APLN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APLN
Entrez Gene ID	8862
Full Name	apelin
Synonyms	APEL,XNPEP2
General protein information	Preferred Names apelin Names apelin AGTRL1 ligand APJ endogenous ligand
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq26.1
Summary	This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016].
Disorder MIM:	300297

mRNA and Protein(s)

mRNA	Protein	Name
NM_017413.5	NP_059109.3	apelin preproprotein
NM_017413.4	NP_059109.3	apelin preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Apln	NP_113800.1
Homo sapiens (human)	APLN	NP_059109.3
Bos taurus (cattle)	APLN	NP_776928.1
Canis lupus familiaris (dog)	APLN	XP_854262.2
Mus musculus (house mouse)	Apln	NP_038940.1

Gene Ontology
Bibliography

Related articles in PubMed

Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting.
Xu S, Zhang J, Xu YL, Wu HB, Xue XD, Wang HS
BioMed research international20177951793(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Apelin-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin levels were associated with a high rate of MACE.
Title: Influence of apelin-12 on troponin levels and the rate of MACE in STEMI patients.

Our results suggest that bisphenol A and its derivatives induce ovarian cancer cell progression by up-regulating apelin, which acts as a mitogenic factor in OVCAR-3 cells.
Title: Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism.

high ACE and low apelin preoperatively have roles in CRP and MDA being increased postoperatively, which may be associated with postoperative atrial fibrillation after off pump coronary artery bypass grafting
Title: Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting.

Apelin concentrations are associated with altered plaque stability mediator levels and atherosclerosis in patients with rheumatoid arthritis. These relations are partially dependent on population origin and systemic inflammatory status.
Title: Apelin concentrations are associated with altered atherosclerotic plaque stability mediator levels and atherosclerosis in rheumatoid arthritis.

Postmenopausal breast cancer patients had high levels of apelin and high BMI scores.
Title: Serum apelin levels and body composition changes in breast cancer patients treated with an aromatase inhibitor.

The following APLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20955	NM_017413.5 Latest version!	Homo sapiens apelin (APLN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20955	NM_017413.4	Homo sapiens apelin (APLN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APLN ( NM_017413.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_059109.3 Homo sapiens apelin (APLN), mRNA.

Price & Availability↑

CloneID	OHu20955
Clone ID Related Accession (Same CDS sequence)	NM_017413.5 , NM_017413.4
Accession Version	NM_017413.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 234bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	apelin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB481574.1, BC021104.1, AL022162.1 and BM992527.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_017413.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.109779.1, BC021104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000429967.3/ ENSP00000391800.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATCTGC GGCTCTGCGT GCAGGCGCTC CTGCTGCTCT GGCTCTCCTT GACCGCGGTG 
TGTGGAGGGT CCCTGATGCC GCTTCCCGAT GGGAATGGGC TGGAAGACGG CAATGTCCGC 
CACCTGGTGC AGCCCAGAGG GTCAAGGAAT GGGCCAGGGC CCTGGCAGGG AGGTCGGAGG 
AAATTCCGCC GCCAGCGGCC CCGCCTCTCC CATAAGGGAC CCATGCCTTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059109.3
CDS	327..560
Translation	MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF

Target ORF information:

RefSeq Version	NM_017413.5
Organism	Homo sapiens(human)
Definition	Homo sapiens apelin (APLN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017413.5

ORF Insert Sequence:

ATGAATCTGC GGCTCTGCGT GCAGGCGCTC CTGCTGCTCT GGCTCTCCTT GACCGCGGTG 
TGTGGAGGGT CCCTGATGCC GCTTCCCGAT GGGAATGGGC TGGAAGACGG CAATGTCCGC 
CACCTGGTGC AGCCCAGAGG GTCAAGGAAT GGGCCAGGGC CCTGGCAGGG AGGTCGGAGG 
AAATTCCGCC GCCAGCGGCC CCGCCTCTCC CATAAGGGAC CCATGCCTTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APLN ( NM_017413.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_059109.3 Homo sapiens apelin (APLN), mRNA.

Price & Availability↑

CloneID	OHu20955
Clone ID Related Accession (Same CDS sequence)	NM_017413.5 , NM_017413.4
Accession Version	NM_017413.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 234bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	apelin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB481574.1, BC021104.1, AL022162.1 and BM992527.1. This sequence is a reference standard in the RefSeqGene project. On Mar 5, 2010 this sequence version replaced NM_017413.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.109779.1, BC021104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCTGC GGCTCTGCGT GCAGGCGCTC CTGCTGCTCT GGCTCTCCTT GACCGCGGTG 
TGTGGAGGGT CCCTGATGCC GCTTCCCGAT GGGAATGGGC TGGAAGACGG CAATGTCCGC 
CACCTGGTGC AGCCCAGAGG GTCAAGGAAT GGGCCAGGGC CCTGGCAGGG AGGTCGGAGG 
AAATTCCGCC GCCAGCGGCC CCGCCTCTCC CATAAGGGAC CCATGCCTTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059109.3
CDS	327..560
Translation	MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF

Target ORF information:

RefSeq Version	NM_017413.4
Organism	Homo sapiens(human)
Definition	Homo sapiens apelin (APLN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017413.4

ORF Insert Sequence:

ATGAATCTGC GGCTCTGCGT GCAGGCGCTC CTGCTGCTCT GGCTCTCCTT GACCGCGGTG 
TGTGGAGGGT CCCTGATGCC GCTTCCCGAT GGGAATGGGC TGGAAGACGG CAATGTCCGC 
CACCTGGTGC AGCCCAGAGG GTCAAGGAAT GGGCCAGGGC CCTGGCAGGG AGGTCGGAGG 
AAATTCCGCC GCCAGCGGCC CCGCCTCTCC CATAAGGGAC CCATGCCTTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting.
BioMed research international20177951793(2017)
Xu S,Zhang J,Xu YL,Wu HB,Xue XD,Wang HS

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APLN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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