CTSD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTSD
Entrez Gene ID	1509
Full Name	cathepsin D
Synonyms	CLN10,CPSD,HEL-S-130P
General protein information	Preferred Names cathepsin D Names cathepsin D ceroid-lipofuscinosis, neuronal 10 epididymis secretory sperm binding protein Li 130P lysosomal aspartyl peptidase lysosomal aspartyl protease
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Summary	This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015].
Disorder MIM:	116840
Disorder Html:	Ceroid lipofuscinosis, neuronal, 10, 610127 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001909.4	NP_001900.1	cathepsin D preproprotein
NM_001909.5	NP_001900.1	cathepsin D preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CTSD	NP_001900.1
Bos taurus (cattle)	CTSD	NP_001159993.1
Rattus norvegicus (Norway rat)	Ctsd	NP_599161.2
Gallus gallus (chicken)	CTSD	NP_990508.1
Danio rerio (zebrafish)	ctsd	NP_571785.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003277	XP_307784.1
Arabidopsis thaliana (thale cress)	AT1G62290	NP_001031219.1
Mus musculus (house mouse)	Ctsd	NP_034113.1
Caenorhabditis elegans (roundworm)	asp-4	NP_510191.1
Saccharomyces cerevisiae (baker's yeast)	PEP4	NP_015171.1
Xenopus tropicalis (tropical clawed frog)	ctsd	NP_988964.1
Xenopus tropicalis (tropical clawed frog)	LOC613063	NP_001136375.1
Canis lupus familiaris (dog)	CTSD	NP_001020792.1
Magnaporthe oryzae (rice blast fungus)	MGG_00922	XP_003718037.1
Neurospora crassa	NCU02273	XP_959917.1
Arabidopsis thaliana (thale cress)	APA1	NP_172655.1
Oryza sativa (rice)	Os05g0567100	NP_001056348.1
Xenopus tropicalis (tropical clawed frog)	LOC101735147	XP_004914286.1
	CTSD	XP_001091601.1
Drosophila melanogaster (fruit fly)	cathD	NP_652013.1
Kluyveromyces lactis	KLLA0D05929g	XP_453326.1
Oryza sativa (rice)	Os01g0663400	NP_001043786.1
Xenopus tropicalis (tropical clawed frog)	LOC100489529	XP_002938948.2

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of cathepsin D activity by the FTLD protein progranulin.
Zhou X, Paushter DH, Feng T, Pardon CM, Mendoza CS, Hu F
Acta neuropathologica134(1)151-153(2017 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

apoptosis is accompanied by degradation of the cysteine cathepsin inhibitor stefin B (StfB). CatD did not exhibit a crucial role in this step. However, this degradation was partially prevented through pre-incubation with the antioxidant N-acetyl cysteine
Title: Tumor Necrosis Factor-? Induced Apoptosis in U937 Cells Promotes Cathepsin D-Independent Stefin B Degradation.

The lysosomal enzyme cathepsin D (CTSD) mediates the proteolytic cleavage of PSAP precursor into saposins A-D. Myc-CLN3 colocalized with CTSD and activity of CTSD decreased as myc-CLN3 expression increased, and clearly decreased under hyperosmotic conditions
Title: Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity.

Study demonstrate that PGRN interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Title: Regulation of cathepsin D activity by the FTLD protein progranulin.

Secreted PGRN is incorporated into cells via sortilin or cation-independent mannose 6-phosphate receptor, and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN levels led to a cell-type-specific increase of insoluble TDP-43. In the brain tissue of FTLD-TDP patients with PGRN deficiency, CTSD and phosphorylated TDP-43 accumulated in neurons
Title: Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

CTSD, in need of its catalytic activity, may promote proliferation in advanced glycation end products-treated human umbilical vein endothelial cells independent of the autophagy-lysosome pathway.
Title: Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D.

The following CTSD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26913	NM_001909.5 Latest version!	Homo sapiens cathepsin D (CTSD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu26913	NM_001909.4	Homo sapiens cathepsin D (CTSD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTSD ( NM_001909.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001900.1 Homo sapiens cathepsin D (CTSD), mRNA.

Price & Availability↑

CloneID	OHu26913
Clone ID Related Accession (Same CDS sequence)	NM_001909.4 , NM_001909.5
Accession Version	NM_001909.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	cathepsin D preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM762986.1, BC016320.2 and BM976200.1. This sequence is a reference standard in the RefSeqGene project. On May 4, 2011 this sequence version replaced NM_001909.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.161834.1, SRR1660805.152336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGCCCT CCAGCCTTCT GCCGCTCGCC CTCTGCCTGC TGGCTGCACC CGCCTCCGCG 
CTCGTCAGGA TCCCGCTGCA CAAGTTCACG TCCATCCGCC GGACCATGTC GGAGGTTGGG 
GGCTCTGTGG AGGACCTGAT TGCCAAAGGC CCCGTCTCAA AGTACTCCCA GGCGGTGCCA 
GCCGTGACCG AGGGGCCCAT TCCCGAGGTG CTCAAGAACT ACATGGACGC CCAGTACTAC 
GGGGAGATTG GCATCGGGAC GCCCCCCCAG TGCTTCACAG TCGTCTTCGA CACGGGCTCC 
TCCAACCTGT GGGTCCCCTC CATCCACTGC AAACTGCTGG ACATCGCTTG CTGGATCCAC 
CACAAGTACA ACAGCGACAA GTCCAGCACC TACGTGAAGA ATGGTACCTC GTTTGACATC 
CACTATGGCT CGGGCAGCCT CTCCGGGTAC CTGAGCCAGG ACACTGTGTC GGTGCCCTGC 
CAGTCAGCGT CGTCAGCCTC TGCCCTGGGC GGTGTCAAAG TGGAGAGGCA GGTCTTTGGG 
GAGGCCACCA AGCAGCCAGG CATCACCTTC ATCGCAGCCA AGTTCGATGG CATCCTGGGC 
ATGGCCTACC CCCGCATCTC CGTCAACAAC GTGCTGCCCG TCTTCGACAA CCTGATGCAG 
CAGAAGCTGG TGGACCAGAA CATCTTCTCC TTCTACCTGA GCAGGGACCC AGATGCGCAG 
CCTGGGGGTG AGCTGATGCT GGGTGGCACA GACTCCAAGT ATTACAAGGG TTCTCTGTCC 
TACCTGAATG TCACCCGCAA GGCCTACTGG CAGGTCCACC TGGACCAGGT GGAGGTGGCC 
AGCGGGCTGA CCCTGTGCAA GGAGGGCTGT GAGGCCATTG TGGACACAGG CACTTCCCTC 
ATGGTGGGCC CGGTGGATGA GGTGCGCGAG CTGCAGAAGG CCATCGGGGC CGTGCCGCTG 
ATTCAGGGCG AGTACATGAT CCCCTGTGAG AAGGTGTCCA CCCTGCCCGC GATCACACTG 
AAGCTGGGAG GCAAAGGCTA CAAGCTGTCC CCAGAGGACT ACACGCTCAA GGTGTCGCAG 
GCCGGGAAGA CCCTCTGCCT GAGCGGCTTC ATGGGCATGG ACATCCCGCC ACCCAGCGGG 
CCACTCTGGA TCCTGGGCGA CGTCTTCATC GGCCGCTACT ACACTGTGTT TGACCGTGAC 
AACAACAGGG TGGGCTTCGC CGAGGCTGCC CGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001900.1
CDS	134..1372
Translation	MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

Target ORF information:

RefSeq Version	NM_001909.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin D (CTSD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001909.4

ORF Insert Sequence:

ATGCAGCCCT CCAGCCTTCT GCCGCTCGCC CTCTGCCTGC TGGCTGCACC CGCCTCCGCG 
CTCGTCAGGA TCCCGCTGCA CAAGTTCACG TCCATCCGCC GGACCATGTC GGAGGTTGGG 
GGCTCTGTGG AGGACCTGAT TGCCAAAGGC CCCGTCTCAA AGTACTCCCA GGCGGTGCCA 
GCCGTGACCG AGGGGCCCAT TCCCGAGGTG CTCAAGAACT ACATGGACGC CCAGTACTAC 
GGGGAGATTG GCATCGGGAC GCCCCCCCAG TGCTTCACAG TCGTCTTCGA CACGGGCTCC 
TCCAACCTGT GGGTCCCCTC CATCCACTGC AAACTGCTGG ACATCGCTTG CTGGATCCAC 
CACAAGTACA ACAGCGACAA GTCCAGCACC TACGTGAAGA ATGGTACCTC GTTTGACATC 
CACTATGGCT CGGGCAGCCT CTCCGGGTAC CTGAGCCAGG ACACTGTGTC GGTGCCCTGC 
CAGTCAGCGT CGTCAGCCTC TGCCCTGGGC GGTGTCAAAG TGGAGAGGCA GGTCTTTGGG 
GAGGCCACCA AGCAGCCAGG CATCACCTTC ATCGCAGCCA AGTTCGATGG CATCCTGGGC 
ATGGCCTACC CCCGCATCTC CGTCAACAAC GTGCTGCCCG TCTTCGACAA CCTGATGCAG 
CAGAAGCTGG TGGACCAGAA CATCTTCTCC TTCTACCTGA GCAGGGACCC AGATGCGCAG 
CCTGGGGGTG AGCTGATGCT GGGTGGCACA GACTCCAAGT ATTACAAGGG TTCTCTGTCC 
TACCTGAATG TCACCCGCAA GGCCTACTGG CAGGTCCACC TGGACCAGGT GGAGGTGGCC 
AGCGGGCTGA CCCTGTGCAA GGAGGGCTGT GAGGCCATTG TGGACACAGG CACTTCCCTC 
ATGGTGGGCC CGGTGGATGA GGTGCGCGAG CTGCAGAAGG CCATCGGGGC CGTGCCGCTG 
ATTCAGGGCG AGTACATGAT CCCCTGTGAG AAGGTGTCCA CCCTGCCCGC GATCACACTG 
AAGCTGGGAG GCAAAGGCTA CAAGCTGTCC CCAGAGGACT ACACGCTCAA GGTGTCGCAG 
GCCGGGAAGA CCCTCTGCCT GAGCGGCTTC ATGGGCATGG ACATCCCGCC ACCCAGCGGG 
CCACTCTGGA TCCTGGGCGA CGTCTTCATC GGCCGCTACT ACACTGTGTT TGACCGTGAC 
AACAACAGGG TGGGCTTCGC CGAGGCTGCC CGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSD ( NM_001909.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001900.1 Homo sapiens cathepsin D (CTSD), mRNA.

Price & Availability↑

CloneID	OHu26913
Clone ID Related Accession (Same CDS sequence)	NM_001909.4 , NM_001909.5
Accession Version	NM_001909.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	cathepsin D preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM762986.1 and BC016320.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001909.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.350777.1, SRR3476690.959075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000236671.7/ ENSP00000236671.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCCCT CCAGCCTTCT GCCGCTCGCC CTCTGCCTGC TGGCTGCACC CGCCTCCGCG 
CTCGTCAGGA TCCCGCTGCA CAAGTTCACG TCCATCCGCC GGACCATGTC GGAGGTTGGG 
GGCTCTGTGG AGGACCTGAT TGCCAAAGGC CCCGTCTCAA AGTACTCCCA GGCGGTGCCA 
GCCGTGACCG AGGGGCCCAT TCCCGAGGTG CTCAAGAACT ACATGGACGC CCAGTACTAC 
GGGGAGATTG GCATCGGGAC GCCCCCCCAG TGCTTCACAG TCGTCTTCGA CACGGGCTCC 
TCCAACCTGT GGGTCCCCTC CATCCACTGC AAACTGCTGG ACATCGCTTG CTGGATCCAC 
CACAAGTACA ACAGCGACAA GTCCAGCACC TACGTGAAGA ATGGTACCTC GTTTGACATC 
CACTATGGCT CGGGCAGCCT CTCCGGGTAC CTGAGCCAGG ACACTGTGTC GGTGCCCTGC 
CAGTCAGCGT CGTCAGCCTC TGCCCTGGGC GGTGTCAAAG TGGAGAGGCA GGTCTTTGGG 
GAGGCCACCA AGCAGCCAGG CATCACCTTC ATCGCAGCCA AGTTCGATGG CATCCTGGGC 
ATGGCCTACC CCCGCATCTC CGTCAACAAC GTGCTGCCCG TCTTCGACAA CCTGATGCAG 
CAGAAGCTGG TGGACCAGAA CATCTTCTCC TTCTACCTGA GCAGGGACCC AGATGCGCAG 
CCTGGGGGTG AGCTGATGCT GGGTGGCACA GACTCCAAGT ATTACAAGGG TTCTCTGTCC 
TACCTGAATG TCACCCGCAA GGCCTACTGG CAGGTCCACC TGGACCAGGT GGAGGTGGCC 
AGCGGGCTGA CCCTGTGCAA GGAGGGCTGT GAGGCCATTG TGGACACAGG CACTTCCCTC 
ATGGTGGGCC CGGTGGATGA GGTGCGCGAG CTGCAGAAGG CCATCGGGGC CGTGCCGCTG 
ATTCAGGGCG AGTACATGAT CCCCTGTGAG AAGGTGTCCA CCCTGCCCGC GATCACACTG 
AAGCTGGGAG GCAAAGGCTA CAAGCTGTCC CCAGAGGACT ACACGCTCAA GGTGTCGCAG 
GCCGGGAAGA CCCTCTGCCT GAGCGGCTTC ATGGGCATGG ACATCCCGCC ACCCAGCGGG 
CCACTCTGGA TCCTGGGCGA CGTCTTCATC GGCCGCTACT ACACTGTGTT TGACCGTGAC 
AACAACAGGG TGGGCTTCGC CGAGGCTGCC CGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001900.1
CDS	69..1307
Translation	MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

Target ORF information:

RefSeq Version	NM_001909.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin D (CTSD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001909.5

ORF Insert Sequence:

ATGCAGCCCT CCAGCCTTCT GCCGCTCGCC CTCTGCCTGC TGGCTGCACC CGCCTCCGCG 
CTCGTCAGGA TCCCGCTGCA CAAGTTCACG TCCATCCGCC GGACCATGTC GGAGGTTGGG 
GGCTCTGTGG AGGACCTGAT TGCCAAAGGC CCCGTCTCAA AGTACTCCCA GGCGGTGCCA 
GCCGTGACCG AGGGGCCCAT TCCCGAGGTG CTCAAGAACT ACATGGACGC CCAGTACTAC 
GGGGAGATTG GCATCGGGAC GCCCCCCCAG TGCTTCACAG TCGTCTTCGA CACGGGCTCC 
TCCAACCTGT GGGTCCCCTC CATCCACTGC AAACTGCTGG ACATCGCTTG CTGGATCCAC 
CACAAGTACA ACAGCGACAA GTCCAGCACC TACGTGAAGA ATGGTACCTC GTTTGACATC 
CACTATGGCT CGGGCAGCCT CTCCGGGTAC CTGAGCCAGG ACACTGTGTC GGTGCCCTGC 
CAGTCAGCGT CGTCAGCCTC TGCCCTGGGC GGTGTCAAAG TGGAGAGGCA GGTCTTTGGG 
GAGGCCACCA AGCAGCCAGG CATCACCTTC ATCGCAGCCA AGTTCGATGG CATCCTGGGC 
ATGGCCTACC CCCGCATCTC CGTCAACAAC GTGCTGCCCG TCTTCGACAA CCTGATGCAG 
CAGAAGCTGG TGGACCAGAA CATCTTCTCC TTCTACCTGA GCAGGGACCC AGATGCGCAG 
CCTGGGGGTG AGCTGATGCT GGGTGGCACA GACTCCAAGT ATTACAAGGG TTCTCTGTCC 
TACCTGAATG TCACCCGCAA GGCCTACTGG CAGGTCCACC TGGACCAGGT GGAGGTGGCC 
AGCGGGCTGA CCCTGTGCAA GGAGGGCTGT GAGGCCATTG TGGACACAGG CACTTCCCTC 
ATGGTGGGCC CGGTGGATGA GGTGCGCGAG CTGCAGAAGG CCATCGGGGC CGTGCCGCTG 
ATTCAGGGCG AGTACATGAT CCCCTGTGAG AAGGTGTCCA CCCTGCCCGC GATCACACTG 
AAGCTGGGAG GCAAAGGCTA CAAGCTGTCC CCAGAGGACT ACACGCTCAA GGTGTCGCAG 
GCCGGGAAGA CCCTCTGCCT GAGCGGCTTC ATGGGCATGG ACATCCCGCC ACCCAGCGGG 
CCACTCTGGA TCCTGGGCGA CGTCTTCATC GGCCGCTACT ACACTGTGTT TGACCGTGAC 
AACAACAGGG TGGGCTTCGC CGAGGCTGCC CGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of cathepsin D activity by the FTLD protein progranulin.
Acta neuropathologica134(1)151-153(2017 07)
Zhou X,Paushter DH,Feng T,Pardon CM,Mendoza CS,Hu F

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CTSD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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