Atp1b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp1b1
Entrez Gene ID	25650
Full Name	ATPase Na+/K+ transporting subunit beta 1
Synonyms	ATPBS
General protein information	Preferred Names ATPase Na+/K+ transporting subunit beta 1 Names sodium/potassium-transporting ATPase subunit beta-1 ATPase, Na+/K+ transporting, beta 1 polypeptide Na,K-ATPase beta 1 subunit sodium/potassium-dependent ATPase subunit beta-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q23
Summary	may regulate oxygen homeostasis in astrocytes; may play a role in cellular resistance to cardiac glycosides [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013113.2	NP_037245.2	sodium/potassium-transporting ATPase subunit beta-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP1B1	NP_001003283.1
Xenopus tropicalis (tropical clawed frog)	atp1b1	NP_001016488.1
Pan troglodytes (chimpanzee)	ATP1B1	NP_001092025.1
Bos taurus (cattle)	ATP1B1	NP_001030411.1
Danio rerio (zebrafish)	atp1b1a	NP_571743.3
Homo sapiens (human)	ATP1B1	NP_001668.1
Mus musculus (house mouse)	Atp1b1	NP_033851.1
Rattus norvegicus (Norway rat)	Atp1b1	NP_037245.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009595	XP_318619.4
	ATP1B1	XP_001093541.1
Danio rerio (zebrafish)	atp1b1b	NP_571746.1
Drosophila melanogaster (fruit fly)	nrv3	NP_001260675.1
Gallus gallus (chicken)	ATP1B1	NP_990851.1

Gene Ontology
Bibliography

Related articles in PubMed

The ?2?2 isoform combination dominates the astrocytic Na
Stoica A, Larsen BR, Assentoft M, Holm R, Holt LM, Vilhardt F, Vilsen B, Lykke-Hartmann K, Olsen ML, MacAulay N
Glia65(11)1777-1793(2017 Nov)

Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities by DRm217.
Yan X, Xun M, Li J, Wu L, Dou X, Zheng J
Acta biochimica et biophysica Sinica48(10)883-893(2016 Oct)

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A, Teunissen CE, de Wit H, Jim?nez CR
Journal of proteomics106191-204(2014 Jun)

Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions.
Swarts HG, Weigand KM, Venselaar H, van den Maagdenberg AM, Russel FG, Koenderink JB
Biochimica et biophysica acta1832(12)2173-9(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that Na(+)/K(+)-ATPase's DR-region specific monoclonal antibody and direct activator DRm217 increased Na(+)/K(+)-ATPase activity and alleviated Ca(2+) level.
Title: Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities by DRm217.

Amino acid region (198-207) is crucial for both trans-dimerization of the Na+/K+-ATPase beta1 subunits and cell-to-cell adhesion.
Title: Identification of the amino acid region involved in the intercellular interaction between the ?1 subunits of Na+/K+ -ATPase.

interactions between the beta subunits of neighboring cells maintain integrity of intercellular junctions
Title: Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase ?? subunits.

analysis of pathways for maturation of the Na,K-ATPase beta1 and beta2 subunits in the endoplasmic reticulum
Title: Diverse pathways for maturation of the Na,K-ATPase ?1 and ?2 subunits in the endoplasmic reticulum of Madin-Darby canine kidney cells.

Data demonstrate that Na(+),K(+)-ATPase beta 1 subunits have sufficient proximity and affinity to permit a direct interaction, without requiring any additional extracellular molecules to span the distance.
Title: The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits.

The following Atp1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02019	NM_013113.2 Latest version!	Rattus norvegicus ATPase Na+/K+ transporting subunit beta 1 (Atp1b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp1b1 ( NM_013113.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037245.2 Rattus norvegicus ATPase Na+/K+ transporting subunit beta 1 (Atp1b1), mRNA.

Price & Availability↑

CloneID	ORa02019
Clone ID Related Accession (Same CDS sequence)	NM_013113.2
Accession Version	NM_013113.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	sodium/potassium-transporting ATPase subunit beta-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078902.1. On Jun 10, 2007 this sequence version replaced NM_013113.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078902.1, J02701.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCCGCG GAAAAGCCAA GGAGGAAGGC AGCTGGAAGA AATTCATCTG GAACTCGGAG 
AAGAAGGAGT TTTTGGGCAG GACCGGTGGT AGTTGGTTTA AGATCCTTCT GTTCTACGTG 
ATATTCTATG GCTGCCTGGC CGGCATCTTC ATCGGGACCA TCCAAGTGAT GCTGCTTACC 
ATCAGTGAGC TGAAACCCAC GTACCAGGAC CGTGTGGCCC CGCCAGGATT GACACAGATT 
CCTCAGATCC AAAAGACTGA AATTTCCTTC CGTCCTAATG ACCCCAAGAG CTACGAGGCC 
TATGTGCTAA ACATCATCAG GTTCCTGGAA AAGTACAAAG ATTCGGCCCA GAAGGACGAC 
ATGATTTTCG AGGATTGTGG CAGTATGCCC AGTGAACCCA AGGAGCGGGG AGAGTTCAAT 
CATGAACGAG GAGAGCGCAA GGTGTGCAGG TTCAAGCTTG ACTGGCTGGG GAACTGCTCT 
GGTCTCAATG ATGAATCCTA CGGCTACAAA GAGGGGAAGC CCTGTATCAT TATCAAGCTC 
AACCGAGTGC TGGGCTTCAA ACCTAAGCCT CCCAAGAATG AATCCTTGGA GACTTACCCT 
CTGACGATGA AGTATAATCC AAACGTCCTA CCTGTCCAGT GCACTGGCAA GCGCGATGAG 
GATAAGGATA AAGTTGGAAA CATAGAGTAC TTTGGGATGG GCGGATTCTA TGGCTTTCCT 
CTGCAGTACT ATCCCTACTA CGGCAAACTC CTGCAGCCCA AGTACCTGCA GCCCCTGCTG 
GCCGTGCAGT TCACCAACCT CACCTTGGAC ACTGAAATCC GCATTGAGTG TAAGGCGTAT 
GGTGAGAACA TTGGGTACAG TGAGAAAGAC CGTTTTCAGG GACGCTTTGA TGTAAAAATT 
GAAGTTAAGA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037245.2
CDS	137..1051
Translation	MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGSMPSEPKERGEFNHERGERKVCRFKLDWLGNCSGLNDESYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPLTMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGFYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTLDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Target ORF information:

RefSeq Version	NM_013113.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATPase Na+/K+ transporting subunit beta 1 (Atp1b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013113.2

ORF Insert Sequence:

ATGGCCCGCG GAAAAGCCAA GGAGGAAGGC AGCTGGAAGA AATTCATCTG GAACTCGGAG 
AAGAAGGAGT TTTTGGGCAG GACCGGTGGT AGTTGGTTTA AGATCCTTCT GTTCTACGTG 
ATATTCTATG GCTGCCTGGC CGGCATCTTC ATCGGGACCA TCCAAGTGAT GCTGCTTACC 
ATCAGTGAGC TGAAACCCAC GTACCAGGAC CGTGTGGCCC CGCCAGGATT GACACAGATT 
CCTCAGATCC AAAAGACTGA AATTTCCTTC CGTCCTAATG ACCCCAAGAG CTACGAGGCC 
TATGTGCTAA ACATCATCAG GTTCCTGGAA AAGTACAAAG ATTCGGCCCA GAAGGACGAC 
ATGATTTTCG AGGATTGTGG CAGTATGCCC AGTGAACCCA AGGAGCGGGG AGAGTTCAAT 
CATGAACGAG GAGAGCGCAA GGTGTGCAGG TTCAAGCTTG ACTGGCTGGG GAACTGCTCT 
GGTCTCAATG ATGAATCCTA CGGCTACAAA GAGGGGAAGC CCTGTATCAT TATCAAGCTC 
AACCGAGTGC TGGGCTTCAA ACCTAAGCCT CCCAAGAATG AATCCTTGGA GACTTACCCT 
CTGACGATGA AGTATAATCC AAACGTCCTA CCTGTCCAGT GCACTGGCAA GCGCGATGAG 
GATAAGGATA AAGTTGGAAA CATAGAGTAC TTTGGGATGG GCGGATTCTA TGGCTTTCCT 
CTGCAGTACT ATCCCTACTA CGGCAAACTC CTGCAGCCCA AGTACCTGCA GCCCCTGCTG 
GCCGTGCAGT TCACCAACCT CACCTTGGAC ACTGAAATCC GCATTGAGTG TAAGGCGTAT 
GGTGAGAACA TTGGGTACAG TGAGAAAGAC CGTTTTCAGG GACGCTTTGA TGTAAAAATT 
GAAGTTAAGA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The ?2?2 isoform combination dominates the astrocytic Na
Glia65(11)1777-1793(2017 Nov)
Stoica A,Larsen BR,Assentoft M,Holm R,Holt LM,Vilhardt F,Vilsen B,Lykke-Hartmann K,Olsen ML,MacAulay N

Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities by DRm217.
Acta biochimica et biophysica Sinica48(10)883-893(2016 Oct)
Yan X,Xun M,Li J,Wu L,Dou X,Zheng J

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Journal of proteomics106191-204(2014 Jun)
Chiasserini D,van Weering JR,Piersma SR,Pham TV,Malekzadeh A,Teunissen CE,de Wit H,Jim?nez CR

Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions.
Biochimica et biophysica acta1832(12)2173-9(2013 Dec)
Swarts HG,Weigand KM,Venselaar H,van den Maagdenberg AM,Russel FG,Koenderink JB

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Atp1b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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