PSEN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSEN2
Entrez Gene ID	5664
Full Name	presenilin 2
Synonyms	AD3L,AD4,CMD1V,PS2,STM2
General protein information	Preferred Names presenilin 2 Names presenilin-2 AD3LP AD5 Alzheimer disease 4 E5-1 PS-2 STM-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.13
Summary	Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	600759
Disorder Html:	Alzheimer disease-4, 606889 (3); Cardiomyopathy, dilated, 1V, 613697 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017001835.1	XP_016857324.1	presenilin-2 isoform X1
XM_005273199.2	XP_005273256.1	presenilin-2 isoform X1
NM_000447.3	NP_000438.2	presenilin-2 isoform 1
NM_012486.2	NP_036618.2	presenilin-2 isoform 2
XM_005273199.3	XP_005273256.1	presenilin-2 isoform X1
XM_005273199.4	XP_005273256.1	presenilin-2 isoform X1
XM_017001836.1	XP_016857325.1	presenilin-2 isoform X2
NM_000447.2	NP_000438.2	presenilin-2 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSEN2	NP_000438.2
	PSEN2	XP_002801954.1
Canis lupus familiaris (dog)	PSEN2	XP_005622685.1
Danio rerio (zebrafish)	psen2	NP_571589.2
Xenopus tropicalis (tropical clawed frog)	psen2	NP_001017181.1
Bos taurus (cattle)	PSEN2	NP_776865.2
Rattus norvegicus (Norway rat)	Psen2	NP_112349.2
Drosophila melanogaster (fruit fly)	Psn	NP_001137988.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002957	XP_311942.4
Gallus gallus (chicken)	PSEN2	NP_989633.1
Oryza sativa (rice)	Os01g0276400	NP_001042728.2
Pan troglodytes (chimpanzee)	PSEN2	XP_003949755.1
Mus musculus (house mouse)	Psen2	NP_001122077.1

Gene Ontology
Bibliography

Related articles in PubMed

Presenilin Mutation Suppresses Lung Tumorigenesis via Inhibition of Peroxiredoxin 6 Activity and Expression.
Park MH, Yun HM, Hwang CJ, Park SI, Han SB, Hwang DY, Yoon DY, Kim S, Hong JT
Theranostics7(15)3624-3637(2017)

Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries.
Bagyinszky E, Youn YC, An SS, Kim S
Clinical interventions in aging111467-1488(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2)/Aph1aL, PS2/Aph1aS and PS2/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.
Title: Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of ?-secretase.

This review reveled that Mutations in APP and PS-1 and PS-2 genes that are associated with early-onset, autosomal, dominantly inherited AD.
Title: Genomics of Alzheimer Disease: A Review.

Study identified a unique motif in PSEN2 that directs gamma-secretase to late endosomes/lysosomes via a phosphorylation-dependent interaction with the AP-1 adaptor complex. PSEN2 selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular Abeta that contains longer Abeta; familial Alzheimer's disease-associated mutations in PSEN2 increased the levels of longer Ab...
Title: Restricted Location of PSEN2/?-Secretase Determines Substrate Specificity and Generates an Intracellular A? Pool.

Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2).
Title: Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.

Most of the early-onset Alzheimer's disease -associated mutations have been detected in PSEN1, and several novel PSEN1 mutations were recently identified in patients from various parts of the world, including Asia. Until 2014, no PSEN2 mutations were found in Asian patients; however, emerging studies from Korea and the People's Republic of China discovered probably pathogenic PSEN2 mutations. [review]
Title: Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries.

The following PSEN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSEN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24950	NM_000447.3 Latest version!	Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu24950	XM_017001835.1 Latest version!	Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu24950	XM_005273199.4 Latest version!	Homo sapiens presenilin 2 (PSEN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu24919	NM_012486.2 Latest version!	Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu24919	XM_017001836.1 Latest version!	Homo sapiens presenilin 2 (PSEN2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu24950	XM_005273199.2	Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu24950	XM_005273199.3	Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu24950	NM_000447.2	Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSEN2 ( NM_000447.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000438.2 Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24950
Clone ID Related Accession (Same CDS sequence)	XM_017001835.1 , XM_005273199.2 , NM_000447.3 , XM_005273199.3 , XM_005273199.4 , NM_000447.2
Accession Version	NM_000447.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	presenilin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, BT006984.1 and L43964.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000447.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.189067.1, SRR1803613.35480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366783.8/ ENSP00000355747.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000438.2
CDS	384..1730
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	NM_000447.3
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000447.3

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( NM_000447.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000438.2 Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24950
Clone ID Related Accession (Same CDS sequence)	XM_017001835.1 , XM_005273199.2 , NM_000447.3 , XM_005273199.3 , XM_005273199.4 , NM_000447.2
Accession Version	NM_000447.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	presenilin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, BT006984.1, L43964.1 and AI091221.1. This sequence is a reference standard in the RefSeqGene project. On Aug 17, 2007 this sequence version replaced NM_000447.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.12768.1, SRR1803611.65262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000438.2
CDS	428..1774
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	NM_000447.2
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000447.2

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( XM_017001835.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016857324.1 Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu24950
Clone ID Related Accession (Same CDS sequence)	XM_017001835.1 , XM_005273199.2 , NM_000447.3 , XM_005273199.3 , XM_005273199.4 , NM_000447.2
Accession Version	XM_017001835.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	presenilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016857324.1
CDS	749..2095
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_017001835.1
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001835.1

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( XM_005273199.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273256.1 Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu24950
Clone ID Related Accession (Same CDS sequence)	XM_017001835.1 , XM_005273199.2 , NM_000447.3 , XM_005273199.3 , XM_005273199.4 , NM_000447.2
Accession Version	XM_005273199.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	presenilin-2 isoform X1
Comment

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005273256.1

Translation

MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_005273199.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273199.2

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( XM_005273199.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273256.1 Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu24950
Clone ID Related Accession (Same CDS sequence)	XM_017001835.1 , XM_005273199.2 , NM_000447.3 , XM_005273199.3 , XM_005273199.4 , NM_000447.2
Accession Version	XM_005273199.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	presenilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005273199.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273256.1
CDS	241..1587
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_005273199.3
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273199.3

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( XM_005273199.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005273256.1 Homo sapiens presenilin 2 (PSEN2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu24950
Clone ID Related Accession (Same CDS sequence)	XM_017001835.1 , XM_005273199.2 , NM_000447.3 , XM_005273199.3 , XM_005273199.4 , NM_000447.2
Accession Version	XM_005273199.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	presenilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005273199.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273256.1
CDS	241..1587
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_005273199.4
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273199.4

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT 
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG 
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG 
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT 
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC 
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC 
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( NM_012486.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036618.2 Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA.

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CloneID	OHu24919
Clone ID Related Accession (Same CDS sequence)	NM_012486.2 , XM_017001836.1
Accession Version	NM_012486.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	presenilin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, U34349.1, L43964.1 and AI091221.1. On Aug 17, 2007 this sequence version replaced NM_012486.1. Transcript Variant: This variant (2) uses an alternate splice acceptor site at exon 10 compared to transcript variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.47201.1, SRR1803617.142539.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG 
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG 
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC 
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG 
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG 
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036618.2
CDS	428..1771
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	NM_012486.2
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012486.2

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG 
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG 
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC 
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG 
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG 
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSEN2 ( XM_017001836.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016857325.1 Homo sapiens presenilin 2 (PSEN2), transcript variant X3, mRNA.

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CloneID	OHu24919
Clone ID Related Accession (Same CDS sequence)	NM_012486.2 , XM_017001836.1
Accession Version	XM_017001836.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	presenilin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG 
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG 
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC 
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG 
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG 
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016857325.1
CDS	241..1584
Translation	MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_017001836.1
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin 2 (PSEN2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001836.1

ORF Insert Sequence:

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT 
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT 
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC 
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC 
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC 
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG 
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC 
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG 
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC 
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT 
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC 
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG 
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG 
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC 
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG 
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG 
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Presenilin Mutation Suppresses Lung Tumorigenesis via Inhibition of Peroxiredoxin 6 Activity and Expression.
Theranostics7(15)3624-3637(2017)
Park MH,Yun HM,Hwang CJ,Park SI,Han SB,Hwang DY,Yoon DY,Kim S,Hong JT

Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries.
Clinical interventions in aging111467-1488(2016)
Bagyinszky E,Youn YC,An SS,Kim S

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PSEN2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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