DEFB103B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB103B
Entrez Gene ID	55894
Full Name	defensin beta 103B
Synonyms	BD-3,DEFB-3,DEFB103,DEFB3,HBD-3,HBD3,HBP-3,HBP3
General protein information	Preferred Names defensin beta 103B Names beta-defensin 103 beta-defensin 3 defensin, beta 103 defensin-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. [provided by RefSeq, Oct 2014].
Disorder MIM:	606611

mRNA and Protein(s)

mRNA	Protein	Name
NM_018661.4	NP_061131.1	beta-defensin 103 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CBD103	NP_001123452.1
Homo sapiens (human)	DEFB103A	NP_001075020.1
Homo sapiens (human)	DEFB103B	NP_061131.1
	DEFB103A	XP_001083420.1

Gene Ontology
Bibliography

Related articles in PubMed

Human ?-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages.
Cui D, Lyu J, Li H, Lei L, Bian T, Li L, Yan F
Molecular immunology9165-74(2017 11)

Expression and antimicrobial character of cells transfected with human ??defensin?3 against periodontitis?associated microbiota in vitro.
Zhu M, Miao B, Zhu J, Wang H, Zhou Z
Molecular medicine reports16(3)2455-2460(2017 Sep)

Surfactant protein A (SP-A) and SP-A-derived peptide attenuate chemotaxis of mast cells induced by human ?-defensin 3.
Uehara Y, Takahashi M, Murata M, Saito A, Takamiya R, Hasegawa Y, Kuronuma K, Chiba H, Hashimoto J, Sawada N, Takahashi H, Kuroki Y, Ariki S
Biochemical and biophysical research communications485(1)107-112(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hBD3 exhibits potent anti-periodontitis properties both in vitro and in vivo, and this effect may be correlated to inhibition of the nuclear factor-kappaB pathway and macrophage polarization.
Title: Human ?-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages.

These results indicated that hBD3 could have therapeutic effect on systemic inflammation associated with periodontal infections via modulating macrophage activation and orientation.
Title: ?-defensin 3 modulates macrophage activation and orientation during acute inflammatory response to Porphyromonas gingivalis lipopolysaccharide.

Different dynamics and pathway of disulfide bonds reduction has been demonstrated for two human defensins, HD5 and HBD-3.
Title: Different dynamics and pathway of disulfide bonds reduction of two human defensins, a molecular dynamics simulation study.

Direct interaction between SP-A or SAP01 and human BD-3 seemed to be responsible for the inhibitory effects on chemotaxis of mast cells.
Title: Surfactant protein A (SP-A) and SP-A-derived peptide attenuate chemotaxis of mast cells induced by human ?-defensin 3.

Per duplication of mRNA in whole blood, the risk of being a carrier increased by 93% for IL17A and decreased by 35% for IFN-gamma. Independent of carriage and DEFB promotor haplotype, a 1-unit increase in IFN-gamma/IL-17A mRNA ratio led to a 24% increase in HBD3 mRNA in wounded skin. A low Th1 to Th17 mRNA ratio increases the risk of colonization, with HBD3 being a potential link.
Title: Ratio of T-Helper Type 1 (Th1) to Th17 Cytokines in Whole Blood Is Associated With Human ?-Defensin 3 Expression in Skin and Persistent Staphylococcus aureus Nasal Carriage.

The following DEFB103B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB103B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu15542	NM_018661.4 Latest version!	Homo sapiens defensin beta 103B (DEFB103B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB103B ( NM_018661.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_061131.1 Homo sapiens defensin beta 103B (DEFB103B), mRNA.

Price & Availability↑

CloneID	OHu15542
Clone ID Related Accession (Same CDS sequence)	NM_018661.4
Accession Version	NM_018661.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-07
Organism	Homo sapiens(human)
Product	beta-defensin 103 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130360.4 and AB037972.1. On Apr 11, 2014 this sequence version replaced NM_018661.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ237673.1, AF295370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000318124.3/ ENSP00000324633.3 Protein has antimicrobial activity :: PMID: 11085990 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061131.1
CDS	219..422
Translation	MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK

Target ORF information:

RefSeq Version	NM_018661.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 103B (DEFB103B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018661.4

ORF Insert Sequence:

ATGAGGATCC ATTATCTTCT GTTTGCTTTG CTCTTCCTGT TTTTGGTGCC TGTTCCAGGT 
CATGGAGGAA TCATAAACAC ATTACAGAAA TATTATTGCA GAGTCAGAGG CGGCCGGTGT 
GCTGTGCTCA GCTGCCTTCC AAAGGAGGAA CAGATCGGCA AGTGCTCGAC GCGTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human ?-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages.
Molecular immunology9165-74(2017 11)
Cui D,Lyu J,Li H,Lei L,Bian T,Li L,Yan F

Expression and antimicrobial character of cells transfected with human ??defensin?3 against periodontitis?associated microbiota in vitro.
Molecular medicine reports16(3)2455-2460(2017 Sep)
Zhu M,Miao B,Zhu J,Wang H,Zhou Z

Surfactant protein A (SP-A) and SP-A-derived peptide attenuate chemotaxis of mast cells induced by human ?-defensin 3.
Biochemical and biophysical research communications485(1)107-112(2017 03)
Uehara Y,Takahashi M,Murata M,Saito A,Takamiya R,Hasegawa Y,Kuronuma K,Chiba H,Hashimoto J,Sawada N,Takahashi H,Kuroki Y,Ariki S

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DEFB103B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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