Trim71 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trim71
Entrez Gene ID	636931
Full Name	tripartite motif-containing 71
Synonyms	2610206G21Rik,AL022943,Gm1127,Lin41,lin-41,mLin41,mlin-41
General protein information	Preferred Names tripartite motif-containing 71 Names E3 ubiquitin-protein ligase TRIM71 RING-type E3 ubiquitin transferase TRIM71 lin-41 homolog protein lin-41 homolog tripartite motif-containing protein 71
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001042503.2	NP_001035968.1	E3 ubiquitin-protein ligase TRIM71

Pathways from BioSystems

Homologies

	TRIM71	XP_001098706.1
Bos taurus (cattle)	TRIM71	XP_002707823.1
Gallus gallus (chicken)	TRIM71	NP_001032352.2
Pan troglodytes (chimpanzee)	TRIM71	XP_516352.3
Rattus norvegicus (Norway rat)	Trim71	NP_001178730.1
Danio rerio (zebrafish)	trim71	XP_690252.5
Caenorhabditis elegans (roundworm)	lin-41	NP_001020998.1
Mus musculus (house mouse)	Trim71	NP_001035968.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005125	XP_314006.4
Homo sapiens (human)	TRIM71	NP_001034200.1
Canis lupus familiaris (dog)	TRIM71	XP_534214.3
Drosophila melanogaster (fruit fly)	wech	NP_001137614.1
Xenopus tropicalis (tropical clawed frog)	LOC100486898	XP_004915429.1

Gene Ontology
Bibliography

Related articles in PubMed

The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation.
Nguyen DTT, Richter D, Michel G, Mitschka S, Kolanus W, Cuevas E, Wulczyn FG
Cell death and differentiation24(6)1063-1078(2017 06)

The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.
Golden EJ, Benito-Gonzalez A, Doetzlhofer A
Proceedings of the National Academy of Sciences of the United States of America112(29)E3864-73(2015 Jul)

Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis.
Schulman BR, Esquela-Kerscher A, Slack FJ
Developmental dynamics : an official publication of the American Association of Anatomists234(4)1046-54(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

suggest that Trim71 keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells
Title: Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (also called Lin41), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
Title: The RNA-binding protein repertoire of embryonic stem cells.

mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 stability, but through FGF signaling.
Title: The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.

The transcripts of mlin-41 and the protein level in mouse adult tissues and embryos from 9.5 to 13 days were detected by RT-PCR and western blot.
Title: Expressing and characterization of mLIN-41 in mouse early embryos and adult muscle tissues.

demonstrate the presence of mLin41 protein in several stem cell niches, including the embryonic ectoderm, epidermis and male germ line.
Title: The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.

The following Trim71 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trim71 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16063	NM_001042503.2 Latest version!	Mus musculus tripartite motif-containing 71 (Trim71), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$503.30 $719.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trim71 ( NM_001042503.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001035968.1 Mus musculus tripartite motif-containing 71 (Trim71), mRNA.

Price & Availability↑

CloneID	OMu16063
Clone ID Related Accession (Same CDS sequence)	NM_001042503.2
Accession Version	NM_001042503.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase TRIM71
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC164109.2. On Dec 12, 2009 this sequence version replaced NM_001042503.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ005956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCGT TCCCGGAGAC CGACTTCCAG ATCTGCCTGC TGTGCAAGGA GATGTGCGGC 
TCGCCCGCGC CGCTCTCCTC CAACTCGTCC GCCTCGTCGT CGTCCTCGCA GACTTCCACG 
TCGTCGGCGG GCGGCGGCGG CCCCGGGGCG GCGGCGCGGC GTCTTCACGT CTTGCCCTGC 
CTGCACGCCT TCTGCCGGCC GTGCCTCGAG GCGCACCGGC TGCCCGCTCC CGGAGGCGCG 
GGCCCCGCCG AGGCGCTGAA GCTGCGCTGC CCCGTATGTG ACCAGAAGGT GGTCCTGGCC 
GAGGCGGCGG GCATGGACGC GCTGCCATCC TCCGCCTTCC TGCTCAGCAA CCTGCTGGAC 
GCCGTGGTGG CCACCGCCGA AGAGCCGCCG CCCAAGAACG GGCGCGCGGG CGGCGGCCCC 
GGGGGCGCGG GCGGCCACAG CAACCACCGG CACCATGCGC ACCACCCGGC CCAGCGCGCC 
GCCGCTCCAG CGCCGCAGCC GCCGCCCGGC CCGGCCGCCT CCCCCGGGTC GCTGCTGATG 
CGCCGGCCGC ACGGCTGCAG CTCCTGCGAC GAGGGCAACG CCGCCTCGTC GCGCTGCCTC 
GACTGCCAGG AACACCTGTG CGACAACTGT GTCCGCGCGC ACCAGCGCGT CCGCCTCACC 
AAGGACCATT ACATCGAGCG CGGCCCTCCG GGGCCTGCGG CCGCCTCCGC GGCACAGCAG 
CTGGGGCTCG GGCCGCCCTT CGCGGGCGCG CCCTTCTCCA TTCTCTCGGT GTTCCCGGAG 
CGCCTCGGCT TCTGCCAGCA CCACGACGAT GAGGTCCTGC ATCTCTACTG TGACACCTGC 
TCTGTCCCCA TCTGCAGAGA GTGCACGCTG GGCCGCCACG GTGGCCACAG CTTCGCCTAC 
CTCCAGGATG CCCTGCAGGA CTCTCGGGCA CTCACCATCC AGCTGCTGGC TGATGCCCAG 
CAGGGCCGCC AGGCTCTCCA GCTGAGCATC GAGCAGGCCC AGACTGTGGC AGAACAGGTG 
GAGATGAAGG CGAAGGTGGT CCAGTCTGAG GTCAAGGCCG TCACAGCTCG CCACAAGAAG 
GCCCTGGAGG ATCGGGAGTG TGAGCTGTTG TGGAAGGTGG AGAAGATCCG GCAGGTGAAG 
GCGAAGTCTC TGTTCCTGCA GGTGGAGAAG CTGCGGCAGA GTCTCAGCAA GCTGGAGAGC 
ACCATCAGCG CCGTGCAGCA GGTCCTGGAA GAGGGCCGCG CCCTGGACAT CCTGCTGGCC 
CGAGACCGGA TGCTGGCCCA GGTGCAGGAG CTCAAGACCA TCCGAGGCCT CCTGCAGCCC 
CAAGAAGATG ACCGCATTAT GTTCACGCCC CCTGACCAGG CCCTGTACCT CGCCCTCAAG 
TCTATTGGCT TTGTCAGCAG CGGGGCCTTC GCCCCGCTCA CGAAGGCTAC AGGAGATGGC 
ATCAAGCGTG CCCTTCAGGG GAAGGTGGCC TCTTTCACTG TCATGGGCTA CGACCACGAT 
GGTGAGCCCC GCCATTCGGG AGGTGACCTG ATGTCAGTTG TGGTCCTCGG CCCCGACGGA 
AACCTGTTTG GTGCAGAAGT GAGCGACCAG CAGAATGGTA CTTACATAGT GAGCTACAGG 
CCCCAGCTTG AGGGTGAGCA CTTGGTGTCG GTGACATTGT ACAATCAGCA TATAGAGAAC 
AGCCCCTTCA AGGTCGTGGT CAAGTCGGGC CGCAGCTACG TGGGCATCGG GCTCCCCGGG 
CTGAGCTTCG GCAGTGAAGG TGACGGGGAG GGCAAGCTCT GCAGGCCCTG GGGCGTGAGT 
GTTGATAAGG AGGGTTTCAT CATAGTGGCT GACCGAAGCA ATAACAGAAT CCAGGTGTTT 
AAGCCCTGTG GTTCCTTCCA CCACAAGTTT GGTACCCTTG GGTCTCGTCC TGGGCAGTTT 
GACCGACCGG CTGGGGTGGC TTGTGACGCC TCCCGCAGGA TCATAGTGGC CGACAAAGAC 
AATCATCGCA TTCAGATCTT CACCTTCGAG GGCCAGTTCC TTCTTAAGTT TGGTGAGAAA 
GGCACCAAGA ACGGGCAGTT TAACTACCCG TGGGATGTAG CAGTGAATTC TGAGGGCAAG 
ATCCTCGTTT CAGACACCCG GAATCATCGC ATCCAGTTGT TCGGACCGGA CGGGGTCTTC 
CTGAACAAGT ACGGCTTCGA GGGATCTCTC TGGAAGCACT TCGACTCTCC ACGGGGCGTG 
GCTTTCAACA ATGAAGGTCA CCTGGTAGTC ACCGACTTCA ACAACCACCG GCTTCTGGTT 
ATTCACCCTG ATTGCCAATC TGCCCGCTTC TTGGGTTCGG AGGGCTCGGG CAATGGGCAG 
TTCCTGCGAC CACAGGGTGT GGCTGTGGAC CAGGAAGGGA GAATCATCGT AGCCGATTCC 
AGAAATCACC GCGTGCAGAT GTTTGAGGCC AATGGCAGCT TCCTGTGCAA GTTTGGTGCT 
CAAGGGAGTG GCTTCGGGCA GATGGACCGC CCCTCAGGTA TCGCGGTCAC CCCGGATGGA 
TTGATCGTCG TGGTGGACTT TGGCAACAAT CGAATCCTCA TCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035968.1
CDS	1253..3820
Translation	MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATAEEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLMRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPPDQALYLALKSIGFVSSGAFAPLTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDGEGKLCRPWGVSVDKEGFIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIIVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVVDFGNNRILIF

Target ORF information:

RefSeq Version	NM_001042503.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus tripartite motif-containing 71 (Trim71), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042503.2

ORF Insert Sequence:

ATGGCTTCGT TCCCGGAGAC CGACTTCCAG ATCTGCCTGC TGTGCAAGGA GATGTGCGGC 
TCGCCCGCGC CGCTCTCCTC CAACTCGTCC GCCTCGTCGT CGTCCTCGCA GACTTCCACG 
TCGTCGGCGG GCGGCGGCGG CCCCGGGGCG GCGGCGCGGC GTCTTCACGT CTTGCCCTGC 
CTGCACGCCT TCTGCCGGCC GTGCCTCGAG GCGCACCGGC TGCCCGCTCC CGGAGGCGCG 
GGCCCCGCCG AGGCGCTGAA GCTGCGCTGC CCCGTATGTG ACCAGAAGGT GGTCCTGGCC 
GAGGCGGCGG GCATGGACGC GCTGCCATCC TCCGCCTTCC TGCTCAGCAA CCTGCTGGAC 
GCCGTGGTGG CCACCGCCGA AGAGCCGCCG CCCAAGAACG GGCGCGCGGG CGGCGGCCCC 
GGGGGCGCGG GCGGCCACAG CAACCACCGG CACCATGCGC ACCACCCGGC CCAGCGCGCC 
GCCGCTCCAG CGCCGCAGCC GCCGCCCGGC CCGGCCGCCT CCCCCGGGTC GCTGCTGATG 
CGCCGGCCGC ACGGCTGCAG CTCCTGCGAC GAGGGCAACG CCGCCTCGTC GCGCTGCCTC 
GACTGCCAGG AACACCTGTG CGACAACTGT GTCCGCGCGC ACCAGCGCGT CCGCCTCACC 
AAGGACCATT ACATCGAGCG CGGCCCTCCG GGGCCTGCGG CCGCCTCCGC GGCACAGCAG 
CTGGGGCTCG GGCCGCCCTT CGCGGGCGCG CCCTTCTCCA TTCTCTCGGT GTTCCCGGAG 
CGCCTCGGCT TCTGCCAGCA CCACGACGAT GAGGTCCTGC ATCTCTACTG TGACACCTGC 
TCTGTCCCCA TCTGCAGAGA GTGCACGCTG GGCCGCCACG GTGGCCACAG CTTCGCCTAC 
CTCCAGGATG CCCTGCAGGA CTCTCGGGCA CTCACCATCC AGCTGCTGGC TGATGCCCAG 
CAGGGCCGCC AGGCTCTCCA GCTGAGCATC GAGCAGGCCC AGACTGTGGC AGAACAGGTG 
GAGATGAAGG CGAAGGTGGT CCAGTCTGAG GTCAAGGCCG TCACAGCTCG CCACAAGAAG 
GCCCTGGAGG ATCGGGAGTG TGAGCTGTTG TGGAAGGTGG AGAAGATCCG GCAGGTGAAG 
GCGAAGTCTC TGTTCCTGCA GGTGGAGAAG CTGCGGCAGA GTCTCAGCAA GCTGGAGAGC 
ACCATCAGCG CCGTGCAGCA GGTCCTGGAA GAGGGCCGCG CCCTGGACAT CCTGCTGGCC 
CGAGACCGGA TGCTGGCCCA GGTGCAGGAG CTCAAGACCA TCCGAGGCCT CCTGCAGCCC 
CAAGAAGATG ACCGCATTAT GTTCACGCCC CCTGACCAGG CCCTGTACCT CGCCCTCAAG 
TCTATTGGCT TTGTCAGCAG CGGGGCCTTC GCCCCGCTCA CGAAGGCTAC AGGAGATGGC 
ATCAAGCGTG CCCTTCAGGG GAAGGTGGCC TCTTTCACTG TCATGGGCTA CGACCACGAT 
GGTGAGCCCC GCCATTCGGG AGGTGACCTG ATGTCAGTTG TGGTCCTCGG CCCCGACGGA 
AACCTGTTTG GTGCAGAAGT GAGCGACCAG CAGAATGGTA CTTACATAGT GAGCTACAGG 
CCCCAGCTTG AGGGTGAGCA CTTGGTGTCG GTGACATTGT ACAATCAGCA TATAGAGAAC 
AGCCCCTTCA AGGTCGTGGT CAAGTCGGGC CGCAGCTACG TGGGCATCGG GCTCCCCGGG 
CTGAGCTTCG GCAGTGAAGG TGACGGGGAG GGCAAGCTCT GCAGGCCCTG GGGCGTGAGT 
GTTGATAAGG AGGGTTTCAT CATAGTGGCT GACCGAAGCA ATAACAGAAT CCAGGTGTTT 
AAGCCCTGTG GTTCCTTCCA CCACAAGTTT GGTACCCTTG GGTCTCGTCC TGGGCAGTTT 
GACCGACCGG CTGGGGTGGC TTGTGACGCC TCCCGCAGGA TCATAGTGGC CGACAAAGAC 
AATCATCGCA TTCAGATCTT CACCTTCGAG GGCCAGTTCC TTCTTAAGTT TGGTGAGAAA 
GGCACCAAGA ACGGGCAGTT TAACTACCCG TGGGATGTAG CAGTGAATTC TGAGGGCAAG 
ATCCTCGTTT CAGACACCCG GAATCATCGC ATCCAGTTGT TCGGACCGGA CGGGGTCTTC 
CTGAACAAGT ACGGCTTCGA GGGATCTCTC TGGAAGCACT TCGACTCTCC ACGGGGCGTG 
GCTTTCAACA ATGAAGGTCA CCTGGTAGTC ACCGACTTCA ACAACCACCG GCTTCTGGTT 
ATTCACCCTG ATTGCCAATC TGCCCGCTTC TTGGGTTCGG AGGGCTCGGG CAATGGGCAG 
TTCCTGCGAC CACAGGGTGT GGCTGTGGAC CAGGAAGGGA GAATCATCGT AGCCGATTCC 
AGAAATCACC GCGTGCAGAT GTTTGAGGCC AATGGCAGCT TCCTGTGCAA GTTTGGTGCT 
CAAGGGAGTG GCTTCGGGCA GATGGACCGC CCCTCAGGTA TCGCGGTCAC CCCGGATGGA 
TTGATCGTCG TGGTGGACTT TGGCAACAAT CGAATCCTCA TCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation.
Cell death and differentiation24(6)1063-1078(2017 06)
Nguyen DTT,Richter D,Michel G,Mitschka S,Kolanus W,Cuevas E,Wulczyn FG

The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.
Proceedings of the National Academy of Sciences of the United States of America112(29)E3864-73(2015 Jul)
Golden EJ,Benito-Gonzalez A,Doetzlhofer A

Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists234(4)1046-54(2005 Dec)
Schulman BR,Esquela-Kerscher A,Slack FJ

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Trim71 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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