Slc25a4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc25a4
Entrez Gene ID	85333
Full Name	solute carrier family 25 member 4
Synonyms	Ant1
General protein information	Preferred Names solute carrier family 25 member 4 Names ADP/ATP translocase 1 ADP,ATP carrier protein 1 ANT 1 adenine nucleotide translocator 1 adenine nucleotide translocator), member 4 mitochondrial adenine nucleotide translocator solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4 solute carrier family 25 (mitochondrial carrier solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q11
Summary	catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053515.1	NP_445967.1	ADP/ATP translocase 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC25A4	NP_777083.1
Anopheles gambiae (African malaria mosquito)	ADT2_ANOGA	XP_003436097.1
Danio rerio (zebrafish)	slc25a4	NP_999867.1
Xenopus tropicalis (tropical clawed frog)	slc25a4	NP_988909.1
	SLC25A4	XP_001084544.1
Canis lupus familiaris (dog)	SLC25A4	XP_532844.2
Mus musculus (house mouse)	Slc25a4	NP_031476.3
Gallus gallus (chicken)	SLC25A4	NP_001006443.1
Drosophila melanogaster (fruit fly)	sesB	NP_727448.1
Homo sapiens (human)	SLC25A4	NP_001142.2
Pan troglodytes (chimpanzee)	SLC25A4	XP_517556.3
Rattus norvegicus (Norway rat)	Slc25a4	NP_445967.1

Gene Ontology
Bibliography

Related articles in PubMed

Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number.
Thompson K, Majd H, Dallabona C, Reinson K, King MS, Alston CL, He L, Lodi T, Jones SA, Fattal-Valevski A, Fraenkel ND, Saada A, Haham A, Isohanni P, Vara R, Barbosa IA, Simpson MA, Deshpande C, Puusepp S, Bonnen PE, Rodenburg RJ, Suomalainen A, ?unap K, Elpeleg O, Ferrero I, McFarland R, Kunji ER, Taylor RW
American journal of human genetics99(4)860-876(2016 10)

Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress.
Klumpe I, Savvatis K, Westermann D, Tsch?pe C, Rauch U, Landmesser U, Schultheiss HP, D?rner A
Journal of molecular medicine (Berlin, Germany)94(6)645-53(2016 Jun)

To involvement the conformation of the adenine nucleotide translocase in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria.
Korotkov SM, Konovalova SA, Brailovskaya IV, Saris NE
Toxicology in vitro : an international journal published in association with BIBRA32320-32(2016 Apr)

Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia via increased ERK1/2 and AKT activation.
Winter J, Klumpe I, Heger J, Rauch U, Schultheiss HP, Landmesser U, D?rner A
Cellular signalling28(1)152-9(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ANT1 overexpression compensates impaired adenine nucleotide translocase activity under oxygen-restricted conditions
Title: Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress.

Our data suggest that conformational changes of ANT may be directly involved in the opening of the Tl(+)-induced mitochondrial permeability transition pore in the inner membrane of Ca(2+)-loaded rat liver mitochondria
Title: To involvement the conformation of the adenine nucleotide translocase in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria.

Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia
Title: Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia via increased ERK1/2 and AKT activation.

The findings reported in this paper demonstrate that ADP inhibits the proapoptotic stimulus supposedly via: i) inhibition of ROS production during early stages of apoptosis, an effect mediated by its interaction with cell receptor/s.
Title: Extracellular ADP prevents neuronal apoptosis via activation of cell antioxidant enzymes and protection of mitochondrial ANT-1.

carbon monoxide protects astrocytes from apoptosis by preventing MMP, acting on ANT (glutathionylation and inhibition of its pore activity) via a preconditioning-like process mediated by ROS and GSSG
Title: Glutathionylation of adenine nucleotide translocase induced by carbon monoxide prevents mitochondrial membrane permeabilization and apoptosis.

The following Slc25a4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc25a4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12486	NM_053515.1 Latest version!	Rattus norvegicus solute carrier family 25 member 4 (Slc25a4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc25a4 ( NM_053515.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445967.1 Rattus norvegicus solute carrier family 25 member 4 (Slc25a4), mRNA.

Price & Availability↑

CloneID	ORa12486
Clone ID Related Accession (Same CDS sequence)	NM_053515.1
Accession Version	NM_053515.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	ADP/ATP translocase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X61667.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ213612.1, FQ213027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGGGGATC AGGCTTTGAG CTTCCTTAAG GACTTCCTGG CAGGTGGCAT CGCCGCCGCC 
GTCTCCAAGA CCGCGGTCGC CCCGATCGAG AGGGTCAAAC TGCTGCTGCA GGTCCAGCAT 
GCCAGCAAAC AGATCAGTGC AGAGAAACAG TACAAAGGCA TCATTGATTG TGTCGTGAGA 
ATCCCCAAGG AGCAGGGCTT TCTCTCCTTC TGGAGGGGTA ACCTGGCCAA CGTGATCCGG 
TACTTCCCCA CCCAAGCTCT CAACTTCGCC TTCAAGGACA AGTACAAGCA GATCTTCCTG 
GGAGGTGTGG ATCGTCATAA GCAGTTCTGG CGCTACTTCG CTGGTAACCT GGCCTCTGGT 
GGGGCAGCTG GGGCTACCTC CCTCTGCTTC GTCTACCCAC TGGACTTTGC TAGGACCAGG 
CTGGCTGCCG ACGTGGGCAA GGGATCTTCC CAGCGTGAGT TCAATGGGCT GGGTGACTGT 
CTCACCAAGA TCTTCAAGTC TGATGGCCTG AAGGGTCTCT ACCAGGGTTT CAGTGTCTCT 
GTGCAGGGCA TCATCATCTA CAGAGCTGCC TACTTCGGAG TCTATGACAC TGCCAAGGGG 
ATGCTGCCAG ACCCCAAGAA TGTGCACATT ATTGTGAGCT GGATGATTGC CCAGAGTGTG 
ACAGCCGTGG CGGGGCTGGT GTCCTATCCA TTTGACACTG TCCGTCGTAG GATGATGATG 
CAGTCTGGCC GGAAAGGGGC TGATATTATG TACACGGGGA CAGTTGACTG CTGGAGGAAG 
ATTGCAAAAG ATGAAGGACG CAAAGCTTTC TTCAAAGGTG CTTGGTCCAA CGTACTGAGA 
GGCATGGGGG GTGCTTTTGT ATTGGTATTG TATGATGAGA TCAAAAAATA TGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445967.1
CDS	109..1005
Translation	MGDQALSFLKDFLAGGIAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGSSQREFNGLGDCLTKIFKSDGLKGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGRKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV

Target ORF information:

RefSeq Version	NM_053515.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 25 member 4 (Slc25a4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053515.1

ORF Insert Sequence:

ATGGGGGATC AGGCTTTGAG CTTCCTTAAG GACTTCCTGG CAGGTGGCAT CGCCGCCGCC 
GTCTCCAAGA CCGCGGTCGC CCCGATCGAG AGGGTCAAAC TGCTGCTGCA GGTCCAGCAT 
GCCAGCAAAC AGATCAGTGC AGAGAAACAG TACAAAGGCA TCATTGATTG TGTCGTGAGA 
ATCCCCAAGG AGCAGGGCTT TCTCTCCTTC TGGAGGGGTA ACCTGGCCAA CGTGATCCGG 
TACTTCCCCA CCCAAGCTCT CAACTTCGCC TTCAAGGACA AGTACAAGCA GATCTTCCTG 
GGAGGTGTGG ATCGTCATAA GCAGTTCTGG CGCTACTTCG CTGGTAACCT GGCCTCTGGT 
GGGGCAGCTG GGGCTACCTC CCTCTGCTTC GTCTACCCAC TGGACTTTGC TAGGACCAGG 
CTGGCTGCCG ACGTGGGCAA GGGATCTTCC CAGCGTGAGT TCAATGGGCT GGGTGACTGT 
CTCACCAAGA TCTTCAAGTC TGATGGCCTG AAGGGTCTCT ACCAGGGTTT CAGTGTCTCT 
GTGCAGGGCA TCATCATCTA CAGAGCTGCC TACTTCGGAG TCTATGACAC TGCCAAGGGG 
ATGCTGCCAG ACCCCAAGAA TGTGCACATT ATTGTGAGCT GGATGATTGC CCAGAGTGTG 
ACAGCCGTGG CGGGGCTGGT GTCCTATCCA TTTGACACTG TCCGTCGTAG GATGATGATG 
CAGTCTGGCC GGAAAGGGGC TGATATTATG TACACGGGGA CAGTTGACTG CTGGAGGAAG 
ATTGCAAAAG ATGAAGGACG CAAAGCTTTC TTCAAAGGTG CTTGGTCCAA CGTACTGAGA 
GGCATGGGGG GTGCTTTTGT ATTGGTATTG TATGATGAGA TCAAAAAATA TGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number.
American journal of human genetics99(4)860-876(2016 10)
Thompson K,Majd H,Dallabona C,Reinson K,King MS,Alston CL,He L,Lodi T,Jones SA,Fattal-Valevski A,Fraenkel ND,Saada A,Haham A,Isohanni P,Vara R,Barbosa IA,Simpson MA,Deshpande C,Puusepp S,Bonnen PE,Rodenburg RJ,Suomalainen A,?unap K,Elpeleg O,Ferrero I,McFarland R,Kunji ER,Taylor RW

Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress.
Journal of molecular medicine (Berlin, Germany)94(6)645-53(2016 Jun)
Klumpe I,Savvatis K,Westermann D,Tsch?pe C,Rauch U,Landmesser U,Schultheiss HP,D?rner A

To involvement the conformation of the adenine nucleotide translocase in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria.
Toxicology in vitro : an international journal published in association with BIBRA32320-32(2016 Apr)
Korotkov SM,Konovalova SA,Brailovskaya IV,Saris NE

Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia via increased ERK1/2 and AKT activation.
Cellular signalling28(1)152-9(2016 Jan)
Winter J,Klumpe I,Heger J,Rauch U,Schultheiss HP,Landmesser U,D?rner A

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Slc25a4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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