FGD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGD1
Entrez Gene ID	2245
Full Name	FYVE, RhoGEF and PH domain containing 1
Synonyms	AAS,FGDY,MRXS16,ZFYVE3
General protein information	Preferred Names FYVE, RhoGEF and PH domain containing 1 Names FYVE, RhoGEF and PH domain-containing protein 1 faciogenital dysplasia 1 protein rho/Rac GEF rho/Rac guanine nucleotide exchange factor FGD1 zinc finger FYVE domain-containing protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.22
Summary	This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017].
Disorder MIM:	300546
Disorder Html:	Aarskog-Scott syndrome, 305400 (3); Mental retardation, X-linked syndromic 16, 305400 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004463.3	NP_004454.2	FYVE, RhoGEF and PH domain-containing protein 1
NM_004463.2	NP_004454.2	FYVE, RhoGEF and PH domain-containing protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fgd1	NP_001032635.1
	FGD1	XP_002806297.1
Bos taurus (cattle)	FGD1	NP_001096014.1
Mus musculus (house mouse)	Fgd1	NP_032027.2
Homo sapiens (human)	FGD1	NP_004454.2
Pan troglodytes (chimpanzee)	FGD1	XP_003317524.1
Canis lupus familiaris (dog)	FGD1	XP_549021.2
Xenopus tropicalis (tropical clawed frog)	fgd1	XP_004914246.1
Danio rerio (zebrafish)	fgd1	XP_688794.3

Gene Ontology
Bibliography

Related articles in PubMed

A novel, putatively null, FGD1 variant leading to Aarskog-Scott syndrome in a family from UAE.
Hamzeh AR, Saif F, Nair P, Binjab AJ, Mohamed M, Al-Ali MT, Bastaki F
BMC pediatrics17(1)31(2017 Jan)

A novel splice site mutation of FGD1 gene in an Aarskog-Scott syndrome patient with a large anterior fontanel.
Par?ltay E, Hazan F, Ataman E, Demir K, Etlik ?, ?zbek E, ?zkan B
Journal of pediatric endocrinology & metabolism : JPEM29(9)1111-4(2016 Sep)

Minireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.
Pedigo NG, Van Delden D, Walters L, Farrell CL
Physiological genomics48(7)446-54(2016 Jul)

Aarskog-Scott syndrome: a novel mutation in the FGD1 gene associated with severe craniofacial dysplasia.
V?lter C, Mart?nez R, Hagen R, Kress W
European journal of pediatrics173(10)1373-6(2014 Oct)

No association between FGD1 gene polymorphisms and intellectual developmental disability in the Qinba mountain area.
Li JL, Li YJ, Zhang KJ, Lan L, Shi JG, Yang X, Zhang MJ, Zhang FC, Gao XC
Genetics and molecular research : GMR13(1)127-33(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel variant in FGD1 (a novel hemizygous mutation in FGD1 c.53del (p.Pro18Argfs*106) for which the mother is heterozygous) was found in an Emirati family with two brothers suffering from Aarskog-Scott syndrome. The variant is predicted to be a null mutation, and this is the first report of its kind from the United Arab Emirates.
Title: A novel, putatively null, FGD1 variant leading to Aarskog-Scott syndrome in a family from UAE.

Splice site mutation of FGD1 gene is associated with Aarskog-Scott syndrome patient with a large anterior fontanel.
Title: A novel splice site mutation of FGD1 gene in an Aarskog-Scott syndrome patient with a large anterior fontanel.

Results identify a novel mutation of FDG1 in a family with Aarskog syndrome and underscore the phenotypical variability of this condition.
Title: Aarskog-Scott syndrome: a novel mutation in the FGD1 gene associated with severe craniofacial dysplasia.

No significant association was observed between IDD and allele or genotype frequencies, or the haplotype of the 5 SNPs of the FGD1 gene in the Chinese population.
Title: No association between FGD1 gene polymorphisms and intellectual developmental disability in the Qinba mountain area.

Mutational analyses revealed a novel mutation (c.308-2G), hemizygous in the boy and heterozygous in the mother with Aarskog syndrome.
Title: A novel mutation in a mother and a son with Aarskog-Scott syndrome.

The following FGD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18582	NM_004463.3 Latest version!	Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu18582	NM_004463.2	Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGD1 ( NM_004463.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004454.2 Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.

Price & Availability↑

CloneID	OHu18582
Clone ID Related Accession (Same CDS sequence)	NM_004463.3 , NM_004463.2
Accession Version	NM_004463.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	FYVE, RhoGEF and PH domain-containing protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z85987.13. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2018 this sequence version replaced NM_004463.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KX085484.1, U11690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375135.4/ ENSP00000364277.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCATGGCC ACCGAGCCCC GGGGGGCGCC GGGCCTTCGG AGCCCGAACA CCCGGCCACG 
AACCCGCCGG GCGCCGCTCC GCCGGCCTGT GCCGACTCGG ACCCTGGAGC CTCGGAACCC 
GGACTGCTGG CGCGCAGGGG CTCAGGTTCG GCTCTTGGCG GCCCACTGGA TCCCCAGTTT 
GTCGGACCCT CGGACACCAG CCTGGGCGCT GCTCCAGGCC ACCGGGTCTT GCCCTGCGGT 
CCCAGTCCAC AGCACCACCG GGCCCTGCGC TTCTCTTACC ACCTGGAGGG CTCGCAGCCT 
CGGCCTGGGC TGCACCAGGG AAACCGGATC CTGGTTAAAA GTTTGTCCCT TGACCCTGGC 
CAAAGCCTAG AGCCTCATCC AGAAGGTCCC CAGCGGCTTC GCTCAGACCC AGGTCCCCCG 
ACTGAAACCC CTAGCCAGCG TCCTTCACCA CTGAAGCGGG CACCGGGCCC GAAGCCACAG 
GTGCCCCCAA AGCCCAGCTA CCTGCAGATG CCCCGGATGC CCCCCCCACT GGAGCCCATC 
CCCCCTCCAC CATCACGCCC ACTGCCTGCC GACCCCCGAG TGGCCAAGGG CCTGGCTCCC 
AGGGCAGAGG CCAGCCCCAG TTCTGCAGCA GTATCCTCAC TGATTGAGAA GTTTGAAAGA 
GAGCCTGTGA TTGTCGCCTC GGATAGACCA GTCCCTGGCC CCAGCCCAGG TCCCCCAGAG 
CCAGTCATGT TGCCACAGCC AACCTCGCAG CCACCAGTGC CCCAGCTCCC CGAGGGTGAG 
GCCTCCCGCT GCCTGTTTCT GCTGGCTCCT GGGCCCCGGG ACGGTGAGAA GGTGCCCAAC 
CGGGACAGCG GCATTGATAG CATCAGCTCG CCATCCAACA GCGAGGAGAC CTGCTTCGTC 
AGTGATGACG GGCCCCCCAG CCACAGCCTC TGCCCTGGGC CCCCTGCCCT GGCTAGTGTG 
CCTGTTGCCT TGGCCGACCC CCACCGGCCT GGCTCCCAAG AGGTTGACAG TGACCTGGAG 
GAGGAGGACG ACGAGGAGGA GGAGGAAGAG AAGGACAGAG AAATCCCAGT GCCCCTGATG 
GAGAGACAGG AGTCTGTGGA GTTGACTGTG CAGCAAAAGG TGTTTCACAT TGCCAATGAG 
CTCCTGCAAA CTGAGAAGGC CTACGTTTCC AGGCTCCATC TCCTGGATCA GGTGTTCTGT 
GCCCGGCTGC TGGAAGAAGC TCGGAACCGC AGTTCCTTCC CGGCCGACGT TGTCCACGGC 
ATCTTCTCTA ACATCTGCTC CATCTATTGC TTCCACCAGC AGTTCCTGCT GCCTGAGCTA 
GAGAAGCGCA TGGAGGAATG GGACCGCTAT CCACGCATTG GAGACATCCT GCAGAAACTG 
GCCCCCTTCC TCAAGATGTA TGGTGAGTAT GTGAAGAACT TTGACCGGGC CGTGGAGCTG 
GTCAACACCT GGACAGAGCG CTCCACCCAG TTTAAAGTCA TCATCCATGA GGTGCAGAAG 
GAGGAAGCCT GTGGCAACCT GACATTGCAG CACCACATGC TGGAGCCTGT GCAGCGCATC 
CCCCGCTATG AGCTTCTTCT CAAGGACTAT CTGTTAAAGC TGCCCCATGG CTCCCCGGAC 
AGCAAGGATG CCCAAAAGTC TCTGGAGCTG ATCGCCACAG CAGCAGAGCA CTCGAATGCT 
GCCATCCGCA AAATGGAGCG AATGCATAAG CTGCTGAAGG TATATGAGCT GTTAGGGGGC 
GAGGAGGACA TTGTCAGCCC CACCAAAGAG CTCATAAAAG AAGGCCACAT CCTTAAGCTG 
TCAGCAAAGA ATGGGACCAC TCAAGACCGA TACCTCATAC TATTCAACGA CCGCCTCCTT 
TACTGCGTGC CCAGGCTGCG GCTCCTTGGC CAGAAGTTTA GCGTGCGGGC ACGCATTGAT 
GTAGATGGCA TGGAGCTAAA GGAGAGCTCC AACCTCAATC TGCCTCGAAC CTTCCTGGTG 
TCAGGAAAGC AGCGCTCCCT CGAGCTCCAG GCCAGGACTG AGGAGGAGAA GAAAGACTGG 
GTCCAGGCCA TCAACTCCAC CCTCCTGAAG CATGAACAGA CGCTGGAGAC TTTCAAACTG 
TTGAACTCAA CAAACAGGGA AGATGAAGAC ACCCCACCCA ACTCTCCAAA CGTGGATCTT 
GGGAAGCGGG CACCTACGCC CATCCGGGAA AAGGAAGTCA CCATGTGCAT GCGCTGCCAG 
GAGCCCTTCA ATTCTATCAC CAAACGCAGG CACCACTGCA AGGCCTGCGG GCATGTGGTT 
TGTGGGAAGT GCTCCGAGTT CCGGGCCCGC CTCGTCTATG ACAACAACCG CTCCAACCGT 
GTGTGCACTG ATTGCTATGT GGCCTTGCAC GGGGTGCCTG GGAGCAGTCC AGCCTGCAGC 
CAGCATACAC CCCAGCGCCG GAGGTCCATC CTGGAGAAAC AGGCCTCAGT GGCTGCAGAG 
AACAGCGTCA TCTGCAGCTT CCTGCACTAC ATGGAGAAGG GTGGCAAAGG ATGGCACAAG 
GCATGGTTCG TGGTCCCTGA AAATGAACCC TTGGTGCTGT ATATCTACGG AGCCCCTCAG 
GATGTGAAAG CCCAGCGCAG CCTGCCCCTC ATTGGCTTCG AGGTGGGACC GCCCGAGGCA 
GGGGAGCGGC CTGACAGAAG GCATGTCTTC AAGATCACCC AGAGCCACCT CAGCTGGTAC 
TTCAGCCCTG AGACAGAGGA ACTACAGCGA CGCTGGATGG CTGTGCTTGG CCGGGCGGGC 
CGAGGGGACA CGTTCTGCCC GGGGCCCACA CTGTCTGAGG ACAGGGAGAT GGAGGAGGCA 
CCGGTGGCTG CTTTAGGAGC CACTGCTGAA CCCCCCGAAT CCCCCCAGAC CCGAGACAAG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004454.2
CDS	803..3688
Translation	MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT

Target ORF information:

RefSeq Version	NM_004463.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004463.3

ORF Insert Sequence:

ATGCATGGCC ACCGAGCCCC GGGGGGCGCC GGGCCTTCGG AGCCCGAACA CCCGGCCACG 
AACCCGCCGG GCGCCGCTCC GCCGGCCTGT GCCGACTCGG ACCCTGGAGC CTCGGAACCC 
GGACTGCTGG CGCGCAGGGG CTCAGGTTCG GCTCTTGGCG GCCCACTGGA TCCCCAGTTT 
GTCGGACCCT CGGACACCAG CCTGGGCGCT GCTCCAGGCC ACCGGGTCTT GCCCTGCGGT 
CCCAGTCCAC AGCACCACCG GGCCCTGCGC TTCTCTTACC ACCTGGAGGG CTCGCAGCCT 
CGGCCTGGGC TGCACCAGGG AAACCGGATC CTGGTTAAAA GTTTGTCCCT TGACCCTGGC 
CAAAGCCTAG AGCCTCATCC AGAAGGTCCC CAGCGGCTTC GCTCAGACCC AGGTCCCCCG 
ACTGAAACCC CTAGCCAGCG TCCTTCACCA CTGAAGCGGG CACCGGGCCC GAAGCCACAG 
GTGCCCCCAA AGCCCAGCTA CCTGCAGATG CCCCGGATGC CCCCCCCACT GGAGCCCATC 
CCCCCTCCAC CATCACGCCC ACTGCCTGCC GACCCCCGAG TGGCCAAGGG CCTGGCTCCC 
AGGGCAGAGG CCAGCCCCAG TTCTGCAGCA GTATCCTCAC TGATTGAGAA GTTTGAAAGA 
GAGCCTGTGA TTGTCGCCTC GGATAGACCA GTCCCTGGCC CCAGCCCAGG TCCCCCAGAG 
CCAGTCATGT TGCCACAGCC AACCTCGCAG CCACCAGTGC CCCAGCTCCC CGAGGGTGAG 
GCCTCCCGCT GCCTGTTTCT GCTGGCTCCT GGGCCCCGGG ACGGTGAGAA GGTGCCCAAC 
CGGGACAGCG GCATTGATAG CATCAGCTCG CCATCCAACA GCGAGGAGAC CTGCTTCGTC 
AGTGATGACG GGCCCCCCAG CCACAGCCTC TGCCCTGGGC CCCCTGCCCT GGCTAGTGTG 
CCTGTTGCCT TGGCCGACCC CCACCGGCCT GGCTCCCAAG AGGTTGACAG TGACCTGGAG 
GAGGAGGACG ACGAGGAGGA GGAGGAAGAG AAGGACAGAG AAATCCCAGT GCCCCTGATG 
GAGAGACAGG AGTCTGTGGA GTTGACTGTG CAGCAAAAGG TGTTTCACAT TGCCAATGAG 
CTCCTGCAAA CTGAGAAGGC CTACGTTTCC AGGCTCCATC TCCTGGATCA GGTGTTCTGT 
GCCCGGCTGC TGGAAGAAGC TCGGAACCGC AGTTCCTTCC CGGCCGACGT TGTCCACGGC 
ATCTTCTCTA ACATCTGCTC CATCTATTGC TTCCACCAGC AGTTCCTGCT GCCTGAGCTA 
GAGAAGCGCA TGGAGGAATG GGACCGCTAT CCACGCATTG GAGACATCCT GCAGAAACTG 
GCCCCCTTCC TCAAGATGTA TGGTGAGTAT GTGAAGAACT TTGACCGGGC CGTGGAGCTG 
GTCAACACCT GGACAGAGCG CTCCACCCAG TTTAAAGTCA TCATCCATGA GGTGCAGAAG 
GAGGAAGCCT GTGGCAACCT GACATTGCAG CACCACATGC TGGAGCCTGT GCAGCGCATC 
CCCCGCTATG AGCTTCTTCT CAAGGACTAT CTGTTAAAGC TGCCCCATGG CTCCCCGGAC 
AGCAAGGATG CCCAAAAGTC TCTGGAGCTG ATCGCCACAG CAGCAGAGCA CTCGAATGCT 
GCCATCCGCA AAATGGAGCG AATGCATAAG CTGCTGAAGG TATATGAGCT GTTAGGGGGC 
GAGGAGGACA TTGTCAGCCC CACCAAAGAG CTCATAAAAG AAGGCCACAT CCTTAAGCTG 
TCAGCAAAGA ATGGGACCAC TCAAGACCGA TACCTCATAC TATTCAACGA CCGCCTCCTT 
TACTGCGTGC CCAGGCTGCG GCTCCTTGGC CAGAAGTTTA GCGTGCGGGC ACGCATTGAT 
GTAGATGGCA TGGAGCTAAA GGAGAGCTCC AACCTCAATC TGCCTCGAAC CTTCCTGGTG 
TCAGGAAAGC AGCGCTCCCT CGAGCTCCAG GCCAGGACTG AGGAGGAGAA GAAAGACTGG 
GTCCAGGCCA TCAACTCCAC CCTCCTGAAG CATGAACAGA CGCTGGAGAC TTTCAAACTG 
TTGAACTCAA CAAACAGGGA AGATGAAGAC ACCCCACCCA ACTCTCCAAA CGTGGATCTT 
GGGAAGCGGG CACCTACGCC CATCCGGGAA AAGGAAGTCA CCATGTGCAT GCGCTGCCAG 
GAGCCCTTCA ATTCTATCAC CAAACGCAGG CACCACTGCA AGGCCTGCGG GCATGTGGTT 
TGTGGGAAGT GCTCCGAGTT CCGGGCCCGC CTCGTCTATG ACAACAACCG CTCCAACCGT 
GTGTGCACTG ATTGCTATGT GGCCTTGCAC GGGGTGCCTG GGAGCAGTCC AGCCTGCAGC 
CAGCATACAC CCCAGCGCCG GAGGTCCATC CTGGAGAAAC AGGCCTCAGT GGCTGCAGAG 
AACAGCGTCA TCTGCAGCTT CCTGCACTAC ATGGAGAAGG GTGGCAAAGG ATGGCACAAG 
GCATGGTTCG TGGTCCCTGA AAATGAACCC TTGGTGCTGT ATATCTACGG AGCCCCTCAG 
GATGTGAAAG CCCAGCGCAG CCTGCCCCTC ATTGGCTTCG AGGTGGGACC GCCCGAGGCA 
GGGGAGCGGC CTGACAGAAG GCATGTCTTC AAGATCACCC AGAGCCACCT CAGCTGGTAC 
TTCAGCCCTG AGACAGAGGA ACTACAGCGA CGCTGGATGG CTGTGCTTGG CCGGGCGGGC 
CGAGGGGACA CGTTCTGCCC GGGGCCCACA CTGTCTGAGG ACAGGGAGAT GGAGGAGGCA 
CCGGTGGCTG CTTTAGGAGC CACTGCTGAA CCCCCCGAAT CCCCCCAGAC CCGAGACAAG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGD1 ( NM_004463.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004454.2 Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.

Price & Availability↑

CloneID	OHu18582
Clone ID Related Accession (Same CDS sequence)	NM_004463.3 , NM_004463.2
Accession Version	NM_004463.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	FYVE, RhoGEF and PH domain-containing protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC034530.1 and U11690.1. This sequence is a reference standard in the RefSeqGene project. On Nov 8, 2002 this sequence version replaced NM_004463.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KX085484.1, U11690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATGGCC ACCGAGCCCC GGGGGGCGCC GGGCCTTCGG AGCCCGAACA CCCGGCCACG 
AACCCGCCGG GCGCCGCTCC GCCGGCCTGT GCCGACTCGG ACCCTGGAGC CTCGGAACCC 
GGACTGCTGG CGCGCAGGGG CTCAGGTTCG GCTCTTGGCG GCCCACTGGA TCCCCAGTTT 
GTCGGACCCT CGGACACCAG CCTGGGCGCT GCTCCAGGCC ACCGGGTCTT GCCCTGCGGT 
CCCAGTCCAC AGCACCACCG GGCCCTGCGC TTCTCTTACC ACCTGGAGGG CTCGCAGCCT 
CGGCCTGGGC TGCACCAGGG AAACCGGATC CTGGTTAAAA GTTTGTCCCT TGACCCTGGC 
CAAAGCCTAG AGCCTCATCC AGAAGGTCCC CAGCGGCTTC GCTCAGACCC AGGTCCCCCG 
ACTGAAACCC CTAGCCAGCG TCCTTCACCA CTGAAGCGGG CACCGGGCCC GAAGCCACAG 
GTGCCCCCAA AGCCCAGCTA CCTGCAGATG CCCCGGATGC CCCCCCCACT GGAGCCCATC 
CCCCCTCCAC CATCACGCCC ACTGCCTGCC GACCCCCGAG TGGCCAAGGG CCTGGCTCCC 
AGGGCAGAGG CCAGCCCCAG TTCTGCAGCA GTATCCTCAC TGATTGAGAA GTTTGAAAGA 
GAGCCTGTGA TTGTCGCCTC GGATAGACCA GTCCCTGGCC CCAGCCCAGG TCCCCCAGAG 
CCAGTCATGT TGCCACAGCC AACCTCGCAG CCACCAGTGC CCCAGCTCCC CGAGGGTGAG 
GCCTCCCGCT GCCTGTTTCT GCTGGCTCCT GGGCCCCGGG ACGGTGAGAA GGTGCCCAAC 
CGGGACAGCG GCATTGATAG CATCAGCTCG CCATCCAACA GCGAGGAGAC CTGCTTCGTC 
AGTGATGACG GGCCCCCCAG CCACAGCCTC TGCCCTGGGC CCCCTGCCCT GGCTAGTGTG 
CCTGTTGCCT TGGCCGACCC CCACCGGCCT GGCTCCCAAG AGGTTGACAG TGACCTGGAG 
GAGGAGGACG ACGAGGAGGA GGAGGAAGAG AAGGACAGAG AAATCCCAGT GCCCCTGATG 
GAGAGACAGG AGTCTGTGGA GTTGACTGTG CAGCAAAAGG TGTTTCACAT TGCCAATGAG 
CTCCTGCAAA CTGAGAAGGC CTACGTTTCC AGGCTCCATC TCCTGGATCA GGTGTTCTGT 
GCCCGGCTGC TGGAAGAAGC TCGGAACCGC AGTTCCTTCC CGGCCGACGT TGTCCACGGC 
ATCTTCTCTA ACATCTGCTC CATCTATTGC TTCCACCAGC AGTTCCTGCT GCCTGAGCTA 
GAGAAGCGCA TGGAGGAATG GGACCGCTAT CCACGCATTG GAGACATCCT GCAGAAACTG 
GCCCCCTTCC TCAAGATGTA TGGTGAGTAT GTGAAGAACT TTGACCGGGC CGTGGAGCTG 
GTCAACACCT GGACAGAGCG CTCCACCCAG TTTAAAGTCA TCATCCATGA GGTGCAGAAG 
GAGGAAGCCT GTGGCAACCT GACATTGCAG CACCACATGC TGGAGCCTGT GCAGCGCATC 
CCCCGCTATG AGCTTCTTCT CAAGGACTAT CTGTTAAAGC TGCCCCATGG CTCCCCGGAC 
AGCAAGGATG CCCAAAAGTC TCTGGAGCTG ATCGCCACAG CAGCAGAGCA CTCGAATGCT 
GCCATCCGCA AAATGGAGCG AATGCATAAG CTGCTGAAGG TATATGAGCT GTTAGGGGGC 
GAGGAGGACA TTGTCAGCCC CACCAAAGAG CTCATAAAAG AAGGCCACAT CCTTAAGCTG 
TCAGCAAAGA ATGGGACCAC TCAAGACCGA TACCTCATAC TATTCAACGA CCGCCTCCTT 
TACTGCGTGC CCAGGCTGCG GCTCCTTGGC CAGAAGTTTA GCGTGCGGGC ACGCATTGAT 
GTAGATGGCA TGGAGCTAAA GGAGAGCTCC AACCTCAATC TGCCTCGAAC CTTCCTGGTG 
TCAGGAAAGC AGCGCTCCCT CGAGCTCCAG GCCAGGACTG AGGAGGAGAA GAAAGACTGG 
GTCCAGGCCA TCAACTCCAC CCTCCTGAAG CATGAACAGA CGCTGGAGAC TTTCAAACTG 
TTGAACTCAA CAAACAGGGA AGATGAAGAC ACCCCACCCA ACTCTCCAAA CGTGGATCTT 
GGGAAGCGGG CACCTACGCC CATCCGGGAA AAGGAAGTCA CCATGTGCAT GCGCTGCCAG 
GAGCCCTTCA ATTCTATCAC CAAACGCAGG CACCACTGCA AGGCCTGCGG GCATGTGGTT 
TGTGGGAAGT GCTCCGAGTT CCGGGCCCGC CTCGTCTATG ACAACAACCG CTCCAACCGT 
GTGTGCACTG ATTGCTATGT GGCCTTGCAC GGGGTGCCTG GGAGCAGTCC AGCCTGCAGC 
CAGCATACAC CCCAGCGCCG GAGGTCCATC CTGGAGAAAC AGGCCTCAGT GGCTGCAGAG 
AACAGCGTCA TCTGCAGCTT CCTGCACTAC ATGGAGAAGG GTGGCAAAGG ATGGCACAAG 
GCATGGTTCG TGGTCCCTGA AAATGAACCC TTGGTGCTGT ATATCTACGG AGCCCCTCAG 
GATGTGAAAG CCCAGCGCAG CCTGCCCCTC ATTGGCTTCG AGGTGGGACC GCCCGAGGCA 
GGGGAGCGGC CTGACAGAAG GCATGTCTTC AAGATCACCC AGAGCCACCT CAGCTGGTAC 
TTCAGCCCTG AGACAGAGGA ACTACAGCGA CGCTGGATGG CTGTGCTTGG CCGGGCGGGC 
CGAGGGGACA CGTTCTGCCC GGGGCCCACA CTGTCTGAGG ACAGGGAGAT GGAGGAGGCA 
CCGGTGGCTG CTTTAGGAGC CACTGCTGAA CCCCCCGAAT CCCCCCAGAC CCGAGACAAG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004454.2
CDS	735..3620
Translation	MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT

Target ORF information:

RefSeq Version	NM_004463.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004463.2

ORF Insert Sequence:

ATGCATGGCC ACCGAGCCCC GGGGGGCGCC GGGCCTTCGG AGCCCGAACA CCCGGCCACG 
AACCCGCCGG GCGCCGCTCC GCCGGCCTGT GCCGACTCGG ACCCTGGAGC CTCGGAACCC 
GGACTGCTGG CGCGCAGGGG CTCAGGTTCG GCTCTTGGCG GCCCACTGGA TCCCCAGTTT 
GTCGGACCCT CGGACACCAG CCTGGGCGCT GCTCCAGGCC ACCGGGTCTT GCCCTGCGGT 
CCCAGTCCAC AGCACCACCG GGCCCTGCGC TTCTCTTACC ACCTGGAGGG CTCGCAGCCT 
CGGCCTGGGC TGCACCAGGG AAACCGGATC CTGGTTAAAA GTTTGTCCCT TGACCCTGGC 
CAAAGCCTAG AGCCTCATCC AGAAGGTCCC CAGCGGCTTC GCTCAGACCC AGGTCCCCCG 
ACTGAAACCC CTAGCCAGCG TCCTTCACCA CTGAAGCGGG CACCGGGCCC GAAGCCACAG 
GTGCCCCCAA AGCCCAGCTA CCTGCAGATG CCCCGGATGC CCCCCCCACT GGAGCCCATC 
CCCCCTCCAC CATCACGCCC ACTGCCTGCC GACCCCCGAG TGGCCAAGGG CCTGGCTCCC 
AGGGCAGAGG CCAGCCCCAG TTCTGCAGCA GTATCCTCAC TGATTGAGAA GTTTGAAAGA 
GAGCCTGTGA TTGTCGCCTC GGATAGACCA GTCCCTGGCC CCAGCCCAGG TCCCCCAGAG 
CCAGTCATGT TGCCACAGCC AACCTCGCAG CCACCAGTGC CCCAGCTCCC CGAGGGTGAG 
GCCTCCCGCT GCCTGTTTCT GCTGGCTCCT GGGCCCCGGG ACGGTGAGAA GGTGCCCAAC 
CGGGACAGCG GCATTGATAG CATCAGCTCG CCATCCAACA GCGAGGAGAC CTGCTTCGTC 
AGTGATGACG GGCCCCCCAG CCACAGCCTC TGCCCTGGGC CCCCTGCCCT GGCTAGTGTG 
CCTGTTGCCT TGGCCGACCC CCACCGGCCT GGCTCCCAAG AGGTTGACAG TGACCTGGAG 
GAGGAGGACG ACGAGGAGGA GGAGGAAGAG AAGGACAGAG AAATCCCAGT GCCCCTGATG 
GAGAGACAGG AGTCTGTGGA GTTGACTGTG CAGCAAAAGG TGTTTCACAT TGCCAATGAG 
CTCCTGCAAA CTGAGAAGGC CTACGTTTCC AGGCTCCATC TCCTGGATCA GGTGTTCTGT 
GCCCGGCTGC TGGAAGAAGC TCGGAACCGC AGTTCCTTCC CGGCCGACGT TGTCCACGGC 
ATCTTCTCTA ACATCTGCTC CATCTATTGC TTCCACCAGC AGTTCCTGCT GCCTGAGCTA 
GAGAAGCGCA TGGAGGAATG GGACCGCTAT CCACGCATTG GAGACATCCT GCAGAAACTG 
GCCCCCTTCC TCAAGATGTA TGGTGAGTAT GTGAAGAACT TTGACCGGGC CGTGGAGCTG 
GTCAACACCT GGACAGAGCG CTCCACCCAG TTTAAAGTCA TCATCCATGA GGTGCAGAAG 
GAGGAAGCCT GTGGCAACCT GACATTGCAG CACCACATGC TGGAGCCTGT GCAGCGCATC 
CCCCGCTATG AGCTTCTTCT CAAGGACTAT CTGTTAAAGC TGCCCCATGG CTCCCCGGAC 
AGCAAGGATG CCCAAAAGTC TCTGGAGCTG ATCGCCACAG CAGCAGAGCA CTCGAATGCT 
GCCATCCGCA AAATGGAGCG AATGCATAAG CTGCTGAAGG TATATGAGCT GTTAGGGGGC 
GAGGAGGACA TTGTCAGCCC CACCAAAGAG CTCATAAAAG AAGGCCACAT CCTTAAGCTG 
TCAGCAAAGA ATGGGACCAC TCAAGACCGA TACCTCATAC TATTCAACGA CCGCCTCCTT 
TACTGCGTGC CCAGGCTGCG GCTCCTTGGC CAGAAGTTTA GCGTGCGGGC ACGCATTGAT 
GTAGATGGCA TGGAGCTAAA GGAGAGCTCC AACCTCAATC TGCCTCGAAC CTTCCTGGTG 
TCAGGAAAGC AGCGCTCCCT CGAGCTCCAG GCCAGGACTG AGGAGGAGAA GAAAGACTGG 
GTCCAGGCCA TCAACTCCAC CCTCCTGAAG CATGAACAGA CGCTGGAGAC TTTCAAACTG 
TTGAACTCAA CAAACAGGGA AGATGAAGAC ACCCCACCCA ACTCTCCAAA CGTGGATCTT 
GGGAAGCGGG CACCTACGCC CATCCGGGAA AAGGAAGTCA CCATGTGCAT GCGCTGCCAG 
GAGCCCTTCA ATTCTATCAC CAAACGCAGG CACCACTGCA AGGCCTGCGG GCATGTGGTT 
TGTGGGAAGT GCTCCGAGTT CCGGGCCCGC CTCGTCTATG ACAACAACCG CTCCAACCGT 
GTGTGCACTG ATTGCTATGT GGCCTTGCAC GGGGTGCCTG GGAGCAGTCC AGCCTGCAGC 
CAGCATACAC CCCAGCGCCG GAGGTCCATC CTGGAGAAAC AGGCCTCAGT GGCTGCAGAG 
AACAGCGTCA TCTGCAGCTT CCTGCACTAC ATGGAGAAGG GTGGCAAAGG ATGGCACAAG 
GCATGGTTCG TGGTCCCTGA AAATGAACCC TTGGTGCTGT ATATCTACGG AGCCCCTCAG 
GATGTGAAAG CCCAGCGCAG CCTGCCCCTC ATTGGCTTCG AGGTGGGACC GCCCGAGGCA 
GGGGAGCGGC CTGACAGAAG GCATGTCTTC AAGATCACCC AGAGCCACCT CAGCTGGTAC 
TTCAGCCCTG AGACAGAGGA ACTACAGCGA CGCTGGATGG CTGTGCTTGG CCGGGCGGGC 
CGAGGGGACA CGTTCTGCCC GGGGCCCACA CTGTCTGAGG ACAGGGAGAT GGAGGAGGCA 
CCGGTGGCTG CTTTAGGAGC CACTGCTGAA CCCCCCGAAT CCCCCCAGAC CCGAGACAAG 
ACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel, putatively null, FGD1 variant leading to Aarskog-Scott syndrome in a family from UAE.
BMC pediatrics17(1)31(2017 Jan)
Hamzeh AR,Saif F,Nair P,Binjab AJ,Mohamed M,Al-Ali MT,Bastaki F

A novel splice site mutation of FGD1 gene in an Aarskog-Scott syndrome patient with a large anterior fontanel.
Journal of pediatric endocrinology & metabolism : JPEM29(9)1111-4(2016 Sep)
Par?ltay E,Hazan F,Ataman E,Demir K,Etlik ?,?zbek E,?zkan B

Minireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.
Physiological genomics48(7)446-54(2016 Jul)
Pedigo NG,Van Delden D,Walters L,Farrell CL

Aarskog-Scott syndrome: a novel mutation in the FGD1 gene associated with severe craniofacial dysplasia.
European journal of pediatrics173(10)1373-6(2014 Oct)
V?lter C,Mart?nez R,Hagen R,Kress W

No association between FGD1 gene polymorphisms and intellectual developmental disability in the Qinba mountain area.
Genetics and molecular research : GMR13(1)127-33(2014 Jan)
Li JL,Li YJ,Zhang KJ,Lan L,Shi JG,Yang X,Zhang MJ,Zhang FC,Gao XC

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FGD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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