REG1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	REG1A
Entrez Gene ID	5967
Full Name	regenerating family member 1 alpha
Synonyms	ICRF,P19,PSP,PSPS,PSPS1,PTP,REG
General protein information	Preferred Names regenerating family member 1 alpha Names lithostathine-1-alpha REG-1-alpha islet cells regeneration factor islet of langerhans regenerating protein pancreatic stone protein, secretory pancreatic thread protein protein-X regenerating islet-derived protein 1-alpha regenerating protein I alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p12
Summary	This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
Disorder MIM:	167770

mRNA and Protein(s)

mRNA	Protein	Name
NM_002909.5	NP_002900.2	lithostathine-1-alpha precursor
NM_002909.4	NP_002900.2	lithostathine-1-alpha precursor

Pathways from BioSystems

Homologies

	REG1A	XP_001112711.2
Homo sapiens (human)	REG1A	NP_002900.2
Pan troglodytes (chimpanzee)	REG1A	XP_001163554.2
Mus musculus (house mouse)	Reg1	NP_033068.1
Rattus norvegicus (Norway rat)	Reg1a	NP_036773.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma.
Xing H, Chen X, Han Y
Biological research50(1)37(2017 Nov)

Procalcitonin and Pancreatic Stone Protein Function as Biomarkers in Early Diagnosis of Pediatric Acute Osteomyelitis.
Cui C, Fu M, Gao B
Medical science monitor : international medical journal of experimental and clinical research235211-5217(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both univariate and multivariate analysis demonstrated that REG1A expression was associated with OS and PFS, and conducted harmful effects on nasopharyngeal carcinoma progression and survival. This study suggested that REG1A expression could serve as an independent adverse factor for survival in nasopharyngeal carcinoma.
Title: Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma.

REG1alpha was overexpressed in bladder cancer tissues compared with adjacent normal samples. Downregulation of REG1alpha expression in urothelial bladder cancer can reduce tumor growth, migration, invasion and angiogenesis.
Title: Decreased REG1? expression suppresses growth, invasion and angiogenesis of bladder cancer.

the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis, was investigated.
Title: Prognostic Value of High-Sensitivity C-Reactive Protein, Procalcitonin and Pancreatic Stone Protein in Pediatric Sepsis.

REG-I is expressed in head and neck squamous cell carcinoma and is associated with a longer survival status.
Title: Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.

Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
Title: Role of regenerating gene I in claudin expression and barrier function in the small intestine.

The following REG1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the REG1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27293	NM_002909.5 Latest version!	Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27293	NM_002909.4	Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

REG1A ( NM_002909.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002900.2 Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.

Price & Availability↑

CloneID	OHu27293
Clone ID Related Accession (Same CDS sequence)	NM_002909.5 , NM_002909.4
Accession Version	NM_002909.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	lithostathine-1-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM769434.1, AK291981.1, W38384.1 and AW873911.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002909.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279838.5622.1, AK291981.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000233735.2/ ENSP00000233735.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCAGA CCAGCTCATA CTTCATGCTG ATCTCCTGCC TGATGTTTCT GTCTCAGAGC 
CAAGGCCAAG AGGCCCAGAC AGAGTTGCCC CAGGCCCGGA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC GTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCGGGC AACCTGGTGT CTGTGCTCAC CCAGGCCGAG 
GGTGCCTTTG TGGCCTCACT GATTAAGGAG AGTGGCACTG ATGACTTCAA TGTCTGGATT 
GGCCTCCATG ACCCCAAAAA GAACCGCCGC TGGCACTGGA GCAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGGCATTGG AGCCCCAAGC AGTGTTAATC CTGGCTACTG TGTGAGCCTG 
ACCTCAAGCA CAGGATTCCA GAAATGGAAG GATGTGCCTT GTGAAGACAA GTTCTCCTTT 
GTCTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002900.2
CDS	74..574
Translation	MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN

Target ORF information:

RefSeq Version	NM_002909.5
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002909.5

ORF Insert Sequence:

ATGGCTCAGA CCAGCTCATA CTTCATGCTG ATCTCCTGCC TGATGTTTCT GTCTCAGAGC 
CAAGGCCAAG AGGCCCAGAC AGAGTTGCCC CAGGCCCGGA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC GTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCGGGC AACCTGGTGT CTGTGCTCAC CCAGGCCGAG 
GGTGCCTTTG TGGCCTCACT GATTAAGGAG AGTGGCACTG ATGACTTCAA TGTCTGGATT 
GGCCTCCATG ACCCCAAAAA GAACCGCCGC TGGCACTGGA GCAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGGCATTGG AGCCCCAAGC AGTGTTAATC CTGGCTACTG TGTGAGCCTG 
ACCTCAAGCA CAGGATTCCA GAAATGGAAG GATGTGCCTT GTGAAGACAA GTTCTCCTTT 
GTCTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG1A ( NM_002909.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002900.2 Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.

Price & Availability↑

CloneID	OHu27293
Clone ID Related Accession (Same CDS sequence)	NM_002909.5 , NM_002909.4
Accession Version	NM_002909.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	lithostathine-1-alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM769434.1, AK291981.1, W38384.1 and AW873911.1. This sequence is a reference standard in the RefSeqGene project. On Jun 8, 2008 this sequence version replaced NM_002909.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP323180.1, ERR279838.140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTCAGA CCAGCTCATA CTTCATGCTG ATCTCCTGCC TGATGTTTCT GTCTCAGAGC 
CAAGGCCAAG AGGCCCAGAC AGAGTTGCCC CAGGCCCGGA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC GTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCGGGC AACCTGGTGT CTGTGCTCAC CCAGGCCGAG 
GGTGCCTTTG TGGCCTCACT GATTAAGGAG AGTGGCACTG ATGACTTCAA TGTCTGGATT 
GGCCTCCATG ACCCCAAAAA GAACCGCCGC TGGCACTGGA GCAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGGCATTGG AGCCCCAAGC AGTGTTAATC CTGGCTACTG TGTGAGCCTG 
ACCTCAAGCA CAGGATTCCA GAAATGGAAG GATGTGCCTT GTGAAGACAA GTTCTCCTTT 
GTCTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002900.2
CDS	104..604
Translation	MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN

Target ORF information:

RefSeq Version	NM_002909.4
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002909.4

ORF Insert Sequence:

ATGGCTCAGA CCAGCTCATA CTTCATGCTG ATCTCCTGCC TGATGTTTCT GTCTCAGAGC 
CAAGGCCAAG AGGCCCAGAC AGAGTTGCCC CAGGCCCGGA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC GTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCGGGC AACCTGGTGT CTGTGCTCAC CCAGGCCGAG 
GGTGCCTTTG TGGCCTCACT GATTAAGGAG AGTGGCACTG ATGACTTCAA TGTCTGGATT 
GGCCTCCATG ACCCCAAAAA GAACCGCCGC TGGCACTGGA GCAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGGCATTGG AGCCCCAAGC AGTGTTAATC CTGGCTACTG TGTGAGCCTG 
ACCTCAAGCA CAGGATTCCA GAAATGGAAG GATGTGCCTT GTGAAGACAA GTTCTCCTTT 
GTCTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma.
Biological research50(1)37(2017 Nov)
Xing H,Chen X,Han Y

Procalcitonin and Pancreatic Stone Protein Function as Biomarkers in Early Diagnosis of Pediatric Acute Osteomyelitis.
Medical science monitor : international medical journal of experimental and clinical research235211-5217(2017 Nov)
Cui C,Fu M,Gao B

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REG1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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