Slc5a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc5a3
Entrez Gene ID	114507
Full Name	solute carrier family 5 member 3
Synonyms	Smit
General protein information	Preferred Names solute carrier family 5 member 3 Names sodium/myo-inositol cotransporter solute carrier family 5 (inositol transporters), member 3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11
Summary	participate in osmoregulation in cells and tissues [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053715.2	NP_446167.2	sodium/myo-inositol cotransporter

Pathways from BioSystems

Homologies

	SLC5A3	XP_001090103.1
Bos taurus (cattle)	SLC5A3	NP_777032.1
Canis lupus familiaris (dog)	LOC100856716	XP_005638920.1
Gallus gallus (chicken)	SLC5A3	XP_004934589.1
Homo sapiens (human)	SLC5A3	NP_008864.3
Pan troglodytes (chimpanzee)	SLC5A3	XP_003949202.1
Canis lupus familiaris (dog)	SLC5A3	NP_001182069.1
Mus musculus (house mouse)	Slc5a3	NP_059087.2
Rattus norvegicus (Norway rat)	Slc5a3	NP_446167.2
Danio rerio (zebrafish)	LOC568338	XP_005167848.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification and Functional Implications of Sodium/
Li SYT, Cheng STW, Zhang D, Leung PS
Diabetes66(5)1258-1271(2017 05)

Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain.
Buccafusca R, Venditti CP, Kenyon LC, Johanson RA, Van Bockstaele E, Ren J, Pagliardini S, Minarcik J, Golden JA, Coady MJ, Greer JJ, Berry GT
Molecular genetics and metabolism95(1-2)81-95(2008 Sep-Oct)

SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.
Shaldubina A, Johanson RA, O'Brien WT, Buccafusca R, Agam G, Belmaker RH, Klein PS, Bersudsky Y, Berry GT
Molecular genetics and metabolism88(4)384-8(2006 Aug)

Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves.
Chau JF, Lee MK, Law JW, Chung SK, Chung SS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology19(13)1887-9(2005 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Myo-inositol transporter SMIT1 is required to maintain a stable phosphoinositide pool in beta-cells in order that phosphoinositide remains available despite its rapid turnover.
Title: Identification and Functional Implications of Sodium/

Basolateral Na+-MI cotransporter activity is maximal at physiological pH values of MTAL cells and interstitium, and a powerful modulation of the transporter activity may be exerted by pHe and pHi.
Title: pH dependence of Na+/myo-inositol cotransporters in rat thick limb cells.

Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat brain.
Title: Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat brain.

The following Slc5a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc5a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41405	NM_053715.2 Latest version!	Rattus norvegicus solute carrier family 5 member 3 (Slc5a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc5a3 ( NM_053715.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446167.2 Rattus norvegicus solute carrier family 5 member 3 (Slc5a3), mRNA.

Price & Availability↑

CloneID	ORa41405
Clone ID Related Accession (Same CDS sequence)	NM_053715.2
Accession Version	NM_053715.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2157bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Rattus norvegicus(Norway rat)
Product	sodium/myo-inositol cotransporter
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA513484.1, AY231162.1 and BE116021.1. On Nov 23, 2005 this sequence version replaced NM_053715.1.

ATGAGGGCTG TGCTGGAGAC AGCAGACATT GCCATAGTGG CCCTGTATTT TGTCCTGGTC 
ATGTGCATTG GTTTCTTTGC CATGTGGAAA TCTAATAGAA GCACTGTGAG TGGATACTTC 
CTGGCCGGGC GCTCTATGAC CTGGGTGGCC ATTGGTGCCT CTCTGTTTGT GAGCAATATT 
GGGAGTGAAC ACTTCATTGG GCTGGCAGGA TCTGGAGCAG CCAGTGGATT TGCAGTGGGC 
GCATGGGAGT TCAATGCCTT GCTGCTCTTG CAACTTCTGG GATGGGTTTT CATCCCTATT 
TACATCCGCT CAGGGGTGTA CACCATGCCT GAATATTTGT CCAAGAGGTT CGGTGGCCAT 
AGGATTCAGG TCTATTTTGC GGCCTTGTCC CTGCTCCTCT ATATCTTCAC CAAGCTCTCG 
GTGGATCTGT ACTCAGGGGC CCTCTTTATC CAGGAGTCCT TGGGTTGGAA CCTTTATGTG 
TCTGTCATCC TGCTCATTGG CATGACTGCT CTGCTGACCG TCACTGGAGG CCTTGTTGCA 
GTGATCTACA CAGACACTCT CCAGGCTCTG CTCATGATCA TTGGGGCACT GACACTTATG 
GTTATTAGCA TGATGAAGGT TGGAGGGTTT GAGGAAGTTA AGAGAAGGTA CATGTTGGCC 
TCACCCAATG TTGCTTCCAT TTTGTTGACA CACAACCTTT CCAACACAAA TTCTTGTATG 
GTGCATCCTA AGGCAGATGC CCTAAAGATG TTGAGAGATC CAACAGATGA AGACGTCCCA 
TGGCCTGGAT TCATTCTTGG GCAGACCCCA GCCTCGGTAT GGTACTGGTG TGCTGACCAA 
GTCATCGTGC AGAGGGTTCT AGCAGCCAAA AACATTGCTC ATGCCAAAGG TTCTACTCTG 
ATGGCTGGCT TCTTGAAGCT CCTACCAATG TTTATCATAG TCGTACCCGG AATGATTTCC 
AGGATACTGT TTGTTGATGA TATAGCTTGC ATCAACCCAG AACACTGCAT GCAAGTGTGT 
GGAAGCAGAG CTGGGTGCTC CAATATTGCT TACCCACGCC TGGTGATGGA GTTGGTTCCC 
GTGGGCCTTC GGGGCCTGAT GATGGCAGTG ATGATTGCAG CTCTGATGAG CGACTTGGAC 
TCCATCTTTA ACAGCGCCAG TACCATATTC ACCCTCGATG TGTACAAGCT TCTCCGCAAC 
AATGCAAGCT CGCGGGAACT GATGATTGTG GGCAGGATAT TTGTGGCTTT TATGGTTGTC 
ATCAGCATAG CATGGGTGCC AATTATTGTG GAGATGCAAG GAGGCCAAAT GTACCTTTAT 
ATCCAGGAGG TGGCGGATTA TCTGACCCCT CCGGTGGCGG CCCTCTTCCT TCTGGCAATT 
TTCTGGAAAC GTTGCAATGA GCAAGGGGCT TTCTATGGTG GAATGGCAGG TTTTGTTCTT 
GGAGCTATCC GTTTGATACT GGCTTTCACC TACCGTGCTC CTGAGTGTGA CCAACCTGAT 
AACAGGCCCA GCTTCATCAA AGACATCCAT TATATGTATG TGGCTACAGC ATTATTTTGG 
ATCACAGGAC TCATTACTGT AATTGTTAGT CTTCTCACAC CACCTCCCAC GAAGGATCAG 
ATTCGTACCA CTACCTTTTG GTCAAAAAAG ACTGTGGTGA CGAAGGAGAG TTGCTCTCAG 
AAAGACGAAC CATATAAAAT GCAAGAGAAG AGTATTCTGC GATGCAGTGA GAATAGTGAA 
GTCGTCAGCC ACACTATTCC CAATGGGAAG TCTGAAGACA GCATTAAGGG GCTCCAACCT 
GAAGACGTTA ATCTGCTGGT GACATGCCGA GAGGAGGGCA ACCCAGTGGC TTCCATGGGT 
CATTCAGAAG CAGAAACACC AGTAGATGCT TATTCCAATG GGCAAGCAGC TCTCATGGGT 
GAGAGAGCGC GAGAGAAGGA AACAGAAAGT AGAAGCCGGT ATTGGAAGTT CATAGACTGG 
TTTTGTGGCT TTAAAAGTAG AAGCCTGAGC AAGAGGAGCC TCAGAGACTC GATGGACGAG 
GAGGCCGTTT GTTTGCAGAT GTTAGAGGAG ACCCCACGAG TCAGAGTGAT CCTAAACATT 
GGACTTTTTG CTGTGTGTTC ACTCGGGATT TTCATGTTTG TTTATTTCTC CTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446167.2
CDS	60..2216
Translation	MRAVLETADIAIVALYFVLVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMMKVGGFEEVKRRYMLASPNVASILLTHNLSNTNSCMVHPKADALKMLRDPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFVDDIACINPEHCMQVCGSRAGCSNIAYPRLVMELVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLLRNNASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAIRLILAFTYRAPECDQPDNRPSFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTVVTKESCSQKDEPYKMQEKSILRCSENSEVVSHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEAETPVDAYSNGQAALMGERAREKETESRSRYWKFIDWFCGFKSRSLSKRSLRDSMDEEAVCLQMLEETPRVRVILNIGLFAVCSLGIFMFVYFSL

Target ORF information:

RefSeq Version	NM_053715.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 5 member 3 (Slc5a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053715.2

ORF Insert Sequence:

ATGAGGGCTG TGCTGGAGAC AGCAGACATT GCCATAGTGG CCCTGTATTT TGTCCTGGTC 
ATGTGCATTG GTTTCTTTGC CATGTGGAAA TCTAATAGAA GCACTGTGAG TGGATACTTC 
CTGGCCGGGC GCTCTATGAC CTGGGTGGCC ATTGGTGCCT CTCTGTTTGT GAGCAATATT 
GGGAGTGAAC ACTTCATTGG GCTGGCAGGA TCTGGAGCAG CCAGTGGATT TGCAGTGGGC 
GCATGGGAGT TCAATGCCTT GCTGCTCTTG CAACTTCTGG GATGGGTTTT CATCCCTATT 
TACATCCGCT CAGGGGTGTA CACCATGCCT GAATATTTGT CCAAGAGGTT CGGTGGCCAT 
AGGATTCAGG TCTATTTTGC GGCCTTGTCC CTGCTCCTCT ATATCTTCAC CAAGCTCTCG 
GTGGATCTGT ACTCAGGGGC CCTCTTTATC CAGGAGTCCT TGGGTTGGAA CCTTTATGTG 
TCTGTCATCC TGCTCATTGG CATGACTGCT CTGCTGACCG TCACTGGAGG CCTTGTTGCA 
GTGATCTACA CAGACACTCT CCAGGCTCTG CTCATGATCA TTGGGGCACT GACACTTATG 
GTTATTAGCA TGATGAAGGT TGGAGGGTTT GAGGAAGTTA AGAGAAGGTA CATGTTGGCC 
TCACCCAATG TTGCTTCCAT TTTGTTGACA CACAACCTTT CCAACACAAA TTCTTGTATG 
GTGCATCCTA AGGCAGATGC CCTAAAGATG TTGAGAGATC CAACAGATGA AGACGTCCCA 
TGGCCTGGAT TCATTCTTGG GCAGACCCCA GCCTCGGTAT GGTACTGGTG TGCTGACCAA 
GTCATCGTGC AGAGGGTTCT AGCAGCCAAA AACATTGCTC ATGCCAAAGG TTCTACTCTG 
ATGGCTGGCT TCTTGAAGCT CCTACCAATG TTTATCATAG TCGTACCCGG AATGATTTCC 
AGGATACTGT TTGTTGATGA TATAGCTTGC ATCAACCCAG AACACTGCAT GCAAGTGTGT 
GGAAGCAGAG CTGGGTGCTC CAATATTGCT TACCCACGCC TGGTGATGGA GTTGGTTCCC 
GTGGGCCTTC GGGGCCTGAT GATGGCAGTG ATGATTGCAG CTCTGATGAG CGACTTGGAC 
TCCATCTTTA ACAGCGCCAG TACCATATTC ACCCTCGATG TGTACAAGCT TCTCCGCAAC 
AATGCAAGCT CGCGGGAACT GATGATTGTG GGCAGGATAT TTGTGGCTTT TATGGTTGTC 
ATCAGCATAG CATGGGTGCC AATTATTGTG GAGATGCAAG GAGGCCAAAT GTACCTTTAT 
ATCCAGGAGG TGGCGGATTA TCTGACCCCT CCGGTGGCGG CCCTCTTCCT TCTGGCAATT 
TTCTGGAAAC GTTGCAATGA GCAAGGGGCT TTCTATGGTG GAATGGCAGG TTTTGTTCTT 
GGAGCTATCC GTTTGATACT GGCTTTCACC TACCGTGCTC CTGAGTGTGA CCAACCTGAT 
AACAGGCCCA GCTTCATCAA AGACATCCAT TATATGTATG TGGCTACAGC ATTATTTTGG 
ATCACAGGAC TCATTACTGT AATTGTTAGT CTTCTCACAC CACCTCCCAC GAAGGATCAG 
ATTCGTACCA CTACCTTTTG GTCAAAAAAG ACTGTGGTGA CGAAGGAGAG TTGCTCTCAG 
AAAGACGAAC CATATAAAAT GCAAGAGAAG AGTATTCTGC GATGCAGTGA GAATAGTGAA 
GTCGTCAGCC ACACTATTCC CAATGGGAAG TCTGAAGACA GCATTAAGGG GCTCCAACCT 
GAAGACGTTA ATCTGCTGGT GACATGCCGA GAGGAGGGCA ACCCAGTGGC TTCCATGGGT 
CATTCAGAAG CAGAAACACC AGTAGATGCT TATTCCAATG GGCAAGCAGC TCTCATGGGT 
GAGAGAGCGC GAGAGAAGGA AACAGAAAGT AGAAGCCGGT ATTGGAAGTT CATAGACTGG 
TTTTGTGGCT TTAAAAGTAG AAGCCTGAGC AAGAGGAGCC TCAGAGACTC GATGGACGAG 
GAGGCCGTTT GTTTGCAGAT GTTAGAGGAG ACCCCACGAG TCAGAGTGAT CCTAAACATT 
GGACTTTTTG CTGTGTGTTC ACTCGGGATT TTCATGTTTG TTTATTTCTC CTTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification and Functional Implications of Sodium/
Diabetes66(5)1258-1271(2017 05)
Li SYT,Cheng STW,Zhang D,Leung PS

Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain.
Molecular genetics and metabolism95(1-2)81-95(2008 Sep-Oct)
Buccafusca R,Venditti CP,Kenyon LC,Johanson RA,Van Bockstaele E,Ren J,Pagliardini S,Minarcik J,Golden JA,Coady MJ,Greer JJ,Berry GT

SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.
Molecular genetics and metabolism88(4)384-8(2006 Aug)
Shaldubina A,Johanson RA,O'Brien WT,Buccafusca R,Agam G,Belmaker RH,Klein PS,Bersudsky Y,Berry GT

Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology19(13)1887-9(2005 Nov)
Chau JF,Lee MK,Law JW,Chung SK,Chung SS

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Slc5a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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