SOS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOS2
Entrez Gene ID	6655
Full Name	SOS Ras/Rho guanine nucleotide exchange factor 2
Synonyms	NS9,SOS-2
General protein information	Preferred Names SOS Ras/Rho guanine nucleotide exchange factor 2 Names son of sevenless homolog 2 guanine nucleotide releasing factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q21.3
Summary	This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016].
Disorder MIM:	601247
Disorder Html:	Noonan syndrome 9, 616559 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006939.3	NP_008870.2	son of sevenless homolog 2
NM_006939.2	NP_008870.2	son of sevenless homolog 2
NM_006939.4	NP_008870.2	son of sevenless homolog 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SOS2	NP_008870.2
Canis lupus familiaris (dog)	SOS2	XP_005623436.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009180	XP_319944.4
Pan troglodytes (chimpanzee)	SOS2	XP_003314439.2
	SOS2	XP_001099864.1
Danio rerio (zebrafish)	sos2	XP_690171.2
Bos taurus (cattle)	SOS2	XP_002707757.2
Mus musculus (house mouse)	Sos2	NP_001129031.1
Rattus norvegicus (Norway rat)	Sos2	NP_001129033.1
Gallus gallus (chicken)	SOS2	XP_421461.4
Xenopus tropicalis (tropical clawed frog)	sos2	XP_002938172.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.
Cordeddu V, Yin JC, Gunnarsson C, Virtanen C, Drunat S, Lepri F, De Luca A, Rossi C, Ciolfi A, Pugh TJ, Bruselles A, Priest JR, Pennacchio LA, Lu Z, Danesh A, Quevedo R, Hamid A, Martinelli S, Pantaleoni F, Gnazzo M, Daniele P, Lissewski C, Bocchinfuso G, Stella L, Odent S, Philip N, Faivre L, Vlckova M, Seemanova E, Digilio C, Zenker M, Zampino G, Verloes A, Dallapiccola B, Roberts AE, Cav? H, Gelb BD, Neel BG, Tartaglia M
Human mutation36(11)1080-7(2015 Nov)

Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.
Yamamoto GL, Aguena M, Gos M, Hung C, Pilch J, Fahiminiya S, Abramowicz A, Cristian I, Buscarilli M, Naslavsky MS, Malaquias AC, Zatz M, Bodamer O, Majewski J, Jorge AA, Pereira AC, Kim CA, Passos-Bueno MR, Bertola DR
Journal of medical genetics52(6)413-21(2015 Jun)

Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
Shaffer JR, Polk DE, Wang X, Feingold E, Weeks DE, Lee MK, Cuenco KT, Weyant RJ, Crout RJ, McNeil DW, Marazita ML
G3 (Bethesda, Md.)4(2)307-14(2014 Feb)

A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome.
Clayton P, Chatelain P, Tat? L, Yoo HW, Ambler GR, Belgorosky A, Quinteiro S, Deal C, Stevens A, Raelson J, Croteau P, Destenaves B, Olivier C
European journal of endocrinology169(3)277-89(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome
Title: Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.

We identified two novel genes, SOS2 and LZTR1, associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies.
Title: Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.

multicenter pharmacogenetic study in children (ages 6-11): Data suggest that SNP in SOS2 (rs13379306) in children with growth hormone deficiency is associated with drug resistance to hormone replacement therapy with recombinant human growth hormone.
Title: A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome.

intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol
Title: Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKC? and ?I to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol.

Observational study of gene-disease association. (HuGE Navigator)
Title: Mutation of ARHGAP9 in patients with coronary spastic angina.

The following SOS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05866	NM_006939.4 Latest version!	Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
View Old Accession Versions >>
OHu05866	NM_006939.2	Homo sapiens son of sevenless homolog 2 (Drosophila) (SOS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
OHu05866	NM_006939.3	Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOS2 ( NM_006939.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008870.2 Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), mRNA.

Price & Availability↑

CloneID	OHu05866
Clone ID Related Accession (Same CDS sequence)	NM_006939.3 , NM_006939.2 , NM_006939.4
Accession Version	NM_006939.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	son of sevenless homolog 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109758.3, AI419975.1, BC117261.1 and R20624.1. This sequence is a reference standard in the RefSeqGene project. On Jul 7, 2016 this sequence version replaced NM_006939.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.78693.1, SRR1803614.79798.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCAGG CGCCGCAGCC TTACGAGTTC TTCAGCGAGG AGAACAGTCC GAAATGGCGG 
GGACTGTTGG TCTCGGCCCT GCGGAAGGTT CAGGAACAAG TGCATCCCAC TCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAG CTGATTTTTC AGCTGCTTAA TAAATTATGC 
ATGGCCCAGC CAAGGACTGT TCAAGATGTA GAGGAGCGAG TTCAGAAGAC CTTTCCTCAC 
CCAATTGATA AATGGGCCAT TGCTGATGCA CAATCTGCTA TAGAAAAACG AAAACGAAGA 
AATCCTCTTT TACTGCCTGT GGACAAAATC CATCCTTCGT TGAAGGAAGT ATTAGGGTAC 
AAAGTGGACT ACCATGTATC CCTATATATT GTGGCTGTAC TAGAGTATAT CTCAGCTGAT 
ATTTTAAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAG 
GACATTAAAG TGTCAATGTG TGCGGATAAG GTTTTGATGG ACATGTTTGA TCAGGATGAC 
ATAGGTTTGG TTTCTCTCTG TGAAGATGAA CCTAGTTCTT CTGGTGAATT AAACTACTAT 
GATCTTGTCA GAACTGAAAT CGCAGAAGAA AGACAGTATC TACGGGAATT AAATATGATC 
ATAAAAGTGT TTCGAGAAGC CTTTCTTTCT GATAGAAAGC TGTTTAAACC TTCTGATATC 
GAAAAGATTT TTAGTAACAT TTCAGATATA CATGAATTGA CTGTGAAACT TTTAGGTTTG 
ATTGAAGACA CAGTTGAAAT GACTGATGAA AGCAGTCCTC ATCCCTTAGC TGGCAGCTGT 
TTTGAAGATT TGGCAGAAGA GCAAGCATTT GATCCTTATG AAACATTATC ACAGGACATT 
CTTTCACCAG AGTTTCATGA ACATTTCAAT AAATTGATGG CCAGACCTGC AGTTGCTCTA 
CACTTTCAGT CCATTGCTGA TGGTTTTAAA GAGGCAGTTC GTTATGTCCT TCCACGTCTT 
ATGCTGGTGC CAGTGTATCA CTGTTGGCAC TACTTTGAGT TACTAAAGCA ATTGAAAGCA 
TGTAGTGAAG AACAAGAAGA CAGAGAATGT TTGAACCAAG CTATTACTGC TCTCATGAAT 
CTCCAAGGTA GCATGGACCG AATTTACAAG CAGTATTCAC CTAGACGTCG ACCTGGAGAT 
CCTGTTTGCC CTTTTTATAG TCACCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAATAT CGATGGATGG GAAGGCAAAG ATATTGGACA GTGTTGTAAT 
GAATTCATTA TGGAGGGACC ATTGACAAGA ATCGGTGCCA AACATGAACG GCATATTTTT 
CTGTTTGATG GCTTAATGAT CAGTTGTAAA CCTAATCATG GCCAGACTCG GCTTCCAGGT 
TACAGTAGTG CAGAATACAG GTTAAAAGAA AAATTTGTCA TGAGGAAAAT ACAAATTTGT 
GATAAAGAAG ATACTTGTGA GCACAAGCAT GCATTTGAAT TAGTATCCAA AGATGAGAAC 
AGCATAATAT TTGCTGCTAA GTCTGCTGAA GAAAAAAACA ACTGGATGGC AGCCCTTATT 
TCTCTTCATT ATCGTAGTAC TCTAGATCGA ATGTTAGATT CAGTATTATT GAAAGAAGAA 
AATGAGCAAC CACTGAGATT ACCAAGTCCT GAAGTATATC GTTTTGTAGT AAAAGACTCT 
GAGGAAAACA TTGTTTTTGA AGACAACTTG CAAAGTAGAA GTGGCATCCC CATTATTAAA 
GGAGGAACTG TAGTGAAATT AATTGAAAGG TTAACATATC ATATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC CACATATCGT TCATTTTGTA AACCACAGGA ATTGCTGAGC 
TTACTGATTG AACGGTTTGA AATTCCAGAG CCAGAACCTA CTGACGCAGA CAAATTGGCA 
ATAGAGAAAG GCGAGCAGCC AATCAGTGCA GACCTTAAAA GATTTCGCAA GGAATATGTC 
CAACCAGTAC AACTTAGGAT CTTAAATGTA TTTCGGCATT GGGTTGAACA TCATTTTTAT 
GACTTTGAAA GAGACTTGGA ATTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCTA TGAAAAAATG GGTAGAGTCA ATTGCTAAGA TCATCAGGAG GAAGAAGCAA 
GCTCAGGCAA ACGGAGTAAG CCATAATATT ACCTTTGAAA GTCCACCTCC ACCAATTGAA 
TGGCATATCA GCAAACCAGG ACAGTTTGAA ACATTTGATC TCATGACACT TCATCCAATA 
GAAATTGCAC GTCAGCTGAC ACTTTTGGAG TCTGATCTTT ACAGGAAAGT TCAACCGTCT 
GAACTTGTAG GGAGTGTGTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAATTTATTA 
AAAATGATTC GCCATACCAC AAATCTCACC CTCTGGTTTG AAAAATGCAT TGTGGAAGCA 
GAAAATTTTG AAGAACGGGT GGCAGTACTA AGTAGAATTA TAGAAATTCT GCAAGTTTTT 
CAAGATTTGA ATAATTTCAA TGGCGTATTG GAGATAGTCA GTGCAGTAAA TTCAGTGTCA 
GTATACAGAC TAGACCATAC CTTTGAGGCA CTGCAGGAAA GGAAAAGGAA AATTTTGGAC 
GAAGCTGTGG AATTAAGTCA AGATCACTTT AAAAAATACC TAGTAAAACT TAAGTCAATC 
AATCCACCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACCGAAGAA 
GGGAATAATG ATTTTTTAAA AAAGAAAGGG AAAGATTTAA TCAATTTCAG TAAGAGGAGG 
AAAGTAGCTG AAATTACTGG AGAAATTCAG CAGTATCAGA ATCAGCCTTA CTGTTTACGG 
ATAGAACCAG ATATGAGGAG ATTCTTTGAA AACCTTAACC CCATGGGAAG TGCATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAG TCACTAGAAA TTGAACCTCG AAACTGCAAA 
CAGCCACCTC GATTTCCTAG GAAATCAACT TTTTCCTTAA AATCTCCTGG AATAAGGCCT 
AACACAGGCC GACATGGCTC TACCTCAGGT ACTTTACGAG GTCACCCAAC ACCATTAGAA 
AGAGAACCAT GTAAAATAAG CTTTAGTCGG ATTGCTGAAA CTGAGCTGGA ATCAACAGTG 
TCAGCACCAA CCTCTCCAAA TACACCATCT ACTCCACCAG TATCTGCTTC TTCAGACCTT 
AGTGTATTTT TAGATGTGGA TCTCAACAGC TCCTGTGGCA GCAATAGCAT CTTTGCTCCA 
GTGCTTTTGC CACATTCAAA GTCTTTCTTT AGTTCATGTG GTAGTTTACA TAAACTAAGT 
GAAGAGCCCC TGATTCCTCC TCCTCTTCCT CCTCGAAAAA AGTTTGATCA TGATGCTTCA 
AATTCCAAGG GAAATATGAA ATCTGATGAT GATCCTCCTG CTATTCCACC GAGACAGCCT 
CCTCCTCCAA AGGTAAAACC CAGAGTTCCT GTTCCTACTG GTGCATTTGA TGGGCCTCTG 
CATAGTCCAC CTCCGCCACC ACCAAGAGAT CCTCTTCCTG ATACCCCTCC ACCAGTTCCC 
CTTCGGCCTC CAGAACACTT TATAAACTGT CCATTTAATC TTCAGCCACC TCCACTGGGG 
CATCTTCACA GAGATTCAGA CTGGCTCAGA GACATTAGTA CGTGTCCAAA TTCGCCAAGC 
ACTCCTCCTA GCACACCCTC TCCAAGGGTA CCGCGTCGAT GCTATGTGCT CAGTTCTAGT 
CAGAATAATC TTGCTCATCC TCCAGCTCCC CCTGTTCCAC CAAGGCAGAA TTCAAGCCCT 
CATCTGCCAA AACTGCCACC AAAGACTTAC AAACGGGAGC TTTCGCACCC CCCATTGTAC 
AGACTGCCTT TGCTAGAAAA TGCAGAAACT CCCCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008870.2
CDS	411..4409
Translation	MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ

Target ORF information:

RefSeq Version	NM_006939.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006939.3

ORF Insert Sequence:

ATGCAGCAGG CGCCGCAGCC TTACGAGTTC TTCAGCGAGG AGAACAGTCC GAAATGGCGG 
GGACTGTTGG TCTCGGCCCT GCGGAAGGTT CAGGAACAAG TGCATCCCAC TCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAG CTGATTTTTC AGCTGCTTAA TAAATTATGC 
ATGGCCCAGC CAAGGACTGT TCAAGATGTA GAGGAGCGAG TTCAGAAGAC CTTTCCTCAC 
CCAATTGATA AATGGGCCAT TGCTGATGCA CAATCTGCTA TAGAAAAACG AAAACGAAGA 
AATCCTCTTT TACTGCCTGT GGACAAAATC CATCCTTCGT TGAAGGAAGT ATTAGGGTAC 
AAAGTGGACT ACCATGTATC CCTATATATT GTGGCTGTAC TAGAGTATAT CTCAGCTGAT 
ATTTTAAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAG 
GACATTAAAG TGTCAATGTG TGCGGATAAG GTTTTGATGG ACATGTTTGA TCAGGATGAC 
ATAGGTTTGG TTTCTCTCTG TGAAGATGAA CCTAGTTCTT CTGGTGAATT AAACTACTAT 
GATCTTGTCA GAACTGAAAT CGCAGAAGAA AGACAGTATC TACGGGAATT AAATATGATC 
ATAAAAGTGT TTCGAGAAGC CTTTCTTTCT GATAGAAAGC TGTTTAAACC TTCTGATATC 
GAAAAGATTT TTAGTAACAT TTCAGATATA CATGAATTGA CTGTGAAACT TTTAGGTTTG 
ATTGAAGACA CAGTTGAAAT GACTGATGAA AGCAGTCCTC ATCCCTTAGC TGGCAGCTGT 
TTTGAAGATT TGGCAGAAGA GCAAGCATTT GATCCTTATG AAACATTATC ACAGGACATT 
CTTTCACCAG AGTTTCATGA ACATTTCAAT AAATTGATGG CCAGACCTGC AGTTGCTCTA 
CACTTTCAGT CCATTGCTGA TGGTTTTAAA GAGGCAGTTC GTTATGTCCT TCCACGTCTT 
ATGCTGGTGC CAGTGTATCA CTGTTGGCAC TACTTTGAGT TACTAAAGCA ATTGAAAGCA 
TGTAGTGAAG AACAAGAAGA CAGAGAATGT TTGAACCAAG CTATTACTGC TCTCATGAAT 
CTCCAAGGTA GCATGGACCG AATTTACAAG CAGTATTCAC CTAGACGTCG ACCTGGAGAT 
CCTGTTTGCC CTTTTTATAG TCACCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAATAT CGATGGATGG GAAGGCAAAG ATATTGGACA GTGTTGTAAT 
GAATTCATTA TGGAGGGACC ATTGACAAGA ATCGGTGCCA AACATGAACG GCATATTTTT 
CTGTTTGATG GCTTAATGAT CAGTTGTAAA CCTAATCATG GCCAGACTCG GCTTCCAGGT 
TACAGTAGTG CAGAATACAG GTTAAAAGAA AAATTTGTCA TGAGGAAAAT ACAAATTTGT 
GATAAAGAAG ATACTTGTGA GCACAAGCAT GCATTTGAAT TAGTATCCAA AGATGAGAAC 
AGCATAATAT TTGCTGCTAA GTCTGCTGAA GAAAAAAACA ACTGGATGGC AGCCCTTATT 
TCTCTTCATT ATCGTAGTAC TCTAGATCGA ATGTTAGATT CAGTATTATT GAAAGAAGAA 
AATGAGCAAC CACTGAGATT ACCAAGTCCT GAAGTATATC GTTTTGTAGT AAAAGACTCT 
GAGGAAAACA TTGTTTTTGA AGACAACTTG CAAAGTAGAA GTGGCATCCC CATTATTAAA 
GGAGGAACTG TAGTGAAATT AATTGAAAGG TTAACATATC ATATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC CACATATCGT TCATTTTGTA AACCACAGGA ATTGCTGAGC 
TTACTGATTG AACGGTTTGA AATTCCAGAG CCAGAACCTA CTGACGCAGA CAAATTGGCA 
ATAGAGAAAG GCGAGCAGCC AATCAGTGCA GACCTTAAAA GATTTCGCAA GGAATATGTC 
CAACCAGTAC AACTTAGGAT CTTAAATGTA TTTCGGCATT GGGTTGAACA TCATTTTTAT 
GACTTTGAAA GAGACTTGGA ATTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCTA TGAAAAAATG GGTAGAGTCA ATTGCTAAGA TCATCAGGAG GAAGAAGCAA 
GCTCAGGCAA ACGGAGTAAG CCATAATATT ACCTTTGAAA GTCCACCTCC ACCAATTGAA 
TGGCATATCA GCAAACCAGG ACAGTTTGAA ACATTTGATC TCATGACACT TCATCCAATA 
GAAATTGCAC GTCAGCTGAC ACTTTTGGAG TCTGATCTTT ACAGGAAAGT TCAACCGTCT 
GAACTTGTAG GGAGTGTGTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAATTTATTA 
AAAATGATTC GCCATACCAC AAATCTCACC CTCTGGTTTG AAAAATGCAT TGTGGAAGCA 
GAAAATTTTG AAGAACGGGT GGCAGTACTA AGTAGAATTA TAGAAATTCT GCAAGTTTTT 
CAAGATTTGA ATAATTTCAA TGGCGTATTG GAGATAGTCA GTGCAGTAAA TTCAGTGTCA 
GTATACAGAC TAGACCATAC CTTTGAGGCA CTGCAGGAAA GGAAAAGGAA AATTTTGGAC 
GAAGCTGTGG AATTAAGTCA AGATCACTTT AAAAAATACC TAGTAAAACT TAAGTCAATC 
AATCCACCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACCGAAGAA 
GGGAATAATG ATTTTTTAAA AAAGAAAGGG AAAGATTTAA TCAATTTCAG TAAGAGGAGG 
AAAGTAGCTG AAATTACTGG AGAAATTCAG CAGTATCAGA ATCAGCCTTA CTGTTTACGG 
ATAGAACCAG ATATGAGGAG ATTCTTTGAA AACCTTAACC CCATGGGAAG TGCATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAG TCACTAGAAA TTGAACCTCG AAACTGCAAA 
CAGCCACCTC GATTTCCTAG GAAATCAACT TTTTCCTTAA AATCTCCTGG AATAAGGCCT 
AACACAGGCC GACATGGCTC TACCTCAGGT ACTTTACGAG GTCACCCAAC ACCATTAGAA 
AGAGAACCAT GTAAAATAAG CTTTAGTCGG ATTGCTGAAA CTGAGCTGGA ATCAACAGTG 
TCAGCACCAA CCTCTCCAAA TACACCATCT ACTCCACCAG TATCTGCTTC TTCAGACCTT 
AGTGTATTTT TAGATGTGGA TCTCAACAGC TCCTGTGGCA GCAATAGCAT CTTTGCTCCA 
GTGCTTTTGC CACATTCAAA GTCTTTCTTT AGTTCATGTG GTAGTTTACA TAAACTAAGT 
GAAGAGCCCC TGATTCCTCC TCCTCTTCCT CCTCGAAAAA AGTTTGATCA TGATGCTTCA 
AATTCCAAGG GAAATATGAA ATCTGATGAT GATCCTCCTG CTATTCCACC GAGACAGCCT 
CCTCCTCCAA AGGTAAAACC CAGAGTTCCT GTTCCTACTG GTGCATTTGA TGGGCCTCTG 
CATAGTCCAC CTCCGCCACC ACCAAGAGAT CCTCTTCCTG ATACCCCTCC ACCAGTTCCC 
CTTCGGCCTC CAGAACACTT TATAAACTGT CCATTTAATC TTCAGCCACC TCCACTGGGG 
CATCTTCACA GAGATTCAGA CTGGCTCAGA GACATTAGTA CGTGTCCAAA TTCGCCAAGC 
ACTCCTCCTA GCACACCCTC TCCAAGGGTA CCGCGTCGAT GCTATGTGCT CAGTTCTAGT 
CAGAATAATC TTGCTCATCC TCCAGCTCCC CCTGTTCCAC CAAGGCAGAA TTCAAGCCCT 
CATCTGCCAA AACTGCCACC AAAGACTTAC AAACGGGAGC TTTCGCACCC CCCATTGTAC 
AGACTGCCTT TGCTAGAAAA TGCAGAAACT CCCCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOS2 ( NM_006939.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_008870.2 Homo sapiens son of sevenless homolog 2 (Drosophila) (SOS2), mRNA.

Price & Availability↑

CloneID	OHu05866
Clone ID Related Accession (Same CDS sequence)	NM_006939.3 , NM_006939.2 , NM_006939.4
Accession Version	NM_006939.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	son of sevenless homolog 2
Comment

ATGCAGCAGG CGCCGCAGCC TTACGAGTTC TTCAGCGAGG AGAACAGTCC GAAATGGCGG 
GGACTGTTGG TCTCGGCCCT GCGGAAGGTT CAGGAACAAG TGCATCCCAC TCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAG CTGATTTTTC AGCTGCTTAA TAAATTATGC 
ATGGCCCAGC CAAGGACTGT TCAAGATGTA GAGGAGCGAG TTCAGAAGAC CTTTCCTCAC 
CCAATTGATA AATGGGCCAT TGCTGATGCA CAATCTGCTA TAGAAAAACG AAAACGAAGA 
AATCCTCTTT TACTGCCTGT GGACAAAATC CATCCTTCGT TGAAGGAAGT ATTAGGGTAC 
AAAGTGGACT ACCATGTATC CCTATATATT GTGGCTGTAC TAGAGTATAT CTCAGCTGAT 
ATTTTAAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAG 
GACATTAAAG TGTCAATGTG TGCGGATAAG GTTTTGATGG ACATGTTTGA TCAGGATGAC 
ATAGGTTTGG TTTCTCTCTG TGAAGATGAA CCTAGTTCTT CTGGTGAATT AAACTACTAT 
GATCTTGTCA GAACTGAAAT CGCAGAAGAA AGACAGTATC TACGGGAATT AAATATGATC 
ATAAAAGTGT TTCGAGAAGC CTTTCTTTCT GATAGAAAGC TGTTTAAACC TTCTGATATC 
GAAAAGATTT TTAGTAACAT TTCAGATATA CATGAATTGA CTGTGAAACT TTTAGGTTTG 
ATTGAAGACA CAGTTGAAAT GACTGATGAA AGCAGTCCTC ATCCCTTAGC TGGCAGCTGT 
TTTGAAGATT TGGCAGAAGA GCAAGCATTT GATCCTTATG AAACATTATC ACAGGACATT 
CTTTCACCAG AGTTTCATGA ACATTTCAAT AAATTGATGG CCAGACCTGC AGTTGCTCTA 
CACTTTCAGT CCATTGCTGA TGGTTTTAAA GAGGCAGTTC GTTATGTCCT TCCACGTCTT 
ATGCTGGTGC CAGTGTATCA CTGTTGGCAC TACTTTGAGT TACTAAAGCA ATTGAAAGCA 
TGTAGTGAAG AACAAGAAGA CAGAGAATGT TTGAACCAAG CTATTACTGC TCTCATGAAT 
CTCCAAGGTA GCATGGACCG AATTTACAAG CAGTATTCAC CTAGACGTCG ACCTGGAGAT 
CCTGTTTGCC CTTTTTATAG TCACCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAATAT CGATGGATGG GAAGGCAAAG ATATTGGACA GTGTTGTAAT 
GAATTCATTA TGGAGGGACC ATTGACAAGA ATCGGTGCCA AACATGAACG GCATATTTTT 
CTGTTTGATG GCTTAATGAT CAGTTGTAAA CCTAATCATG GCCAGACTCG GCTTCCAGGT 
TACAGTAGTG CAGAATACAG GTTAAAAGAA AAATTTGTCA TGAGGAAAAT ACAAATTTGT 
GATAAAGAAG ATACTTGTGA GCACAAGCAT GCATTTGAAT TAGTATCCAA AGATGAGAAC 
AGCATAATAT TTGCTGCTAA GTCTGCTGAA GAAAAAAACA ACTGGATGGC AGCCCTTATT 
TCTCTTCATT ATCGTAGTAC TCTAGATCGA ATGTTAGATT CAGTATTATT GAAAGAAGAA 
AATGAGCAAC CACTGAGATT ACCAAGTCCT GAAGTATATC GTTTTGTAGT AAAAGACTCT 
GAGGAAAACA TTGTTTTTGA AGACAACTTG CAAAGTAGAA GTGGCATCCC CATTATTAAA 
GGAGGAACTG TAGTGAAATT AATTGAAAGG TTAACATATC ATATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC CACATATCGT TCATTTTGTA AACCACAGGA ATTGCTGAGC 
TTACTGATTG AACGGTTTGA AATTCCAGAG CCAGAACCTA CTGACGCAGA CAAATTGGCA 
ATAGAGAAAG GCGAGCAGCC AATCAGTGCA GACCTTAAAA GATTTCGCAA GGAATATGTC 
CAACCAGTAC AACTTAGGAT CTTAAATGTA TTTCGGCATT GGGTTGAACA TCATTTTTAT 
GACTTTGAAA GAGACTTGGA ATTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCTA TGAAAAAATG GGTAGAGTCA ATTGCTAAGA TCATCAGGAG GAAGAAGCAA 
GCTCAGGCAA ACGGAGTAAG CCATAATATT ACCTTTGAAA GTCCACCTCC ACCAATTGAA 
TGGCATATCA GCAAACCAGG ACAGTTTGAA ACATTTGATC TCATGACACT TCATCCAATA 
GAAATTGCAC GTCAGCTGAC ACTTTTGGAG TCTGATCTTT ACAGGAAAGT TCAACCGTCT 
GAACTTGTAG GGAGTGTGTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAATTTATTA 
AAAATGATTC GCCATACCAC AAATCTCACC CTCTGGTTTG AAAAATGCAT TGTGGAAGCA 
GAAAATTTTG AAGAACGGGT GGCAGTACTA AGTAGAATTA TAGAAATTCT GCAAGTTTTT 
CAAGATTTGA ATAATTTCAA TGGCGTATTG GAGATAGTCA GTGCAGTAAA TTCAGTGTCA 
GTATACAGAC TAGACCATAC CTTTGAGGCA CTGCAGGAAA GGAAAAGGAA AATTTTGGAC 
GAAGCTGTGG AATTAAGTCA AGATCACTTT AAAAAATACC TAGTAAAACT TAAGTCAATC 
AATCCACCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACCGAAGAA 
GGGAATAATG ATTTTTTAAA AAAGAAAGGG AAAGATTTAA TCAATTTCAG TAAGAGGAGG 
AAAGTAGCTG AAATTACTGG AGAAATTCAG CAGTATCAGA ATCAGCCTTA CTGTTTACGG 
ATAGAACCAG ATATGAGGAG ATTCTTTGAA AACCTTAACC CCATGGGAAG TGCATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAG TCACTAGAAA TTGAACCTCG AAACTGCAAA 
CAGCCACCTC GATTTCCTAG GAAATCAACT TTTTCCTTAA AATCTCCTGG AATAAGGCCT 
AACACAGGCC GACATGGCTC TACCTCAGGT ACTTTACGAG GTCACCCAAC ACCATTAGAA 
AGAGAACCAT GTAAAATAAG CTTTAGTCGG ATTGCTGAAA CTGAGCTGGA ATCAACAGTG 
TCAGCACCAA CCTCTCCAAA TACACCATCT ACTCCACCAG TATCTGCTTC TTCAGACCTT 
AGTGTATTTT TAGATGTGGA TCTCAACAGC TCCTGTGGCA GCAATAGCAT CTTTGCTCCA 
GTGCTTTTGC CACATTCAAA GTCTTTCTTT AGTTCATGTG GTAGTTTACA TAAACTAAGT 
GAAGAGCCCC TGATTCCTCC TCCTCTTCCT CCTCGAAAAA AGTTTGATCA TGATGCTTCA 
AATTCCAAGG GAAATATGAA ATCTGATGAT GATCCTCCTG CTATTCCACC GAGACAGCCT 
CCTCCTCCAA AGGTAAAACC CAGAGTTCCT GTTCCTACTG GTGCATTTGA TGGGCCTCTG 
CATAGTCCAC CTCCGCCACC ACCAAGAGAT CCTCTTCCTG ATACCCCTCC ACCAGTTCCC 
CTTCGGCCTC CAGAACACTT TATAAACTGT CCATTTAATC TTCAGCCACC TCCACTGGGG 
CATCTTCACA GAGATTCAGA CTGGCTCAGA GACATTAGTA CGTGTCCAAA TTCGCCAAGC 
ACTCCTCCTA GCACACCCTC TCCAAGGGTA CCGCGTCGAT GCTATGTGCT CAGTTCTAGT 
CAGAATAATC TTGCTCATCC TCCAGCTCCC CCTGTTCCAC CAAGGCAGAA TTCAAGCCCT 
CATCTGCCAA AACTGCCACC AAAGACTTAC AAACGGGAGC TTTCGCACCC CCCATTGTAC 
AGACTGCCTT TGCTAGAAAA TGCAGAAACT CCCCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_008870.2

Translation

MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ

Target ORF information:

RefSeq Version	NM_006939.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens son of sevenless homolog 2 (Drosophila) (SOS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006939.2

ORF Insert Sequence:

ATGCAGCAGG CGCCGCAGCC TTACGAGTTC TTCAGCGAGG AGAACAGTCC GAAATGGCGG 
GGACTGTTGG TCTCGGCCCT GCGGAAGGTT CAGGAACAAG TGCATCCCAC TCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAG CTGATTTTTC AGCTGCTTAA TAAATTATGC 
ATGGCCCAGC CAAGGACTGT TCAAGATGTA GAGGAGCGAG TTCAGAAGAC CTTTCCTCAC 
CCAATTGATA AATGGGCCAT TGCTGATGCA CAATCTGCTA TAGAAAAACG AAAACGAAGA 
AATCCTCTTT TACTGCCTGT GGACAAAATC CATCCTTCGT TGAAGGAAGT ATTAGGGTAC 
AAAGTGGACT ACCATGTATC CCTATATATT GTGGCTGTAC TAGAGTATAT CTCAGCTGAT 
ATTTTAAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAG 
GACATTAAAG TGTCAATGTG TGCGGATAAG GTTTTGATGG ACATGTTTGA TCAGGATGAC 
ATAGGTTTGG TTTCTCTCTG TGAAGATGAA CCTAGTTCTT CTGGTGAATT AAACTACTAT 
GATCTTGTCA GAACTGAAAT CGCAGAAGAA AGACAGTATC TACGGGAATT AAATATGATC 
ATAAAAGTGT TTCGAGAAGC CTTTCTTTCT GATAGAAAGC TGTTTAAACC TTCTGATATC 
GAAAAGATTT TTAGTAACAT TTCAGATATA CATGAATTGA CTGTGAAACT TTTAGGTTTG 
ATTGAAGACA CAGTTGAAAT GACTGATGAA AGCAGTCCTC ATCCCTTAGC TGGCAGCTGT 
TTTGAAGATT TGGCAGAAGA GCAAGCATTT GATCCTTATG AAACATTATC ACAGGACATT 
CTTTCACCAG AGTTTCATGA ACATTTCAAT AAATTGATGG CCAGACCTGC AGTTGCTCTA 
CACTTTCAGT CCATTGCTGA TGGTTTTAAA GAGGCAGTTC GTTATGTCCT TCCACGTCTT 
ATGCTGGTGC CAGTGTATCA CTGTTGGCAC TACTTTGAGT TACTAAAGCA ATTGAAAGCA 
TGTAGTGAAG AACAAGAAGA CAGAGAATGT TTGAACCAAG CTATTACTGC TCTCATGAAT 
CTCCAAGGTA GCATGGACCG AATTTACAAG CAGTATTCAC CTAGACGTCG ACCTGGAGAT 
CCTGTTTGCC CTTTTTATAG TCACCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAATAT CGATGGATGG GAAGGCAAAG ATATTGGACA GTGTTGTAAT 
GAATTCATTA TGGAGGGACC ATTGACAAGA ATCGGTGCCA AACATGAACG GCATATTTTT 
CTGTTTGATG GCTTAATGAT CAGTTGTAAA CCTAATCATG GCCAGACTCG GCTTCCAGGT 
TACAGTAGTG CAGAATACAG GTTAAAAGAA AAATTTGTCA TGAGGAAAAT ACAAATTTGT 
GATAAAGAAG ATACTTGTGA GCACAAGCAT GCATTTGAAT TAGTATCCAA AGATGAGAAC 
AGCATAATAT TTGCTGCTAA GTCTGCTGAA GAAAAAAACA ACTGGATGGC AGCCCTTATT 
TCTCTTCATT ATCGTAGTAC TCTAGATCGA ATGTTAGATT CAGTATTATT GAAAGAAGAA 
AATGAGCAAC CACTGAGATT ACCAAGTCCT GAAGTATATC GTTTTGTAGT AAAAGACTCT 
GAGGAAAACA TTGTTTTTGA AGACAACTTG CAAAGTAGAA GTGGCATCCC CATTATTAAA 
GGAGGAACTG TAGTGAAATT AATTGAAAGG TTAACATATC ATATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC CACATATCGT TCATTTTGTA AACCACAGGA ATTGCTGAGC 
TTACTGATTG AACGGTTTGA AATTCCAGAG CCAGAACCTA CTGACGCAGA CAAATTGGCA 
ATAGAGAAAG GCGAGCAGCC AATCAGTGCA GACCTTAAAA GATTTCGCAA GGAATATGTC 
CAACCAGTAC AACTTAGGAT CTTAAATGTA TTTCGGCATT GGGTTGAACA TCATTTTTAT 
GACTTTGAAA GAGACTTGGA ATTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCTA TGAAAAAATG GGTAGAGTCA ATTGCTAAGA TCATCAGGAG GAAGAAGCAA 
GCTCAGGCAA ACGGAGTAAG CCATAATATT ACCTTTGAAA GTCCACCTCC ACCAATTGAA 
TGGCATATCA GCAAACCAGG ACAGTTTGAA ACATTTGATC TCATGACACT TCATCCAATA 
GAAATTGCAC GTCAGCTGAC ACTTTTGGAG TCTGATCTTT ACAGGAAAGT TCAACCGTCT 
GAACTTGTAG GGAGTGTGTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAATTTATTA 
AAAATGATTC GCCATACCAC AAATCTCACC CTCTGGTTTG AAAAATGCAT TGTGGAAGCA 
GAAAATTTTG AAGAACGGGT GGCAGTACTA AGTAGAATTA TAGAAATTCT GCAAGTTTTT 
CAAGATTTGA ATAATTTCAA TGGCGTATTG GAGATAGTCA GTGCAGTAAA TTCAGTGTCA 
GTATACAGAC TAGACCATAC CTTTGAGGCA CTGCAGGAAA GGAAAAGGAA AATTTTGGAC 
GAAGCTGTGG AATTAAGTCA AGATCACTTT AAAAAATACC TAGTAAAACT TAAGTCAATC 
AATCCACCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACCGAAGAA 
GGGAATAATG ATTTTTTAAA AAAGAAAGGG AAAGATTTAA TCAATTTCAG TAAGAGGAGG 
AAAGTAGCTG AAATTACTGG AGAAATTCAG CAGTATCAGA ATCAGCCTTA CTGTTTACGG 
ATAGAACCAG ATATGAGGAG ATTCTTTGAA AACCTTAACC CCATGGGAAG TGCATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAG TCACTAGAAA TTGAACCTCG AAACTGCAAA 
CAGCCACCTC GATTTCCTAG GAAATCAACT TTTTCCTTAA AATCTCCTGG AATAAGGCCT 
AACACAGGCC GACATGGCTC TACCTCAGGT ACTTTACGAG GTCACCCAAC ACCATTAGAA 
AGAGAACCAT GTAAAATAAG CTTTAGTCGG ATTGCTGAAA CTGAGCTGGA ATCAACAGTG 
TCAGCACCAA CCTCTCCAAA TACACCATCT ACTCCACCAG TATCTGCTTC TTCAGACCTT 
AGTGTATTTT TAGATGTGGA TCTCAACAGC TCCTGTGGCA GCAATAGCAT CTTTGCTCCA 
GTGCTTTTGC CACATTCAAA GTCTTTCTTT AGTTCATGTG GTAGTTTACA TAAACTAAGT 
GAAGAGCCCC TGATTCCTCC TCCTCTTCCT CCTCGAAAAA AGTTTGATCA TGATGCTTCA 
AATTCCAAGG GAAATATGAA ATCTGATGAT GATCCTCCTG CTATTCCACC GAGACAGCCT 
CCTCCTCCAA AGGTAAAACC CAGAGTTCCT GTTCCTACTG GTGCATTTGA TGGGCCTCTG 
CATAGTCCAC CTCCGCCACC ACCAAGAGAT CCTCTTCCTG ATACCCCTCC ACCAGTTCCC 
CTTCGGCCTC CAGAACACTT TATAAACTGT CCATTTAATC TTCAGCCACC TCCACTGGGG 
CATCTTCACA GAGATTCAGA CTGGCTCAGA GACATTAGTA CGTGTCCAAA TTCGCCAAGC 
ACTCCTCCTA GCACACCCTC TCCAAGGGTA CCGCGTCGAT GCTATGTGCT CAGTTCTAGT 
CAGAATAATC TTGCTCATCC TCCAGCTCCC CCTGTTCCAC CAAGGCAGAA TTCAAGCCCT 
CATCTGCCAA AACTGCCACC AAAGACTTAC AAACGGGAGC TTTCGCACCC CCCATTGTAC 
AGACTGCCTT TGCTAGAAAA TGCAGAAACT CCCCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOS2 ( NM_006939.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008870.2 Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), mRNA.

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CloneID	OHu05866
Clone ID Related Accession (Same CDS sequence)	NM_006939.3 , NM_006939.2 , NM_006939.4
Accession Version	NM_006939.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	son of sevenless homolog 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109758.3, AI419975.1, BC117261.1 and R20624.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006939.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.78693.1, SRR1803614.79798.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216373.10/ ENSP00000216373.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCAGG CGCCGCAGCC TTACGAGTTC TTCAGCGAGG AGAACAGTCC GAAATGGCGG 
GGACTGTTGG TCTCGGCCCT GCGGAAGGTT CAGGAACAAG TGCATCCCAC TCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAG CTGATTTTTC AGCTGCTTAA TAAATTATGC 
ATGGCCCAGC CAAGGACTGT TCAAGATGTA GAGGAGCGAG TTCAGAAGAC CTTTCCTCAC 
CCAATTGATA AATGGGCCAT TGCTGATGCA CAATCTGCTA TAGAAAAACG AAAACGAAGA 
AATCCTCTTT TACTGCCTGT GGACAAAATC CATCCTTCGT TGAAGGAAGT ATTAGGGTAC 
AAAGTGGACT ACCATGTATC CCTATATATT GTGGCTGTAC TAGAGTATAT CTCAGCTGAT 
ATTTTAAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAG 
GACATTAAAG TGTCAATGTG TGCGGATAAG GTTTTGATGG ACATGTTTGA TCAGGATGAC 
ATAGGTTTGG TTTCTCTCTG TGAAGATGAA CCTAGTTCTT CTGGTGAATT AAACTACTAT 
GATCTTGTCA GAACTGAAAT CGCAGAAGAA AGACAGTATC TACGGGAATT AAATATGATC 
ATAAAAGTGT TTCGAGAAGC CTTTCTTTCT GATAGAAAGC TGTTTAAACC TTCTGATATC 
GAAAAGATTT TTAGTAACAT TTCAGATATA CATGAATTGA CTGTGAAACT TTTAGGTTTG 
ATTGAAGACA CAGTTGAAAT GACTGATGAA AGCAGTCCTC ATCCCTTAGC TGGCAGCTGT 
TTTGAAGATT TGGCAGAAGA GCAAGCATTT GATCCTTATG AAACATTATC ACAGGACATT 
CTTTCACCAG AGTTTCATGA ACATTTCAAT AAATTGATGG CCAGACCTGC AGTTGCTCTA 
CACTTTCAGT CCATTGCTGA TGGTTTTAAA GAGGCAGTTC GTTATGTCCT TCCACGTCTT 
ATGCTGGTGC CAGTGTATCA CTGTTGGCAC TACTTTGAGT TACTAAAGCA ATTGAAAGCA 
TGTAGTGAAG AACAAGAAGA CAGAGAATGT TTGAACCAAG CTATTACTGC TCTCATGAAT 
CTCCAAGGTA GCATGGACCG AATTTACAAG CAGTATTCAC CTAGACGTCG ACCTGGAGAT 
CCTGTTTGCC CTTTTTATAG TCACCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAATAT CGATGGATGG GAAGGCAAAG ATATTGGACA GTGTTGTAAT 
GAATTCATTA TGGAGGGACC ATTGACAAGA ATCGGTGCCA AACATGAACG GCATATTTTT 
CTGTTTGATG GCTTAATGAT CAGTTGTAAA CCTAATCATG GCCAGACTCG GCTTCCAGGT 
TACAGTAGTG CAGAATACAG GTTAAAAGAA AAATTTGTCA TGAGGAAAAT ACAAATTTGT 
GATAAAGAAG ATACTTGTGA GCACAAGCAT GCATTTGAAT TAGTATCCAA AGATGAGAAC 
AGCATAATAT TTGCTGCTAA GTCTGCTGAA GAAAAAAACA ACTGGATGGC AGCCCTTATT 
TCTCTTCATT ATCGTAGTAC TCTAGATCGA ATGTTAGATT CAGTATTATT GAAAGAAGAA 
AATGAGCAAC CACTGAGATT ACCAAGTCCT GAAGTATATC GTTTTGTAGT AAAAGACTCT 
GAGGAAAACA TTGTTTTTGA AGACAACTTG CAAAGTAGAA GTGGCATCCC CATTATTAAA 
GGAGGAACTG TAGTGAAATT AATTGAAAGG TTAACATATC ATATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC CACATATCGT TCATTTTGTA AACCACAGGA ATTGCTGAGC 
TTACTGATTG AACGGTTTGA AATTCCAGAG CCAGAACCTA CTGACGCAGA CAAATTGGCA 
ATAGAGAAAG GCGAGCAGCC AATCAGTGCA GACCTTAAAA GATTTCGCAA GGAATATGTC 
CAACCAGTAC AACTTAGGAT CTTAAATGTA TTTCGGCATT GGGTTGAACA TCATTTTTAT 
GACTTTGAAA GAGACTTGGA ATTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCTA TGAAAAAATG GGTAGAGTCA ATTGCTAAGA TCATCAGGAG GAAGAAGCAA 
GCTCAGGCAA ACGGAGTAAG CCATAATATT ACCTTTGAAA GTCCACCTCC ACCAATTGAA 
TGGCATATCA GCAAACCAGG ACAGTTTGAA ACATTTGATC TCATGACACT TCATCCAATA 
GAAATTGCAC GTCAGCTGAC ACTTTTGGAG TCTGATCTTT ACAGGAAAGT TCAACCGTCT 
GAACTTGTAG GGAGTGTGTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAATTTATTA 
AAAATGATTC GCCATACCAC AAATCTCACC CTCTGGTTTG AAAAATGCAT TGTGGAAGCA 
GAAAATTTTG AAGAACGGGT GGCAGTACTA AGTAGAATTA TAGAAATTCT GCAAGTTTTT 
CAAGATTTGA ATAATTTCAA TGGCGTATTG GAGATAGTCA GTGCAGTAAA TTCAGTGTCA 
GTATACAGAC TAGACCATAC CTTTGAGGCA CTGCAGGAAA GGAAAAGGAA AATTTTGGAC 
GAAGCTGTGG AATTAAGTCA AGATCACTTT AAAAAATACC TAGTAAAACT TAAGTCAATC 
AATCCACCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACCGAAGAA 
GGGAATAATG ATTTTTTAAA AAAGAAAGGG AAAGATTTAA TCAATTTCAG TAAGAGGAGG 
AAAGTAGCTG AAATTACTGG AGAAATTCAG CAGTATCAGA ATCAGCCTTA CTGTTTACGG 
ATAGAACCAG ATATGAGGAG ATTCTTTGAA AACCTTAACC CCATGGGAAG TGCATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAG TCACTAGAAA TTGAACCTCG AAACTGCAAA 
CAGCCACCTC GATTTCCTAG GAAATCAACT TTTTCCTTAA AATCTCCTGG AATAAGGCCT 
AACACAGGCC GACATGGCTC TACCTCAGGT ACTTTACGAG GTCACCCAAC ACCATTAGAA 
AGAGAACCAT GTAAAATAAG CTTTAGTCGG ATTGCTGAAA CTGAGCTGGA ATCAACAGTG 
TCAGCACCAA CCTCTCCAAA TACACCATCT ACTCCACCAG TATCTGCTTC TTCAGACCTT 
AGTGTATTTT TAGATGTGGA TCTCAACAGC TCCTGTGGCA GCAATAGCAT CTTTGCTCCA 
GTGCTTTTGC CACATTCAAA GTCTTTCTTT AGTTCATGTG GTAGTTTACA TAAACTAAGT 
GAAGAGCCCC TGATTCCTCC TCCTCTTCCT CCTCGAAAAA AGTTTGATCA TGATGCTTCA 
AATTCCAAGG GAAATATGAA ATCTGATGAT GATCCTCCTG CTATTCCACC GAGACAGCCT 
CCTCCTCCAA AGGTAAAACC CAGAGTTCCT GTTCCTACTG GTGCATTTGA TGGGCCTCTG 
CATAGTCCAC CTCCGCCACC ACCAAGAGAT CCTCTTCCTG ATACCCCTCC ACCAGTTCCC 
CTTCGGCCTC CAGAACACTT TATAAACTGT CCATTTAATC TTCAGCCACC TCCACTGGGG 
CATCTTCACA GAGATTCAGA CTGGCTCAGA GACATTAGTA CGTGTCCAAA TTCGCCAAGC 
ACTCCTCCTA GCACACCCTC TCCAAGGGTA CCGCGTCGAT GCTATGTGCT CAGTTCTAGT 
CAGAATAATC TTGCTCATCC TCCAGCTCCC CCTGTTCCAC CAAGGCAGAA TTCAAGCCCT 
CATCTGCCAA AACTGCCACC AAAGACTTAC AAACGGGAGC TTTCGCACCC CCCATTGTAC 
AGACTGCCTT TGCTAGAAAA TGCAGAAACT CCCCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008870.2
CDS	296..4294
Translation	MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ

Target ORF information:

RefSeq Version	NM_006939.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006939.4

ORF Insert Sequence:

ATGCAGCAGG CGCCGCAGCC TTACGAGTTC TTCAGCGAGG AGAACAGTCC GAAATGGCGG 
GGACTGTTGG TCTCGGCCCT GCGGAAGGTT CAGGAACAAG TGCATCCCAC TCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAG CTGATTTTTC AGCTGCTTAA TAAATTATGC 
ATGGCCCAGC CAAGGACTGT TCAAGATGTA GAGGAGCGAG TTCAGAAGAC CTTTCCTCAC 
CCAATTGATA AATGGGCCAT TGCTGATGCA CAATCTGCTA TAGAAAAACG AAAACGAAGA 
AATCCTCTTT TACTGCCTGT GGACAAAATC CATCCTTCGT TGAAGGAAGT ATTAGGGTAC 
AAAGTGGACT ACCATGTATC CCTATATATT GTGGCTGTAC TAGAGTATAT CTCAGCTGAT 
ATTTTAAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAG 
GACATTAAAG TGTCAATGTG TGCGGATAAG GTTTTGATGG ACATGTTTGA TCAGGATGAC 
ATAGGTTTGG TTTCTCTCTG TGAAGATGAA CCTAGTTCTT CTGGTGAATT AAACTACTAT 
GATCTTGTCA GAACTGAAAT CGCAGAAGAA AGACAGTATC TACGGGAATT AAATATGATC 
ATAAAAGTGT TTCGAGAAGC CTTTCTTTCT GATAGAAAGC TGTTTAAACC TTCTGATATC 
GAAAAGATTT TTAGTAACAT TTCAGATATA CATGAATTGA CTGTGAAACT TTTAGGTTTG 
ATTGAAGACA CAGTTGAAAT GACTGATGAA AGCAGTCCTC ATCCCTTAGC TGGCAGCTGT 
TTTGAAGATT TGGCAGAAGA GCAAGCATTT GATCCTTATG AAACATTATC ACAGGACATT 
CTTTCACCAG AGTTTCATGA ACATTTCAAT AAATTGATGG CCAGACCTGC AGTTGCTCTA 
CACTTTCAGT CCATTGCTGA TGGTTTTAAA GAGGCAGTTC GTTATGTCCT TCCACGTCTT 
ATGCTGGTGC CAGTGTATCA CTGTTGGCAC TACTTTGAGT TACTAAAGCA ATTGAAAGCA 
TGTAGTGAAG AACAAGAAGA CAGAGAATGT TTGAACCAAG CTATTACTGC TCTCATGAAT 
CTCCAAGGTA GCATGGACCG AATTTACAAG CAGTATTCAC CTAGACGTCG ACCTGGAGAT 
CCTGTTTGCC CTTTTTATAG TCACCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAATAT CGATGGATGG GAAGGCAAAG ATATTGGACA GTGTTGTAAT 
GAATTCATTA TGGAGGGACC ATTGACAAGA ATCGGTGCCA AACATGAACG GCATATTTTT 
CTGTTTGATG GCTTAATGAT CAGTTGTAAA CCTAATCATG GCCAGACTCG GCTTCCAGGT 
TACAGTAGTG CAGAATACAG GTTAAAAGAA AAATTTGTCA TGAGGAAAAT ACAAATTTGT 
GATAAAGAAG ATACTTGTGA GCACAAGCAT GCATTTGAAT TAGTATCCAA AGATGAGAAC 
AGCATAATAT TTGCTGCTAA GTCTGCTGAA GAAAAAAACA ACTGGATGGC AGCCCTTATT 
TCTCTTCATT ATCGTAGTAC TCTAGATCGA ATGTTAGATT CAGTATTATT GAAAGAAGAA 
AATGAGCAAC CACTGAGATT ACCAAGTCCT GAAGTATATC GTTTTGTAGT AAAAGACTCT 
GAGGAAAACA TTGTTTTTGA AGACAACTTG CAAAGTAGAA GTGGCATCCC CATTATTAAA 
GGAGGAACTG TAGTGAAATT AATTGAAAGG TTAACATATC ATATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC CACATATCGT TCATTTTGTA AACCACAGGA ATTGCTGAGC 
TTACTGATTG AACGGTTTGA AATTCCAGAG CCAGAACCTA CTGACGCAGA CAAATTGGCA 
ATAGAGAAAG GCGAGCAGCC AATCAGTGCA GACCTTAAAA GATTTCGCAA GGAATATGTC 
CAACCAGTAC AACTTAGGAT CTTAAATGTA TTTCGGCATT GGGTTGAACA TCATTTTTAT 
GACTTTGAAA GAGACTTGGA ATTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCTA TGAAAAAATG GGTAGAGTCA ATTGCTAAGA TCATCAGGAG GAAGAAGCAA 
GCTCAGGCAA ACGGAGTAAG CCATAATATT ACCTTTGAAA GTCCACCTCC ACCAATTGAA 
TGGCATATCA GCAAACCAGG ACAGTTTGAA ACATTTGATC TCATGACACT TCATCCAATA 
GAAATTGCAC GTCAGCTGAC ACTTTTGGAG TCTGATCTTT ACAGGAAAGT TCAACCGTCT 
GAACTTGTAG GGAGTGTGTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAATTTATTA 
AAAATGATTC GCCATACCAC AAATCTCACC CTCTGGTTTG AAAAATGCAT TGTGGAAGCA 
GAAAATTTTG AAGAACGGGT GGCAGTACTA AGTAGAATTA TAGAAATTCT GCAAGTTTTT 
CAAGATTTGA ATAATTTCAA TGGCGTATTG GAGATAGTCA GTGCAGTAAA TTCAGTGTCA 
GTATACAGAC TAGACCATAC CTTTGAGGCA CTGCAGGAAA GGAAAAGGAA AATTTTGGAC 
GAAGCTGTGG AATTAAGTCA AGATCACTTT AAAAAATACC TAGTAAAACT TAAGTCAATC 
AATCCACCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACCGAAGAA 
GGGAATAATG ATTTTTTAAA AAAGAAAGGG AAAGATTTAA TCAATTTCAG TAAGAGGAGG 
AAAGTAGCTG AAATTACTGG AGAAATTCAG CAGTATCAGA ATCAGCCTTA CTGTTTACGG 
ATAGAACCAG ATATGAGGAG ATTCTTTGAA AACCTTAACC CCATGGGAAG TGCATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAG TCACTAGAAA TTGAACCTCG AAACTGCAAA 
CAGCCACCTC GATTTCCTAG GAAATCAACT TTTTCCTTAA AATCTCCTGG AATAAGGCCT 
AACACAGGCC GACATGGCTC TACCTCAGGT ACTTTACGAG GTCACCCAAC ACCATTAGAA 
AGAGAACCAT GTAAAATAAG CTTTAGTCGG ATTGCTGAAA CTGAGCTGGA ATCAACAGTG 
TCAGCACCAA CCTCTCCAAA TACACCATCT ACTCCACCAG TATCTGCTTC TTCAGACCTT 
AGTGTATTTT TAGATGTGGA TCTCAACAGC TCCTGTGGCA GCAATAGCAT CTTTGCTCCA 
GTGCTTTTGC CACATTCAAA GTCTTTCTTT AGTTCATGTG GTAGTTTACA TAAACTAAGT 
GAAGAGCCCC TGATTCCTCC TCCTCTTCCT CCTCGAAAAA AGTTTGATCA TGATGCTTCA 
AATTCCAAGG GAAATATGAA ATCTGATGAT GATCCTCCTG CTATTCCACC GAGACAGCCT 
CCTCCTCCAA AGGTAAAACC CAGAGTTCCT GTTCCTACTG GTGCATTTGA TGGGCCTCTG 
CATAGTCCAC CTCCGCCACC ACCAAGAGAT CCTCTTCCTG ATACCCCTCC ACCAGTTCCC 
CTTCGGCCTC CAGAACACTT TATAAACTGT CCATTTAATC TTCAGCCACC TCCACTGGGG 
CATCTTCACA GAGATTCAGA CTGGCTCAGA GACATTAGTA CGTGTCCAAA TTCGCCAAGC 
ACTCCTCCTA GCACACCCTC TCCAAGGGTA CCGCGTCGAT GCTATGTGCT CAGTTCTAGT 
CAGAATAATC TTGCTCATCC TCCAGCTCCC CCTGTTCCAC CAAGGCAGAA TTCAAGCCCT 
CATCTGCCAA AACTGCCACC AAAGACTTAC AAACGGGAGC TTTCGCACCC CCCATTGTAC 
AGACTGCCTT TGCTAGAAAA TGCAGAAACT CCCCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.
Human mutation36(11)1080-7(2015 Nov)
Cordeddu V,Yin JC,Gunnarsson C,Virtanen C,Drunat S,Lepri F,De Luca A,Rossi C,Ciolfi A,Pugh TJ,Bruselles A,Priest JR,Pennacchio LA,Lu Z,Danesh A,Quevedo R,Hamid A,Martinelli S,Pantaleoni F,Gnazzo M,Daniele P,Lissewski C,Bocchinfuso G,Stella L,Odent S,Philip N,Faivre L,Vlckova M,Seemanova E,Digilio C,Zenker M,Zampino G,Verloes A,Dallapiccola B,Roberts AE,Cav? H,Gelb BD,Neel BG,Tartaglia M

Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.
Journal of medical genetics52(6)413-21(2015 Jun)
Yamamoto GL,Aguena M,Gos M,Hung C,Pilch J,Fahiminiya S,Abramowicz A,Cristian I,Buscarilli M,Naslavsky MS,Malaquias AC,Zatz M,Bodamer O,Majewski J,Jorge AA,Pereira AC,Kim CA,Passos-Bueno MR,Bertola DR

Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
G3 (Bethesda, Md.)4(2)307-14(2014 Feb)
Shaffer JR,Polk DE,Wang X,Feingold E,Weeks DE,Lee MK,Cuenco KT,Weyant RJ,Crout RJ,McNeil DW,Marazita ML

A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome.
European journal of endocrinology169(3)277-89(2013 Sep)
Clayton P,Chatelain P,Tat? L,Yoo HW,Ambler GR,Belgorosky A,Quinteiro S,Deal C,Stevens A,Raelson J,Croteau P,Destenaves B,Olivier C

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SOS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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