names solute carrier family 5 (inositol transporters), member 3 Names sodium/myo-inositol cotransporter Na(+)/myo-inositol cotransporter sodium myo-inositol transporter 1 solute carrier family 5, member 3 solute carrier family 5, member alpha 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_017391.3	NP_059087.2	sodium/myo-inositol cotransporter

Pathways from BioSystems

Homologies

	SLC5A3	XP_001090103.1
Bos taurus (cattle)	SLC5A3	NP_777032.1
Canis lupus familiaris (dog)	LOC100856716	XP_005638920.1
Gallus gallus (chicken)	SLC5A3	XP_004934589.1
Homo sapiens (human)	SLC5A3	NP_008864.3
Pan troglodytes (chimpanzee)	SLC5A3	XP_003949202.1
Canis lupus familiaris (dog)	SLC5A3	NP_001182069.1
Mus musculus (house mouse)	Slc5a3	NP_059087.2
Rattus norvegicus (Norway rat)	Slc5a3	NP_446167.2
Danio rerio (zebrafish)	LOC568338	XP_005167848.1

Gene Ontology
Bibliography

Related articles in PubMed

Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).
C?rdenas AM, Fern?ndez-Olivares P, D?az-Franulic I, Gonz?lez-Jamett AM, Shimahara T, Segura-Aguilar J, Caviedes R, Caviedes P
Neurotoxicity research32(4)614-623(2017 Nov)

KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk.
Neverisky DL, Abbott GW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(7)2828-2838(2017 Jul)

IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.
Sade Y, Toker L, Kara NZ, Einat H, Rapoport S, Moechars D, Berry GT, Bersudsky Y, Agam G
Translational psychiatry6(12)e968(2016 12)

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.
Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT
Science signaling7(315)ra22(2014 Mar)

Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury.
Mak KM, Lo AC, Lam AK, Yeung PK, Ko BC, Chung SS, Chung SK
Neuro-Signals20(4)237-51(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior
Title: IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.

KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability.
Title: KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification
Title: Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH.

These findings add Mus spicilegus endogenous retrovirus HEMV as a second member to the murine leukemia virus subgroup that uses mSMIT1 to gain entry into cells.
Title: Mus spicilegus endogenous retrovirus HEMV uses murine sodium-dependent myo-inositol transporter 1 as a receptor.

activation of NFAT5 and its downstream SMIT induction is important in protecting neurons from ischemia-induced oxidative stress
Title: Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury.

The following Slc5a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc5a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10736	NM_017391.3 Latest version!	Mus musculus solute carrier family 5 (inositol transporters), member 3 (Slc5a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc5a3 ( NM_017391.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059087.2 Mus musculus solute carrier family 5 (inositol transporters), member 3 (Slc5a3), mRNA.

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CloneID	OMu10736
Clone ID Related Accession (Same CDS sequence)	NM_017391.3
Accession Version	NM_017391.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2157bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	sodium/myo-inositol cotransporter
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK144718.1, AC144408.3 and BF318171.1. On Nov 24, 2007 this sequence version replaced NM_017391.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144718.1, BB649023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGCTG TACTGGAGGC AGCAGACATT GCCGTAGTGG CCCTGTATTT TATCCTGGTC 
ATGTGCATTG GCTTTTTTGC CATGTGGAAA TCTAATAGAA GCACTGTGAG TGGATACTTC 
CTGGCCGGGC GCTCTATGAC CTGGGTGGCG ATTGGTGCCT CTCTGTTTGT GAGCAATATT 
GGGAGTGAAC ACTTCATTGG GCTGGCAGGA TCTGGAGCAG CAAGTGGATT TGCAGTGGGC 
GCATGGGAAT TCAATGCCTT ACTGCTCTTG CAACTTCTGG GATGGGTTTT CATCCCCATT 
TACATCCGGT CAGGGGTATA TACCATGCCT GAATACTTGT CCAAGAGGTT CGGTGGCCAT 
AGGATTCAGG TCTATTTTGC AGCCTTGTCT CTGCTTCTCT ATATCTTCAC CAAGCTCTCA 
GTGGATCTGT ATTCAGGGGC CCTCTTTATC CAGGAGTCCT TGGGTTGGAA CCTTTATGTG 
TCTGTCATCC TGCTCATTGG CATGACTGCT CTGCTGACTG TCACCGGAGG CCTTGTTGCA 
GTGATCTACA CAGACACTCT GCAGGCCCTG CTCATGATCA TTGGGGCGCT CACACTTATG 
GTTATTAGCA TGGTGAAGAT TGGAGGGTTT GAGGAAGTTA AGAGAAGGTA CATGTTGGCC 
TCACCTGATG TTGCTTCCAT TTTGTTGAAG TACAACCTTT CCAACACAAA TGCTTGTATG 
GTCCATCCTA AGGCGAATGC CCTAAAAATG TTGAGAGACC CAACAGATGA AGATGTTCCA 
TGGCCTGGAT TCATTCTTGG GCAAACCCCA GCCTCGGTAT GGTACTGGTG TGCTGACCAA 
GTCATCGTAC AGAGGGTTCT AGCAGCCAAA AACATTGCTC ATGCCAAAGG CTCCACTCTA 
ATGGCTGGCT TCTTGAAGCT TCTACCAATG TTTATCATAG TTGTACCAGG AATGATTTCC 
AGGATAGTGT TTGCTGATGA GATAGCTTGC ATCAACCCAG AACACTGCAT GCAAGTGTGT 
GGAAGCAGAG CTGGCTGCTC CAATATTGCT TACCCACGCC TGGTGATGAC CTTGGTTCCT 
GTGGGCCTTC GGGGCCTGAT GATGGCAGTG ATGATTGCAG CTCTGATGAG TGACTTGGAC 
TCCATCTTTA ACAGCGCCAG TACCATATTC ACCCTCGATG TGTACAAACT TATCCGCAAG 
AGTGCAAGCT CCCGGGAACT AATGATTGTG GGCAGGATAT TTGTGGCTTT TATGGTTGTC 
ATCAGCATAG CATGGGTGCC AATTATTGTG GAGATGCAAG GAGGCCAAAT GTACCTTTAC 
ATCCAGGAGG TGGCAGATTA TCTGACTCCT CCCGTGGCAG CCCTCTTCCT TCTGGCAATT 
TTCTGGAAAC GCTGCAATGA GCAAGGGGCT TTTTATGGTG GAATGGCAGG CTTTGTTCTT 
GGAGCTGTCC GTTTGATACT GGCTTTTACC TACCGTGCTC CTGAGTGTGA TCAACCTGAT 
AACAGGCCAG GCTTCATCAA AGACATCCAT TATATGTACG TGGCTACGGC ATTATTTTGG 
ATCACAGGAC TCATTACTGT GATTGTTAGT CTTCTCACAC CACCTCCCAC AAAGGATCAG 
ATTCGTACCA CTACCTTTTG GTCAAAGAAG ACCCTGGTGA CAAAGGAGAG CTGTTCTCAG 
AAAGACGAAC CATACAAAAT GCAAGAGAAG AGCATCCTGC AGTGCAGCGA GAATAGCGAA 
GTCATCAGCC ATACTATTCC CAACGGGAAG TCTGAAGACA GCATTAAGGG ACTGCAACCT 
GAAGACGTTA ATCTGCTGGT GACATGCCGA GAAGAGGGCA ACCCAGTGGC TTCCATGGGT 
CATTCAGAGG CAGAAACACC AGTAGATGCT TATTCCAATG GGCAAGCAGC TCTCATGGGT 
GAGAGAGAAA GAGAGAAGGA AACGGAAAAT AGAAGCCGGT ATTGGAAGTT CATAGACTGG 
TTTTGTGGCT TTAAGAGTAA AAGCCTTAGC AAGAGGAGCC TCAGAGACTT GATGGATGAG 
GAGGCTGTGT GTTTACAAAT GTTAGAAGAG ACTCCACAAG TTAAAGTGAT CCTAAACATT 
GGACTTTTTG CTGTGTGTTC ACTTGGAATT TTCATGTTTG TTTATTTCTC CTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059087.2
CDS	497..2653
Translation	MRAVLEAADIAVVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMVKIGGFEEVKRRYMLASPDVASILLKYNLSNTNACMVHPKANALKMLRDPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRIVFADEIACINPEHCMQVCGSRAGCSNIAYPRLVMTLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFTYRAPECDQPDNRPGFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTLVTKESCSQKDEPYKMQEKSILQCSENSEVISHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEAETPVDAYSNGQAALMGEREREKETENRSRYWKFIDWFCGFKSKSLSKRSLRDLMDEEAVCLQMLEETPQVKVILNIGLFAVCSLGIFMFVYFSL

Target ORF information:

RefSeq Version	NM_017391.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 5 (inositol transporters), member 3 (Slc5a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017391.3

ORF Insert Sequence:

ATGAGGGCTG TACTGGAGGC AGCAGACATT GCCGTAGTGG CCCTGTATTT TATCCTGGTC 
ATGTGCATTG GCTTTTTTGC CATGTGGAAA TCTAATAGAA GCACTGTGAG TGGATACTTC 
CTGGCCGGGC GCTCTATGAC CTGGGTGGCG ATTGGTGCCT CTCTGTTTGT GAGCAATATT 
GGGAGTGAAC ACTTCATTGG GCTGGCAGGA TCTGGAGCAG CAAGTGGATT TGCAGTGGGC 
GCATGGGAAT TCAATGCCTT ACTGCTCTTG CAACTTCTGG GATGGGTTTT CATCCCCATT 
TACATCCGGT CAGGGGTATA TACCATGCCT GAATACTTGT CCAAGAGGTT CGGTGGCCAT 
AGGATTCAGG TCTATTTTGC AGCCTTGTCT CTGCTTCTCT ATATCTTCAC CAAGCTCTCA 
GTGGATCTGT ATTCAGGGGC CCTCTTTATC CAGGAGTCCT TGGGTTGGAA CCTTTATGTG 
TCTGTCATCC TGCTCATTGG CATGACTGCT CTGCTGACTG TCACCGGAGG CCTTGTTGCA 
GTGATCTACA CAGACACTCT GCAGGCCCTG CTCATGATCA TTGGGGCGCT CACACTTATG 
GTTATTAGCA TGGTGAAGAT TGGAGGGTTT GAGGAAGTTA AGAGAAGGTA CATGTTGGCC 
TCACCTGATG TTGCTTCCAT TTTGTTGAAG TACAACCTTT CCAACACAAA TGCTTGTATG 
GTCCATCCTA AGGCGAATGC CCTAAAAATG TTGAGAGACC CAACAGATGA AGATGTTCCA 
TGGCCTGGAT TCATTCTTGG GCAAACCCCA GCCTCGGTAT GGTACTGGTG TGCTGACCAA 
GTCATCGTAC AGAGGGTTCT AGCAGCCAAA AACATTGCTC ATGCCAAAGG CTCCACTCTA 
ATGGCTGGCT TCTTGAAGCT TCTACCAATG TTTATCATAG TTGTACCAGG AATGATTTCC 
AGGATAGTGT TTGCTGATGA GATAGCTTGC ATCAACCCAG AACACTGCAT GCAAGTGTGT 
GGAAGCAGAG CTGGCTGCTC CAATATTGCT TACCCACGCC TGGTGATGAC CTTGGTTCCT 
GTGGGCCTTC GGGGCCTGAT GATGGCAGTG ATGATTGCAG CTCTGATGAG TGACTTGGAC 
TCCATCTTTA ACAGCGCCAG TACCATATTC ACCCTCGATG TGTACAAACT TATCCGCAAG 
AGTGCAAGCT CCCGGGAACT AATGATTGTG GGCAGGATAT TTGTGGCTTT TATGGTTGTC 
ATCAGCATAG CATGGGTGCC AATTATTGTG GAGATGCAAG GAGGCCAAAT GTACCTTTAC 
ATCCAGGAGG TGGCAGATTA TCTGACTCCT CCCGTGGCAG CCCTCTTCCT TCTGGCAATT 
TTCTGGAAAC GCTGCAATGA GCAAGGGGCT TTTTATGGTG GAATGGCAGG CTTTGTTCTT 
GGAGCTGTCC GTTTGATACT GGCTTTTACC TACCGTGCTC CTGAGTGTGA TCAACCTGAT 
AACAGGCCAG GCTTCATCAA AGACATCCAT TATATGTACG TGGCTACGGC ATTATTTTGG 
ATCACAGGAC TCATTACTGT GATTGTTAGT CTTCTCACAC CACCTCCCAC AAAGGATCAG 
ATTCGTACCA CTACCTTTTG GTCAAAGAAG ACCCTGGTGA CAAAGGAGAG CTGTTCTCAG 
AAAGACGAAC CATACAAAAT GCAAGAGAAG AGCATCCTGC AGTGCAGCGA GAATAGCGAA 
GTCATCAGCC ATACTATTCC CAACGGGAAG TCTGAAGACA GCATTAAGGG ACTGCAACCT 
GAAGACGTTA ATCTGCTGGT GACATGCCGA GAAGAGGGCA ACCCAGTGGC TTCCATGGGT 
CATTCAGAGG CAGAAACACC AGTAGATGCT TATTCCAATG GGCAAGCAGC TCTCATGGGT 
GAGAGAGAAA GAGAGAAGGA AACGGAAAAT AGAAGCCGGT ATTGGAAGTT CATAGACTGG 
TTTTGTGGCT TTAAGAGTAA AAGCCTTAGC AAGAGGAGCC TCAGAGACTT GATGGATGAG 
GAGGCTGTGT GTTTACAAAT GTTAGAAGAG ACTCCACAAG TTAAAGTGAT CCTAAACATT 
GGACTTTTTG CTGTGTGTTC ACTTGGAATT TTCATGTTTG TTTATTTCTC CTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).
Neurotoxicity research32(4)614-623(2017 Nov)
C?rdenas AM,Fern?ndez-Olivares P,D?az-Franulic I,Gonz?lez-Jamett AM,Shimahara T,Segura-Aguilar J,Caviedes R,Caviedes P

KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(7)2828-2838(2017 Jul)
Neverisky DL,Abbott GW

IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.
Translational psychiatry6(12)e968(2016 12)
Sade Y,Toker L,Kara NZ,Einat H,Rapoport S,Moechars D,Berry GT,Bersudsky Y,Agam G

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.
Science signaling7(315)ra22(2014 Mar)
Abbott GW,Tai KK,Neverisky DL,Hansler A,Hu Z,Roepke TK,Lerner DJ,Chen Q,Liu L,Zupan B,Toth M,Haynes R,Huang X,Demirbas D,Buccafusca R,Gross SS,Kanda VA,Berry GT

Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury.
Neuro-Signals20(4)237-51(2012)
Mak KM,Lo AC,Lam AK,Yeung PK,Ko BC,Chung SS,Chung SK

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Slc5a3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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