CBD103 cDNA ORF clone, Canis lupus familiaris(Dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CBD103
Entrez Gene ID	100170103
Full Name	beta-defensin 103
Gene Type	protein-coding
Organism	Canis lupus familiaris(Dog)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005629923.2	XP_005629980.1	beta-defensin 14 isoform X2
NM_001129980.1	NP_001123452.1	beta-defensin 14 precursor
XM_005629922.2	XP_005629979.1	beta-defensin 14 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CBD103	NP_001123452.1
Homo sapiens (human)	DEFB103A	NP_001075020.1
Homo sapiens (human)	DEFB103B	NP_061131.1
	DEFB103A	XP_001083420.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
Ciampolini R, Cecchi F, Spaterna A, Bramante A, Bardet SM, Oulmouden A
Animal genetics44(1)114-7(2013 Feb)

Signature of balancing selection at the MC1R gene in Kunming dog populations.
Wang GD, Cheng LG, Fan RX, Irwin DM, Tang SS, Peng JG, Zhang YP
PloS one8(2)e55469(2013)

Activity, expression and genetic variation of canine ?-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs.
Leonard BC, Marks SL, Outerbridge CA, Affolter VK, Kananurak A, Young A, Moore PF, Bannasch DL, Bevins CL
Journal of innate immunity4(3)248-59(2012)

Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
Oguro-Okano M, Honda M, Yamazaki K, Okano K
The Journal of veterinary medical science73(7)853-8(2011 Jul)

Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.
van Damme CM, Willemse T, van Dijk A, Haagsman HP, Veldhuizen EJ
Molecular immunology46(13)2449-55(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs.
Title: Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.

the similarities of CBD103 and its human ortholog reported here support the notion that the domestic dog may serve as a valuable model for studying beta-defensin biology in the skin.
Title: Activity, expression and genetic variation of canine ?-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs.

2 key mutations in the MC1R gene and the CBD103 gene are associated with the phenotypic discriminations among brindle, red/sesame, and white coats.
Title: Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.

Data show thatc ontrary to cBD1, expression of cBD103 was slightly (2-fold) downregulated in skin of atopic dogs.
Title: Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.

study identifies the K locus as beta-defensin 103 (CBD103) and shows that its protein product binds with high affinity to the melanocortin 1 receptor and has a simple and strong effect on pigment type-switching [CBD103]
Title: A -defensin mutation causes black coat color in domestic dogs.

The following CBD103 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CBD103 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe18411	NM_001129980.1 Latest version!	Canis lupus familiaris beta-defensin 103 (CBD103), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OCe18410	XM_005629922.2 Latest version!	Canis lupus familiaris beta-defensin 103 (CBD103), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OCe18411	XM_005629923.2 Latest version!	Canis lupus familiaris beta-defensin 103 (CBD103), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CBD103 ( NM_001129980.1 ) cDNA ORF clone, Canis lupus familiaris(Dog) -> NP_001123452.1 Canis lupus familiaris beta-defensin 103 (CBD103), mRNA.

Price & Availability↑

CloneID	OCe18411
Clone ID Related Accession (Same CDS sequence)	XM_005629923.2 , NM_001129980.1
Accession Version	NM_001129980.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Canis lupus familiaris(dog)
Product	beta-defensin 14 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ011972.1. ##Evidence-Data-START## Transcript exon combination :: DQ011972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547739, SAMEA4547741 [ECO:0000348] ##Evidence-Data-END##

ATGAGGATCT ATTACCTTCT CCTCCTGTTG CCCTTGCTGT TCTTGATGCC TGTTCCAGGA 
AATGGGGGAA TTATAAATAC CCTGCAGAGG TATTATTGCA GAATAAGGAG CGGTCGGTGC 
GCCTTGCTGA GCTGCCTGCC AAAGGAGGAG CAGATAGGCC GCTGTTCTTC CACTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123452.1
CDS	114..317
Translation	MRIYYLLLLLPLLFLMPVPGNGGIINTLQRYYCRIRSGRCALLSCLPKEEQIGRCSSTGRKCCRRKK

Target ORF information:

RefSeq Version	NM_001129980.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris beta-defensin 103 (CBD103), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001129980.1

ORF Insert Sequence:

ATGAGGATCT ATTACCTTCT CCTCCTGTTG CCCTTGCTGT TCTTGATGCC TGTTCCAGGA 
AATGGGGGAA TTATAAATAC CCTGCAGAGG TATTATTGCA GAATAAGGAG CGGTCGGTGC 
GCCTTGCTGA GCTGCCTGCC AAAGGAGGAG CAGATAGGCC GCTGTTCTTC CACTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CBD103 ( XM_005629922.2 ) cDNA ORF clone, Canis lupus familiaris(Dog) -> XP_005629979.1 Canis lupus familiaris beta-defensin 103 (CBD103), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe18410
Clone ID Related Accession (Same CDS sequence)	XM_005629922.2
Accession Version	XM_005629922.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	beta-defensin 14 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726088.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005629922.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACTCCT GGAGCCTAGA GGGCATCAGG ATAGCTGTGT GCTCACATCA GGAATTGCAG 
CCGCTGCTTA CTTGTACCTA TGGCTGTGTG TCCTGCAACC TTATAAAGTG GACGAGTGCA 
CGCACCTTGC CATCCAGTCT CAGCCTGTCG CGAAGCCTGT TGGTCATGAG GATCTATTAC 
CTTCTCCTCC TGTTGCCCTT GCTGTTCTTG ATGCCTGTTC CAGGAAATGG GGGAATTATA 
AATACCCTGC AGAGGTATTA TTGCAGAATA AGGAGCGGTC GGTGCGCCTT GCTGAGCTGC 
CTGCCAAAGG AGGAGCAGAT AGGCCGCTGT TCTTCCACTG GCCGAAAATG CTGCCGAAGA 
AAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005629979.1
CDS	32..400
Translation	MHSWSLEGIRIAVCSHQELQPLLTCTYGCVSCNLIKWTSARTLPSSLSLSRSLLVMRIYYLLLLLPLLFLMPVPGNGGIINTLQRYYCRIRSGRCALLSCLPKEEQIGRCSSTGRKCCRRKK

Target ORF information:

RefSeq Version	XM_005629922.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris beta-defensin 103 (CBD103), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005629922.2

ORF Insert Sequence:

ATGCACTCCT GGAGCCTAGA GGGCATCAGG ATAGCTGTGT GCTCACATCA GGAATTGCAG 
CCGCTGCTTA CTTGTACCTA TGGCTGTGTG TCCTGCAACC TTATAAAGTG GACGAGTGCA 
CGCACCTTGC CATCCAGTCT CAGCCTGTCG CGAAGCCTGT TGGTCATGAG GATCTATTAC 
CTTCTCCTCC TGTTGCCCTT GCTGTTCTTG ATGCCTGTTC CAGGAAATGG GGGAATTATA 
AATACCCTGC AGAGGTATTA TTGCAGAATA AGGAGCGGTC GGTGCGCCTT GCTGAGCTGC 
CTGCCAAAGG AGGAGCAGAT AGGCCGCTGT TCTTCCACTG GCCGAAAATG CTGCCGAAGA 
AAGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CBD103 ( XM_005629923.2 ) cDNA ORF clone, Canis lupus familiaris(Dog) -> XP_005629980.1 Canis lupus familiaris beta-defensin 103 (CBD103), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe18411
Clone ID Related Accession (Same CDS sequence)	XM_005629923.2 , NM_001129980.1
Accession Version	XM_005629923.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 204bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	beta-defensin 14 isoform X2
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726088.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005629923.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATCT ATTACCTTCT CCTCCTGTTG CCCTTGCTGT TCTTGATGCC TGTTCCAGGA 
AATGGGGGAA TTATAAATAC CCTGCAGAGG TATTATTGCA GAATAAGGAG CGGTCGGTGC 
GCCTTGCTGA GCTGCCTGCC AAAGGAGGAG CAGATAGGCC GCTGTTCTTC CACTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005629980.1
CDS	377..580
Translation	MRIYYLLLLLPLLFLMPVPGNGGIINTLQRYYCRIRSGRCALLSCLPKEEQIGRCSSTGRKCCRRKK

Target ORF information:

RefSeq Version	XM_005629923.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris beta-defensin 103 (CBD103), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005629923.2

ORF Insert Sequence:

ATGAGGATCT ATTACCTTCT CCTCCTGTTG CCCTTGCTGT TCTTGATGCC TGTTCCAGGA 
AATGGGGGAA TTATAAATAC CCTGCAGAGG TATTATTGCA GAATAAGGAG CGGTCGGTGC 
GCCTTGCTGA GCTGCCTGCC AAAGGAGGAG CAGATAGGCC GCTGTTCTTC CACTGGCCGA 
AAATGCTGCC GAAGAAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
Animal genetics44(1)114-7(2013 Feb)
Ciampolini R,Cecchi F,Spaterna A,Bramante A,Bardet SM,Oulmouden A

Signature of balancing selection at the MC1R gene in Kunming dog populations.
PloS one8(2)e55469(2013)
Wang GD,Cheng LG,Fan RX,Irwin DM,Tang SS,Peng JG,Zhang YP

Activity, expression and genetic variation of canine ?-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs.
Journal of innate immunity4(3)248-59(2012)
Leonard BC,Marks SL,Outerbridge CA,Affolter VK,Kananurak A,Young A,Moore PF,Bannasch DL,Bevins CL

Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
The Journal of veterinary medical science73(7)853-8(2011 Jul)
Oguro-Okano M,Honda M,Yamazaki K,Okano K

Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.
Molecular immunology46(13)2449-55(2009 Aug)
van Damme CM,Willemse T,van Dijk A,Haagsman HP,Veldhuizen EJ

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CBD103 cDNA ORF clone, Canis lupus familiaris(Dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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