Wfs1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Wfs1
Entrez Gene ID	22393
Full Name	wolframin ER transmembrane glycoprotein
Synonyms	AI481085,wolframin
General protein information	Preferred Names wolframin ER transmembrane glycoprotein Names wolframin Wolfram syndrome 1 homolog Wolfram syndrome 1 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_011716.2	NP_035846.1	wolframin

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	WFS1	XP_003310288.1
Danio rerio (zebrafish)	wfs1b	XP_005157280.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004409	XP_313695.5
Homo sapiens (human)	WFS1	NP_001139325.1
	WFS1	XP_001092811.1
Xenopus tropicalis (tropical clawed frog)	wfs1	NP_001106459.1
Canis lupus familiaris (dog)	WFS1	XP_539234.4
Bos taurus (cattle)	WFS1	XP_002688446.1
Gallus gallus (chicken)	WFS1	XP_420803.2
Drosophila melanogaster (fruit fly)	wfs1	NP_001189267.1
Mus musculus (house mouse)	Wfs1	NP_035846.1
Rattus norvegicus (Norway rat)	Wfs1	NP_114011.1

Gene Ontology
Bibliography

Related articles in PubMed

Mild stress induces brain region-specific alterations of selective ER stress markers' mRNA expression in Wfs1-deficient mice.
Altpere A, Raud S, S?tt S, Reimets R, Visnapuu T, Toots M, Vasar E
Behavioural brain research(2017 Sep)

Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.
Tekko T, Lakspere T, Allikalt A, End J, K?lvart KR, Jagom?e T, Terasmaa A, Philips MA, Visnapuu T, V??rtn?u F, Gilbert SF, Rinken A, Vasar E, Lillev?li K
PloS one12(3)e0172825(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the functional link between Wfs1 and D1-like dopamine receptors is evolutionarily conserved and plays an important role in adjusting behavioral reactions to environmental stimuli.
Title: Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.

Three muscle-specific nuclear membrane proteins, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate their repression during myogenesis.
Title: Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.

RNA-sequencing of pancreatic islets from WFS1-deficient mice showed that Trpm5 is downregulated and the pathways related to tissue morphology, and endocrine system development/function/molecular transport network are influenced.
Title: RNA-sequencing of WFS1-deficient pancreatic islets.

WFS1-knockout mice develop a metabolic phenotype characterized with several physiological dysfunctions.
Title: Analysis of metabolic effects of menthol on WFS1-deficient mice.

Study demonstrates that Wfs1 deficiency in mice induces alterations in specific behavioural effects of ethanol like the increased anxiolytic-like and hypnotic action, but the decreased sedation
Title: Deletion of the Wolfram syndrome-related gene Wfs1 results in increased sensitivity to ethanol in female mice.

The following Wfs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wfs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08681	NM_011716.2 Latest version!	Mus musculus wolframin ER transmembrane glycoprotein (Wfs1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Wfs1 ( NM_011716.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035846.1 Mus musculus wolframin ER transmembrane glycoprotein (Wfs1), mRNA.

Price & Availability↑

CloneID	OMu08681
Clone ID Related Accession (Same CDS sequence)	NM_011716.2
Accession Version	NM_011716.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2673bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Mus musculus(house mouse)
Product	wolframin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY063019.1, BY296480.1, AK144561.1, CX562372.1 and AC115722.12. On Dec 20, 2006 this sequence version replaced NM_011716.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145023.1, AK170180.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAACTCAG GCACCCCACC TCCGAGCCCC TCTGGCCCAC CTCCTCCACC CGCACCACAG 
CCCCAGGCCC GGGCCCGGCT CAATGCCACC GCCTCACTGG AGCAGGACAA GATTGAACCG 
CCTCGTGCTC CCAGACCTCA GGCTGACCCC AGTGCTGGAC GAAGTGCTGG GGAAGCAGCC 
GCTCCGGAGC CTCGGGCCCC TCAAACCGGC AGCCGGGAAG AAACGGACAG AGCTGGTCCC 
ATGAAGGCAG ATGTGGAGAT CCCCTTTGAA GAAGTCCTGG AGAAAGCCAA GGCTGGAGAC 
CCCAAAGCAC AGACTGAGGT GGGCAAACAC TACCTACGCC TTGCCAACGA TGCAGATGAA 
GAACTCAACA GCTGCTCAGC CGTAGCCTGG CTAATCCTGG CAGCCAAGCA GGGCAGGCGG 
GAGGCCGTGA AGCTGCTGAG GCGGTGCCTA GCTGACCGGA AAGGCATCAC TTCTGAGAAC 
GAGGCTGAGG TGAAGCAGCT ATCCTCTGAG ACCGACCTGG AAAGGGCTGT GCGCAAGGCT 
GCCCTGGTCA TGTACTGGAA ACTCAACCCC AAGAAGAAGA AGCAGGTGGC TGTGTCCGAG 
CTGCTGGAGA ATGTTGGACA GGTCAACGAG CAGGATGGAG GGGCGCAGCC AGGCCCAGTC 
CCCAAGTCCC TGCAGAAGCA GAGGCGCATG CTGGAGCGCC TCGTCAGCAG TGAATCCAAG 
AACTACATTG CTCTGGACGA TTTTGTGGAG CTCACCAAGA AGTACGCCAA GGGCATCATT 
CCCACCAACC TGTTCCTGCA GGATGAGGAT GAAGATGAGG ACGAGCTGGC AGGGAAGAGC 
CCCGAGGACC TGCCACTACG CCAGAAGGTG GTGAAGTACC CTTTACACGC CATCATGGAG 
ATCAAAGAGT ACCTGATTGA CGTAGCCTCC AAGGCCGGCA TGCACTGGCT CTCCACCATT 
GTACCCACCC ATCACATCAA CGCCCTCATC TTCTTCTTCA TCATCAGCAA CCTAACCATC 
GACTTCTTCG CCTTCTTCAT CCCCCTGGTG GTCTTCTATC TGTCCTTTGT GTCCATGGTC 
ATCTGCACGC TCAAGGTGTT CCAGGACAGC AAGGCCTGGG AGAACTTCCG TACTCTCACC 
GACCTGCTGC TGCGCTTCGA GCCCAACCTA GACGTGGAGC AGGCCGAAGT GAACTTCGGC 
TGGAACCACC TGGAGCCCTA CATCCACTTC CTACTGTCAG TCGTCTTTGT CATCTTCTCC 
TTCCCGCTGG CCAGCAAGGA CTGCATCCCC TGCTCGGAGC TGGCCGTCAT CTCCACCTTC 
TTCACGGTGA CCAGCTACAT GAGCCTGAGC AGCTCTGCTG AGCCCTATAC CAGGCGTGCC 
CTGGTCACCG AGGTGGCTGC CGGCTTGCTG TCCCTTCTGC CCACCGTGCC TGTGGACTGG 
CGCTTCCTGA AAGTACTCGG CCAGACTTTC TTCACTGTGC CCGTTGGCCA CTTCATCATC 
CTCAACGTCA GCCTCCCCTG CCTGCTCTAT GTCTATCTCT TTTACCTCTT CTTCCGCATG 
GCCCAGCTGA GGAACTTCAA GGGCACTTAT TGCTACCTGG TGCCCTACCT GGTGTGCTTC 
ATGTGGTGTG AACTGTCCGT GGTCATCCTG CTCCAGTCTA CCGGCCTGGG CTTGGTCCGG 
GCCTCCATCG GCTACTTCCT CTTCCTCTTT GCCCTCCCCA TCCTGGTGGC TGGCCTCGCC 
TTGATGGGCA CGGTGCAGTT TGCCCGATGG TTCCTGTCGC TGGACCTCAC CAAGATCATG 
GTCACCACGG TGATCTGCGG CGTACCCCTG CTTTTCCGTT GGTGGACCAA GGCCAACTTC 
TCAGTGATGG GGATGGTCAA GTCCCTGACG AAGAGCTCCA TGGTGAAGCT CATTCTGGTG 
TGGCTAACGG CCATCCTGCT CTTCTGCTGG TTCTACGTGT ACCGCTCAGA AGGCATGAAG 
GTCTACAACT CCACACTCAC CTGGCAGCAA TATGGCTTCC TATGTGGGCC CCGGGCCTGG 
AAGGAAACTA ACATGGCCCG GACCCAGATC CTGTGCAGCC ACCTGGAGGG CCACAGGGTC 
ACGTGGACAG GCCGCTTCAA GTATGTCCGA GTGACCGAGA TCGACAACAG TGCTGAGTCG 
GCCATCAACA TGCTCCCGTT CTTCCTGGGC GATTGGATGC GCTGCCTGTA TGGCGAGGCC 
TACCCATCTT GTAGCTCTGG TAACACGTCC ACGGCAGAGG AGGAGCTCTG CCGTCTCAAG 
CAGCTGGCCA AGCACCCCTG CCACATCAAG AAGTTTGACC GCTACAAATT TGAGATCACA 
GTGGGCATGC CCTTTGGCAC CAACGGCAAC CGCGGCCATG AAGAGGACGA CATCACCAAG 
GACATTGTTC TCCGTGCCAG CAGCGAGTTC AAGGACGTGC TGCTGAACCT GCGCCAGGGG 
AGCCTCATAG AGTTCAGCAC CATCCTCGAG GGCCGCCTGG GTAGCAAGTG GCCCGTCTTC 
GAGCTCAAGG CCATCAGCTG CCTCAACTGC ATGACGCAGC TGTCACCTGC CCGGAGGCAC 
GTGAAGATCG AACAGGACTG GCGTAGCACA GTGCACGGTG CCCTCAAGTT TGCCTTCGAC 
TTCTTCTTCT TCCCATTCCT GTCTGCCGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035846.1
CDS	123..2795
Translation	MNSGTPPPSPSGPPPPPAPQPQARARLNATASLEQDKIEPPRAPRPQADPSAGRSAGEAAAPEPRAPQTGSREETDRAGPMKADVEIPFEEVLEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPTNLFLQDEDEDEDELAGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFTVTSYMSLSSSAEPYTRRALVTEVAAGLLSLLPTVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMGMVKSLTKSSMVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA

Target ORF information:

RefSeq Version	NM_011716.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus wolframin ER transmembrane glycoprotein (Wfs1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011716.2

ORF Insert Sequence:

ATGAACTCAG GCACCCCACC TCCGAGCCCC TCTGGCCCAC CTCCTCCACC CGCACCACAG 
CCCCAGGCCC GGGCCCGGCT CAATGCCACC GCCTCACTGG AGCAGGACAA GATTGAACCG 
CCTCGTGCTC CCAGACCTCA GGCTGACCCC AGTGCTGGAC GAAGTGCTGG GGAAGCAGCC 
GCTCCGGAGC CTCGGGCCCC TCAAACCGGC AGCCGGGAAG AAACGGACAG AGCTGGTCCC 
ATGAAGGCAG ATGTGGAGAT CCCCTTTGAA GAAGTCCTGG AGAAAGCCAA GGCTGGAGAC 
CCCAAAGCAC AGACTGAGGT GGGCAAACAC TACCTACGCC TTGCCAACGA TGCAGATGAA 
GAACTCAACA GCTGCTCAGC CGTAGCCTGG CTAATCCTGG CAGCCAAGCA GGGCAGGCGG 
GAGGCCGTGA AGCTGCTGAG GCGGTGCCTA GCTGACCGGA AAGGCATCAC TTCTGAGAAC 
GAGGCTGAGG TGAAGCAGCT ATCCTCTGAG ACCGACCTGG AAAGGGCTGT GCGCAAGGCT 
GCCCTGGTCA TGTACTGGAA ACTCAACCCC AAGAAGAAGA AGCAGGTGGC TGTGTCCGAG 
CTGCTGGAGA ATGTTGGACA GGTCAACGAG CAGGATGGAG GGGCGCAGCC AGGCCCAGTC 
CCCAAGTCCC TGCAGAAGCA GAGGCGCATG CTGGAGCGCC TCGTCAGCAG TGAATCCAAG 
AACTACATTG CTCTGGACGA TTTTGTGGAG CTCACCAAGA AGTACGCCAA GGGCATCATT 
CCCACCAACC TGTTCCTGCA GGATGAGGAT GAAGATGAGG ACGAGCTGGC AGGGAAGAGC 
CCCGAGGACC TGCCACTACG CCAGAAGGTG GTGAAGTACC CTTTACACGC CATCATGGAG 
ATCAAAGAGT ACCTGATTGA CGTAGCCTCC AAGGCCGGCA TGCACTGGCT CTCCACCATT 
GTACCCACCC ATCACATCAA CGCCCTCATC TTCTTCTTCA TCATCAGCAA CCTAACCATC 
GACTTCTTCG CCTTCTTCAT CCCCCTGGTG GTCTTCTATC TGTCCTTTGT GTCCATGGTC 
ATCTGCACGC TCAAGGTGTT CCAGGACAGC AAGGCCTGGG AGAACTTCCG TACTCTCACC 
GACCTGCTGC TGCGCTTCGA GCCCAACCTA GACGTGGAGC AGGCCGAAGT GAACTTCGGC 
TGGAACCACC TGGAGCCCTA CATCCACTTC CTACTGTCAG TCGTCTTTGT CATCTTCTCC 
TTCCCGCTGG CCAGCAAGGA CTGCATCCCC TGCTCGGAGC TGGCCGTCAT CTCCACCTTC 
TTCACGGTGA CCAGCTACAT GAGCCTGAGC AGCTCTGCTG AGCCCTATAC CAGGCGTGCC 
CTGGTCACCG AGGTGGCTGC CGGCTTGCTG TCCCTTCTGC CCACCGTGCC TGTGGACTGG 
CGCTTCCTGA AAGTACTCGG CCAGACTTTC TTCACTGTGC CCGTTGGCCA CTTCATCATC 
CTCAACGTCA GCCTCCCCTG CCTGCTCTAT GTCTATCTCT TTTACCTCTT CTTCCGCATG 
GCCCAGCTGA GGAACTTCAA GGGCACTTAT TGCTACCTGG TGCCCTACCT GGTGTGCTTC 
ATGTGGTGTG AACTGTCCGT GGTCATCCTG CTCCAGTCTA CCGGCCTGGG CTTGGTCCGG 
GCCTCCATCG GCTACTTCCT CTTCCTCTTT GCCCTCCCCA TCCTGGTGGC TGGCCTCGCC 
TTGATGGGCA CGGTGCAGTT TGCCCGATGG TTCCTGTCGC TGGACCTCAC CAAGATCATG 
GTCACCACGG TGATCTGCGG CGTACCCCTG CTTTTCCGTT GGTGGACCAA GGCCAACTTC 
TCAGTGATGG GGATGGTCAA GTCCCTGACG AAGAGCTCCA TGGTGAAGCT CATTCTGGTG 
TGGCTAACGG CCATCCTGCT CTTCTGCTGG TTCTACGTGT ACCGCTCAGA AGGCATGAAG 
GTCTACAACT CCACACTCAC CTGGCAGCAA TATGGCTTCC TATGTGGGCC CCGGGCCTGG 
AAGGAAACTA ACATGGCCCG GACCCAGATC CTGTGCAGCC ACCTGGAGGG CCACAGGGTC 
ACGTGGACAG GCCGCTTCAA GTATGTCCGA GTGACCGAGA TCGACAACAG TGCTGAGTCG 
GCCATCAACA TGCTCCCGTT CTTCCTGGGC GATTGGATGC GCTGCCTGTA TGGCGAGGCC 
TACCCATCTT GTAGCTCTGG TAACACGTCC ACGGCAGAGG AGGAGCTCTG CCGTCTCAAG 
CAGCTGGCCA AGCACCCCTG CCACATCAAG AAGTTTGACC GCTACAAATT TGAGATCACA 
GTGGGCATGC CCTTTGGCAC CAACGGCAAC CGCGGCCATG AAGAGGACGA CATCACCAAG 
GACATTGTTC TCCGTGCCAG CAGCGAGTTC AAGGACGTGC TGCTGAACCT GCGCCAGGGG 
AGCCTCATAG AGTTCAGCAC CATCCTCGAG GGCCGCCTGG GTAGCAAGTG GCCCGTCTTC 
GAGCTCAAGG CCATCAGCTG CCTCAACTGC ATGACGCAGC TGTCACCTGC CCGGAGGCAC 
GTGAAGATCG AACAGGACTG GCGTAGCACA GTGCACGGTG CCCTCAAGTT TGCCTTCGAC 
TTCTTCTTCT TCCCATTCCT GTCTGCCGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mild stress induces brain region-specific alterations of selective ER stress markers' mRNA expression in Wfs1-deficient mice.
Behavioural brain research(2017 Sep)
Altpere A,Raud S,S?tt S,Reimets R,Visnapuu T,Toots M,Vasar E

Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.
PloS one12(3)e0172825(2017)
Tekko T,Lakspere T,Allikalt A,End J,K?lvart KR,Jagom?e T,Terasmaa A,Philips MA,Visnapuu T,V??rtn?u F,Gilbert SF,Rinken A,Vasar E,Lillev?li K

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Wfs1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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