ATP1B1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP1B1
Entrez Gene ID	403966
Full Name	ATPase Na+/K+ transporting subunit beta 1
General protein information	Preferred Names ATPase Na+/K+ transporting subunit beta 1 Names sodium/potassium-transporting ATPase subunit beta-1 ATPase, Na+/K+ transporting, beta 1 polypeptide sodium/potassium-dependent ATPase subunit beta-1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003283.2	NP_001003283.2	sodium/potassium-transporting ATPase subunit beta-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP1B1	NP_001003283.1
Xenopus tropicalis (tropical clawed frog)	atp1b1	NP_001016488.1
Pan troglodytes (chimpanzee)	ATP1B1	NP_001092025.1
Bos taurus (cattle)	ATP1B1	NP_001030411.1
Danio rerio (zebrafish)	atp1b1a	NP_571743.3
Homo sapiens (human)	ATP1B1	NP_001668.1
Mus musculus (house mouse)	Atp1b1	NP_033851.1
Rattus norvegicus (Norway rat)	Atp1b1	NP_037245.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009595	XP_318619.4
	ATP1B1	XP_001093541.1
Danio rerio (zebrafish)	atp1b1b	NP_571746.1
Drosophila melanogaster (fruit fly)	nrv3	NP_001260675.1
Gallus gallus (chicken)	ATP1B1	NP_990851.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the amino acid region involved in the intercellular interaction between the ?1 subunits of Na+/K+ -ATPase.
Tokhtaeva E, Sachs G, Sun H, Dada LA, Sznajder JI, Vagin O
Journal of cell science125(Pt 6)1605-16(2012 Mar)

Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase ?? subunits.
Tokhtaeva E, Sachs G, Souda P, Bassilian S, Whitelegge JP, Shoshani L, Vagin O
The Journal of biological chemistry286(29)25801-12(2011 Jul)

The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits.
Padilla-Benavides T, Rold?n ML, Larre I, Flores-Benitez D, Villegas-Sep?lveda N, Contreras RG, Cereijido M, Shoshani L
Molecular biology of the cell21(13)2217-25(2010 Jul)

Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum.
Tokhtaeva E, Sachs G, Vagin O
Biochemistry48(48)11421-31(2009 Dec)

Lack of Na(+),K (+)-ATPase expression in intercalated cells may be compensated by Na(+)-ATPase: a study on MDCK - C11 cells.
Sampaio MS, Bezerra IP, Pe?anha FL, Fonseca PH, Capella MA, Lopes AG
Cellular and molecular life sciences : CMLS65(19)3093-9(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Amino acid region (198-207) is crucial for both trans-dimerization of the Na+/K+-ATPase beta1 subunits and cell-cell adhesion.
Title: Identification of the amino acid region involved in the intercellular interaction between the ?1 subunits of Na+/K+ -ATPase.

interactions between the beta subunits of neighboring cells maintain integrity of intercellular junctions
Title: Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase ?? subunits.

Data demonstrate that Na(+),K(+)-ATPase beta 1 subunits have sufficient proximity and affinity to permit a direct interaction, without requiring any additional extracellular molecules to span the distance.
Title: The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits.

the ER quality control system allows export only of assembled alpha-beta complexes to the Golgi, whereas the number of alpha(1) subunits in the ER determines the amount of the alpha-beta complexes
Title: Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum.

Data suggest that the presence of Na(+)-ATPase in intercalated cells may explain the adequate survival of cells that lack Na(+),K(+)-ATPase.
Title: Lack of Na(+),K (+)-ATPase expression in intercalated cells may be compensated by Na(+)-ATPase: a study on MDCK - C11 cells.

The following ATP1B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe140226	NM_001003283.2 Latest version!	Canis lupus familiaris ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP1B1 ( NM_001003283.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003283.2 Canis lupus familiaris ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.

Price & Availability↑

CloneID	OCe140226
Clone ID Related Accession (Same CDS sequence)	NM_001003283.2
Accession Version	NM_001003283.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Canis lupus familiaris(dog)
Product	sodium/potassium-transporting ATPase subunit beta-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN392617.1 and DN393833.1. On Sep 2, 2015 this sequence version replaced NM_001003283.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCGCG GAAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCGGAG 
AAGAAGGAGT TTTTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT GTTCTACGTG 
ATATTTTACG GCTGCTTGGC TGGGATCTTC ATTGGGACCA TTCAAGTGAT GCTGCTCACC 
ATCAGCGAAT TCAAGCCCAC ATACCAGGAC CGTGTGGCCC CACCAGGATT AACACAGATT 
CCTCAGATCC AAAAGACTGA AATTTCCTTT CGCCCTAACG ATCCCAAGAG CTATGAGGAA 
TATGTGCGCA ACATAGTCAG GTTCCTGGAG AAGTACAAAG ATTCAGCCCA GAAGGATGAA 
ATGATTTTTG AAGATTGTGG CAATATGCCC AGCGAAATCA AAGAACGAGG AGAATTTAAC 
AATGAACGAG GAGAGCGGAA AGTCTGCAGG TTCAAGCTTG AGTGGTTGGG CAATTGCTCC 
GGAATCAACG ATGAGACTTA TGGCTACAGA GACGGCAAAC CGTGTGTCCT AATAAAGCTC 
AACCGAGTTC TGGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCCTGGA GGCTTACCCA 
GTGATGAAAT ACAATCCTTA CGTCCTGCCG GTTCAGTGCA CTGGCAAGCG AGACGAAGAC 
AAGGATAGAA TTGGGAACGT GGAGTATTTT GGCCTGGGCG GCTACCCGGG CTTTCCTCTG 
CAATATTACC CCTACTACGG CAAGTTGCTC CAGCCCAAGT ATCTGCAGCC CCTGCTCGCC 
GTGCAGTTCA CCAACCTCAC CATGGACACT GAAATTCGCA TCGAGTGTAA GGCTTACGGG 
GAGAACATTG GTTACAGTGA GAAAGACCGT TTTCAGGGAC GCTTTGATGT AAAAATTGAA 
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003283.2
CDS	125..1036
Translation	MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEEYVRNIVRFLEKYKDSAQKDEMIFEDCGNMPSEIKERGEFNNERGERKVCRFKLEWLGNCSGINDETYGYRDGKPCVLIKLNRVLGFKPKPPKNESLEAYPVMKYNPYVLPVQCTGKRDEDKDRIGNVEYFGLGGYPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Target ORF information:

RefSeq Version	NM_001003283.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris ATPase Na+/K+ transporting subunit beta 1 (ATP1B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003283.2

ORF Insert Sequence:

ATGGCCCGCG GAAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCGGAG 
AAGAAGGAGT TTTTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT GTTCTACGTG 
ATATTTTACG GCTGCTTGGC TGGGATCTTC ATTGGGACCA TTCAAGTGAT GCTGCTCACC 
ATCAGCGAAT TCAAGCCCAC ATACCAGGAC CGTGTGGCCC CACCAGGATT AACACAGATT 
CCTCAGATCC AAAAGACTGA AATTTCCTTT CGCCCTAACG ATCCCAAGAG CTATGAGGAA 
TATGTGCGCA ACATAGTCAG GTTCCTGGAG AAGTACAAAG ATTCAGCCCA GAAGGATGAA 
ATGATTTTTG AAGATTGTGG CAATATGCCC AGCGAAATCA AAGAACGAGG AGAATTTAAC 
AATGAACGAG GAGAGCGGAA AGTCTGCAGG TTCAAGCTTG AGTGGTTGGG CAATTGCTCC 
GGAATCAACG ATGAGACTTA TGGCTACAGA GACGGCAAAC CGTGTGTCCT AATAAAGCTC 
AACCGAGTTC TGGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCCTGGA GGCTTACCCA 
GTGATGAAAT ACAATCCTTA CGTCCTGCCG GTTCAGTGCA CTGGCAAGCG AGACGAAGAC 
AAGGATAGAA TTGGGAACGT GGAGTATTTT GGCCTGGGCG GCTACCCGGG CTTTCCTCTG 
CAATATTACC CCTACTACGG CAAGTTGCTC CAGCCCAAGT ATCTGCAGCC CCTGCTCGCC 
GTGCAGTTCA CCAACCTCAC CATGGACACT GAAATTCGCA TCGAGTGTAA GGCTTACGGG 
GAGAACATTG GTTACAGTGA GAAAGACCGT TTTCAGGGAC GCTTTGATGT AAAAATTGAA 
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of the amino acid region involved in the intercellular interaction between the ?1 subunits of Na+/K+ -ATPase.
Journal of cell science125(Pt 6)1605-16(2012 Mar)
Tokhtaeva E,Sachs G,Sun H,Dada LA,Sznajder JI,Vagin O

Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase ?? subunits.
The Journal of biological chemistry286(29)25801-12(2011 Jul)
Tokhtaeva E,Sachs G,Souda P,Bassilian S,Whitelegge JP,Shoshani L,Vagin O

The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits.
Molecular biology of the cell21(13)2217-25(2010 Jul)
Padilla-Benavides T,Rold?n ML,Larre I,Flores-Benitez D,Villegas-Sep?lveda N,Contreras RG,Cereijido M,Shoshani L

Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum.
Biochemistry48(48)11421-31(2009 Dec)
Tokhtaeva E,Sachs G,Vagin O

Lack of Na(+),K (+)-ATPase expression in intercalated cells may be compensated by Na(+)-ATPase: a study on MDCK - C11 cells.
Cellular and molecular life sciences : CMLS65(19)3093-9(2008 Oct)
Sampaio MS,Bezerra IP,Pe?anha FL,Fonseca PH,Capella MA,Lopes AG

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ATP1B1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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