Gene Symbol | CTSD |
Entrez Gene ID | 282883 |
Full Name | cathepsin D |
Synonyms | CATD |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » CTSD cDNA ORF clone
Gene Symbol | CTSD |
Entrez Gene ID | 282883 |
Full Name | cathepsin D |
Synonyms | CATD |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_005227296.2 | XP_005227353.1 | cathepsin D isoform X2 |
XM_005227296.3 | XP_005227353.1 | cathepsin D isoform X3 |
NM_001166521.1 | NP_001159993.1 | cathepsin D precursor |
NM_001166521.2 | NP_001159993.1 | cathepsin D precursor |
XM_005227295.3 | XP_005227352.1 | cathepsin D isoform X1 |
XM_005227295.4 | XP_005227352.1 | cathepsin D isoform X1 |
XM_024986989.1 | XP_024842757.1 | cathepsin D isoform X2 |
Homo sapiens (human) | CTSD | NP_001900.1 |
Bos taurus (cattle) | CTSD | NP_001159993.1 |
Rattus norvegicus (Norway rat) | Ctsd | NP_599161.2 |
Gallus gallus (chicken) | CTSD | NP_990508.1 |
Danio rerio (zebrafish) | ctsd | NP_571785.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003277 | XP_307784.1 |
Arabidopsis thaliana (thale cress) | AT1G62290 | NP_001031219.1 |
Mus musculus (house mouse) | Ctsd | NP_034113.1 |
Caenorhabditis elegans (roundworm) | asp-4 | NP_510191.1 |
Saccharomyces cerevisiae (baker's yeast) | PEP4 | NP_015171.1 |
Xenopus tropicalis (tropical clawed frog) | ctsd | NP_988964.1 |
Xenopus tropicalis (tropical clawed frog) | LOC613063 | NP_001136375.1 |
Canis lupus familiaris (dog) | CTSD | NP_001020792.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00922 | XP_003718037.1 |
Neurospora crassa | NCU02273 | XP_959917.1 |
Arabidopsis thaliana (thale cress) | APA1 | NP_172655.1 |
Oryza sativa (rice) | Os05g0567100 | NP_001056348.1 |
Xenopus tropicalis (tropical clawed frog) | LOC101735147 | XP_004914286.1 |
CTSD | XP_001091601.1 | |
Drosophila melanogaster (fruit fly) | cathD | NP_652013.1 |
Kluyveromyces lactis | KLLA0D05929g | XP_453326.1 |
Oryza sativa (rice) | Os01g0663400 | NP_001043786.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100489529 | XP_002938948.2 |
Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
Ribeca C, Bonfatti V, Cecchinato A, Albera A, Maretto F, Gallo L, Carnier P
Animal genetics44(2)193-6(2013 Apr)
A novel approach for characterization of cathepsin D protease and its effect on tau and ?-amyloid proteins.
Malik M, Fenko MD, Sheikh AM, Wen G, Li X
Neurochemical research36(5)754-60(2011 May)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.
Metcalf P, Fusek M
The EMBO journal12(4)1293-302(1993 Apr)
Procathepsin D cannot autoactivate to cathepsin D at acid pH.
Larsen LB, Boisen A, Petersen TE
FEBS letters319(1-2)54-8(1993 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
Title: Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease
Title: A novel approach for characterization of cathepsin D protease and its effect on tau and ?-amyloid proteins.
The following CTSD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa44555 | |
Clone ID Related Accession (Same CDS sequence) | NM_001166521.1 , NM_001166521.2 | |
Accession Version | NM_001166521.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-22 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DAAA02063738.1. On Oct 27, 2009 this sequence version replaced XM_609913.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00120238, SAMN02822088 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001159993.1 |
CDS | 90..1322 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001166521.1 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa44555 | |
Clone ID Related Accession (Same CDS sequence) | NM_001166521.1 , NM_001166521.2 | |
Accession Version | NM_001166521.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from NKLS02000029.1. On May 29, 2018 this sequence version replaced NM_001166521.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145425, SAMN03145428 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001159993.1 |
CDS | 90..1322 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001166521.2 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa34980 | |
Clone ID Related Accession (Same CDS sequence) | XM_005227295.3 , XM_005227295.4 | |
Accession Version | XM_005227295.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104648.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005227295.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005227352.1 |
CDS | 90..1484 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005227295.3 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa34980 | |
Clone ID Related Accession (Same CDS sequence) | XM_005227295.3 , XM_005227295.4 | |
Accession Version | XM_005227295.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037356.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005227295.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005227352.1 |
CDS | 87..1481 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005227295.4 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa34981 | |
Clone ID Related Accession (Same CDS sequence) | XM_005227296.2 , XM_005227296.3 | |
Accession Version | XM_005227296.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104648.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 30, 2014 this sequence version replaced XM_005227296.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005227353.1 |
CDS | 94..1332 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005227296.2 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa34981 | |
Clone ID Related Accession (Same CDS sequence) | XM_005227296.2 , XM_005227296.3 | |
Accession Version | XM_005227296.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037356.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005227296.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005227353.1 |
CDS | 153..1391 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005227296.3 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa231845 | |
Clone ID Related Accession (Same CDS sequence) | XM_024986989.1 | |
Accession Version | XM_024986989.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | cathepsin D isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037356.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024842757.1 |
CDS | 87..1352 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024986989.1 |
1 | ATGCAGACGC CCAGACTGCT GCCGCTGCTG CTCGCCCTCG GCCTGCTGGC CGCGCCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle. |
A novel approach for characterization of cathepsin D protease and its effect on tau and ?-amyloid proteins. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. |
Procathepsin D cannot autoactivate to cathepsin D at acid pH. |