Reg1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Reg1
Entrez Gene ID	19692
Full Name	regenerating islet-derived 1
General protein information	Preferred Names regenerating islet-derived 1 Names lithostathine-1 PSP PTP REG 1 islet of Langerhans regenerating protein 1 pancreatic stone protein 1 pancreatic thread protein 1 regenerating islet-derived, mouse homolog 1 regenerating protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 C3\|6 34.77 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_011241261.1	XP_011239563.1	lithostathine-1 isoform X1
NM_009042.2	NP_033068.1	lithostathine-1 precursor
NM_009042.1	NP_033068.1	lithostathine-1 precursor

Pathways from BioSystems

Homologies

	REG1A	XP_001112711.2
Homo sapiens (human)	REG1A	NP_002900.2
Pan troglodytes (chimpanzee)	REG1A	XP_001163554.2
Mus musculus (house mouse)	Reg1	NP_033068.1
Rattus norvegicus (Norway rat)	Reg1a	NP_036773.1

Gene Ontology
Bibliography

Related articles in PubMed

Regnase-1, an immuno-modulator, limits the IL-36/IL-36R auto-stimulatory loop in keratinocytes to suppress skin inflammation.
Takaishi M, Satoh T, Akira S, Sano S
The Journal of investigative dermatology(2018 Jan)

The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Reding T, Palmiere C, Pazhepurackel C, Schiesser M, Bimmler D, Schlegel A, S?ss U, Steiner S, Mancina L, Seleznik G, Graf R
Oncotarget8(18)30162-30174(2017 May)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

Role of regenerating gene I in claudin expression and barrier function in the small intestine.
Kitayama Y, Fukui H, Hara K, Eda H, Kodani M, Yang M, Sun C, Yamagishi H, Tomita T, Oshima T, Watari J, Takasawa S, Miwa H
Translational research : the journal of laboratory and clinical medicine17392-100(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
Title: Role of regenerating gene I in claudin expression and barrier function in the small intestine.

Members of the Reg gene family show distinct profiles of expression in the GI tract, and Reg I independently plays a role in protecting the GI mucosa against NSAID-induced injury.
Title: Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin.

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats
Title: Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.

This study implicates the Reg1 pathway in beta-cell regeneration and describes altered programming of gene expression in low protein offspring.
Title: Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice.

Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.
Title: Regenerating islet-derived 1? (Reg-1?) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.

The following Reg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Reg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03407	NM_009042.2 Latest version!	Mus musculus regenerating islet-derived 1 (Reg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu03407	XM_011241261.1 Latest version!	Mus musculus regenerating islet-derived 1 (Reg1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu03407	NM_009042.1	Mus musculus regenerating islet-derived 1 (Reg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Reg1 ( NM_009042.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033068.1 Mus musculus regenerating islet-derived 1 (Reg1), mRNA.

Price & Availability↑

CloneID	OMu03407
Clone ID Related Accession (Same CDS sequence)	XM_011241261.1 , NM_009042.2 , NM_009042.1
Accession Version	NM_009042.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	lithostathine-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK133506.1 and BE848902.1. On Feb 24, 2018 this sequence version replaced NM_009042.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133506.1, CJ042702.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGCTAGGA ACGCCTACTT CATCCTGCTC TCATGCCTGA TCGTCCTGTC TCCAAGCCAA 
GGCCAGGAAG CTGAAGAAGA CCTGCCATCT GCCAGGATCA GTTGCCCAGA AGGTTCCAAT 
GCCTACAGCT CCTATTGTTA CTACTTCACT GAAGACCGTT TAACTTGGGC TGATGCAGAT 
CTTTTTTGCC AGAACATGAA TTCAGGCTAC CTGGTGTCAG TTCTCAGTCA GGCTGAGGGC 
AACTTTGTGG CCTCTCTGAT TAAGGAGAGT GGCACTACAG ACGCCAATGT CTGGACTGGA 
CTCCATGATC CCAAAAGGAA TCGTCGCTGG CACTGGAGCA GTGGGTCTCT GTTTCTCTAC 
AAATCCTGGG CAACTGGGTC TCCTAACAGT TCCAATCGTG GCTACTGTGT ATCTCTGACT 
TCAAACACAG GATACAAGAA ATGGAAGGAT GACAACTGTG ATGCCCAATA CTCATTTGTC 
TGCAAGTTCA AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033068.1
CDS	72..569
Translation	MARNAYFILLSCLIVLSPSQGQEAEEDLPSARISCPEGSNAYSSYCYYFTEDRLTWADADLFCQNMNSGYLVSVLSQAEGNFVASLIKESGTTDANVWTGLHDPKRNRRWHWSSGSLFLYKSWATGSPNSSNRGYCVSLTSNTGYKKWKDDNCDAQYSFVCKFKG

Target ORF information:

RefSeq Version	NM_009042.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived 1 (Reg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009042.2

ORF Insert Sequence:

ATGGCTAGGA ACGCCTACTT CATCCTGCTC TCATGCCTGA TCGTCCTGTC TCCAAGCCAA 
GGCCAGGAAG CTGAAGAAGA CCTGCCATCT GCCAGGATCA GTTGCCCAGA AGGTTCCAAT 
GCCTACAGCT CCTATTGTTA CTACTTCACT GAAGACCGTT TAACTTGGGC TGATGCAGAT 
CTTTTTTGCC AGAACATGAA TTCAGGCTAC CTGGTGTCAG TTCTCAGTCA GGCTGAGGGC 
AACTTTGTGG CCTCTCTGAT TAAGGAGAGT GGCACTACAG ACGCCAATGT CTGGACTGGA 
CTCCATGATC CCAAAAGGAA TCGTCGCTGG CACTGGAGCA GTGGGTCTCT GTTTCTCTAC 
AAATCCTGGG CAACTGGGTC TCCTAACAGT TCCAATCGTG GCTACTGTGT ATCTCTGACT 
TCAAACACAG GATACAAGAA ATGGAAGGAT GACAACTGTG ATGCCCAATA CTCATTTGTC 
TGCAAGTTCA AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Reg1 ( NM_009042.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033068.1 Mus musculus regenerating islet-derived 1 (Reg1), mRNA.

Price & Availability↑

CloneID	OMu03407
Clone ID Related Accession (Same CDS sequence)	XM_011241261.1 , NM_009042.2 , NM_009042.1
Accession Version	NM_009042.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Mus musculus(house mouse)
Product	lithostathine-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D14010.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133506.1, CJ042702.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGCTAGGA ACGCCTACTT CATCCTGCTC TCATGCCTGA TCGTCCTGTC TCCAAGCCAA 
GGCCAGGAAG CTGAAGAAGA CCTGCCATCT GCCAGGATCA GTTGCCCAGA AGGTTCCAAT 
GCCTACAGCT CCTATTGTTA CTACTTCACT GAAGACCGTT TAACTTGGGC TGATGCAGAT 
CTTTTTTGCC AGAACATGAA TTCAGGCTAC CTGGTGTCAG TTCTCAGTCA GGCTGAGGGC 
AACTTTGTGG CCTCTCTGAT TAAGGAGAGT GGCACTACAG ACGCCAATGT CTGGACTGGA 
CTCCATGATC CCAAAAGGAA TCGTCGCTGG CACTGGAGCA GTGGGTCTCT GTTTCTCTAC 
AAATCCTGGG CAACTGGGTC TCCTAACAGT TCCAATCGTG GCTACTGTGT ATCTCTGACT 
TCAAACACAG GATACAAGAA ATGGAAGGAT GACAACTGTG ATGCCCAATA CTCATTTGTC 
TGCAAGTTCA AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033068.1
CDS	72..569
Translation	MARNAYFILLSCLIVLSPSQGQEAEEDLPSARISCPEGSNAYSSYCYYFTEDRLTWADADLFCQNMNSGYLVSVLSQAEGNFVASLIKESGTTDANVWTGLHDPKRNRRWHWSSGSLFLYKSWATGSPNSSNRGYCVSLTSNTGYKKWKDDNCDAQYSFVCKFKG

Target ORF information:

RefSeq Version	NM_009042.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived 1 (Reg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009042.1

ORF Insert Sequence:

ATGGCTAGGA ACGCCTACTT CATCCTGCTC TCATGCCTGA TCGTCCTGTC TCCAAGCCAA 
GGCCAGGAAG CTGAAGAAGA CCTGCCATCT GCCAGGATCA GTTGCCCAGA AGGTTCCAAT 
GCCTACAGCT CCTATTGTTA CTACTTCACT GAAGACCGTT TAACTTGGGC TGATGCAGAT 
CTTTTTTGCC AGAACATGAA TTCAGGCTAC CTGGTGTCAG TTCTCAGTCA GGCTGAGGGC 
AACTTTGTGG CCTCTCTGAT TAAGGAGAGT GGCACTACAG ACGCCAATGT CTGGACTGGA 
CTCCATGATC CCAAAAGGAA TCGTCGCTGG CACTGGAGCA GTGGGTCTCT GTTTCTCTAC 
AAATCCTGGG CAACTGGGTC TCCTAACAGT TCCAATCGTG GCTACTGTGT ATCTCTGACT 
TCAAACACAG GATACAAGAA ATGGAAGGAT GACAACTGTG ATGCCCAATA CTCATTTGTC 
TGCAAGTTCA AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Reg1 ( XM_011241261.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239563.1 Mus musculus regenerating islet-derived 1 (Reg1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu03407
Clone ID Related Accession (Same CDS sequence)	XM_011241261.1 , NM_009042.2 , NM_009042.1
Accession Version	XM_011241261.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	lithostathine-1 isoform X1
Comment

ATGGCTAGGA ACGCCTACTT CATCCTGCTC TCATGCCTGA TCGTCCTGTC TCCAAGCCAA 
GGCCAGGAAG CTGAAGAAGA CCTGCCATCT GCCAGGATCA GTTGCCCAGA AGGTTCCAAT 
GCCTACAGCT CCTATTGTTA CTACTTCACT GAAGACCGTT TAACTTGGGC TGATGCAGAT 
CTTTTTTGCC AGAACATGAA TTCAGGCTAC CTGGTGTCAG TTCTCAGTCA GGCTGAGGGC 
AACTTTGTGG CCTCTCTGAT TAAGGAGAGT GGCACTACAG ACGCCAATGT CTGGACTGGA 
CTCCATGATC CCAAAAGGAA TCGTCGCTGG CACTGGAGCA GTGGGTCTCT GTTTCTCTAC 
AAATCCTGGG CAACTGGGTC TCCTAACAGT TCCAATCGTG GCTACTGTGT ATCTCTGACT 
TCAAACACAG GATACAAGAA ATGGAAGGAT GACAACTGTG ATGCCCAATA CTCATTTGTC 
TGCAAGTTCA AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239563.1
Translation	MARNAYFILLSCLIVLSPSQGQEAEEDLPSARISCPEGSNAYSSYCYYFTEDRLTWADADLFCQNMNSGYLVSVLSQAEGNFVASLIKESGTTDANVWTGLHDPKRNRRWHWSSGSLFLYKSWATGSPNSSNRGYCVSLTSNTGYKKWKDDNCDAQYSFVCKFKG

Target ORF information:

RefSeq Version	XM_011241261.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus regenerating islet-derived 1 (Reg1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241261.1

ORF Insert Sequence:

ATGGCTAGGA ACGCCTACTT CATCCTGCTC TCATGCCTGA TCGTCCTGTC TCCAAGCCAA 
GGCCAGGAAG CTGAAGAAGA CCTGCCATCT GCCAGGATCA GTTGCCCAGA AGGTTCCAAT 
GCCTACAGCT CCTATTGTTA CTACTTCACT GAAGACCGTT TAACTTGGGC TGATGCAGAT 
CTTTTTTGCC AGAACATGAA TTCAGGCTAC CTGGTGTCAG TTCTCAGTCA GGCTGAGGGC 
AACTTTGTGG CCTCTCTGAT TAAGGAGAGT GGCACTACAG ACGCCAATGT CTGGACTGGA 
CTCCATGATC CCAAAAGGAA TCGTCGCTGG CACTGGAGCA GTGGGTCTCT GTTTCTCTAC 
AAATCCTGGG CAACTGGGTC TCCTAACAGT TCCAATCGTG GCTACTGTGT ATCTCTGACT 
TCAAACACAG GATACAAGAA ATGGAAGGAT GACAACTGTG ATGCCCAATA CTCATTTGTC 
TGCAAGTTCA AAGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regnase-1, an immuno-modulator, limits the IL-36/IL-36R auto-stimulatory loop in keratinocytes to suppress skin inflammation.
The Journal of investigative dermatology(2018 Jan)
Takaishi M,Satoh T,Akira S,Sano S

The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Oncotarget8(18)30162-30174(2017 May)
Reding T,Palmiere C,Pazhepurackel C,Schiesser M,Bimmler D,Schlegel A,S?ss U,Steiner S,Mancina L,Seleznik G,Graf R

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

Role of regenerating gene I in claudin expression and barrier function in the small intestine.
Translational research : the journal of laboratory and clinical medicine17392-100(2016 Jul)
Kitayama Y,Fukui H,Hara K,Eda H,Kodani M,Yang M,Sun C,Yamagishi H,Tomita T,Oshima T,Watari J,Takasawa S,Miwa H

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Reg1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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