SGPL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SGPL1
Entrez Gene ID	8879
Full Name	sphingosine-1-phosphate lyase 1
Synonyms	NPHS14,S1PL,SPL
General protein information	Preferred Names sphingosine-1-phosphate lyase 1 Names sphingosine-1-phosphate lyase 1 SP-lyase 1 SPL 1 hSPL sphingosine-1-phosphate aldolase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q22.1
Disorder MIM:	603729
Disorder Html:	Nephrotic syndrome 14, 617575 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011540316.1	XP_011538618.1	sphingosine-1-phosphate lyase 1 isoform X1
NM_003901.3	NP_003892.2	sphingosine-1-phosphate lyase 1
NM_003901.4	NP_003892.2	sphingosine-1-phosphate lyase 1
XM_005270263.1	XP_005270320.1	sphingosine-1-phosphate lyase 1 isoform X1
XM_006718053.1	XP_006718116.1	sphingosine-1-phosphate lyase 1 isoform X2
XM_011540316.2	XP_011538618.1	sphingosine-1-phosphate lyase 1 isoform X1
XM_011540318.1	XP_011538620.1	sphingosine-1-phosphate lyase 1 isoform X2
XM_011540317.1	XP_011538619.1	sphingosine-1-phosphate lyase 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SGPL1	XP_001171432.1
	SGPL1	XP_001106861.2
Saccharomyces cerevisiae (baker's yeast)	DPL1	NP_010580.1
Oryza sativa (rice)	Os01g0100900	NP_001041740.2
Canis lupus familiaris (dog)	SGPL1	XP_546150.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001724	XP_321361.5
Caenorhabditis elegans (roundworm)	tag-38	NP_505372.1
Magnaporthe oryzae (rice blast fungus)	MGG_07162	XP_003715360.1
Xenopus tropicalis (tropical clawed frog)	sgpl1	XP_002943540.2
Bos taurus (cattle)	SGPL1	NP_001091522.1
Homo sapiens (human)	SGPL1	NP_003892.2
Mus musculus (house mouse)	Sgpl1	NP_033189.2
Rattus norvegicus (Norway rat)	Sgpl1	NP_775139.1
Gallus gallus (chicken)	SGPL1	NP_001007947.1
Danio rerio (zebrafish)	sgpl1	NP_001082938.1
Drosophila melanogaster (fruit fly)	Sply	NP_725652.1
Kluyveromyces lactis	KLLA0C10505g	XP_452668.1
Neurospora crassa	NCU06761	XP_963533.1
Arabidopsis thaliana (thale cress)	DPL1	NP_174119.1

Gene Ontology
Bibliography

Related articles in PubMed

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.
Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E
Nature communications8(1)623(2017 09)

Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.
Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B
Journal of immunology (Baltimore, Md. : 1950)199(2)677-687(2017 Jul)

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely DM, Vuono R, Castaldo S, Digilio AF, Scalabr? F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V
Scientific reports7(1)5280(2017 Jul)

Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.
Janecke AR, Xu R, Steichen-Gersdorf E, Waldegger S, Entenmann A, Giner T, Krainer I, Huber LA, Hess MW, Frishberg Y, Barash H, Tzur S, Schreyer-Shafir N, Sukenik-Halevy R, Zehavi T, Raas-Rothschild A, Mao C, M?ller T
Human mutation38(4)365-372(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study verifies the role of a high-ranked gene in dysregulation of sphingolipid metabolism in the disease and demonstrate that inhibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's disease models.
Title: Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL
Title: Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.

Loss of SGPL1 function is associated with congenital nephrotic syndrome (CNS), adrenal calcifications, and hypogonadism.
Title: Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
Title: Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
Title: Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.

The following SGPL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SGPL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03609	NM_003901.4 Latest version!	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu03609	XM_011540316.2 Latest version!	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu03609	XM_005270263.1 Latest version!	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu03609	XM_011540317.1 Latest version!	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu44661	XM_006718053.1 Latest version!	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu44661	XM_011540318.1 Latest version!	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OHu03609	NM_003901.3	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu03609	XM_011540316.1	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SGPL1 ( NM_003901.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003892.2 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), mRNA.

Price & Availability↑

CloneID	OHu03609
Clone ID Related Accession (Same CDS sequence)	XM_011540316.1 , NM_003901.3 , NM_003901.4 , XM_005270263.1 , XM_011540316.2 , XM_011540317.1
Accession Version	NM_003901.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP314104.1, BC052991.1 and AC073176.8. On Aug 27, 2008 this sequence version replaced NM_003901.2. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB033078.1, SRR1803611.239280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003892.2
CDS	223..1929
Translation	MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	NM_003901.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003901.3

ORF Insert Sequence:

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( NM_003901.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003892.2 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), mRNA.

Price & Availability↑

CloneID	OHu03609
Clone ID Related Accession (Same CDS sequence)	XM_011540316.1 , NM_003901.3 , NM_003901.4 , XM_005270263.1 , XM_011540316.2 , XM_011540317.1
Accession Version	NM_003901.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP314104.1, BC052991.1 and AC073176.8. On May 17, 2019 this sequence version replaced NM_003901.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB033078.1, SRR1803611.239280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373202.8/ ENSP00000362298.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003892.2
CDS	223..1929
Translation	MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	NM_003901.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003901.4

ORF Insert Sequence:

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( XM_011540316.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538618.1 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03609
Clone ID Related Accession (Same CDS sequence)	XM_011540316.1 , NM_003901.3 , NM_003901.4 , XM_005270263.1 , XM_011540316.2 , XM_011540317.1
Accession Version	XM_011540316.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	sphingosine-1-phosphate lyase 1 isoform X1
Comment

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011538618.1

Translation

MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	XM_011540316.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540316.1

ORF Insert Sequence:

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( XM_005270263.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270320.1 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03609
Clone ID Related Accession (Same CDS sequence)	XM_011540316.1 , NM_003901.3 , NM_003901.4 , XM_005270263.1 , XM_011540316.2 , XM_011540317.1
Accession Version	XM_005270263.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270320.1
CDS	236..1942
Translation	MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	XM_005270263.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270263.1

ORF Insert Sequence:

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( XM_011540316.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538618.1 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03609
Clone ID Related Accession (Same CDS sequence)	XM_011540316.1 , NM_003901.3 , NM_003901.4 , XM_005270263.1 , XM_011540316.2 , XM_011540317.1
Accession Version	XM_011540316.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011540316.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538618.1
CDS	282..1988
Translation	MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	XM_011540316.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540316.2

ORF Insert Sequence:

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( XM_011540317.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538619.1 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu03609
Clone ID Related Accession (Same CDS sequence)	XM_011540316.1 , NM_003901.3 , NM_003901.4 , XM_005270263.1 , XM_011540316.2 , XM_011540317.1
Accession Version	XM_011540317.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538619.1
CDS	132..1838
Translation	MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	XM_011540317.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540317.1

ORF Insert Sequence:

ATGCCTAGCA CAGACCTTCT GATGTTGAAG GCCTTTGAGC CCTACTTAGA GATTTTGGAA 
GTATACTCCA CAAAAGCCAA GAATTATGTA AATGGACATT GCACCAAGTA TGAGCCCTGG 
CAGCTAATTG CATGGAGTGT CGTGTGGACC CTGCTGATAG TCTGGGGATA TGAGTTTGTC 
TTCCAGCCAG AGAGTTTATG GTCAAGGTTT AAAAAGAAAT GTTTTAAGCT CACCAGGAAG 
ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( XM_006718053.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_006718116.1 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu44661
Clone ID Related Accession (Same CDS sequence)	XM_006718053.1 , XM_011540318.1
Accession Version	XM_006718053.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006718116.1
CDS	578..2044
Translation	MPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	XM_006718053.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718053.1

ORF Insert Sequence:

ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SGPL1 ( XM_011540318.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538620.1 Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu44661
Clone ID Related Accession (Same CDS sequence)	XM_006718053.1 , XM_011540318.1
Accession Version	XM_011540318.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingosine-1-phosphate lyase 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538620.1
CDS	393..1859
Translation	MPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

Target ORF information:

RefSeq Version	XM_011540318.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate lyase 1 (SGPL1), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540318.1

ORF Insert Sequence:

ATGCCCATTA TTGGTCGTAA GATTCAAGAC AAGTTGAACA AGACCAAGGA TGATATTAGC 
AAGAACATGT CATTCCTGAA AGTGGACAAA GAGTATGTGA AAGCTTTACC CTCCCAGGGT 
CTGAGCTCAT CTGCTGTTTT GGAGAAACTT AAGGAGTACA GCTCTATGGA CGCCTTCTGG 
CAAGAGGGGA GAGCCTCTGG AACAGTGTAC AGTGGGGAGG AGAAGCTCAC TGAGCTCCTT 
GTGAAGGCTT ATGGAGATTT TGCATGGAGT AACCCCCTGC ATCCAGATAT CTTCCCAGGA 
CTACGCAAGA TAGAGGCAGA AATCGTGAGG ATAGCTTGTT CCCTGTTCAA TGGGGGACCA 
GATTCGTGTG GATGTGTGAC TTCTGGGGGA ACAGAAAGCA TACTGATGGC CTGCAAAGCA 
TATCGGGATC TGGCCTTTGA GAAGGGGATC AAAACTCCAG AAATTGTGGC TCCCCAAAGT 
GCCCATGCTG CATTTAACAA AGCAGCCAGT TACTTTGGGA TGAAGATTGT GCGGGTCCCA 
TTGACGAAGA TGATGGAGGT GGATGTGCGG GCAATGAGAA GAGCTATCTC CAGGAACACT 
GCCATGCTCG TCTGTTCTAC CCCACAGTTT CCTCATGGTG TAATAGATCC TGTCCCTGAA 
GTGGCCAAGC TGGCTGTCAA ATACAAAATA CCCCTTCATG TCGACGCTTG TCTGGGAGGC 
TTCCTCATCG TCTTTATGGA GAAAGCAGGA TACCCACTGG AGCACCCATT TGATTTCCGG 
GTGAAAGGTG TAACCAGCAT TTCAGCTGAC ACCCATAAGT ATGGCTATGC CCCAAAAGGC 
TCATCATTGG TGTTGTATAG TGACAAGAAG TACAGGAACT ATCAGTTCTT CGTCGATACA 
GATTGGCAGG GTGGCATCTA TGCTTCCCCA ACCATCGCAG GCTCACGGCC TGGTGGCATT 
AGCGCAGCCT GTTGGGCTGC CTTGATGCAC TTCGGTGAGA ACGGCTATGT TGAAGCTACC 
AAACAGATCA TCAAAACTGC TCGCTTCCTC AAGTCAGAAC TGGAAAATAT CAAAGGCATC 
TTTGTTTTTG GGAATCCCCA ATTGTCAGTC ATTGCTCTGG GATCCCGTGA TTTTGACATC 
TACCGACTAT CAAACCTGAT GACTGCTAAG GGGTGGAACT TGAACCAGTT GCAGTTCCCA 
CCCAGTATTC ATTTCTGCAT CACATTACTA CACGCCCGGA AACGAGTAGC TATACAATTC 
CTAAAGGACA TTCGAGAATC TGTCACTCAA ATCATGAAGA ATCCTAAAGC GAAGACCACA 
GGAATGGGTG CCATCTATGG CATGGCCCAG ACAACTGTTG ACAGGAATAT GGTTGCAGAA 
TTGTCCTCAG TCTTCTTGGA CAGCTTGTAC AGCACCGACA CTGTCACCCA GGGCAGCCAG 
ATGAATGGTT CTCCAAAACC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.
Nature communications8(1)623(2017 09)
Pirhaji L,Milani P,Dalin S,Wassie BT,Dunn DE,Fenster RJ,Avila-Pacheco J,Greengard P,Clish CB,Heiman M,Lo DC,Fraenkel E

Sphingosine 1-Phosphate Lyase Enhances the Activation of IKK? To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)199(2)677-687(2017 Jul)
Vijayan M,Xia C,Song YE,Ngo H,Studstill CJ,Drews K,Fox TE,Johnson MC,Hiscott J,Kester M,Alexander S,Hahm B

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Scientific reports7(1)5280(2017 Jul)
Di Pardo A,Amico E,Basit A,Armirotti A,Joshi P,Neely DM,Vuono R,Castaldo S,Digilio AF,Scalabr? F,Pepe G,Elifani F,Madonna M,Jeong SK,Park BM,D'Esposito M,Bowman AB,Barker RA,Maglione V

Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.
Human mutation38(4)365-372(2017 Apr)
Janecke AR,Xu R,Steichen-Gersdorf E,Waldegger S,Entenmann A,Giner T,Krainer I,Huber LA,Hess MW,Frishberg Y,Barash H,Tzur S,Schreyer-Shafir N,Sukenik-Halevy R,Zehavi T,Raas-Rothschild A,Mao C,M?ller T

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SGPL1 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

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Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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