CDSN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDSN
Entrez Gene ID	1041
Full Name	corneodesmosin
Synonyms	HTSS,HTSS1,HYPT2,PSS,PSS1,S
General protein information	Preferred Names corneodesmosin Names corneodesmosin differentiated keratinocyte S protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014].
Disorder MIM:	602593
Disorder Html:	Hypotrichosis 2, 146520 (3); Peeling skin syndrome 1, 270300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001264.4	NP_001255.3	corneodesmosin precursor
NM_001264.5	NP_001255.4	corneodesmosin precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CDSN	XP_848729.1
	CDSN	NP_001098639.1
Homo sapiens (human)	CDSN	NP_001255.3
Pan troglodytes (chimpanzee)	CDSN	NP_001038969.1

Gene Ontology
Bibliography

Related articles in PubMed

Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate.
Leslie EJ, Carlson JC, Shaffer JR, Bux? CJ, Castilla EE, Christensen K, Deleyiannis FWB, Field LL, Hecht JT, Moreno L, Orioli IM, Padilla C, Vieira AR, Wehby GL, Feingold E, Weinberg SM, Murray JC, Marazita ML
American journal of medical genetics. Part A173(6)1531-1538(2017 Jun)

Increased expression of caspase-1 and interleukin-18 in peeling skin disease, and a novel mutation of corneodesmosin.
Valentin F, Oji V, Hausser I, Liebau E, Tarinski T, Metze D, Breitkreutz D, Traupe H, Jonca N, Terheyden P
Acta dermato-venereologica95(8)1019-21(2015 Nov)

Analysis of protein-protein interaction between late cornified envelope proteins and corneodesmosin.
Bergboer JG, Dulak MG, van Vlijmen-Willems IM, Jonca N, van Wijk E, Hendriks WJ, Zeeuwen PL, Schalkwijk J
Experimental dermatology23(10)769-71(2014 Oct)

Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin.
Levy-Nissenbaum E, Betz RC, Frydman M, Simon M, Lahat H, Bakhan T, Goldman B, Bygum A, Pierick M, Hillmer AM, Jonca N, Toribio J, Kruse R, Dewald G, Cichon S, Kubisch C, Guerrin M, Serre G, N?then MM, Pras E
Nature genetics34(2)151-3(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found that a burden of low-frequency coding variants in N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL/P
Title: Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate.

we report a patient with PSD caused by a novel homozygous large deletion in the 6p21.3 region encompassing the CDSN gene, which abrogates CDSN expression
Title: Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease.

Investigated potential direct protein-protein interactions between six late cornified envelope (LCE) proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN was observed in normal and psoriasis skin.
Title: Analysis of protein-protein interaction between late cornified envelope proteins and corneodesmosin.

Case Report: homozygous deletion of CDSN was considered to be responsible for generalized peeling skin disease.
Title: Homozygous deletion of six genes including corneodesmosin on chromosome 6p21.3 is associated with generalized peeling skin disease.

PSORS1C1/CDSN gene may play a pathogenic role in ankylosing spondylitis
Title: PSORS1C1/CDSN is associated with ankylosing spondylitis.

The following CDSN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDSN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu107639	NM_001264.5 Latest version!	Homo sapiens corneodesmosin (CDSN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu20558	NM_001264.4 Latest version!	Homo sapiens corneodesmosin (CDSN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$224.50-$314.30 $449.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDSN ( NM_001264.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001255.4 Homo sapiens corneodesmosin (CDSN), mRNA.

Price & Availability↑

CloneID	OHu107639
Clone ID Related Accession (Same CDS sequence)	NM_001264.5
Accession Version	NM_001264.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	corneodesmosin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662844.12. On Nov 22, 2018 this sequence version replaced NM_001264.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L20815.1, AK292636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376288.3/ ENSP00000365465.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCTCGT CTCGGGCACC CTGGATGGGG CGTGTGGGTG GGCACGGGAT GATGGCACTG 
CTGCTGGCTG GTCTCCTCCT GCCAGGGACC TTGGCTAAGA GCATTGGCAC CTTCTCAGAC 
CCTTGTAAGG ACCCCACGCG TATCACCTCC CCTAACGACC CCTGCCTCAC TGGGAAGGGT 
GACTCCAGCG GTTTCAGTAG CTACAGTGGC TCCAGCAGTT CTGGCAGCTC CATTTCCAGT 
GCCAGAAGCT CTGGTGGTGG CTCCAGTGGT AGCTCCAGCG GATCCAGCAT TGCCCAGGGT 
GGTTCTGCAG GATCTTTTAA GCCAGGAACG GGGTATTCCC AGGTCAGCTA CTCCTCCGGA 
TCTGGCTCTA GTCTACAAGG TGCATCCGGT TCCTCCCAGC TGGGGAGCAG CAGCTCTCAC 
TCGGGAAACA GCGGCTCTCA CTCGGGAAGC AGCAGCTCTC ATTCGAGCAG CAGCAGCAGC 
TTTCAGTTCA GCAGCAGCAG CTTCCAAGTA GGGAATGGCT CTGCTCTGCC AACCAATGAC 
AACTCTTACC GCGGAATACT AAACCCTTCC CAGCCTGGAC AAAGCTCTTC CTCTTCCCAG 
ACCTTTGGGG TATCCAGCAG TGGCCAAAGC GTCAGCTCCA ACCAGCGTCC CTGTAGTTCG 
GACATCCCCG ACTCTCCCTG CAGTGGAGGG CCCATCGTCT CGCACTCCGG CCCCTACATC 
CCCAGCTCCC ACTCTGTGTC AGGGGGTCAG AGGCCTGTGG TGGTGGTGGT GGACCAGCAC 
GGTTCTGGTG CCCCTGGAGT GGTTCAAGGT CCCCCCTGTA GCAATGGTGG CCTTCCAGGC 
AAGCCCTGTC CCCCAATCAC CTCTGTAGAC AAATCCTATG GTGGCTACGA GGTGGTGGGT 
GGCTCCTCTG ACAGTTATCT GGTTCCAGGC ATGACCTACA GTAAGGGTAA AATCTACCCT 
GTGGGCTACT TCACCAAAGA GAACCCTGTG AAAGGCTCTC CAGGGGTCCC TTCCTTTGCA 
GCTGGGCCCC CCATCTCTGA GGGCAAATAC TTCTCCAGCA ACCCCATCAT CCCCAGCCAG 
TCGGCAGCTT CCTCGGCCAT TGCATTCCAG CCAGTGGGGA CTGGTGGGGT CCAGCTCTGT 
GGAGGCGGCT CCACGGGCTC CAAGGGACCC TGCTCTCCCT CCAGTTCTCG AGTCCCCAGC 
AGTTCTAGCA TTTCCAGCAG CTCCGGTTTA CCCTACCATC CCTGCGGCAG TGCTTCCCAG 
AGCCCCTGCT CCCCACCAGG CACCGGCTCC TTCAGCAGCA GCTCCAGTTC CCAATCCAGT 
GGCAAAATCA TCCTTCAGCC TTGTGGCAGC AAGTCCAGCT CTTCTGGTCA CCCTTGCATG 
TCTGTCTCCT CCTTGACACT GACTGGGGGC CCCGATGGCT CTCCCCATCC TGATCCCTCC 
GCTGGTGCCA AGCCCTGTGG CTCCAGCAGT GCTGGAAAGA TCCCCTGCCG CTCCATCCGG 
GATATCCTAG CCCAAGTGAA GCCTCTGGGG CCCCAGCTAG CTGACCCTGA AGTTTTCCTA 
CCCCAAGGAG AGTTACTCAA CAGTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001255.4
CDS	28..1617
Translation	MGSSRAPWMGRVGGHGMMALLLAGLLLPGTLAKSIGTFSDPCKDPTRITSPNDPCLTGKGDSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSGSGSSLQGASGSSQLGSSSSHSGNSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTNDNSYRGILNPSQPGQSSSSSQTFGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYIPSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVGGSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQSAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGLPYHPCGSASQSPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLNSP

Target ORF information:

RefSeq Version	NM_001264.5
Organism	Homo sapiens(human)
Definition	Homo sapiens corneodesmosin (CDSN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001264.5

ORF Insert Sequence:

ATGGGCTCGT CTCGGGCACC CTGGATGGGG CGTGTGGGTG GGCACGGGAT GATGGCACTG 
CTGCTGGCTG GTCTCCTCCT GCCAGGGACC TTGGCTAAGA GCATTGGCAC CTTCTCAGAC 
CCTTGTAAGG ACCCCACGCG TATCACCTCC CCTAACGACC CCTGCCTCAC TGGGAAGGGT 
GACTCCAGCG GTTTCAGTAG CTACAGTGGC TCCAGCAGTT CTGGCAGCTC CATTTCCAGT 
GCCAGAAGCT CTGGTGGTGG CTCCAGTGGT AGCTCCAGCG GATCCAGCAT TGCCCAGGGT 
GGTTCTGCAG GATCTTTTAA GCCAGGAACG GGGTATTCCC AGGTCAGCTA CTCCTCCGGA 
TCTGGCTCTA GTCTACAAGG TGCATCCGGT TCCTCCCAGC TGGGGAGCAG CAGCTCTCAC 
TCGGGAAACA GCGGCTCTCA CTCGGGAAGC AGCAGCTCTC ATTCGAGCAG CAGCAGCAGC 
TTTCAGTTCA GCAGCAGCAG CTTCCAAGTA GGGAATGGCT CTGCTCTGCC AACCAATGAC 
AACTCTTACC GCGGAATACT AAACCCTTCC CAGCCTGGAC AAAGCTCTTC CTCTTCCCAG 
ACCTTTGGGG TATCCAGCAG TGGCCAAAGC GTCAGCTCCA ACCAGCGTCC CTGTAGTTCG 
GACATCCCCG ACTCTCCCTG CAGTGGAGGG CCCATCGTCT CGCACTCCGG CCCCTACATC 
CCCAGCTCCC ACTCTGTGTC AGGGGGTCAG AGGCCTGTGG TGGTGGTGGT GGACCAGCAC 
GGTTCTGGTG CCCCTGGAGT GGTTCAAGGT CCCCCCTGTA GCAATGGTGG CCTTCCAGGC 
AAGCCCTGTC CCCCAATCAC CTCTGTAGAC AAATCCTATG GTGGCTACGA GGTGGTGGGT 
GGCTCCTCTG ACAGTTATCT GGTTCCAGGC ATGACCTACA GTAAGGGTAA AATCTACCCT 
GTGGGCTACT TCACCAAAGA GAACCCTGTG AAAGGCTCTC CAGGGGTCCC TTCCTTTGCA 
GCTGGGCCCC CCATCTCTGA GGGCAAATAC TTCTCCAGCA ACCCCATCAT CCCCAGCCAG 
TCGGCAGCTT CCTCGGCCAT TGCATTCCAG CCAGTGGGGA CTGGTGGGGT CCAGCTCTGT 
GGAGGCGGCT CCACGGGCTC CAAGGGACCC TGCTCTCCCT CCAGTTCTCG AGTCCCCAGC 
AGTTCTAGCA TTTCCAGCAG CTCCGGTTTA CCCTACCATC CCTGCGGCAG TGCTTCCCAG 
AGCCCCTGCT CCCCACCAGG CACCGGCTCC TTCAGCAGCA GCTCCAGTTC CCAATCCAGT 
GGCAAAATCA TCCTTCAGCC TTGTGGCAGC AAGTCCAGCT CTTCTGGTCA CCCTTGCATG 
TCTGTCTCCT CCTTGACACT GACTGGGGGC CCCGATGGCT CTCCCCATCC TGATCCCTCC 
GCTGGTGCCA AGCCCTGTGG CTCCAGCAGT GCTGGAAAGA TCCCCTGCCG CTCCATCCGG 
GATATCCTAG CCCAAGTGAA GCCTCTGGGG CCCCAGCTAG CTGACCCTGA AGTTTTCCTA 
CCCCAAGGAG AGTTACTCAA CAGTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDSN ( NM_001264.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001255.3 Homo sapiens corneodesmosin (CDSN), mRNA.

Price & Availability↑

CloneID	OHu20558
Clone ID Related Accession (Same CDS sequence)	NM_001264.4
Accession Version	NM_001264.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	corneodesmosin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662844.12 and AF030130.1. This sequence is a reference standard in the RefSeqGene project. On Jul 29, 2010 this sequence version replaced NM_001264.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L20815.1, AK292636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTCGT CTCGGGCACC CTGGATGGGG CGTGTGGGTG GGCACGGGAT GATGGCACTG 
CTGCTGGCTG GTCTCCTCCT GCCAGGGACC TTGGCTAAGA GCATTGGCAC CTTCTCAGAC 
CCCTGTAAGG ACCCCACGCG TATCACCTCC CCTAACGACC CCTGCCTCAC TGGGAAGGGT 
GACTCCAGCG GCTTCAGTAG CTACAGTGGC TCCAGCAGTT CTGGCAGCTC CATTTCCAGT 
GCCAGAAGCT CTGGTGGTGG CTCCAGTGGT AGCTCCAGCG GATCCAGCAT TGCCCAGGGT 
GGTTCTGCAG GATCTTTTAA GCCAGGAACG GGGTATTCCC AGGTCAGCTA CTCCTCCGGA 
TCTGGCTCTA GTCTACAAGG TGCATCCGGT TCCTCCCAGC TGGGGAGCAG CAGCTCTCAC 
TCGGGAAGCA GCGGCTCTCA CTCGGGAAGC AGCAGCTCTC ATTCGAGCAG CAGCAGCAGC 
TTTCAGTTCA GCAGCAGCAG CTTCCAAGTA GGGAATGGCT CTGCTCTGCC AACCAATGAC 
AACTCTTACC GCGGAATACT AAACCCTTCC CAGCCTGGAC AAAGCTCTTC CTCTTCCCAG 
ACCTTTGGGG TATCCAGCAG TGGCCAAAGC GTCAGCTCCA ACCAGCGTCC CTGTAGTTCG 
GACATCCCCG ACTCTCCCTG CAGTGGAGGG CCCATCGTCT CGCACTCCGG CCCCTACATC 
CCCAGCTCCC ACTCTGTGTC AGGGGGTCAG AGGCCTGTGG TGGTGGTGGT GGACCAGCAC 
GGTTCTGGTG CCCCTGGAGT GGTTCAAGGT CCCCCCTGTA GCAATGGTGG CCTTCCAGGC 
AAGCCCTGTC CCCCAATCAC CTCTGTAGAC AAATCCTATG GTGGCTACGA GGTGGTGGGT 
GGCTCCTCTG ACAGTTATCT GGTTCCAGGC ATGACCTACA GTAAGGGTAA AATCTACCCT 
GTGGGCTACT TCACCAAAGA GAACCCTGTG AAAGGCTCTC CAGGGGTCCC TTCCTTTGCA 
GCTGGGCCCC CCATCTCTGA GGGCAAATAC TTCTCCAGCA ACCCCATCAT CCCCAGCCAG 
TCGGCAGCTT CCTCGGCCAT TGCATTCCAG CCAGTGGGGA CTGGTGGGGT CCAGCTCTGT 
GGAGGCGGCT CCACGGGCTC CAAGGGACCC TGCTCTCCCT CCAGTTCTCG AGTCCCCAGC 
AGTTCTAGCA TTTCCAGCAG CTCCGGTTTA CCCTACCATC CCTGCGGCAG TGCTTCCCAG 
AGCCCCTGCT CCCCACCAGG CACCGGCTCC TTCAGCAGCA GCTCCAGTTC CCAATCCAGT 
GGCAAAATCA TCCTTCAGCC TTGTGGCAGC AAGTCCAGCT CTTCTGGTCA CCCTTGCATG 
TCTGTCTCCT CCTTGACACT GACTGGGGGC CCCGATGGCT CTCCCCATCC TGATCCCTCC 
GCTGGTGCCA AGCCCTGTGG CTCCAGCAGT GCTGGAAAGA TCCCCTGCCG CTCCATCCGG 
GATATCCTAG CCCAAGTGAA GCCTCTGGGG CCCCAGCTAG CTGACCCTGA AGTTTTCCTA 
CCCCAAGGAG AGTTACTCAA CAGTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001255.3
CDS	57..1646
Translation	MGSSRAPWMGRVGGHGMMALLLAGLLLPGTLAKSIGTFSDPCKDPTRITSPNDPCLTGKGDSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSGSGSSLQGASGSSQLGSSSSHSGSSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTNDNSYRGILNPSQPGQSSSSSQTFGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYIPSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVGGSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQSAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGLPYHPCGSASQSPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLNSP

Target ORF information:

RefSeq Version	NM_001264.4
Organism	Homo sapiens(human)
Definition	Homo sapiens corneodesmosin (CDSN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001264.4

ORF Insert Sequence:

ATGGGCTCGT CTCGGGCACC CTGGATGGGG CGTGTGGGTG GGCACGGGAT GATGGCACTG 
CTGCTGGCTG GTCTCCTCCT GCCAGGGACC TTGGCTAAGA GCATTGGCAC CTTCTCAGAC 
CCCTGTAAGG ACCCCACGCG TATCACCTCC CCTAACGACC CCTGCCTCAC TGGGAAGGGT 
GACTCCAGCG GCTTCAGTAG CTACAGTGGC TCCAGCAGTT CTGGCAGCTC CATTTCCAGT 
GCCAGAAGCT CTGGTGGTGG CTCCAGTGGT AGCTCCAGCG GATCCAGCAT TGCCCAGGGT 
GGTTCTGCAG GATCTTTTAA GCCAGGAACG GGGTATTCCC AGGTCAGCTA CTCCTCCGGA 
TCTGGCTCTA GTCTACAAGG TGCATCCGGT TCCTCCCAGC TGGGGAGCAG CAGCTCTCAC 
TCGGGAAGCA GCGGCTCTCA CTCGGGAAGC AGCAGCTCTC ATTCGAGCAG CAGCAGCAGC 
TTTCAGTTCA GCAGCAGCAG CTTCCAAGTA GGGAATGGCT CTGCTCTGCC AACCAATGAC 
AACTCTTACC GCGGAATACT AAACCCTTCC CAGCCTGGAC AAAGCTCTTC CTCTTCCCAG 
ACCTTTGGGG TATCCAGCAG TGGCCAAAGC GTCAGCTCCA ACCAGCGTCC CTGTAGTTCG 
GACATCCCCG ACTCTCCCTG CAGTGGAGGG CCCATCGTCT CGCACTCCGG CCCCTACATC 
CCCAGCTCCC ACTCTGTGTC AGGGGGTCAG AGGCCTGTGG TGGTGGTGGT GGACCAGCAC 
GGTTCTGGTG CCCCTGGAGT GGTTCAAGGT CCCCCCTGTA GCAATGGTGG CCTTCCAGGC 
AAGCCCTGTC CCCCAATCAC CTCTGTAGAC AAATCCTATG GTGGCTACGA GGTGGTGGGT 
GGCTCCTCTG ACAGTTATCT GGTTCCAGGC ATGACCTACA GTAAGGGTAA AATCTACCCT 
GTGGGCTACT TCACCAAAGA GAACCCTGTG AAAGGCTCTC CAGGGGTCCC TTCCTTTGCA 
GCTGGGCCCC CCATCTCTGA GGGCAAATAC TTCTCCAGCA ACCCCATCAT CCCCAGCCAG 
TCGGCAGCTT CCTCGGCCAT TGCATTCCAG CCAGTGGGGA CTGGTGGGGT CCAGCTCTGT 
GGAGGCGGCT CCACGGGCTC CAAGGGACCC TGCTCTCCCT CCAGTTCTCG AGTCCCCAGC 
AGTTCTAGCA TTTCCAGCAG CTCCGGTTTA CCCTACCATC CCTGCGGCAG TGCTTCCCAG 
AGCCCCTGCT CCCCACCAGG CACCGGCTCC TTCAGCAGCA GCTCCAGTTC CCAATCCAGT 
GGCAAAATCA TCCTTCAGCC TTGTGGCAGC AAGTCCAGCT CTTCTGGTCA CCCTTGCATG 
TCTGTCTCCT CCTTGACACT GACTGGGGGC CCCGATGGCT CTCCCCATCC TGATCCCTCC 
GCTGGTGCCA AGCCCTGTGG CTCCAGCAGT GCTGGAAAGA TCCCCTGCCG CTCCATCCGG 
GATATCCTAG CCCAAGTGAA GCCTCTGGGG CCCCAGCTAG CTGACCCTGA AGTTTTCCTA 
CCCCAAGGAG AGTTACTCAA CAGTCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate.
American journal of medical genetics. Part A173(6)1531-1538(2017 Jun)
Leslie EJ,Carlson JC,Shaffer JR,Bux? CJ,Castilla EE,Christensen K,Deleyiannis FWB,Field LL,Hecht JT,Moreno L,Orioli IM,Padilla C,Vieira AR,Wehby GL,Feingold E,Weinberg SM,Murray JC,Marazita ML

Increased expression of caspase-1 and interleukin-18 in peeling skin disease, and a novel mutation of corneodesmosin.
Acta dermato-venereologica95(8)1019-21(2015 Nov)
Valentin F,Oji V,Hausser I,Liebau E,Tarinski T,Metze D,Breitkreutz D,Traupe H,Jonca N,Terheyden P

Analysis of protein-protein interaction between late cornified envelope proteins and corneodesmosin.
Experimental dermatology23(10)769-71(2014 Oct)
Bergboer JG,Dulak MG,van Vlijmen-Willems IM,Jonca N,van Wijk E,Hendriks WJ,Zeeuwen PL,Schalkwijk J

Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin.
Nature genetics34(2)151-3(2003 Jun)
Levy-Nissenbaum E,Betz RC,Frydman M,Simon M,Lahat H,Bakhan T,Goldman B,Bygum A,Pierick M,Hillmer AM,Jonca N,Toribio J,Kruse R,Dewald G,Cichon S,Kubisch C,Guerrin M,Serre G,N?then MM,Pras E

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CDSN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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