DEFB103A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB103A
Entrez Gene ID	414325
Full Name	defensin beta 103A
Synonyms	BD-3,DEFB-3,DEFB103,DEFB3,HBD3,HBP-3,HBP3,hBD-3
General protein information	Preferred Names defensin beta 103A Names beta-defensin 103 beta-defensin 3 defensin, beta 103 defensin, beta 3 defensin-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017030192.1	XP_016885681.1	beta-defensin 103 isoform X1
NM_001081551.4	NP_001075020.1	beta-defensin 103 precursor
NM_001081551.3	NP_001075020.1	beta-defensin 103 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CBD103	NP_001123452.1
Homo sapiens (human)	DEFB103A	NP_001075020.1
Homo sapiens (human)	DEFB103B	NP_061131.1
	DEFB103A	XP_001083420.1

Gene Ontology
Bibliography

Related articles in PubMed

Human ?-defensin 3 increases the TLR9-dependent response to bacterial DNA.
McGlasson SL, Semple F, MacPherson H, Gray M, Davidson DJ, Dorin JR
European journal of immunology47(4)658-664(2017 04)

Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.
Cai G, Xia Q, Fan D, Li X, Ding N, Hu Y, Yang X, Liu L, Xin L, Wang L, Xu S, Xu J, Zou Y, Ding C, Pan F
Tissue antigens86(3)195-8(2015 Sep)

Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus.
Bai X, Tian T, Wang P, Yang X, Wang Z, Dong M
Journal of medical virology87(3)375-9(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that hBD3 amplifies the response to bacterial DNA in both mouse and human immune cells in a TLR9-dependent manner
Title: Human ?-defensin 3 increases the TLR9-dependent response to bacterial DNA.

the role of DEFB103 gene copy number variation (CNV) in ankylosing spondylitis (AS) susceptibility, was investigated.
Title: Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.

It may be concluded hepatitis B virus up-regulates HBD-3 and A3G expression in vivo and in vitro in placental trophoblast and lack of this up-regulation is possibly associated with intrauterine transmission of hepatitis B.
Title: Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus.

study demonstrates that HBD2 and 3 activate plasmacytoid dendritic cells by enhancing the intracellular uptake of CpG and self DNA and promote DNA-induced IFN-alpha production in a TLR9-dependent manner
Title: ?-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-? production by human plasmacytoid dendritic cells, and promote inflammation.

Mapping of key residues in the interaction between human Beta-defensin 3 and CXCR4 reveals key defensin motifs involved in protein binding.
Title: Human ?-defensin-3 structure motifs that are important in CXCR4 antagonism.

The following DEFB103A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB103A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15542	NM_001081551.4 Latest version!	Homo sapiens defensin beta 103A (DEFB103A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15542	XM_017030192.1 Latest version!	Homo sapiens defensin beta 103A (DEFB103A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15542	NM_001081551.3	Homo sapiens defensin beta 103A (DEFB103A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB103A ( NM_001081551.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001075020.1 Homo sapiens defensin beta 103A (DEFB103A), mRNA.

Price & Availability↑

CloneID	OHu15542
Clone ID Related Accession (Same CDS sequence)	XM_017030192.1 , NM_001081551.4 , NM_001081551.3
Accession Version	NM_001081551.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	beta-defensin 103 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130365.5. On Jul 25, 2019 this sequence version replaced NM_001081551.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ354967.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11085990 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075020.1
CDS	31..234
Translation	MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK

Target ORF information:

RefSeq Version	NM_001081551.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 103A (DEFB103A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081551.4

ORF Insert Sequence:

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB103A ( NM_001081551.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001075020.1 Homo sapiens defensin beta 103A (DEFB103A), mRNA.

Price & Availability↑

CloneID	OHu15542
Clone ID Related Accession (Same CDS sequence)	XM_017030192.1 , NM_001081551.4 , NM_001081551.3
Accession Version	NM_001081551.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	beta-defensin 103 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF301470.1 and AC130365.5. On Apr 12, 2014 this sequence version replaced NM_001081551.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ354967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11085990 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075020.1
CDS	219..422
Translation	MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK

Target ORF information:

RefSeq Version	NM_001081551.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 103A (DEFB103A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081551.3

ORF Insert Sequence:

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB103A ( XM_017030192.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885681.1 Homo sapiens defensin beta 103A (DEFB103A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu15542
Clone ID Related Accession (Same CDS sequence)	XM_017030192.1 , NM_001081551.4 , NM_001081551.3
Accession Version	XM_017030192.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	beta-defensin 103 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_187570.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885681.1
CDS	219..422
Translation	MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK

Target ORF information:

RefSeq Version	XM_017030192.1
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 103A (DEFB103A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030192.1

ORF Insert Sequence:

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human ?-defensin 3 increases the TLR9-dependent response to bacterial DNA.
European journal of immunology47(4)658-664(2017 04)
McGlasson SL,Semple F,MacPherson H,Gray M,Davidson DJ,Dorin JR

Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.
Tissue antigens86(3)195-8(2015 Sep)
Cai G,Xia Q,Fan D,Li X,Ding N,Hu Y,Yang X,Liu L,Xin L,Wang L,Xu S,Xu J,Zou Y,Ding C,Pan F

Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus.
Journal of medical virology87(3)375-9(2015 Mar)
Bai X,Tian T,Wang P,Yang X,Wang Z,Dong M

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DEFB103A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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