ATP1B1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP1B1
Entrez Gene ID	481
Full Name	ATPase Na+/K+ transporting subunit beta 1
Synonyms	ATP1B
General protein information	Preferred Names ATPase Na+/K+ transporting subunit beta 1 Names sodium/potassium-transporting ATPase subunit beta-1 ATPase, Na+/K+ transporting, beta 1 polypeptide Beta 1-subunit of Na(+),K(+)-ATPase Na, K-ATPase beta-1 polypeptide adenosinetriphosphatase sodium pump subunit beta-1 sodium-potassium ATPase subunit beta 1 (non-catalytic) sodium/potassium-dependent ATPase beta-1 subunit sodium/potassium-transporting ATPase beta-1 chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Summary	The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010].
Disorder MIM:	182330
Disorder Html:	[Blood pressure regulation QTL], 145500 (2)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001677.3	NP_001668.1	sodium/potassium-transporting ATPase subunit beta-1
NM_001677.4	NP_001668.1	sodium/potassium-transporting ATPase subunit beta-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP1B1	NP_001003283.1
Xenopus tropicalis (tropical clawed frog)	atp1b1	NP_001016488.1
Pan troglodytes (chimpanzee)	ATP1B1	NP_001092025.1
Bos taurus (cattle)	ATP1B1	NP_001030411.1
Danio rerio (zebrafish)	atp1b1a	NP_571743.3
Homo sapiens (human)	ATP1B1	NP_001668.1
Mus musculus (house mouse)	Atp1b1	NP_033851.1
Rattus norvegicus (Norway rat)	Atp1b1	NP_037245.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009595	XP_318619.4
	ATP1B1	XP_001093541.1
Danio rerio (zebrafish)	atp1b1b	NP_571746.1
Drosophila melanogaster (fruit fly)	nrv3	NP_001260675.1
Gallus gallus (chicken)	ATP1B1	NP_990851.1

Gene Ontology
Bibliography

Related articles in PubMed

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.
Avery CL, Wassel CL, Richard MA, Highland HM, Bien S, Zubair N, Soliman EZ, Fornage M, Bielinski SJ, Tao R, Seyerle AA, Shah SJ, Lloyd-Jones DM, Buyske S, Rotter JI, Post WS, Rich SS, Hindorff LA, Jeff JM, Shohet RV, Sotoodehnia N, Lin DY, Whitsel EA, Peters U, Haiman CA, Crawford DC, Kooperberg C, North KE
Heart rhythm14(4)572-580(2017 Apr)

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gand?a J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morat? X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pr?ulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I
Molecular systems biology13(3)918(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study reports molecular dynamic simulations of the human NaK-ATPase alpha1 beta 1 isoform embedded into 1,2-oleoylphosphatidylcholine bilayer.
Title: Ion Pathways in the Na

Expression of miR-26a and miR-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
Title: MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues.

the ratio between FXYD5 and alpha1-beta1 heterodimer determines whether the Na,K-ATPase acts as a positive or negative regulator of intercellular adhesion.
Title: The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase ?1 subunits.

Our study describes the potent inhibition of Chikungunya virus and related alphaviruses by the cardiac glycoside digoxin and demonstrates a function for the sodium-potassium ATPase in Chikungunya virus infection.
Title: Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection.

Overexpression of ATP1B1 is associated with cytogenetically normal acute myeloid leukemia.
Title: Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia.

The following ATP1B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18298	NM_001677.4 Latest version!	Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18298	NM_001677.3	Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP1B1 ( NM_001677.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001668.1 Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.

Price & Availability↑

CloneID	OHu18298
Clone ID Related Accession (Same CDS sequence)	NM_001677.3 , NM_001677.4
Accession Version	NM_001677.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit beta-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ934151.1, BC000006.2, CD722755.1, BM762099.1, AA514770.1, U16799.1 and BE223067.1. This sequence is a reference standard in the RefSeqGene project. On Jul 1, 2004 this sequence version replaced NM_001677.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.113294.1, SRR1803612.1272.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA 
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC 
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT 
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA 
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC 
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT 
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT 
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC 
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA 
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT 
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG 
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC 
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT 
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA 
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001668.1
CDS	122..1033
Translation	MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Target ORF information:

RefSeq Version	NM_001677.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001677.3

ORF Insert Sequence:

ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA 
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC 
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT 
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA 
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC 
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT 
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT 
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC 
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA 
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT 
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG 
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC 
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT 
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA 
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP1B1 ( NM_001677.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001668.1 Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.

Price & Availability↑

CloneID	OHu18298
Clone ID Related Accession (Same CDS sequence)	NM_001677.3 , NM_001677.4
Accession Version	NM_001677.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	sodium/potassium-transporting ATPase subunit beta-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031726.23, BQ934151.1, BC000006.2, CD722755.1, BM762099.1, AA514770.1, U16799.1 and BE223067.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001677.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.911261.1, SRR3476690.784626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367815.9/ ENSP00000356789.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA 
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC 
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT 
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA 
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC 
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT 
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT 
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC 
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA 
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT 
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG 
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC 
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT 
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA 
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001668.1
CDS	141..1052
Translation	MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Target ORF information:

RefSeq Version	NM_001677.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001677.4

ORF Insert Sequence:

ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA 
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC 
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT 
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA 
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC 
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT 
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT 
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC 
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA 
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT 
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG 
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC 
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT 
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA 
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.
Heart rhythm14(4)572-580(2017 Apr)
Avery CL,Wassel CL,Richard MA,Highland HM,Bien S,Zubair N,Soliman EZ,Fornage M,Bielinski SJ,Tao R,Seyerle AA,Shah SJ,Lloyd-Jones DM,Buyske S,Rotter JI,Post WS,Rich SS,Hindorff LA,Jeff JM,Shohet RV,Sotoodehnia N,Lin DY,Whitsel EA,Peters U,Haiman CA,Crawford DC,Kooperberg C,North KE

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Molecular systems biology13(3)918(2017 03)
Sokolina K,Kittanakom S,Snider J,Kotlyar M,Maurice P,Gand?a J,Benleulmi-Chaachoua A,Tadagaki K,Oishi A,Wong V,Malty RH,Deineko V,Aoki H,Amin S,Yao Z,Morat? X,Otasek D,Kobayashi H,Menendez J,Auerbach D,Angers S,Pr?ulj N,Bouvier M,Babu M,Ciruela F,Jockers R,Jurisica I,Stagljar I

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ATP1B1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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