Gene Symbol | PEP4 |
Entrez Gene ID | 855949 |
Full Name | proteinase A |
Synonyms | PHO9,PRA1,yscA |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » PEP4 cDNA ORF clone
Gene Symbol | PEP4 |
Entrez Gene ID | 855949 |
Full Name | proteinase A |
Synonyms | PHO9,PRA1,yscA |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183968.1 | NP_015171.1 | proteinase A |
Homo sapiens (human) | CTSD | NP_001900.1 |
Bos taurus (cattle) | CTSD | NP_001159993.1 |
Rattus norvegicus (Norway rat) | Ctsd | NP_599161.2 |
Gallus gallus (chicken) | CTSD | NP_990508.1 |
Danio rerio (zebrafish) | ctsd | NP_571785.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003277 | XP_307784.1 |
Arabidopsis thaliana (thale cress) | AT1G62290 | NP_001031219.1 |
Mus musculus (house mouse) | Ctsd | NP_034113.1 |
Caenorhabditis elegans (roundworm) | asp-4 | NP_510191.1 |
Saccharomyces cerevisiae (baker's yeast) | PEP4 | NP_015171.1 |
Xenopus tropicalis (tropical clawed frog) | ctsd | NP_988964.1 |
Xenopus tropicalis (tropical clawed frog) | LOC613063 | NP_001136375.1 |
Canis lupus familiaris (dog) | CTSD | NP_001020792.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00922 | XP_003718037.1 |
Neurospora crassa | NCU02273 | XP_959917.1 |
Arabidopsis thaliana (thale cress) | APA1 | NP_172655.1 |
Oryza sativa (rice) | Os05g0567100 | NP_001056348.1 |
Xenopus tropicalis (tropical clawed frog) | LOC101735147 | XP_004914286.1 |
CTSD | XP_001091601.1 | |
Drosophila melanogaster (fruit fly) | cathD | NP_652013.1 |
Kluyveromyces lactis | KLLA0D05929g | XP_453326.1 |
Oryza sativa (rice) | Os01g0663400 | NP_001043786.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100489529 | XP_002938948.2 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The propeptide of yeast cathepsin D inhibits programmed necrosis.
Title: The propeptide of yeast cathepsin D inhibits programmed necrosis.
The finding that both mitochondrial AAC proteins and the vacuolar Pep4p interfere with mitochondrial degradation suggests a complex regulation and interplay between mitochondria and the vacuole in yeast programmed cell death.[Pep4 & AAC]
Title: Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier.
the lag phase of cell growth of partial PrA (PEP4) gene deletion mutant (36 h) and PrA-negative mutant (48 h) was significantly extended, compared with the wild type strain (24 h) (P<0.05), but PrA had no effect on glucose metabolism
Title: Effects of proteinase A on cultivation and viability characteristics of industrial Saccharomyces cerevisiae WZ65.
results indicate that Pep4p is important for protein turnover after oxidative damage; however, increased removal of oxidized proteins is not sufficient to enhance lifespan
Title: The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae.
concluded that increases in reactive-oxygen species and nuclear pore complex permeability occur relatively early during H2O2-induced cell death; later, Pep4p migrates out of vacuoles and degrades nucleoporins after the cells are effectively dead
Title: Increased nuclear envelope permeability and Pep4p-dependent degradation of nucleoporins during hydrogen peroxide-induced cell death.
The following PEP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PEP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04820 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183968.1 | |
Accession Version | NM_001183968.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | proteinase A | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTTCAGCT TGAAAGCATT ATTGCCATTG GCCTTGTTGT TGGTCAGCGC CAACCAAGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_015171.1 |
CDS | 1..1218 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTCAGCT TGAAAGCATT ATTGCCATTG GCCTTGTTGT TGGTCAGCGC CAACCAAGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
Life with 6000 genes. |