COA5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COA5
Entrez Gene ID	493753
Full Name	cytochrome c oxidase assembly factor 5
Synonyms	6330578E17Rik,C2orf64,CEMCOX3,Pet191
General protein information	Preferred Names cytochrome c oxidase assembly factor 5 Names cytochrome c oxidase assembly factor 5 protein C2orf64
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q11.2
Summary	This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011].
Disorder MIM:	613920
Disorder Html:	?Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, 616500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008215.2	NP_001008216.1	cytochrome c oxidase assembly factor 5
NM_001008215.3	NP_001008216.1	cytochrome c oxidase assembly factor 5

Pathways from BioSystems

Homologies

	COA5	XP_002799389.1
Canis lupus familiaris (dog)	COA5	XP_854444.1
Mus musculus (house mouse)	Coa5	NP_932123.3
Rattus norvegicus (Norway rat)	Coa5	NP_001182417.1
Pan troglodytes (chimpanzee)	COA5	XP_003949912.1
Homo sapiens (human)	COA5	NP_001008216.1
Danio rerio (zebrafish)	coa5	NP_001154969.1
Gallus gallus (chicken)	COA5	XP_004938550.1
Xenopus tropicalis (tropical clawed frog)	coa5	NP_001039098.1
Bos taurus (cattle)	COA5	NP_001181953.1

Gene Ontology
Bibliography

Related articles in PubMed

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Szklarczyk R, Wanschers BF, Cuypers TD, Esseling JJ, Riemersma M, van den Brand MA, Gloerich J, Lasonder E, van den Heuvel LP, Nijtmans LG, Huynen MA
Genome biology13(2)R12(2012 Feb)

A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy.
Huigsloot M, Nijtmans LG, Szklarczyk R, Baars MJ, van den Brand MA, Hendriksfranssen MG, van den Heuvel LP, Smeitink JA, Huynen MA, Rodenburg RJ
American journal of human genetics88(4)488-93(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ortholog of fungal COX assembly protein PET191
Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.

C2orf64 is essential for complex IV assembly, and C2orf64 mutational analysis should be considered for complex IV deficient patients, in particular those with hypertrophic cardiomyopathy
Title: A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy.

The following COA5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COA5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19994	NM_001008215.3 Latest version!	Homo sapiens cytochrome c oxidase assembly factor 5 (COA5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19994	NM_001008215.2	Homo sapiens cytochrome c oxidase assembly factor 5 (COA5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COA5 ( NM_001008215.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008216.1 Homo sapiens cytochrome c oxidase assembly factor 5 (COA5), mRNA.

Price & Availability↑

CloneID	OHu19994
Clone ID Related Accession (Same CDS sequence)	NM_001008215.2 , NM_001008215.3
Accession Version	NM_001008215.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly factor 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA214157.1, AK131034.1, BC047722.1 and AI002968.1. This sequence is a reference standard in the RefSeqGene project. On Dec 13, 2011 this sequence version replaced NM_001008215.1. ##Evidence-Data-START## Transcript exon combination :: DA214157.1, SRR1660805.204594.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTAAGT ATTATGAGGA CAAGCCGCAG GGCGGCGCGT GCGCGGGCCT GAAGGAGGAC 
CTGGGCGCGT GTCTGCTGCA GTCGGACTGT GTGGTCCAGG AAGGAAAATC ACCTCGGCAG 
TGTTTGAAGG AAGGATACTG CAACTCTTTG AAGTACGCAT TTTTTGAGTG TAAAAGATCA 
GTGTTGGATA ACAGGGCAAG ATTCAGAGGA AGAAAAGGAT ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008216.1
CDS	114..338
Translation	MPKYYEDKPQGGACAGLKEDLGACLLQSDCVVQEGKSPRQCLKEGYCNSLKYAFFECKRSVLDNRARFRGRKGY

Target ORF information:

RefSeq Version	NM_001008215.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor 5 (COA5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008215.2

ORF Insert Sequence:

ATGCCTAAGT ATTATGAGGA CAAGCCGCAG GGCGGCGCGT GCGCGGGCCT GAAGGAGGAC 
CTGGGCGCGT GTCTGCTGCA GTCGGACTGT GTGGTCCAGG AAGGAAAATC ACCTCGGCAG 
TGTTTGAAGG AAGGATACTG CAACTCTTTG AAGTACGCAT TTTTTGAGTG TAAAAGATCA 
GTGTTGGATA ACAGGGCAAG ATTCAGAGGA AGAAAAGGAT ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COA5 ( NM_001008215.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008216.1 Homo sapiens cytochrome c oxidase assembly factor 5 (COA5), mRNA.

Price & Availability↑

CloneID	OHu19994
Clone ID Related Accession (Same CDS sequence)	NM_001008215.2 , NM_001008215.3
Accession Version	NM_001008215.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly factor 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK131034.1, BC047722.1, AI002968.1 and AC010134.5. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001008215.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.239150.1, SRR1660805.204594.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328709.8/ ENSP00000330730.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTAAGT ATTATGAGGA CAAGCCGCAG GGCGGCGCGT GCGCGGGCCT GAAGGAGGAC 
CTGGGCGCGT GTCTGCTGCA GTCGGACTGT GTGGTCCAGG AAGGAAAATC ACCTCGGCAG 
TGTTTGAAGG AAGGATACTG CAACTCTTTG AAGTACGCAT TTTTTGAGTG TAAAAGATCA 
GTGTTGGATA ACAGGGCAAG ATTCAGAGGA AGAAAAGGAT ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008216.1
CDS	108..332
Translation	MPKYYEDKPQGGACAGLKEDLGACLLQSDCVVQEGKSPRQCLKEGYCNSLKYAFFECKRSVLDNRARFRGRKGY

Target ORF information:

RefSeq Version	NM_001008215.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor 5 (COA5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008215.3

ORF Insert Sequence:

ATGCCTAAGT ATTATGAGGA CAAGCCGCAG GGCGGCGCGT GCGCGGGCCT GAAGGAGGAC 
CTGGGCGCGT GTCTGCTGCA GTCGGACTGT GTGGTCCAGG AAGGAAAATC ACCTCGGCAG 
TGTTTGAAGG AAGGATACTG CAACTCTTTG AAGTACGCAT TTTTTGAGTG TAAAAGATCA 
GTGTTGGATA ACAGGGCAAG ATTCAGAGGA AGAAAAGGAT ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Genome biology13(2)R12(2012 Feb)
Szklarczyk R,Wanschers BF,Cuypers TD,Esseling JJ,Riemersma M,van den Brand MA,Gloerich J,Lasonder E,van den Heuvel LP,Nijtmans LG,Huynen MA

A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy.
American journal of human genetics88(4)488-93(2011 Apr)
Huigsloot M,Nijtmans LG,Szklarczyk R,Baars MJ,van den Brand MA,Hendriksfranssen MG,van den Heuvel LP,Smeitink JA,Huynen MA,Rodenburg RJ

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COA5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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