TAS2R40 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R40
Entrez Gene ID	259286
Full Name	taste 2 receptor member 40
Synonyms	GPR60,T2R40,T2R58
General protein information	Preferred Names taste 2 receptor member 40 Names taste receptor type 2 member 40 G-protein coupled receptor 60 taste receptor type 2 member 58 taste receptor, type 2, member 40
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017].
Disorder MIM:	613964

mRNA and Protein(s)

mRNA	Protein	Name
NM_176882.2	NP_795363.1	taste receptor type 2 member 40
NM_176882.1	NP_795363.1	taste receptor type 2 member 40

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tas2r144	NP_001001453.1
	TAS2R40	NP_001074233.1
Gallus gallus (chicken)	LOC101749182	XP_004938201.1
Homo sapiens (human)	TAS2R40	NP_795363.1
Pan troglodytes (chimpanzee)	TAS2R40	NP_001009129.1
Rattus norvegicus (Norway rat)	Tas2r144	NP_001020321.1
Canis lupus familiaris (dog)	TAS2R40	NP_001138967.1

Gene Ontology
Bibliography

Related articles in PubMed

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.
Thalmann S, Behrens M, Meyerhof W
Biochemical and biophysical research communications435(2)267-73(2013 May)

Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues.
Onoda K, Hirai R, Takao K, Kokubun S, Ikeda M
The Laryngoscope121(12)2592-7(2011 Dec)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Go Y, Satta Y, Takenaka O, Takahata N
Genetics170(1)313-26(2005 May)

Evolution of bitter taste receptors in humans and apes.
Fischer A, Gilad Y, Man O, P??bo S
Molecular biology and evolution22(3)432-6(2005 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TAS2R40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29688	NM_176882.2 Latest version!	Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu29688	NM_176882.1	Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R40 ( NM_176882.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_795363.1 Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA.

Price & Availability↑

CloneID	OHu29688
Clone ID Related Accession (Same CDS sequence)	NM_176882.2 , NM_176882.1
Accession Version	NM_176882.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 40
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC101795.1. On Jul 20, 2017 this sequence version replaced NM_176882.1. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000408947.4/ ENSP00000386210.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCAACGG TGAACACAGA TGCCACAGAT AAAGACATAT CCAAGTTCAA GGTCACCTTC 
ACTTTGGTGG TCTCCGGAAT AGAGTGCATC ACTGGCATCC TTGGGAGTGG CTTCATCACG 
GCCATCTATG GGGCTGAGTG GGCCAGGGGC AAAACACTCC CCACTGGTGA CCGCATTATG 
TTGATGCTGA GCTTTTCCAG GCTCTTGCTA CAGATTTGGA TGATGCTGGA GAACATTTTC 
AGTCTGCTAT TCCGAATTGT TTATAACCAA AACTCAGTGT ATATCCTCTT CAAAGTCATC 
ACTGTCTTTC TGAACCATTC CAATCTCTGG TTTGCTGCCT GGCTCAAAGT CTTCTATTGT 
CTTAGAATTG CAAACTTCAA TCATCCTTTG TTCTTCCTGA TGAAGAGGAA AATCATAGTG 
CTGATGCCTT GGCTTCTCAG GCTGTCAGTG TTGGTTTCCT TAAGCTTCAG CTTTCCTCTC 
TCGAGAGATG TCTTCAATGT GTATGTGAAT AGCTCCATTC CTATCCCCTC CTCCAACTCC 
ACGGAGAAGA AGTACTTCTC TGAGACCAAT ATGGTCAACC TGGTATTTTT CTATAACATG 
GGGATCTTCG TTCCTCTGAT CATGTTCATC CTGGCAGCCA CCCTGCTGAT CCTCTCTCTC 
AAGAGACACA CCCTACACAT GGGAAGCAAT GCCACAGGGT CCAGGGACCC CAGCATGAAG 
GCTCACATAG GGGCCATCAA AGCCACCAGC TACTTTCTCA TCCTCTACAT TTTCAATGCA 
ATTGCTCTAT TTCTTTCCAC GTCCAACATC TTTGACACTT ACAGTTCCTG GAATATTTTG 
TGCAAGATCA TCATGGCTGC CTACCCTGCC GGCCACTCAG TACAACTGAT CTTGGGCAAC 
CCTGGGCTGA GAAGAGCCTG GAAGCGGTTT CAGCACCAAG TTCCTCTTTA CCTAAAAGGG 
CAGACTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795363.1
CDS	43..1014
Translation	MATVNTDATDKDISKFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDRIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNSVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRDVFNVYVNSSIPIPSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSTSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL

Target ORF information:

RefSeq Version	NM_176882.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176882.2

ORF Insert Sequence:

ATGGCAACGG TGAACACAGA TGCCACAGAT AAAGACATAT CCAAGTTCAA GGTCACCTTC 
ACTTTGGTGG TCTCCGGAAT AGAGTGCATC ACTGGCATCC TTGGGAGTGG CTTCATCACG 
GCCATCTATG GGGCTGAGTG GGCCAGGGGC AAAACACTCC CCACTGGTGA CCGCATTATG 
TTGATGCTGA GCTTTTCCAG GCTCTTGCTA CAGATTTGGA TGATGCTGGA GAACATTTTC 
AGTCTGCTAT TCCGAATTGT TTATAACCAA AACTCAGTGT ATATCCTCTT CAAAGTCATC 
ACTGTCTTTC TGAACCATTC CAATCTCTGG TTTGCTGCCT GGCTCAAAGT CTTCTATTGT 
CTTAGAATTG CAAACTTCAA TCATCCTTTG TTCTTCCTGA TGAAGAGGAA AATCATAGTG 
CTGATGCCTT GGCTTCTCAG GCTGTCAGTG TTGGTTTCCT TAAGCTTCAG CTTTCCTCTC 
TCGAGAGATG TCTTCAATGT GTATGTGAAT AGCTCCATTC CTATCCCCTC CTCCAACTCC 
ACGGAGAAGA AGTACTTCTC TGAGACCAAT ATGGTCAACC TGGTATTTTT CTATAACATG 
GGGATCTTCG TTCCTCTGAT CATGTTCATC CTGGCAGCCA CCCTGCTGAT CCTCTCTCTC 
AAGAGACACA CCCTACACAT GGGAAGCAAT GCCACAGGGT CCAGGGACCC CAGCATGAAG 
GCTCACATAG GGGCCATCAA AGCCACCAGC TACTTTCTCA TCCTCTACAT TTTCAATGCA 
ATTGCTCTAT TTCTTTCCAC GTCCAACATC TTTGACACTT ACAGTTCCTG GAATATTTTG 
TGCAAGATCA TCATGGCTGC CTACCCTGCC GGCCACTCAG TACAACTGAT CTTGGGCAAC 
CCTGGGCTGA GAAGAGCCTG GAAGCGGTTT CAGCACCAAG TTCCTCTTTA CCTAAAAGGG 
CAGACTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAS2R40 ( NM_176882.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_795363.1 Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA.

Price & Availability↑

CloneID	OHu29688
Clone ID Related Accession (Same CDS sequence)	NM_176882.2 , NM_176882.1
Accession Version	NM_176882.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-08-31
Organism	Homo sapiens(Human)
Product	taste receptor type 2 member 40
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF494229.1. ##Evidence-Data-START## Transcript is intronless :: BC101795.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCAACGG TGAACACAGA TGCCACAGAT AAAGACATAT CCAAGTTCAA GGTCACCTTC 
ACTTTGGTGG TCTCCGGAAT AGAGTGCATC ACTGGCATCC TTGGGAGTGG CTTCATCACG 
GCCATCTATG GGGCTGAGTG GGCCAGGGGC AAAACACTCC CCACTGGTGA CCGCATTATG 
TTGATGCTGA GCTTTTCCAG GCTCTTGCTA CAGATTTGGA TGATGCTGGA GAACATTTTC 
AGTCTGCTAT TCCGAATTGT TTATAACCAA AACTCAGTGT ATATCCTCTT CAAAGTCATC 
ACTGTCTTTC TGAACCATTC CAATCTCTGG TTTGCTGCCT GGCTCAAAGT CTTCTATTGT 
CTTAGAATTG CAAACTTCAA TCATCCTTTG TTCTTCCTGA TGAAGAGGAA AATCATAGTG 
CTGATGCCTT GGCTTCTCAG GCTGTCAGTG TTGGTTTCCT TAAGCTTCAG CTTTCCTCTC 
TCGAGAGATG TCTTCAATGT GTATGTGAAT AGCTCCATTC CTATCCCCTC CTCCAACTCC 
ACGGAGAAGA AGTACTTCTC TGAGACCAAT ATGGTCAACC TGGTATTTTT CTATAACATG 
GGGATCTTCG TTCCTCTGAT CATGTTCATC CTGGCAGCCA CCCTGCTGAT CCTCTCTCTC 
AAGAGACACA CCCTACACAT GGGAAGCAAT GCCACAGGGT CCAGGGACCC CAGCATGAAG 
GCTCACATAG GGGCCATCAA AGCCACCAGC TACTTTCTCA TCCTCTACAT TTTCAATGCA 
ATTGCTCTAT TTCTTTCCAC GTCCAACATC TTTGACACTT ACAGTTCCTG GAATATTTTG 
TGCAAGATCA TCATGGCTGC CTACCCTGCC GGCCACTCAG TACAACTGAT CTTGGGCAAC 
CCTGGGCTGA GAAGAGCCTG GAAGCGGTTT CAGCACCAAG TTCCTCTTTA CCTAAAAGGG 
CAGACTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795363.1
CDS	1..972
Translation	MATVNTDATDKDISKFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDRIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNSVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRDVFNVYVNSSIPIPSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSTSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL

Target ORF information:

RefSeq Version	NM_176882.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens taste 2 receptor member 40 (TAS2R40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176882.1

ORF Insert Sequence:

ATGGCAACGG TGAACACAGA TGCCACAGAT AAAGACATAT CCAAGTTCAA GGTCACCTTC 
ACTTTGGTGG TCTCCGGAAT AGAGTGCATC ACTGGCATCC TTGGGAGTGG CTTCATCACG 
GCCATCTATG GGGCTGAGTG GGCCAGGGGC AAAACACTCC CCACTGGTGA CCGCATTATG 
TTGATGCTGA GCTTTTCCAG GCTCTTGCTA CAGATTTGGA TGATGCTGGA GAACATTTTC 
AGTCTGCTAT TCCGAATTGT TTATAACCAA AACTCAGTGT ATATCCTCTT CAAAGTCATC 
ACTGTCTTTC TGAACCATTC CAATCTCTGG TTTGCTGCCT GGCTCAAAGT CTTCTATTGT 
CTTAGAATTG CAAACTTCAA TCATCCTTTG TTCTTCCTGA TGAAGAGGAA AATCATAGTG 
CTGATGCCTT GGCTTCTCAG GCTGTCAGTG TTGGTTTCCT TAAGCTTCAG CTTTCCTCTC 
TCGAGAGATG TCTTCAATGT GTATGTGAAT AGCTCCATTC CTATCCCCTC CTCCAACTCC 
ACGGAGAAGA AGTACTTCTC TGAGACCAAT ATGGTCAACC TGGTATTTTT CTATAACATG 
GGGATCTTCG TTCCTCTGAT CATGTTCATC CTGGCAGCCA CCCTGCTGAT CCTCTCTCTC 
AAGAGACACA CCCTACACAT GGGAAGCAAT GCCACAGGGT CCAGGGACCC CAGCATGAAG 
GCTCACATAG GGGCCATCAA AGCCACCAGC TACTTTCTCA TCCTCTACAT TTTCAATGCA 
ATTGCTCTAT TTCTTTCCAC GTCCAACATC TTTGACACTT ACAGTTCCTG GAATATTTTG 
TGCAAGATCA TCATGGCTGC CTACCCTGCC GGCCACTCAG TACAACTGAT CTTGGGCAAC 
CCTGGGCTGA GAAGAGCCTG GAAGCGGTTT CAGCACCAAG TTCCTCTTTA CCTAAAAGGG 
CAGACTCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.
Biochemical and biophysical research communications435(2)267-73(2013 May)
Thalmann S,Behrens M,Meyerhof W

Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues.
The Laryngoscope121(12)2592-7(2011 Dec)
Onoda K,Hirai R,Takao K,Kokubun S,Ikeda M

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
Genetics170(1)313-26(2005 May)
Go Y,Satta Y,Takenaka O,Takahata N

Evolution of bitter taste receptors in humans and apes.
Molecular biology and evolution22(3)432-6(2005 Mar)
Fischer A,Gilad Y,Man O,P??bo S

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TAS2R40 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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