Atp1b1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp1b1
Entrez Gene ID	11931
Full Name	ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms	Atp4b,Atpb,Atpb-1,NKbeta1
General protein information	Preferred Names ATPase, Na+/K+ transporting, beta 1 polypeptide Names sodium/potassium-transporting ATPase subunit beta-1 sodium/potassium ATPase beta subunit sodium/potassium-dependent ATPase subunit beta-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H2.2\|1 71.75 cM
Summary	This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009721.6	NP_033851.1	sodium/potassium-transporting ATPase subunit beta-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP1B1	NP_001003283.1
Xenopus tropicalis (tropical clawed frog)	atp1b1	NP_001016488.1
Pan troglodytes (chimpanzee)	ATP1B1	NP_001092025.1
Bos taurus (cattle)	ATP1B1	NP_001030411.1
Danio rerio (zebrafish)	atp1b1a	NP_571743.3
Homo sapiens (human)	ATP1B1	NP_001668.1
Mus musculus (house mouse)	Atp1b1	NP_033851.1
Rattus norvegicus (Norway rat)	Atp1b1	NP_037245.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009595	XP_318619.4
	ATP1B1	XP_001093541.1
Danio rerio (zebrafish)	atp1b1b	NP_571746.1
Drosophila melanogaster (fruit fly)	nrv3	NP_001260675.1
Gallus gallus (chicken)	ATP1B1	NP_990851.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular architecture underlying fluid absorption by the developing inner ear.
Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ
eLife6(2017 Oct)

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.
Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M
Cell reports20(4)960-972(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FXYD5 mediates metastatic progression through regulation of the beta Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model.
Title: FXYD5 (dysadherin) may mediate metastatic progression through regulation of the ?-Na

Activities of AE1 and the sodium pump are coregulated in kidney.
Title: Physical and functional links between anion exchanger-1 and sodium pump.

Atp1b1 was highly expressed in luminal epithelium during peri-implantation and upregulated by progesterone.
Title: Progesterone regulation of Na/K-ATPase ?1 subunit expression in the mouse uterus during the peri-implantation period.

Na,K-beta(1) plays an essential role in regulating cardiac contractility and that its loss is associated with significant pathophysiology of the heart.
Title: Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.

Inhibition of the Atp1b1 isoenzyme of the sodium potassium exchanging ATPase by 8-methoxycoumestrol is reported.
Title: Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.

The following Atp1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04710	NM_009721.6 Latest version!	Mus musculus ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp1b1 ( NM_009721.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033851.1 Mus musculus ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA.

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CloneID	OMu04710
Clone ID Related Accession (Same CDS sequence)	NM_009721.6
Accession Version	NM_009721.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	sodium/potassium-transporting ATPase subunit beta-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK010677.1, AK005071.1 and AK160405.1. On Mar 19, 2013 this sequence version replaced NM_009721.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK160405.1, AK010677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849378, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGCG GAAAAGCCAA GGAGGAAGGC AGCTGGAAGA AATTCATCTG GAACTCGGAG 
AAGAAGGAGT TTTTGGGCAG GACCGGTGGT AGTTGGTTTA AGATCCTTCT GTTCTACGTG 
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGGACCA TCCAAGTAAT GCTGCTAACC 
ATCAGTGAAC TGAAGCCCAC ATACCAGGAC CGAGTGGCCC CGCCAGGATT GACACAGATT 
CCCCAGATCC AGAAGACTGA GATCTCCTTC CGTCCTAATG ACCCCAAGAG CTACGAGGCC 
TACGTGCTAA ACATCATCAG GTTCCTGGAA AAGTACAAGG ATTCAGCCCA GAAGGACGAC 
ATGATTTTCG AGGACTGTGG CAATGTTCCC AGTGAACCCA AGGAACGGGG CGACATCAAT 
CACGAACGAG GAGAGAGGAA GGTGTGCAGG TTCAAGCTTG ACTGGCTGGG GAACTGCTCC 
GGTCTCAATG ATGACTCTTA CGGCTACAGA GAGGGGAAGC CCTGCATCAT TATCAAGCTC 
AACCGAGTGT TGGGCTTCAA ACCGAAGCCT CCCAAGAATG AATCCTTGGA GACTTACCCA 
CTGATGATGA AGTATAATCC AAATGTCCTG CCTGTTCAGT GCACTGGCAA GAGAGATGAA 
GATAAGGATA AAGTCGGGAA CATAGAGTAC TTTGGGATGG GCGGATACTA CGGCTTCCCT 
CTGCAGTATT ATCCCTACTA CGGCAAACTC CTGCAGCCCA AGTACCTGCA GCCCCTGCTG 
GCCGTGCAGT TCACCAACCT CACCGTGGAC ACTGAAATCC GCGTCGAGTG TAAGGCGTAT 
GGTGAGAACA TTGGGTACAG TGAGAAAGAC CGTTTTCAGG GACGCTTTGA TGTAAAAATT 
GAAATTAAGA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033851.1
CDS	499..1413
Translation	MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGNVPSEPKERGDINHERGERKVCRFKLDWLGNCSGLNDDSYGYREGKPCIIIKLNRVLGFKPKPPKNESLETYPLMMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGYYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTVDTEIRVECKAYGENIGYSEKDRFQGRFDVKIEIKS

Target ORF information:

RefSeq Version	NM_009721.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009721.6

ORF Insert Sequence:

ATGGCCCGCG GAAAAGCCAA GGAGGAAGGC AGCTGGAAGA AATTCATCTG GAACTCGGAG 
AAGAAGGAGT TTTTGGGCAG GACCGGTGGT AGTTGGTTTA AGATCCTTCT GTTCTACGTG 
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGGACCA TCCAAGTAAT GCTGCTAACC 
ATCAGTGAAC TGAAGCCCAC ATACCAGGAC CGAGTGGCCC CGCCAGGATT GACACAGATT 
CCCCAGATCC AGAAGACTGA GATCTCCTTC CGTCCTAATG ACCCCAAGAG CTACGAGGCC 
TACGTGCTAA ACATCATCAG GTTCCTGGAA AAGTACAAGG ATTCAGCCCA GAAGGACGAC 
ATGATTTTCG AGGACTGTGG CAATGTTCCC AGTGAACCCA AGGAACGGGG CGACATCAAT 
CACGAACGAG GAGAGAGGAA GGTGTGCAGG TTCAAGCTTG ACTGGCTGGG GAACTGCTCC 
GGTCTCAATG ATGACTCTTA CGGCTACAGA GAGGGGAAGC CCTGCATCAT TATCAAGCTC 
AACCGAGTGT TGGGCTTCAA ACCGAAGCCT CCCAAGAATG AATCCTTGGA GACTTACCCA 
CTGATGATGA AGTATAATCC AAATGTCCTG CCTGTTCAGT GCACTGGCAA GAGAGATGAA 
GATAAGGATA AAGTCGGGAA CATAGAGTAC TTTGGGATGG GCGGATACTA CGGCTTCCCT 
CTGCAGTATT ATCCCTACTA CGGCAAACTC CTGCAGCCCA AGTACCTGCA GCCCCTGCTG 
GCCGTGCAGT TCACCAACCT CACCGTGGAC ACTGAAATCC GCGTCGAGTG TAAGGCGTAT 
GGTGAGAACA TTGGGTACAG TGAGAAAGAC CGTTTTCAGG GACGCTTTGA TGTAAAAATT 
GAAATTAAGA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular architecture underlying fluid absorption by the developing inner ear.
eLife6(2017 Oct)
Honda K,Kim SH,Kelly MC,Burns JC,Constance L,Li X,Zhou F,Hoa M,Kelley MW,Wangemann P,Morell RJ,Griffith AJ

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.
Cell reports20(4)960-972(2017 Jul)
Takagishi M,Sawada M,Ohata S,Asai N,Enomoto A,Takahashi K,Weng L,Ushida K,Ara H,Matsui S,Kaibuchi K,Sawamoto K,Takahashi M

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Atp1b1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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