PCSK6 gene cDNA ORF clone, Homo sapiens(human)

mRNA	Protein	Name
NM_138319.3	NP_612192.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AII preproprotein
NM_002570.4	NP_002561.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
NM_002570.5	NP_002561.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
NM_138325.3	NP_612198.2	proprotein convertase subtilisin/kexin type 6 isoform f preproprotein
NM_138322.4	NP_612195.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4B preproprotein
NM_138322.3	NP_612195.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4B preproprotein
NM_138323.2	NP_612196.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4CS preproprotein
NM_001291309.1	NP_001278238.1	proprotein convertase subtilisin/kexin type 6 isoform i preproprotein
NM_138324.2	NP_612197.1	proprotein convertase subtilisin/kexin type 6 isoform PACE4C preproprotein

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23340	NM_138323.2 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$370.30 $529.00
OHu23375	NM_138319.3 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$657.30 $939.00
OHu23536	NM_138322.4 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$286.30 $409.00
OHu23548	NM_138325.3 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu23849	NM_001291309.1 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 9, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00
OHu23906	NM_138324.2 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
OHu27938	NM_002570.5 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$657.30 $939.00
View Old Accession Versions >>
OHu27938	NM_002570.4	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$657.30 $939.00
OHu23536	NM_138322.3	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$286.30 $409.00
Hide Old Accession Versions >>

PCSK6 ( NM_138323.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_612196.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu23340
Clone ID Related Accession (Same CDS sequence)	NM_138323.2
Accession Version	NM_138323.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1872bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4CS preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1, AL545278.3, BX428035.2, D28513.1 and AC023024.6. On Apr 3, 2014 this sequence version replaced NM_138323.1. Transcript Variant: This variant (5) uses an alternate exon in the 3' coding region and lacks several downstream exons when compared to variant 1. These differences cause a frameshift and thus isoform PACE4CS has a distinct C-terminus compared to isoform PACE4-AI. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AACCTGGACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612196.1
CDS	315..2186
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGNLD

Target ORF information:

RefSeq Version	NM_138323.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138323.2

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AACCTGGACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_138319.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612192.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23375
Clone ID Related Accession (Same CDS sequence)	NM_138319.3
Accession Version	NM_138319.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2871bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AII preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1, AL545278.3, BX428035.2 and BU732171.1. On Apr 3, 2014 this sequence version replaced NM_138319.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (PACE4-AII) is shorter but maintains the same reading frame, compared to isoform PACE4-AI. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D87995.1, SRR1803617.143235.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AAGTTGAAAG AATGGAGCCT CATACTGTAT GGCACAGCAG AGCACCCGTA CCACACCTTC 
AGTGCCCATC AGTCCCGCTC GCGGATGCTG GAGCTCTCAG CCCCAGAGCT GGAGCCACCC 
AAGGCTGCCC TGTCACCCTC CCAGGTGGAA GTTCCTGAAG ATGAGGAAGA TTACACAGGT 
GTGTGCCATC CGGAGTGTGG TGACAAAGGC TGTGATGGCC CCAATGCAGA CCAGTGCTTG 
AACTGCGTCC ACTTCAGCCT GGGGAGTGTC AAGACCAGCA GGAAGTGCGT GAGTGTGTGC 
CCCTTGGGCT ACTTTGGGGA CACAGCAGCA AGACGCTGTC GCCGGTGCCA CAAGGGGTGT 
GAGACCTGCT CCAGCAGAGC TGCGACGCAG TGCCTGTCTT GCCGCCGCGG GTTCTATCAC 
CACCAGGAGA TGAACACCTG TGTGACCCTC TGTCCTGCAG GATTTTATGC TGATGAAAGT 
CAGAAAAATT GCCTTAAATG CCACCCAAGC TGTAAAAAGT GCGTGGATGA ACCTGAGAAA 
TGTACTGTCT GTAAAGAAGG ATTCAGCCTT GCACGGGGCA GCTGCATTCC TGACTGTGAG 
CCAGGCACCT ACTTTGACTC AGAGCTGATC AGATGTGGGG AATGCCATCA CACCTGCGGA 
ACCTGCGTGG GGCCAGGCAG AGAAGAGTGC ATTCACTGTG CGAAAAACTT CCACTTCCAC 
GACTGGAAGT GTGTGCCAGC CTGTGGTGAG GGCTTCTACC CAGAAGAGAT GCCGGGCTTG 
CCCCACAAAG TGTGTCGAAG GTGTGACGAG AACTGCTTGA GCTGTGCAGG CTCCAGCAGG 
AACTGTAGCA GGTGTAAGAC GGGCTTCACA CAGCTGGGGA CCTCCTGCAT CACCAACCAC 
ACGTGCAGCA ACGCTGACGA GACATTCTGC GAGATGGTGA AGTCCAACCG GCTGTGCGAA 
CGGAAGCTCT TCATTCAGTT CTGCTGCCGC ACGTGCCTCC TGGCCGGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612192.1
CDS	315..3185
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG

Target ORF information:

RefSeq Version	NM_138319.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138319.3

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AAGTTGAAAG AATGGAGCCT CATACTGTAT GGCACAGCAG AGCACCCGTA CCACACCTTC 
AGTGCCCATC AGTCCCGCTC GCGGATGCTG GAGCTCTCAG CCCCAGAGCT GGAGCCACCC 
AAGGCTGCCC TGTCACCCTC CCAGGTGGAA GTTCCTGAAG ATGAGGAAGA TTACACAGGT 
GTGTGCCATC CGGAGTGTGG TGACAAAGGC TGTGATGGCC CCAATGCAGA CCAGTGCTTG 
AACTGCGTCC ACTTCAGCCT GGGGAGTGTC AAGACCAGCA GGAAGTGCGT GAGTGTGTGC 
CCCTTGGGCT ACTTTGGGGA CACAGCAGCA AGACGCTGTC GCCGGTGCCA CAAGGGGTGT 
GAGACCTGCT CCAGCAGAGC TGCGACGCAG TGCCTGTCTT GCCGCCGCGG GTTCTATCAC 
CACCAGGAGA TGAACACCTG TGTGACCCTC TGTCCTGCAG GATTTTATGC TGATGAAAGT 
CAGAAAAATT GCCTTAAATG CCACCCAAGC TGTAAAAAGT GCGTGGATGA ACCTGAGAAA 
TGTACTGTCT GTAAAGAAGG ATTCAGCCTT GCACGGGGCA GCTGCATTCC TGACTGTGAG 
CCAGGCACCT ACTTTGACTC AGAGCTGATC AGATGTGGGG AATGCCATCA CACCTGCGGA 
ACCTGCGTGG GGCCAGGCAG AGAAGAGTGC ATTCACTGTG CGAAAAACTT CCACTTCCAC 
GACTGGAAGT GTGTGCCAGC CTGTGGTGAG GGCTTCTACC CAGAAGAGAT GCCGGGCTTG 
CCCCACAAAG TGTGTCGAAG GTGTGACGAG AACTGCTTGA GCTGTGCAGG CTCCAGCAGG 
AACTGTAGCA GGTGTAAGAC GGGCTTCACA CAGCTGGGGA CCTCCTGCAT CACCAACCAC 
ACGTGCAGCA ACGCTGACGA GACATTCTGC GAGATGGTGA AGTCCAACCG GCTGTGCGAA 
CGGAAGCTCT TCATTCAGTT CTGCTGCCGC ACGTGCCTCC TGGCCGGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_138322.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_612195.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.

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CloneID	OHu23536
Clone ID Related Accession (Same CDS sequence)	NM_138322.4 , NM_138322.3
Accession Version	NM_138322.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1464bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M80482.1, AM491522.1, HY122769.1 and AC087528.15. On Jun 1, 2019 this sequence version replaced NM_138322.3. Transcript Variant: This variant (3) has multiple differences in the coding region, one of which is a frameshift, compared to variant 1. The encoded isoform PACE4B (also known as PACE4.1) has a distinct C-terminus compared to isoform PACE4-AI. This isoform is thought to be catalytically inactive. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGGTGCGG CAGTGGCGTT CTGGTGGACC 
ATTGGGTGGC CCTGGAATGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612195.1
CDS	38..1501
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKGAAVAFWWTIGWPWNV

Target ORF information:

RefSeq Version	NM_138322.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138322.4

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGGTGCGG CAGTGGCGTT CTGGTGGACC 
ATTGGGTGGC CCTGGAATGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_138322.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612195.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.

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CloneID	OHu23536
Clone ID Related Accession (Same CDS sequence)	NM_138322.4 , NM_138322.3
Accession Version	NM_138322.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1464bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1 and HY122769.1. On Apr 3, 2014 this sequence version replaced NM_138322.2. Transcript Variant: This variant (3) has multiple differences in the coding region, one of which is a frameshift, compared to variant 1. The encoded isoform PACE4B (also known as PACE4.1) has a distinct C-terminus compared to isoform PACE4-AI. This isoform is thought to be catalytically inactive. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGGTGCGG CAGTGGCGTT CTGGTGGACC 
ATTGGGTGGC CCTGGAATGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612195.1
CDS	315..1778
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKGAAVAFWWTIGWPWNV

Target ORF information:

RefSeq Version	NM_138322.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138322.3

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGGTGCGG CAGTGGCGTT CTGGTGGACC 
ATTGGGTGGC CCTGGAATGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_138325.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612198.2 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu23548
Clone ID Related Accession (Same CDS sequence)	NM_138325.3
Accession Version	NM_138325.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1995bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform f preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1, AL545278.3, BX428035.2, D28514.1, HY205376.1 and AC023024.6. On Apr 3, 2014 this sequence version replaced NM_138325.2. Transcript Variant: This variant (6) lacks multiple 3' exons and uses an alternate 3' terminal exon, compared to variant 1. This results in a shorter isoform (f) that has a distinct C-terminus, compared to isoform PACE4-AI. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGT 
GATCTTGAGA CTCCTGTTGC AAATCAACTG ACCACAGAAG AGAGGTTCGT TTCCACACTC 
TCGATTCTGT TCCATTGGTC TGTATATCTA TCTTGGAGTC AGTACCATAT TGTTTTGATC 
ACTGTAGCTT TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612198.2
CDS	315..2309
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGDLETPVANQLTTEERFVSTLSILFHWSVYLSWSQYHIVLITVAL

Target ORF information:

RefSeq Version	NM_138325.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138325.3

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGT 
GATCTTGAGA CTCCTGTTGC AAATCAACTG ACCACAGAAG AGAGGTTCGT TTCCACACTC 
TCGATTCTGT TCCATTGGTC TGTATATCTA TCTTGGAGTC AGTACCATAT TGTTTTGATC 
ACTGTAGCTT TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_001291309.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278238.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 9, mRNA.

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CloneID	OHu23849
Clone ID Related Accession (Same CDS sequence)	NM_001291309.1
Accession Version	NM_001291309.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2688bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform i preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1, AB208955.1, DB143095.1 and BU732171.1. Transcript Variant: This variant (9) lacks two consecutive exons in the central coding region but maintains reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform PACE4-AI. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA GAGCATCCCC 
TTAGTGCAGG TGCTGCGGAC TACGGCCCTG ACCAGCGCCT GCGCGGAGCA CTCGGACCAG 
CGGGTGGTCT ACTTGGAGCA CGTGGTGGTT CGCACCTCCA TCTCACACCC ACGCCGAGGA 
GACCTCCAGA TCTACCTGGT TTCTCCCTCG GGAACCAAGT CTCAACTTCT GGCAAAGAGG 
TTGCTGGATC TTTCCAATGA AGGGTTTACA AACTGGGAAT TCATGACTGT CCACTGCTGG 
GGAGAAAAGG CTGAAGGGCA GTGGACCTTG GAAATCCAAG ATCTGCCATC CCAGGTCCGC 
AACCCGGAGA AGCAAGGGAA GTTGAAAGAA TGGAGCCTCA TACTGTATGG CACAGCAGAG 
CACCCGTACC ACACCTTCAG TGCCCATCAG TCCCGCTCGC GGATGCTGGA GCTCTCAGCC 
CCAGAGCTGG AGCCACCCAA GGCTGCCCTG TCACCCTCCC AGGTGGAAGT TCCTGAAGAT 
GAGGAAGATT ACACAGCTCA ATCCACCCCA GGCTCTGCTA ATATTTTACA GACCAGTGTG 
TGCCATCCGG AGTGTGGTGA CAAAGGCTGT GATGGCCCCA ATGCAGACCA GTGCTTGAAC 
TGCGTCCACT TCAGCCTGGG GAGTGTCAAG ACCAGCAGGA AGTGCGTGAG TGTGTGCCCC 
TTGGGCTACT TTGGGGACAC AGCAGCAAGA CGCTGTCGCC GGTGCCACAA GGGGTGTGAG 
ACCTGCTCCA GCAGAGCTGC GACGCAGTGC CTGTCTTGCC GCCGCGGGTT CTATCACCAC 
CAGGAGATGA ACACCTGTGT GACCCTCTGT CCTGCAGGAT TTTATGCTGA TGAAAGTCAG 
AAAAATTGCC TTAAATGCCA CCCAAGCTGT AAAAAGTGCG TGGATGAACC TGAGAAATGT 
ACTGTCTGTA AAGAAGGATT CAGCCTTGCA CGGGGCAGCT GCATTCCTGA CTGTGAGCCA 
GGCACCTACT TTGACTCAGA GCTGATCAGA TGTGGGGAAT GCCATCACAC CTGCGGAACC 
TGCGTGGGGC CAGGCAGAGA AGAGTGCATT CACTGTGCGA AAAACTTCCA CTTCCACGAC 
TGGAAGTGTG TGCCAGCCTG TGGTGAGGGC TTCTACCCAG AAGAGATGCC GGGCTTGCCC 
CACAAAGTGT GTCGAAGGTG TGACGAGAAC TGCTTGAGCT GTGCAGGCTC CAGCAGGAAC 
TGTAGCAGGT GTAAGACGGG CTTCACACAG CTGGGGACCT CCTGCATCAC CAACCACACG 
TGCAGCAACG CTGACGAGAC ATTCTGCGAG ATGGTGAAGT CCAACCGGCT GTGCGAACGG 
AAGCTCTTCA TTCAGTTCTG CTGCCGCACG TGCCTCCTGG CCGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278238.1
CDS	315..3002
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEAKSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG

Target ORF information:

RefSeq Version	NM_001291309.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 9, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291309.1

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA GAGCATCCCC 
TTAGTGCAGG TGCTGCGGAC TACGGCCCTG ACCAGCGCCT GCGCGGAGCA CTCGGACCAG 
CGGGTGGTCT ACTTGGAGCA CGTGGTGGTT CGCACCTCCA TCTCACACCC ACGCCGAGGA 
GACCTCCAGA TCTACCTGGT TTCTCCCTCG GGAACCAAGT CTCAACTTCT GGCAAAGAGG 
TTGCTGGATC TTTCCAATGA AGGGTTTACA AACTGGGAAT TCATGACTGT CCACTGCTGG 
GGAGAAAAGG CTGAAGGGCA GTGGACCTTG GAAATCCAAG ATCTGCCATC CCAGGTCCGC 
AACCCGGAGA AGCAAGGGAA GTTGAAAGAA TGGAGCCTCA TACTGTATGG CACAGCAGAG 
CACCCGTACC ACACCTTCAG TGCCCATCAG TCCCGCTCGC GGATGCTGGA GCTCTCAGCC 
CCAGAGCTGG AGCCACCCAA GGCTGCCCTG TCACCCTCCC AGGTGGAAGT TCCTGAAGAT 
GAGGAAGATT ACACAGCTCA ATCCACCCCA GGCTCTGCTA ATATTTTACA GACCAGTGTG 
TGCCATCCGG AGTGTGGTGA CAAAGGCTGT GATGGCCCCA ATGCAGACCA GTGCTTGAAC 
TGCGTCCACT TCAGCCTGGG GAGTGTCAAG ACCAGCAGGA AGTGCGTGAG TGTGTGCCCC 
TTGGGCTACT TTGGGGACAC AGCAGCAAGA CGCTGTCGCC GGTGCCACAA GGGGTGTGAG 
ACCTGCTCCA GCAGAGCTGC GACGCAGTGC CTGTCTTGCC GCCGCGGGTT CTATCACCAC 
CAGGAGATGA ACACCTGTGT GACCCTCTGT CCTGCAGGAT TTTATGCTGA TGAAAGTCAG 
AAAAATTGCC TTAAATGCCA CCCAAGCTGT AAAAAGTGCG TGGATGAACC TGAGAAATGT 
ACTGTCTGTA AAGAAGGATT CAGCCTTGCA CGGGGCAGCT GCATTCCTGA CTGTGAGCCA 
GGCACCTACT TTGACTCAGA GCTGATCAGA TGTGGGGAAT GCCATCACAC CTGCGGAACC 
TGCGTGGGGC CAGGCAGAGA AGAGTGCATT CACTGTGCGA AAAACTTCCA CTTCCACGAC 
TGGAAGTGTG TGCCAGCCTG TGGTGAGGGC TTCTACCCAG AAGAGATGCC GGGCTTGCCC 
CACAAAGTGT GTCGAAGGTG TGACGAGAAC TGCTTGAGCT GTGCAGGCTC CAGCAGGAAC 
TGTAGCAGGT GTAAGACGGG CTTCACACAG CTGGGGACCT CCTGCATCAC CAACCACACG 
TGCAGCAACG CTGACGAGAC ATTCTGCGAG ATGGTGAAGT CCAACCGGCT GTGCGAACGG 
AAGCTCTTCA TTCAGTTCTG CTGCCGCACG TGCCTCCTGG CCGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_138324.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_612197.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 4, mRNA.

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CloneID	OHu23906
Clone ID Related Accession (Same CDS sequence)	NM_138324.2
Accession Version	NM_138324.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4C preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1, AL545278.3, BX428035.2, D28513.1 and AC023024.6. On Apr 3, 2014 this sequence version replaced NM_138324.1. Transcript Variant: This variant (4) uses two alternate exons in the 3' coding region and lacks several downstream exons when compared to variant 1. These differences cause a frameshift and thus isoform PACE4C has a distinct C-terminus compared to isoform PACE4-AI. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D28513.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGT 
GATCTTGAGA CTCCTGTTGC AAATCAACTG ACCACAGAAG AGAGGGAACC TGGACTAAAA 
CACGTGTTCC GGTGGCAGAT TGAACAAGAG CTTTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612197.1
CDS	315..2273
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGDLETPVANQLTTEEREPGLKHVFRWQIEQELW

Target ORF information:

RefSeq Version	NM_138324.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138324.2

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGT 
GATCTTGAGA CTCCTGTTGC AAATCAACTG ACCACAGAAG AGAGGGAACC TGGACTAAAA 
CACGTGTTCC GGTGGCAGAT TGAACAAGAG CTTTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_002570.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002561.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA.

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CloneID	OHu27938
Clone ID Related Accession (Same CDS sequence)	NM_002570.4 , NM_002570.5
Accession Version	NM_002570.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2910bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087528.15, M80482.1, AM491522.1, AL545278.3, BX428035.2 and BU732171.1. This sequence is a reference standard in the RefSeqGene project. On Apr 3, 2014 this sequence version replaced NM_002570.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the predominant isoform (PACE4-AI, also known as PACE4 and PACE4-A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M80482.1, SRR1803617.132000.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AAGTTGAAAG AATGGAGCCT CATACTGTAT GGCACAGCAG AGCACCCGTA CCACACCTTC 
AGTGCCCATC AGTCCCGCTC GCGGATGCTG GAGCTCTCAG CCCCAGAGCT GGAGCCACCC 
AAGGCTGCCC TGTCACCCTC CCAGGTGGAA GTTCCTGAAG ATGAGGAAGA TTACACAGCT 
CAATCCACCC CAGGCTCTGC TAATATTTTA CAGACCAGTG TGTGCCATCC GGAGTGTGGT 
GACAAAGGCT GTGATGGCCC CAATGCAGAC CAGTGCTTGA ACTGCGTCCA CTTCAGCCTG 
GGGAGTGTCA AGACCAGCAG GAAGTGCGTG AGTGTGTGCC CCTTGGGCTA CTTTGGGGAC 
ACAGCAGCAA GACGCTGTCG CCGGTGCCAC AAGGGGTGTG AGACCTGCTC CAGCAGAGCT 
GCGACGCAGT GCCTGTCTTG CCGCCGCGGG TTCTATCACC ACCAGGAGAT GAACACCTGT 
GTGACCCTCT GTCCTGCAGG ATTTTATGCT GATGAAAGTC AGAAAAATTG CCTTAAATGC 
CACCCAAGCT GTAAAAAGTG CGTGGATGAA CCTGAGAAAT GTACTGTCTG TAAAGAAGGA 
TTCAGCCTTG CACGGGGCAG CTGCATTCCT GACTGTGAGC CAGGCACCTA CTTTGACTCA 
GAGCTGATCA GATGTGGGGA ATGCCATCAC ACCTGCGGAA CCTGCGTGGG GCCAGGCAGA 
GAAGAGTGCA TTCACTGTGC GAAAAACTTC CACTTCCACG ACTGGAAGTG TGTGCCAGCC 
TGTGGTGAGG GCTTCTACCC AGAAGAGATG CCGGGCTTGC CCCACAAAGT GTGTCGAAGG 
TGTGACGAGA ACTGCTTGAG CTGTGCAGGC TCCAGCAGGA ACTGTAGCAG GTGTAAGACG 
GGCTTCACAC AGCTGGGGAC CTCCTGCATC ACCAACCACA CGTGCAGCAA CGCTGACGAG 
ACATTCTGCG AGATGGTGAA GTCCAACCGG CTGTGCGAAC GGAAGCTCTT CATTCAGTTC 
TGCTGCCGCA CGTGCCTCCT GGCCGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002561.1
CDS	315..3224
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG

Target ORF information:

RefSeq Version	NM_002570.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002570.4

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AAGTTGAAAG AATGGAGCCT CATACTGTAT GGCACAGCAG AGCACCCGTA CCACACCTTC 
AGTGCCCATC AGTCCCGCTC GCGGATGCTG GAGCTCTCAG CCCCAGAGCT GGAGCCACCC 
AAGGCTGCCC TGTCACCCTC CCAGGTGGAA GTTCCTGAAG ATGAGGAAGA TTACACAGCT 
CAATCCACCC CAGGCTCTGC TAATATTTTA CAGACCAGTG TGTGCCATCC GGAGTGTGGT 
GACAAAGGCT GTGATGGCCC CAATGCAGAC CAGTGCTTGA ACTGCGTCCA CTTCAGCCTG 
GGGAGTGTCA AGACCAGCAG GAAGTGCGTG AGTGTGTGCC CCTTGGGCTA CTTTGGGGAC 
ACAGCAGCAA GACGCTGTCG CCGGTGCCAC AAGGGGTGTG AGACCTGCTC CAGCAGAGCT 
GCGACGCAGT GCCTGTCTTG CCGCCGCGGG TTCTATCACC ACCAGGAGAT GAACACCTGT 
GTGACCCTCT GTCCTGCAGG ATTTTATGCT GATGAAAGTC AGAAAAATTG CCTTAAATGC 
CACCCAAGCT GTAAAAAGTG CGTGGATGAA CCTGAGAAAT GTACTGTCTG TAAAGAAGGA 
TTCAGCCTTG CACGGGGCAG CTGCATTCCT GACTGTGAGC CAGGCACCTA CTTTGACTCA 
GAGCTGATCA GATGTGGGGA ATGCCATCAC ACCTGCGGAA CCTGCGTGGG GCCAGGCAGA 
GAAGAGTGCA TTCACTGTGC GAAAAACTTC CACTTCCACG ACTGGAAGTG TGTGCCAGCC 
TGTGGTGAGG GCTTCTACCC AGAAGAGATG CCGGGCTTGC CCCACAAAGT GTGTCGAAGG 
TGTGACGAGA ACTGCTTGAG CTGTGCAGGC TCCAGCAGGA ACTGTAGCAG GTGTAAGACG 
GGCTTCACAC AGCTGGGGAC CTCCTGCATC ACCAACCACA CGTGCAGCAA CGCTGACGAG 
ACATTCTGCG AGATGGTGAA GTCCAACCGG CTGTGCGAAC GGAAGCTCTT CATTCAGTTC 
TGCTGCCGCA CGTGCCTCCT GGCCGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK6 ( NM_002570.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002561.1 Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA.

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CloneID	OHu27938
Clone ID Related Accession (Same CDS sequence)	NM_002570.4 , NM_002570.5
Accession Version	NM_002570.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2910bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M80482.1, AM491522.1, AL545278.3, BX428035.2 and BU732171.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002570.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the predominant isoform (PACE4-AI, also known as PACE4 and PACE4-A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M80482.1, SRR1803617.132000.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000611716.5/ ENSP00000482760.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AAGTTGAAAG AATGGAGCCT CATACTGTAT GGCACAGCAG AGCACCCGTA CCACACCTTC 
AGTGCCCATC AGTCCCGCTC GCGGATGCTG GAGCTCTCAG CCCCAGAGCT GGAGCCACCC 
AAGGCTGCCC TGTCACCCTC CCAGGTGGAA GTTCCTGAAG ATGAGGAAGA TTACACAGCT 
CAATCCACCC CAGGCTCTGC TAATATTTTA CAGACCAGTG TGTGCCATCC GGAGTGTGGT 
GACAAAGGCT GTGATGGCCC CAATGCAGAC CAGTGCTTGA ACTGCGTCCA CTTCAGCCTG 
GGGAGTGTCA AGACCAGCAG GAAGTGCGTG AGTGTGTGCC CCTTGGGCTA CTTTGGGGAC 
ACAGCAGCAA GACGCTGTCG CCGGTGCCAC AAGGGGTGTG AGACCTGCTC CAGCAGAGCT 
GCGACGCAGT GCCTGTCTTG CCGCCGCGGG TTCTATCACC ACCAGGAGAT GAACACCTGT 
GTGACCCTCT GTCCTGCAGG ATTTTATGCT GATGAAAGTC AGAAAAATTG CCTTAAATGC 
CACCCAAGCT GTAAAAAGTG CGTGGATGAA CCTGAGAAAT GTACTGTCTG TAAAGAAGGA 
TTCAGCCTTG CACGGGGCAG CTGCATTCCT GACTGTGAGC CAGGCACCTA CTTTGACTCA 
GAGCTGATCA GATGTGGGGA ATGCCATCAC ACCTGCGGAA CCTGCGTGGG GCCAGGCAGA 
GAAGAGTGCA TTCACTGTGC GAAAAACTTC CACTTCCACG ACTGGAAGTG TGTGCCAGCC 
TGTGGTGAGG GCTTCTACCC AGAAGAGATG CCGGGCTTGC CCCACAAAGT GTGTCGAAGG 
TGTGACGAGA ACTGCTTGAG CTGTGCAGGC TCCAGCAGGA ACTGTAGCAG GTGTAAGACG 
GGCTTCACAC AGCTGGGGAC CTCCTGCATC ACCAACCACA CGTGCAGCAA CGCTGACGAG 
ACATTCTGCG AGATGGTGAA GTCCAACCGG CTGTGCGAAC GGAAGCTCTT CATTCAGTTC 
TGCTGCCGCA CGTGCCTCCT GGCCGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002561.1
CDS	38..2947
Translation	MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG

Target ORF information:

RefSeq Version	NM_002570.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002570.5

ORF Insert Sequence:

ATGCCTCCGC GCGCGCCGCC TGCGCCCGGG CCCCGGCCGC CGCCCCGGGC CGCCGCCGCC 
ACCGACACCG CCGCGGGCGC GGGGGGCGCG GGGGGCGCGG GGGGCGCCGG CGGGCCCGGG 
TTCCGGCCGC TCGCGCCGCG TCCCTGGCGC TGGCTGCTGC TGCTGGCGCT GCCTGCCGCC 
TGCTCCGCGC CCCCGCCGCG CCCCGTCTAC ACCAACCACT GGGCGGTGCA AGTGCTGGGC 
GGCCCGGCCG AGGCGGACCG CGTGGCGGCG GCGCACGGGT ACCTCAACTT GGGCCAGATT 
GGAAACCTGG AAGATTACTA CCATTTTTAT CACAGCAAAA CCTTTAAAAG ATCAACCTTG 
AGTAGCAGAG GCCCTCACAC CTTCCTCAGA ATGGACCCCC AGGTGAAATG GCTCCAGCAA 
CAGGAAGTGA AACGAAGGGT GAAGAGACAG GTGCGAAGTG ACCCGCAGGC CCTTTACTTC 
AACGACCCCA TTTGGTCCAA CATGTGGTAC CTGCATTGTG GCGACAAGAA CAGTCGCTGC 
CGGTCGGAAA TGAATGTCCA GGCAGCGTGG AAGAGGGGCT ACACAGGAAA AAACGTGGTG 
GTCACCATCC TTGATGATGG CATAGAGAGA AATCACCCTG ACCTGGCCCC AAATTATGAT 
TCCTACGCCA GCTACGACGT GAACGGCAAT GATTATGACC CATCTCCACG ATATGATGCC 
AGCAATGAAA ATAAACACGG CACTCGTTGT GCGGGAGAAG TTGCTGCTTC AGCAAACAAT 
TCCTACTGCA TCGTGGGCAT AGCGTACAAT GCCAAAATAG GAGGCATCCG CATGCTGGAC 
GGCGATGTCA CAGATGTGGT CGAGGCAAAG TCGCTGGGCA TCAGACCCAA CTACATCGAC 
ATTTACAGTG CCAGCTGGGG GCCGGACGAC GACGGCAAGA CGGTGGACGG GCCCGGCCGA 
CTGGCTAAGC AGGCTTTCGA GTATGGCATT AAAAAGGGCC GGCAGGGCCT GGGCTCCATT 
TTCGTCTGGG CATCTGGGAA TGGCGGGAGA GAGGGGGACT ACTGCTCGTG CGATGGCTAC 
ACCAACAGCA TCTACACCAT CTCCGTCAGC AGCGCCACCG AGAATGGCTA CAAGCCCTGG 
TACCTGGAAG AGTGTGCCTC CACCCTGGCC ACCACCTACA GCAGTGGGGC CTTTTATGAG 
CGAAAAATCG TCACCACGGA TCTGCGTCAG CGCTGTACCG ATGGCCACAC TGGGACCTCA 
GTCTCTGCCC CCATGGTGGC GGGCATCATC GCCTTGGCTC TAGAAGCAAA CAGCCAGTTA 
ACCTGGAGGG ACGTCCAGCA CCTGCTAGTG AAGACATCCC GGCCGGCCCA CCTGAAAGCG 
AGCGACTGGA AAGTGAACGG CGCGGGTCAT AAAGTTAGCC ATTTCTATGG ATTTGGTTTG 
GTGGACGCAG AAGCTCTCGT TGTGGAGGCA AAGAAGTGGA CAGCAGTGCC ATCGCAGCAC 
ATGTGTGTGG CCGCCTCGGA CAAGAGACCC AGGAGCATCC CCTTAGTGCA GGTGCTGCGG 
ACTACGGCCC TGACCAGCGC CTGCGCGGAG CACTCGGACC AGCGGGTGGT CTACTTGGAG 
CACGTGGTGG TTCGCACCTC CATCTCACAC CCACGCCGAG GAGACCTCCA GATCTACCTG 
GTTTCTCCCT CGGGAACCAA GTCTCAACTT CTGGCAAAGA GGTTGCTGGA TCTTTCCAAT 
GAAGGGTTTA CAAACTGGGA ATTCATGACT GTCCACTGCT GGGGAGAAAA GGCTGAAGGG 
CAGTGGACCT TGGAAATCCA AGATCTGCCA TCCCAGGTCC GCAACCCGGA GAAGCAAGGG 
AAGTTGAAAG AATGGAGCCT CATACTGTAT GGCACAGCAG AGCACCCGTA CCACACCTTC 
AGTGCCCATC AGTCCCGCTC GCGGATGCTG GAGCTCTCAG CCCCAGAGCT GGAGCCACCC 
AAGGCTGCCC TGTCACCCTC CCAGGTGGAA GTTCCTGAAG ATGAGGAAGA TTACACAGCT 
CAATCCACCC CAGGCTCTGC TAATATTTTA CAGACCAGTG TGTGCCATCC GGAGTGTGGT 
GACAAAGGCT GTGATGGCCC CAATGCAGAC CAGTGCTTGA ACTGCGTCCA CTTCAGCCTG 
GGGAGTGTCA AGACCAGCAG GAAGTGCGTG AGTGTGTGCC CCTTGGGCTA CTTTGGGGAC 
ACAGCAGCAA GACGCTGTCG CCGGTGCCAC AAGGGGTGTG AGACCTGCTC CAGCAGAGCT 
GCGACGCAGT GCCTGTCTTG CCGCCGCGGG TTCTATCACC ACCAGGAGAT GAACACCTGT 
GTGACCCTCT GTCCTGCAGG ATTTTATGCT GATGAAAGTC AGAAAAATTG CCTTAAATGC 
CACCCAAGCT GTAAAAAGTG CGTGGATGAA CCTGAGAAAT GTACTGTCTG TAAAGAAGGA 
TTCAGCCTTG CACGGGGCAG CTGCATTCCT GACTGTGAGC CAGGCACCTA CTTTGACTCA 
GAGCTGATCA GATGTGGGGA ATGCCATCAC ACCTGCGGAA CCTGCGTGGG GCCAGGCAGA 
GAAGAGTGCA TTCACTGTGC GAAAAACTTC CACTTCCACG ACTGGAAGTG TGTGCCAGCC 
TGTGGTGAGG GCTTCTACCC AGAAGAGATG CCGGGCTTGC CCCACAAAGT GTGTCGAAGG 
TGTGACGAGA ACTGCTTGAG CTGTGCAGGC TCCAGCAGGA ACTGTAGCAG GTGTAAGACG 
GGCTTCACAC AGCTGGGGAC CTCCTGCATC ACCAACCACA CGTGCAGCAA CGCTGACGAG 
ACATTCTGCG AGATGGTGAA GTCCAACCGG CTGTGCGAAC GGAAGCTCTT CATTCAGTTC 
TGCTGCCGCA CGTGCCTCCT GGCCGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gene Symbol	PCSK6
Entrez Gene ID	5046
Full Name	proprotein convertase subtilisin/kexin type 6
Synonyms	PACE4,SPC4
General protein information	Preferred Names proprotein convertase subtilisin/kexin type 6 Names proprotein convertase subtilisin/kexin type 6 paired basic amino acid cleaving enzyme 4 paired basic amino acid cleaving system 4 subtilisin-like proprotein convertase 4 subtilisin/kexin-like protease PACE4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q26.3
Summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014].
Disorder MIM:	167405

Homo sapiens (human)	PCSK6	NP_002561.1
Canis lupus familiaris (dog)	PCSK6	XP_005618782.1
Bos taurus (cattle)	PCSK6	XP_002696700.3
Mus musculus (house mouse)	Pcsk6	NP_035178.1
Rattus norvegicus (Norway rat)	Pcsk6	NP_037131.1
Pan troglodytes (chimpanzee)	PCSK6	XP_001146976.3
Gallus gallus (chicken)	PCSK6	XP_413892.4
	LOC100429418	XP_002805017.1
Xenopus tropicalis (tropical clawed frog)	pcsk6	XP_002939308.2

Next-day Shipping ORF Clones ( in default vector with tag)
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PCSK6 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

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