Wfs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.
Plaas M, Seppa K, Reimets R, Jagom?e T, Toots M, Koppel T, Vallisoo T, Nigul M, Heinla I, Meier R, Kaasik A, Piirsoo A, Hickey MA, Terasmaa A, Vasar E
Scientific reports7(1)10220(2017 Aug)

WFS1 variants in Finnish patients with diabetes mellitus, sensorineural hearing impairment or optic atrophy, and in suicide victims.
Kyt?vuori L, Sepp?nen A, Martikainen MH, Moilanen JS, Kamppari S, S?rkioja T, Remes AM, R?s?nen P, R?nnemaa T, Majamaa K
Journal of human genetics58(8)495-500(2013 Aug)

Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment.
Rendtorff ND, Lodahl M, Boulahbel H, Johansen IR, Pandya A, Welch KO, Norris VW, Arnos KS, Bitner-Glindzicz M, Emery SB, Mets MB, Fagerheim T, Eriksson K, Hansen L, Bruhn H, M?ller C, Lindholm S, Ensgaard S, Lesperance MM, Tranebjaerg L
American journal of medical genetics. Part A155A(6)1298-313(2011 Jun)

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
Fonseca SG, Ishigaki S, Oslowski CM, Lu S, Lipson KL, Ghosh R, Hayashi E, Ishihara H, Oka Y, Permutt MA, Urano F
The Journal of clinical investigation120(3)744-55(2010 Mar)

A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.
Chistiakov DA, Khodyrev DS, Smetanina SA, Bel'chikova LN, Suplotova LA, Nosikov VV
The review of diabetic studies : RDS7(4)285-92(2010)

a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes.
Title: Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.

WFS1 may be involved in some aspects of rat pancreatic development
Title: Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas.

demonstrated that three mutations (Ala127Thr, Ala134Thr, and Arg178Pro) associated with Wolfram syndrome completely abolished CaM binding of wolframin
Title: Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein.

This study identified alterations in the Wolframin gene in the CA1 and amygdala regions, specifically in exposed PTSD-like rats.
Title: WFS1 gene as a putative biomarker for development of post-traumatic syndrome in an animal model.

Role of increased expression of the wolframin gene in the regulation of emotional behavior.
Title: Cat odour exposure increases the expression of wolframin gene in the amygdaloid area of rat.