Psen2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psen2
Entrez Gene ID	19165
Full Name	presenilin 2
Synonyms	ALG-3,Ad4h,Alg3,PS-2,PS2,Psnl2,STM2
General protein information	Preferred Names presenilin 2 Names presenilin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H4\|1 84.19 cM
Summary	This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006496712.2	XP_006496775.1	presenilin-2 isoform X2
XM_006496712.3	XP_006496775.1	presenilin-2 isoform X2
XM_011238776.2	XP_011237078.1	presenilin-2 isoform X1
NM_011183.3	NP_035313.2	presenilin-2
NM_001128605.1	NP_001122077.1	presenilin-2
XM_011238776.3	XP_011237078.1	presenilin-2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSEN2	NP_000438.2
	PSEN2	XP_002801954.1
Canis lupus familiaris (dog)	PSEN2	XP_005622685.1
Danio rerio (zebrafish)	psen2	NP_571589.2
Xenopus tropicalis (tropical clawed frog)	psen2	NP_001017181.1
Bos taurus (cattle)	PSEN2	NP_776865.2
Rattus norvegicus (Norway rat)	Psen2	NP_112349.2
Drosophila melanogaster (fruit fly)	Psn	NP_001137988.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002957	XP_311942.4
Gallus gallus (chicken)	PSEN2	NP_989633.1
Oryza sativa (rice)	Os01g0276400	NP_001042728.2
Pan troglodytes (chimpanzee)	PSEN2	XP_003949755.1
Mus musculus (house mouse)	Psen2	NP_001122077.1

Gene Ontology
Bibliography

Related articles in PubMed

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.
Zhang D, Zhang C, Ho A, Kirkwood A, S?dhof TC, Shen J
Journal of neurochemistry115(5)1215-21(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline
Title: Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.

Study shows that the binding of HSF-1, Cdx1, Ets-1 and Sp1 to Presenilin 1 promoter and that of Nkx2.2, HFH-2, Cdx1 and NF-kappaB to Presenilin 2 promoter regulate their differential expression during brain development.
Title: Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex.

ARF4 is required for Presenilin basal body localization, Notch signaling, and subsequent epidermal differentiation.
Title: A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.

Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2).
Title: Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.

Results suggest that mutation of PS2 can lead to NF-kappaB mediate amyloidogensis, and this effect can be amplified by the absence of estrogen.
Title: Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-?B dependent beta-secretase activation in presenilin 2 mutant mice.

The following Psen2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psen2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22571	NM_011183.3 Latest version!	Mus musculus presenilin 2 (Psen2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu22571	NM_001128605.1 Latest version!	Mus musculus presenilin 2 (Psen2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu22571	XM_011238776.3 Latest version!	Mus musculus presenilin 2 (Psen2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu28660	XM_006496712.3 Latest version!	Mus musculus presenilin 2 (Psen2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu28660	XM_006496712.2	Mus musculus presenilin 2 (Psen2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu22571	XM_011238776.2	Mus musculus presenilin 2 (Psen2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psen2 ( NM_011183.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035313.2 Mus musculus presenilin 2 (Psen2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22571
Clone ID Related Accession (Same CDS sequence)	XM_011238776.2 , NM_011183.3 , NM_001128605.1 , XM_011238776.3
Accession Version	NM_011183.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	presenilin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132436.3, BM935552.1 and AI118332.1. On Apr 5, 2011 this sequence version replaced NM_011183.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U57324.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035313.2
CDS	91..1437
Translation	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	NM_011183.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin 2 (Psen2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011183.3

ORF Insert Sequence:

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psen2 ( NM_001128605.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001122077.1 Mus musculus presenilin 2 (Psen2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu22571
Clone ID Related Accession (Same CDS sequence)	XM_011238776.2 , NM_011183.3 , NM_001128605.1 , XM_011238776.3
Accession Version	NM_001128605.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	presenilin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK148111.1 and AI118332.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154119.1, AK148111.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001122077.1
CDS	82..1428
Translation	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	NM_001128605.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin 2 (Psen2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128605.1

ORF Insert Sequence:

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psen2 ( XM_011238776.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011237078.1 Mus musculus presenilin 2 (Psen2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22571
Clone ID Related Accession (Same CDS sequence)	XM_011238776.2 , NM_011183.3 , NM_001128605.1 , XM_011238776.3
Accession Version	XM_011238776.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	presenilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011238776.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011237078.1
CDS	103..1449
Translation	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_011238776.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin 2 (Psen2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011238776.2

ORF Insert Sequence:

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psen2 ( XM_006496712.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496775.1 Mus musculus presenilin 2 (Psen2), transcript variant X2, mRNA.

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CloneID	OMu28660
Clone ID Related Accession (Same CDS sequence)	XM_006496712.2 , XM_006496712.3
Accession Version	XM_006496712.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	presenilin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006496712.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGACTCCTA CGACAGTTTT GGAGAACCCT CATACCCTGA AGCCTTCGAA 
GCCCCCCTGC CTGGCTACCC AGGGGAGGAG CTGGAGGAGG AGGAGGAAAG GGGCGTGAAG 
CTCGGCCTGG GAGACTTCAT CTTCTACAGC GTCCTGGTGG GCAAGGCTGC AGCCACTGGC 
AACGGAGACT GGAACACTAC GCTGGCCTGT TTTATCGCCA TCCTCATTGG CTTGTGTCTC 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCTCTGCCCG CCCTCCCCAT CTCCATCACC 
TTTGGACTCA TCTTCTACTT CTCCACAGAC AACCTGGTGC GCCCTTTCAT GGACACTCTG 
GCCTCCCACC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496775.1
CDS	90..1433
Translation	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_006496712.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin 2 (Psen2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496712.2

ORF Insert Sequence:

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGACTCCTA CGACAGTTTT GGAGAACCCT CATACCCTGA AGCCTTCGAA 
GCCCCCCTGC CTGGCTACCC AGGGGAGGAG CTGGAGGAGG AGGAGGAAAG GGGCGTGAAG 
CTCGGCCTGG GAGACTTCAT CTTCTACAGC GTCCTGGTGG GCAAGGCTGC AGCCACTGGC 
AACGGAGACT GGAACACTAC GCTGGCCTGT TTTATCGCCA TCCTCATTGG CTTGTGTCTC 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCTCTGCCCG CCCTCCCCAT CTCCATCACC 
TTTGGACTCA TCTTCTACTT CTCCACAGAC AACCTGGTGC GCCCTTTCAT GGACACTCTG 
GCCTCCCACC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psen2 ( XM_011238776.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011237078.1 Mus musculus presenilin 2 (Psen2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22571
Clone ID Related Accession (Same CDS sequence)	XM_011238776.2 , NM_011183.3 , NM_001128605.1 , XM_011238776.3
Accession Version	XM_011238776.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	presenilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011238776.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011237078.1
CDS	92..1438
Translation	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_011238776.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin 2 (Psen2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011238776.3

ORF Insert Sequence:

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGAAGACTC CTACGACAGT TTTGGAGAAC CCTCATACCC TGAAGCCTTC 
GAAGCCCCCC TGCCTGGCTA CCCAGGGGAG GAGCTGGAGG AGGAGGAGGA AAGGGGCGTG 
AAGCTCGGCC TGGGAGACTT CATCTTCTAC AGCGTCCTGG TGGGCAAGGC TGCAGCCACT 
GGCAACGGAG ACTGGAACAC TACGCTGGCC TGTTTTATCG CCATCCTCAT TGGCTTGTGT 
CTCACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCTCTGC CCGCCCTCCC CATCTCCATC 
ACCTTTGGAC TCATCTTCTA CTTCTCCACA GACAACCTGG TGCGCCCTTT CATGGACACT 
CTGGCCTCCC ACCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psen2 ( XM_006496712.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496775.1 Mus musculus presenilin 2 (Psen2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu28660
Clone ID Related Accession (Same CDS sequence)	XM_006496712.2 , XM_006496712.3
Accession Version	XM_006496712.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	presenilin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006496712.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGACTCCTA CGACAGTTTT GGAGAACCCT CATACCCTGA AGCCTTCGAA 
GCCCCCCTGC CTGGCTACCC AGGGGAGGAG CTGGAGGAGG AGGAGGAAAG GGGCGTGAAG 
CTCGGCCTGG GAGACTTCAT CTTCTACAGC GTCCTGGTGG GCAAGGCTGC AGCCACTGGC 
AACGGAGACT GGAACACTAC GCTGGCCTGT TTTATCGCCA TCCTCATTGG CTTGTGTCTC 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCTCTGCCCG CCCTCCCCAT CTCCATCACC 
TTTGGACTCA TCTTCTACTT CTCCACAGAC AACCTGGTGC GCCCTTTCAT GGACACTCTG 
GCCTCCCACC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496775.1
CDS	111..1454
Translation	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Target ORF information:

RefSeq Version	XM_006496712.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin 2 (Psen2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496712.3

ORF Insert Sequence:

ATGCTCGCAT TCATGGCCTC TGACAGCGAG GAAGAGGTGT GTGATGAGCG GACGTCCTTG 
ATGTCAGCCG AGAGCCCCAC ATCTCGCTCC TGCCAGGAAG GCAGGCCAGG CCCGGAGGAT 
GGAGAGAGCA CTGCCCAGTG GAGGACTCAG GAGAGCGAAG AAGACTGTGA AGAGGACCCG 
GACCGCTACG CATGCAGTGG GGCTCCTGGG CGACCGTCGG GCCTGGAGGA AGAGCTGACC 
CTCAAGTATG GGGCGAAGCA TGTGATCATG CTATTCGTGC CTGTCACGCT GTGTATGATC 
GTGGTGGTGG CCACTATCAA GTCTGTGCGT TTCTACACTG AGAAGAACGG GCAGCTCATC 
TACACGCCCT TCACGGAGGA CACGCCCTCG GTGGGCCAGC GGCTCCTCAA CTCCGTGCTT 
AACACCCTCA TCATGATCAG CGTCATCGTA GTCATGACCA TCTTCCTCGT GGTACTCTAC 
AAGTATCGAT GCTACAAGTT CATCCATGGC TGGCTGATCA TGTCCTCCCT GATGCTCCTC 
TTCTTGTTCA CCTACATCTA CCTCGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC 
TATCCCACAC TCTTCCTGGC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC 
TGGAAGGGGC CTCTGGTGCT GCAGCAGGCT TACCTTATTG TGATCAGCGC ACTCATGGCC 
CTGGTGTTCA TCAAGTACCT GCCGGAGTGG TCTGCCTGGG TCATCTTGGG TGCCATCTCT 
GTGTACGATC TCGTGGCCGT GCTGTGCCCC AAAGGGCCAC TGAGGATGCT GGTGGAAACT 
GCCCAGGAGA GAAATGAGCC CATATTTCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG 
ACGGTGGGCA TGGCAAAGCT GGACCCCTCC TCTCAAGGAG CGCTGCAGCT CCCCTATGAC 
CCAGAGATGG AAGACTCCTA CGACAGTTTT GGAGAACCCT CATACCCTGA AGCCTTCGAA 
GCCCCCCTGC CTGGCTACCC AGGGGAGGAG CTGGAGGAGG AGGAGGAAAG GGGCGTGAAG 
CTCGGCCTGG GAGACTTCAT CTTCTACAGC GTCCTGGTGG GCAAGGCTGC AGCCACTGGC 
AACGGAGACT GGAACACTAC GCTGGCCTGT TTTATCGCCA TCCTCATTGG CTTGTGTCTC 
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCTCTGCCCG CCCTCCCCAT CTCCATCACC 
TTTGGACTCA TCTTCTACTT CTCCACAGAC AACCTGGTGC GCCCTTTCAT GGACACTCTG 
GCCTCCCACC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.
Journal of neurochemistry115(5)1215-21(2010 Dec)
Zhang D,Zhang C,Ho A,Kirkwood A,S?dhof TC,Shen J

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Psen2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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