DDX10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DDX10
Entrez Gene ID	1662
Full Name	DEAD-box helicase 10
Synonyms	Dbp4,HRH-J8
General protein information	Preferred Names DEAD-box helicase 10 Names probable ATP-dependent RNA helicase DDX10 DDX10-NUP98 fusion protein type 2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 DEAD box protein 10 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q22.3
Summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008].
Disorder MIM:	601235

mRNA and Protein(s)

mRNA	Protein	Name
NM_004398.4	NP_004389.2	probable ATP-dependent RNA helicase DDX10
NM_004398.3	NP_004389.2	probable ATP-dependent RNA helicase DDX10

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DDX10	XP_001141618.1
Canis lupus familiaris (dog)	DDX10	XP_536583.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001057	XP_001230842.3
Mus musculus (house mouse)	Ddx10	NP_084212.2
Drosophila melanogaster (fruit fly)	CG5800	NP_573230.1
Caenorhabditis elegans (roundworm)	Y23H5B.6	NP_490989.1
Danio rerio (zebrafish)	ddx10	XP_001922220.1
Homo sapiens (human)	DDX10	NP_004389.2
Rattus norvegicus (Norway rat)	Ddx10	NP_001100290.1
Xenopus tropicalis (tropical clawed frog)	ddx10	NP_001096151.1
Bos taurus (cattle)	DDX10	NP_001070349.1
Gallus gallus (chicken)	DDX10	NP_001073193.1

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-?B pathway in ovarian cancer.
Gai M, Bo Q, Qi L
Biochemical and biophysical research communications469(4)1000-5(2016 Jan)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S
Journal of proteome research11(4)2533-43(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, in current study, we found a novel tumor suppressor, DDX10, is epigenetic silenced by miR-155-5p in ovarian cancer, and the down-regulated expression pattern of DDX10 promotes ovarian cancer proliferation through Akt/NF-kappaB pathway.
Title: Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-?B pathway in ovarian cancer.

A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

The 50S U3 snoRNP is an small subunit assembly intermediate that is likely recruited to the pre-rRNA through the RNA-binding proteins nucleolin and RRP5.[RRP5, DBP4]
Title: A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4.

The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.
Title: The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.

The following DDX10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DDX10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00566	NM_004398.4 Latest version!	Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$265.30 $379.00
View Old Accession Versions >>
OHu00566	NM_004398.3	Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DDX10 ( NM_004398.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004389.2 Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.

Price & Availability↑

CloneID	OHu00566
Clone ID Related Accession (Same CDS sequence)	NM_004398.4 , NM_004398.3
Accession Version	NM_004398.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	probable ATP-dependent RNA helicase DDX10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC401755.1 and BC091521.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004398.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.195133.1, BC091521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322536.8/ ENSP00000314348.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAAAA CGGCCAACTC TCCGGGTTCG GGAGCCCGAC CCGACCCGGT GCGGAGCTTC 
AATCGCTGGA AGAAAAAACA CAGCCATAGG CAGAACAAAA AGAAGCAGTT GAGGAAGCAA 
CTGAAGAAAC CCGAATGGCA GGTCGAGCGC GAGAGTATCA GCCGCCTCAT GCAGAACTAT 
GAAAAGATAA ATGTAAATGA AATCACAAGA TTTTCAGATT TTCCCTTGTC CAAAAAAACA 
TTGAAAGGTT TGCAAGAAGC TCAGTACCGT TTGGTGACTG AGATACAGAA GCAGACCATT 
GGATTGGCTT TGCAAGGTAA AGATGTACTT GGAGCGGCCA AAACTGGATC TGGCAAGACT 
CTGGCTTTTC TTGTTCCAGT GCTGGAAGCC TTATATCGTC TGCAATGGAC TTCAACAGAT 
GGGCTGGGGG TTCTCATAAT ATCACCTACG AGAGAACTGG CCTATCAGAC CTTTGAGGTT 
CTCCGAAAAG TAGGAAAGAA TCATGACTTC TCAGCTGGTC TCATCATTGG TGGAAAGGAT 
CTAAAACACG AAGCTGAGAG GATCAACAAC ATAAATATAC TCGTGTGCAC ACCAGGTCGG 
CTTCTTCAAC ACATGGATGA AACAGTATCT TTTCATGCTA CCGACCTCCA AATGTTAGTT 
CTTGATGAAG CAGATAGAAT CTTGGATATG GGCTTTGCTG ATACCATGAA TGCTGTTATT 
GAAAATCTCC CCAAGAAACG TCAGACTTTA CTTTTCTCAG CAACACAAAC TAAATCTGTA 
AAGGACCTTG CACGCTTGAG TTTGAAAAAC CCTGAGTATG TCTGGGTTCA TGAAAAAGCA 
AAATATAGCA CCCCTGCCAC TTTGGAACAG AACTACATAG TCTGTGAGCT GCAGCAAAAA 
ATAAGTGTGC TGTATTCCTT TTTGAGAAGC CATCTGAAGA AGAAGAGCAT TGTATTTTTT 
TCCAGTTGCA AAGAGGTCCA GTATCTGTAC CGAGTGTTTT GCCGGCTACG TCCTGGTGTT 
TCTATCCTTG CACTCCATGG TCGACAGCAG CAAATGAGAA GAATGGAAGT CTATAATGAG 
TTTGTCCGTA AGAGAGCTGC AGTACTCTTT GCTACTGATA TTGCAGCCAG GGGTCTGGAT 
TTCCCGGCCG TGAATTGGGT TCTTCAGTTT GATTGTCCTG AGGATGCCAA CACATATATT 
CACAGAGCAG GTAGAACTGC CAGGTACAAA GAGGATGGTG AAGCTTTGCT AATTTTGCTA 
CCCTCAGAAA AAGCTATGGT GCAGCAGCTT CTTCAGAAGA AAGTACCTGT GAAGGAAATC 
AAAATCAATC CAGAAAAACT TATAGATGTC CAGAAAAAAT TGGAATCTAT TTTAGCTCAA 
GATCAAGATT TAAAAGAAAG AGCTCAAAGG TGTTTCGTCT CCTATGTACG ATCTGTATAT 
CTGATGAAGG ATAAAGAAGT ATTTGATGTG AGCAAGTTAC CTATACCTGA ATATGCCCTG 
TCTCTTGGTC TTGCTGTGGC ACCACGCGTA AGATTTCTTC AGAAAATGCA GAAACAACCC 
ACCAAAGAAT TGGTAAGGAG CCAAGCCGAT AAAGTAATTG AGCCAAGGGC TCCCTCCCTC 
ACCAATGACG AAGTGGAAGA ATTTAGAGCC TACTTCAATG AGAAAATGTC CATCCTTCAA 
AAAGGTGGAA AAAGACTCGA AGGGACAGAG CACAGACAGG ATAATGATAC TGGTAATGAA 
GAACAGGAAG AAGAAGAAGA CGATGAAGAA GAAATGGAAG AGAAACTGGC AAAAGCAAAA 
GGATCTCAAG CCCCATCTCT TCCTAACACC AGTGAGGCAC AGAAGATCAA GGAAGTTCCT 
ACACAGTTCT TGGACAGAGA TGAGGAGGAA GAAGATGCTG ATTTCTTGAA GGTGAAGCGG 
CATAATGTGT TTGGATTGGA CCTTAAAGAC GAGAAAACAT TACAGAAGAA AGAACCTTCT 
AAATCCAGCA TCAAGAAAAA AATGACCAAA GTTGCAGAAG CAAAAAAAGT AATGAAGAGA 
AATTTTAAAG TGAATAAGAA GATAACATTT ACTGATGAAG GGGAGTTGGT TCAGCAGTGG 
CCACAAATGC AGAAATCTGC CATCAAGGAT GCTGAGGAAG ATGATGACAC AGGTGGTATC 
AACTTACATA AAGCAAAGGA AAGACTTCAG GAAGAGGACA AATTTGACAA AGAAGAATAT 
AGGAAAAAAA TTAAGGCAAA GCATCGGGAG AAAAGACTGA AAGAAAGGGA AGCCAGAAGA 
GAAGCCAACA AGAGACAAGC AAAGGCCAAA GATGAAGAGG AAGCCTTTCT GGATTGGAGT 
GATGATGATG ATGATGATGA TGATGGATTT GATCCAAGCA CACTCCCAGA TCCAGATAAA 
TACAGAAGCT CTGAAGATTC AGATAGTGAA GATATGGAAA ATAAAATAAG TGATACCAAG 
AAGAAGCAGG GGATGAAGAA GAGGAGCAAC AGTGAAGTGG AAGACGTGGG ACCAACAAGT 
CATAACAGAA AGAAGGCCAG GTGGGACACT TTAGAGCCTT TGGATACCGG CCTGTCTTTA 
GCAGAGGATG AAGAGCTGGT GTTACATCTG CTAAGAAGTC AAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004389.2
CDS	86..2713
Translation	MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPSKSSIKKKMTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAEDEELVLHLLRSQS

Target ORF information:

RefSeq Version	NM_004398.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004398.4

ORF Insert Sequence:

ATGGGCAAAA CGGCCAACTC TCCGGGTTCG GGAGCCCGAC CCGACCCGGT GCGGAGCTTC 
AATCGCTGGA AGAAAAAACA CAGCCATAGG CAGAACAAAA AGAAGCAGTT GAGGAAGCAA 
CTGAAGAAAC CCGAATGGCA GGTCGAGCGC GAGAGTATCA GCCGCCTCAT GCAGAACTAT 
GAAAAGATAA ATGTAAATGA AATCACAAGA TTTTCAGATT TTCCCTTGTC CAAAAAAACA 
TTGAAAGGTT TGCAAGAAGC TCAGTACCGT TTGGTGACTG AGATACAGAA GCAGACCATT 
GGATTGGCTT TGCAAGGTAA AGATGTACTT GGAGCGGCCA AAACTGGATC TGGCAAGACT 
CTGGCTTTTC TTGTTCCAGT GCTGGAAGCC TTATATCGTC TGCAATGGAC TTCAACAGAT 
GGGCTGGGGG TTCTCATAAT ATCACCTACG AGAGAACTGG CCTATCAGAC CTTTGAGGTT 
CTCCGAAAAG TAGGAAAGAA TCATGACTTC TCAGCTGGTC TCATCATTGG TGGAAAGGAT 
CTAAAACACG AAGCTGAGAG GATCAACAAC ATAAATATAC TCGTGTGCAC ACCAGGTCGG 
CTTCTTCAAC ACATGGATGA AACAGTATCT TTTCATGCTA CCGACCTCCA AATGTTAGTT 
CTTGATGAAG CAGATAGAAT CTTGGATATG GGCTTTGCTG ATACCATGAA TGCTGTTATT 
GAAAATCTCC CCAAGAAACG TCAGACTTTA CTTTTCTCAG CAACACAAAC TAAATCTGTA 
AAGGACCTTG CACGCTTGAG TTTGAAAAAC CCTGAGTATG TCTGGGTTCA TGAAAAAGCA 
AAATATAGCA CCCCTGCCAC TTTGGAACAG AACTACATAG TCTGTGAGCT GCAGCAAAAA 
ATAAGTGTGC TGTATTCCTT TTTGAGAAGC CATCTGAAGA AGAAGAGCAT TGTATTTTTT 
TCCAGTTGCA AAGAGGTCCA GTATCTGTAC CGAGTGTTTT GCCGGCTACG TCCTGGTGTT 
TCTATCCTTG CACTCCATGG TCGACAGCAG CAAATGAGAA GAATGGAAGT CTATAATGAG 
TTTGTCCGTA AGAGAGCTGC AGTACTCTTT GCTACTGATA TTGCAGCCAG GGGTCTGGAT 
TTCCCGGCCG TGAATTGGGT TCTTCAGTTT GATTGTCCTG AGGATGCCAA CACATATATT 
CACAGAGCAG GTAGAACTGC CAGGTACAAA GAGGATGGTG AAGCTTTGCT AATTTTGCTA 
CCCTCAGAAA AAGCTATGGT GCAGCAGCTT CTTCAGAAGA AAGTACCTGT GAAGGAAATC 
AAAATCAATC CAGAAAAACT TATAGATGTC CAGAAAAAAT TGGAATCTAT TTTAGCTCAA 
GATCAAGATT TAAAAGAAAG AGCTCAAAGG TGTTTCGTCT CCTATGTACG ATCTGTATAT 
CTGATGAAGG ATAAAGAAGT ATTTGATGTG AGCAAGTTAC CTATACCTGA ATATGCCCTG 
TCTCTTGGTC TTGCTGTGGC ACCACGCGTA AGATTTCTTC AGAAAATGCA GAAACAACCC 
ACCAAAGAAT TGGTAAGGAG CCAAGCCGAT AAAGTAATTG AGCCAAGGGC TCCCTCCCTC 
ACCAATGACG AAGTGGAAGA ATTTAGAGCC TACTTCAATG AGAAAATGTC CATCCTTCAA 
AAAGGTGGAA AAAGACTCGA AGGGACAGAG CACAGACAGG ATAATGATAC TGGTAATGAA 
GAACAGGAAG AAGAAGAAGA CGATGAAGAA GAAATGGAAG AGAAACTGGC AAAAGCAAAA 
GGATCTCAAG CCCCATCTCT TCCTAACACC AGTGAGGCAC AGAAGATCAA GGAAGTTCCT 
ACACAGTTCT TGGACAGAGA TGAGGAGGAA GAAGATGCTG ATTTCTTGAA GGTGAAGCGG 
CATAATGTGT TTGGATTGGA CCTTAAAGAC GAGAAAACAT TACAGAAGAA AGAACCTTCT 
AAATCCAGCA TCAAGAAAAA AATGACCAAA GTTGCAGAAG CAAAAAAAGT AATGAAGAGA 
AATTTTAAAG TGAATAAGAA GATAACATTT ACTGATGAAG GGGAGTTGGT TCAGCAGTGG 
CCACAAATGC AGAAATCTGC CATCAAGGAT GCTGAGGAAG ATGATGACAC AGGTGGTATC 
AACTTACATA AAGCAAAGGA AAGACTTCAG GAAGAGGACA AATTTGACAA AGAAGAATAT 
AGGAAAAAAA TTAAGGCAAA GCATCGGGAG AAAAGACTGA AAGAAAGGGA AGCCAGAAGA 
GAAGCCAACA AGAGACAAGC AAAGGCCAAA GATGAAGAGG AAGCCTTTCT GGATTGGAGT 
GATGATGATG ATGATGATGA TGATGGATTT GATCCAAGCA CACTCCCAGA TCCAGATAAA 
TACAGAAGCT CTGAAGATTC AGATAGTGAA GATATGGAAA ATAAAATAAG TGATACCAAG 
AAGAAGCAGG GGATGAAGAA GAGGAGCAAC AGTGAAGTGG AAGACGTGGG ACCAACAAGT 
CATAACAGAA AGAAGGCCAG GTGGGACACT TTAGAGCCTT TGGATACCGG CCTGTCTTTA 
GCAGAGGATG AAGAGCTGGT GTTACATCTG CTAAGAAGTC AAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DDX10 ( NM_004398.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004389.2 Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.

Price & Availability↑

CloneID	OHu00566
Clone ID Related Accession (Same CDS sequence)	NM_004398.4 , NM_004398.3
Accession Version	NM_004398.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	probable ATP-dependent RNA helicase DDX10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC401755.1 and BC091521.1. This sequence is a reference standard in the RefSeqGene project. On Sep 7, 2013 this sequence version replaced NM_004398.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC091521.1, SRR1803612.54218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAAA CGGCCAACTC TCCGGGTTCG GGAGCCCGAC CCGACCCGGT GCGGAGCTTC 
AATCGCTGGA AGAAAAAACA CAGCCATAGG CAGAACAAAA AGAAGCAGTT GAGGAAGCAA 
CTGAAGAAAC CCGAATGGCA GGTCGAGCGC GAGAGTATCA GCCGCCTCAT GCAGAACTAT 
GAAAAGATAA ATGTAAATGA AATCACAAGA TTTTCAGATT TTCCCTTGTC CAAAAAAACA 
TTGAAAGGTT TGCAAGAAGC TCAGTACCGT TTGGTGACTG AGATACAGAA GCAGACCATT 
GGATTGGCTT TGCAAGGTAA AGATGTACTT GGAGCGGCCA AAACTGGATC TGGCAAGACT 
CTGGCTTTTC TTGTTCCAGT GCTGGAAGCC TTATATCGTC TGCAATGGAC TTCAACAGAT 
GGGCTGGGGG TTCTCATAAT ATCACCTACG AGAGAACTGG CCTATCAGAC CTTTGAGGTT 
CTCCGAAAAG TAGGAAAGAA TCATGACTTC TCAGCTGGTC TCATCATTGG TGGAAAGGAT 
CTAAAACACG AAGCTGAGAG GATCAACAAC ATAAATATAC TCGTGTGCAC ACCAGGTCGG 
CTTCTTCAAC ACATGGATGA AACAGTATCT TTTCATGCTA CCGACCTCCA AATGTTAGTT 
CTTGATGAAG CAGATAGAAT CTTGGATATG GGCTTTGCTG ATACCATGAA TGCTGTTATT 
GAAAATCTCC CCAAGAAACG TCAGACTTTA CTTTTCTCAG CAACACAAAC TAAATCTGTA 
AAGGACCTTG CACGCTTGAG TTTGAAAAAC CCTGAGTATG TCTGGGTTCA TGAAAAAGCA 
AAATATAGCA CCCCTGCCAC TTTGGAACAG AACTACATAG TCTGTGAGCT GCAGCAAAAA 
ATAAGTGTGC TGTATTCCTT TTTGAGAAGC CATCTGAAGA AGAAGAGCAT TGTATTTTTT 
TCCAGTTGCA AAGAGGTCCA GTATCTGTAC CGAGTGTTTT GCCGGCTACG TCCTGGTGTT 
TCTATCCTTG CACTCCATGG TCGACAGCAG CAAATGAGAA GAATGGAAGT CTATAATGAG 
TTTGTCCGTA AGAGAGCTGC AGTACTCTTT GCTACTGATA TTGCAGCCAG GGGTCTGGAT 
TTCCCGGCCG TGAATTGGGT TCTTCAGTTT GATTGTCCTG AGGATGCCAA CACATATATT 
CACAGAGCAG GTAGAACTGC CAGGTACAAA GAGGATGGTG AAGCTTTGCT AATTTTGCTA 
CCCTCAGAAA AAGCTATGGT GCAGCAGCTT CTTCAGAAGA AAGTACCTGT GAAGGAAATC 
AAAATCAATC CAGAAAAACT TATAGATGTC CAGAAAAAAT TGGAATCTAT TTTAGCTCAA 
GATCAAGATT TAAAAGAAAG AGCTCAAAGG TGTTTCGTCT CCTATGTACG ATCTGTATAT 
CTGATGAAGG ATAAAGAAGT ATTTGATGTG AGCAAGTTAC CTATACCTGA ATATGCCCTG 
TCTCTTGGTC TTGCTGTGGC ACCACGCGTA AGATTTCTTC AGAAAATGCA GAAACAACCC 
ACCAAAGAAT TGGTAAGGAG CCAAGCCGAT AAAGTAATTG AGCCAAGGGC TCCCTCCCTC 
ACCAATGACG AAGTGGAAGA ATTTAGAGCC TACTTCAATG AGAAAATGTC CATCCTTCAA 
AAAGGTGGAA AAAGACTCGA AGGGACAGAG CACAGACAGG ATAATGATAC TGGTAATGAA 
GAACAGGAAG AAGAAGAAGA CGATGAAGAA GAAATGGAAG AGAAACTGGC AAAAGCAAAA 
GGATCTCAAG CCCCATCTCT TCCTAACACC AGTGAGGCAC AGAAGATCAA GGAAGTTCCT 
ACACAGTTCT TGGACAGAGA TGAGGAGGAA GAAGATGCTG ATTTCTTGAA GGTGAAGCGG 
CATAATGTGT TTGGATTGGA CCTTAAAGAC GAGAAAACAT TACAGAAGAA AGAACCTTCT 
AAATCCAGCA TCAAGAAAAA AATGACCAAA GTTGCAGAAG CAAAAAAAGT AATGAAGAGA 
AATTTTAAAG TGAATAAGAA GATAACATTT ACTGATGAAG GGGAGTTGGT TCAGCAGTGG 
CCACAAATGC AGAAATCTGC CATCAAGGAT GCTGAGGAAG ATGATGACAC AGGTGGTATC 
AACTTACATA AAGCAAAGGA AAGACTTCAG GAAGAGGACA AATTTGACAA AGAAGAATAT 
AGGAAAAAAA TTAAGGCAAA GCATCGGGAG AAAAGACTGA AAGAAAGGGA AGCCAGAAGA 
GAAGCCAACA AGAGACAAGC AAAGGCCAAA GATGAAGAGG AAGCCTTTCT GGATTGGAGT 
GATGATGATG ATGATGATGA TGATGGATTT GATCCAAGCA CACTCCCAGA TCCAGATAAA 
TACAGAAGCT CTGAAGATTC AGATAGTGAA GATATGGAAA ATAAAATAAG TGATACCAAG 
AAGAAGCAGG GGATGAAGAA GAGGAGCAAC AGTGAAGTGG AAGACGTGGG ACCAACAAGT 
CATAACAGAA AGAAGGCCAG GTGGGACACT TTAGAGCCTT TGGATACCGG CCTGTCTTTA 
GCAGAGGATG AAGAGCTGGT GTTACATCTG CTAAGAAGTC AAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004389.2
CDS	130..2757
Translation	MGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKVKRHNVFGLDLKDEKTLQKKEPSKSSIKKKMTKVAEAKKVMKRNFKVNKKITFTDEGELVQQWPQMQKSAIKDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAEDEELVLHLLRSQS

Target ORF information:

RefSeq Version	NM_004398.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DEAD-box helicase 10 (DDX10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004398.3

ORF Insert Sequence:

ATGGGCAAAA CGGCCAACTC TCCGGGTTCG GGAGCCCGAC CCGACCCGGT GCGGAGCTTC 
AATCGCTGGA AGAAAAAACA CAGCCATAGG CAGAACAAAA AGAAGCAGTT GAGGAAGCAA 
CTGAAGAAAC CCGAATGGCA GGTCGAGCGC GAGAGTATCA GCCGCCTCAT GCAGAACTAT 
GAAAAGATAA ATGTAAATGA AATCACAAGA TTTTCAGATT TTCCCTTGTC CAAAAAAACA 
TTGAAAGGTT TGCAAGAAGC TCAGTACCGT TTGGTGACTG AGATACAGAA GCAGACCATT 
GGATTGGCTT TGCAAGGTAA AGATGTACTT GGAGCGGCCA AAACTGGATC TGGCAAGACT 
CTGGCTTTTC TTGTTCCAGT GCTGGAAGCC TTATATCGTC TGCAATGGAC TTCAACAGAT 
GGGCTGGGGG TTCTCATAAT ATCACCTACG AGAGAACTGG CCTATCAGAC CTTTGAGGTT 
CTCCGAAAAG TAGGAAAGAA TCATGACTTC TCAGCTGGTC TCATCATTGG TGGAAAGGAT 
CTAAAACACG AAGCTGAGAG GATCAACAAC ATAAATATAC TCGTGTGCAC ACCAGGTCGG 
CTTCTTCAAC ACATGGATGA AACAGTATCT TTTCATGCTA CCGACCTCCA AATGTTAGTT 
CTTGATGAAG CAGATAGAAT CTTGGATATG GGCTTTGCTG ATACCATGAA TGCTGTTATT 
GAAAATCTCC CCAAGAAACG TCAGACTTTA CTTTTCTCAG CAACACAAAC TAAATCTGTA 
AAGGACCTTG CACGCTTGAG TTTGAAAAAC CCTGAGTATG TCTGGGTTCA TGAAAAAGCA 
AAATATAGCA CCCCTGCCAC TTTGGAACAG AACTACATAG TCTGTGAGCT GCAGCAAAAA 
ATAAGTGTGC TGTATTCCTT TTTGAGAAGC CATCTGAAGA AGAAGAGCAT TGTATTTTTT 
TCCAGTTGCA AAGAGGTCCA GTATCTGTAC CGAGTGTTTT GCCGGCTACG TCCTGGTGTT 
TCTATCCTTG CACTCCATGG TCGACAGCAG CAAATGAGAA GAATGGAAGT CTATAATGAG 
TTTGTCCGTA AGAGAGCTGC AGTACTCTTT GCTACTGATA TTGCAGCCAG GGGTCTGGAT 
TTCCCGGCCG TGAATTGGGT TCTTCAGTTT GATTGTCCTG AGGATGCCAA CACATATATT 
CACAGAGCAG GTAGAACTGC CAGGTACAAA GAGGATGGTG AAGCTTTGCT AATTTTGCTA 
CCCTCAGAAA AAGCTATGGT GCAGCAGCTT CTTCAGAAGA AAGTACCTGT GAAGGAAATC 
AAAATCAATC CAGAAAAACT TATAGATGTC CAGAAAAAAT TGGAATCTAT TTTAGCTCAA 
GATCAAGATT TAAAAGAAAG AGCTCAAAGG TGTTTCGTCT CCTATGTACG ATCTGTATAT 
CTGATGAAGG ATAAAGAAGT ATTTGATGTG AGCAAGTTAC CTATACCTGA ATATGCCCTG 
TCTCTTGGTC TTGCTGTGGC ACCACGCGTA AGATTTCTTC AGAAAATGCA GAAACAACCC 
ACCAAAGAAT TGGTAAGGAG CCAAGCCGAT AAAGTAATTG AGCCAAGGGC TCCCTCCCTC 
ACCAATGACG AAGTGGAAGA ATTTAGAGCC TACTTCAATG AGAAAATGTC CATCCTTCAA 
AAAGGTGGAA AAAGACTCGA AGGGACAGAG CACAGACAGG ATAATGATAC TGGTAATGAA 
GAACAGGAAG AAGAAGAAGA CGATGAAGAA GAAATGGAAG AGAAACTGGC AAAAGCAAAA 
GGATCTCAAG CCCCATCTCT TCCTAACACC AGTGAGGCAC AGAAGATCAA GGAAGTTCCT 
ACACAGTTCT TGGACAGAGA TGAGGAGGAA GAAGATGCTG ATTTCTTGAA GGTGAAGCGG 
CATAATGTGT TTGGATTGGA CCTTAAAGAC GAGAAAACAT TACAGAAGAA AGAACCTTCT 
AAATCCAGCA TCAAGAAAAA AATGACCAAA GTTGCAGAAG CAAAAAAAGT AATGAAGAGA 
AATTTTAAAG TGAATAAGAA GATAACATTT ACTGATGAAG GGGAGTTGGT TCAGCAGTGG 
CCACAAATGC AGAAATCTGC CATCAAGGAT GCTGAGGAAG ATGATGACAC AGGTGGTATC 
AACTTACATA AAGCAAAGGA AAGACTTCAG GAAGAGGACA AATTTGACAA AGAAGAATAT 
AGGAAAAAAA TTAAGGCAAA GCATCGGGAG AAAAGACTGA AAGAAAGGGA AGCCAGAAGA 
GAAGCCAACA AGAGACAAGC AAAGGCCAAA GATGAAGAGG AAGCCTTTCT GGATTGGAGT 
GATGATGATG ATGATGATGA TGATGGATTT GATCCAAGCA CACTCCCAGA TCCAGATAAA 
TACAGAAGCT CTGAAGATTC AGATAGTGAA GATATGGAAA ATAAAATAAG TGATACCAAG 
AAGAAGCAGG GGATGAAGAA GAGGAGCAAC AGTGAAGTGG AAGACGTGGG ACCAACAAGT 
CATAACAGAA AGAAGGCCAG GTGGGACACT TTAGAGCCTT TGGATACCGG CCTGTCTTTA 
GCAGAGGATG AAGAGCTGGT GTTACATCTG CTAAGAAGTC AAAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-?B pathway in ovarian cancer.
Biochemical and biophysical research communications469(4)1000-5(2016 Jan)
Gai M,Bo Q,Qi L

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Journal of proteome research11(4)2533-43(2012 Apr)
Martins-de-Souza D,Guest PC,Mann DM,Roeber S,Rahmoune H,Bauder C,Kretzschmar H,Volk B,Baborie A,Bahn S

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DDX10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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