TH cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	TH
Entrez Gene ID	395592
Full Name	tyrosine hydroxylase
General protein information	Preferred Names tyrosine hydroxylase Names tyrosine 3-monooxygenase
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204805.2	NP_990136.1	tyrosine 3-monooxygenase

Pathways from BioSystems

Homologies

Homo sapiens (human)	TH	NP_954987.2
Mus musculus (house mouse)	Th	NP_033403.1
Drosophila melanogaster (fruit fly)	ple	NP_476897.1
Bos taurus (cattle)	TH	NP_776309.1
Rattus norvegicus (Norway rat)	Th	NP_036872.1
	TH	XP_002799487.1
Canis lupus familiaris (dog)	TH	NP_001002966.1
Pan troglodytes (chimpanzee)	TH	XP_003312902.2
Gallus gallus (chicken)	TH	NP_990136.1
Danio rerio (zebrafish)	th	NP_571224.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006023	XP_316061.3
Xenopus tropicalis (tropical clawed frog)	LOC100488900	XP_002938944.2
Caenorhabditis elegans (roundworm)	cat-2	NP_001254009.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypothalamic vasotocin and tyrosine hydroxylase levels following maternal care and selection for low mortality in laying hens.
Hewlett SE, Zeinstra EC, van Eerdenburg FJ, Rodenburg T, van Kooten PJ, van der Staay F, Nordquist RE
BMC veterinary research10167(2014 Jul)

Effects of maternal care and selection for low mortality on tyrosine hydroxylase concentrations and cell soma size in hippocampus and nidopallium caudolaterale in adult laying hen.
Nordquist RE, Zeinstra EC, Rodenburg TB, van der Staay FJ
Journal of animal science91(1)137-46(2013 Jan)

Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation.
L?pez-S?nchez C, B?rtulos O, Mart?nez-Campos E, Ga??n C, Valenciano AI, Garc?a-Mart?nez V, De Pablo F, Hern?ndez-S?nchez C
Cardiovascular research88(1)111-20(2010 Oct)

The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells.
Ernsberger U, Patzke H, Tissier-Seta JP, Reh T, Goridis C, Rohrer H
Mechanisms of development52(1)125-36(1995 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The effect of foster hen rearing on the two genetic lines and their hypothalamic morphology, and the role of tyrosine hydroxylase and vasotocin levels in feather pecking, are reported.
Title: Hypothalamic vasotocin and tyrosine hydroxylase levels following maternal care and selection for low mortality in laying hens.

These results indicate that morphological changes in brain induced in very early life can be detected in adult hens, and that genetic selection against mortality due to cannibalism impacts tyrosine hydroxylase in the brain of laying hens.
Title: Effects of maternal care and selection for low mortality on tyrosine hydroxylase concentrations and cell soma size in hippocampus and nidopallium caudolaterale in adult laying hen.

TH is expressed in a dynamic pattern during the primitive heart tube formation. TH induces cardiac differentiation in vivo and it is a key regulator of the heart patterning, conferring atriogenic identity.
Title: Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation.

The following TH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26643	NM_204805.2 Latest version!	Gallus gallus tyrosine hydroxylase (TH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TH ( NM_204805.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990136.1 Gallus gallus tyrosine hydroxylase (TH), mRNA.

Price & Availability↑

CloneID	OGa26643
Clone ID Related Accession (Same CDS sequence)	NM_204805.2
Accession Version	NM_204805.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1476bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	tyrosine 3-monooxygenase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ251387.1. On Jan 7, 2015 this sequence version replaced NM_204805.1. ##Evidence-Data-START## Transcript exon combination :: AJ251387.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCAACCC CCAACATCTC CACCTCTGCA GCCAAAGGCT TCCGCAGGGC GGTGTCAGAG 
CTGGACTCCA AGCAAGCTGA GGCCATCATG TCTCCACGGT TCATTGGTAG ACGCCAAAGC 
CTCATTGAAG ATGCCAGGAA GGAACGAGAG GCTGCAGCTG CAGCCACCGA TGCTGCAGAG 
TCCACAGAGA CAATTGTTTT TGAGGAGAAG GACGGGAGAG CCATGCTGAA CCTGTTCTTC 
ATGCTCAAGG GTGCCAAGAC CTCTCCGCTC TCACGAGCGC TTAAGGTGTT TGAGACATTT 
GAAGCTAAAA TCCACCACTT GGAGACAAGA CTCAGCCGAA AGCCCCGTGA AGGGACTGCT 
GAACTGGAGT ATTTTGTGCG CTGTGAGGTG CACAGCTCTG ACCTCAATAC TTTCATTAGC 
TCCATCAAGA GGGTAGCAGA AGATGTGAGG ACCACTAAGG AAGACAAATT TCACTGGTTT 
CCCAGAAAAA TATGTGAACT GGACAAGTGT CACCATTTGG TCACAAAGTT TGACCCTGAC 
TTAGACTTGG ATCATCCGGG CTACTCTGAC CAGGTATATC GCCAGAGGAG GAAATCAATA 
GCAGAAATCG CTTTTCACTA TAAGCATGGG GACCCAATCC CTCGTGTGGA GTACACAGCA 
GAGGAGACTG CTACCTGGAA GGAGGTTTAC AGCACTCTGA AGAGCCTGTA TCCAACCCAT 
GCCTGCAAGG AGTACCTAGA AGCTTTTAAT CTACTGGAGA AATTCTGCGG CTACAATGAG 
AACAACATCC CCCAGCTGGA GGAGGTCTCC CGCTTCCTGA AAGAGAGGAC TGGCTTCCAG 
CTCCGGCCTG TGGCTGGCCT GTTGTCTGCA CGTGACTTCC TCGCCAGCCT GGCCTTCCGT 
GTGTTCCAGT GCACACAGTA TATCCGCCAC GCATCTTCGC CCATGCACTC CCCTGAGCCG 
GACTGCTGTC ATGAGCTACT GGGGCATGTC CCAATGCTGG CTGACAAGAC GTTTGCCCAG 
TTCTCCCAGG ACATTGGGCT TGCATCTCTG GGAGCAACTG ATGAAGAAAT TGAGAAACTG 
GCAACACTTT ACTGGTTTAC AGTGGAGTTT GGACTCTGCA GACAGAATGG GATAGTCAAA 
GCCTATGGGG CAGGGCTCCT GTCTTCCTAT GGGGAGCTCA TACACTCCTT GTCAGATGAA 
CCAGAGGTAC GAGACTTTGA TCCTGATGCT GCTGCAGTTC AGCCCTACCA GGACCAGAAC 
TACCAGCCTG TGTATTTTGT GTCTGAGAGC TTCAGTGATG CCAAAAACAA GCTGAGGAAC 
TACGCAGCAC ATATCAAGAG GCCCTTCTCA GTGAAATACG AGCCCTACAC CCACAGCATC 
GAGCTCCTGG ACAGCCCCCA GACCATCTGC CACTCCCTGG AGAGTGTAAG GGACGAGCTT 
CATTCGCTGA TTAACGCGCT CAATGTGATC AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990136.1
CDS	8..1483
Translation	MPTPNISTSAAKGFRRAVSELDSKQAEAIMSPRFIGRRQSLIEDARKEREAAAAATDAAESTETIVFEEKDGRAMLNLFFMLKGAKTSPLSRALKVFETFEAKIHHLETRLSRKPREGTAELEYFVRCEVHSSDLNTFISSIKRVAEDVRTTKEDKFHWFPRKICELDKCHHLVTKFDPDLDLDHPGYSDQVYRQRRKSIAEIAFHYKHGDPIPRVEYTAEETATWKEVYSTLKSLYPTHACKEYLEAFNLLEKFCGYNENNIPQLEEVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADKTFAQFSQDIGLASLGATDEEIEKLATLYWFTVEFGLCRQNGIVKAYGAGLLSSYGELIHSLSDEPEVRDFDPDAAAVQPYQDQNYQPVYFVSESFSDAKNKLRNYAAHIKRPFSVKYEPYTHSIELLDSPQTICHSLESVRDELHSLINALNVIS

Target ORF information:

RefSeq Version	NM_204805.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus tyrosine hydroxylase (TH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204805.2

ORF Insert Sequence:

ATGCCAACCC CCAACATCTC CACCTCTGCA GCCAAAGGCT TCCGCAGGGC GGTGTCAGAG 
CTGGACTCCA AGCAAGCTGA GGCCATCATG TCTCCACGGT TCATTGGTAG ACGCCAAAGC 
CTCATTGAAG ATGCCAGGAA GGAACGAGAG GCTGCAGCTG CAGCCACCGA TGCTGCAGAG 
TCCACAGAGA CAATTGTTTT TGAGGAGAAG GACGGGAGAG CCATGCTGAA CCTGTTCTTC 
ATGCTCAAGG GTGCCAAGAC CTCTCCGCTC TCACGAGCGC TTAAGGTGTT TGAGACATTT 
GAAGCTAAAA TCCACCACTT GGAGACAAGA CTCAGCCGAA AGCCCCGTGA AGGGACTGCT 
GAACTGGAGT ATTTTGTGCG CTGTGAGGTG CACAGCTCTG ACCTCAATAC TTTCATTAGC 
TCCATCAAGA GGGTAGCAGA AGATGTGAGG ACCACTAAGG AAGACAAATT TCACTGGTTT 
CCCAGAAAAA TATGTGAACT GGACAAGTGT CACCATTTGG TCACAAAGTT TGACCCTGAC 
TTAGACTTGG ATCATCCGGG CTACTCTGAC CAGGTATATC GCCAGAGGAG GAAATCAATA 
GCAGAAATCG CTTTTCACTA TAAGCATGGG GACCCAATCC CTCGTGTGGA GTACACAGCA 
GAGGAGACTG CTACCTGGAA GGAGGTTTAC AGCACTCTGA AGAGCCTGTA TCCAACCCAT 
GCCTGCAAGG AGTACCTAGA AGCTTTTAAT CTACTGGAGA AATTCTGCGG CTACAATGAG 
AACAACATCC CCCAGCTGGA GGAGGTCTCC CGCTTCCTGA AAGAGAGGAC TGGCTTCCAG 
CTCCGGCCTG TGGCTGGCCT GTTGTCTGCA CGTGACTTCC TCGCCAGCCT GGCCTTCCGT 
GTGTTCCAGT GCACACAGTA TATCCGCCAC GCATCTTCGC CCATGCACTC CCCTGAGCCG 
GACTGCTGTC ATGAGCTACT GGGGCATGTC CCAATGCTGG CTGACAAGAC GTTTGCCCAG 
TTCTCCCAGG ACATTGGGCT TGCATCTCTG GGAGCAACTG ATGAAGAAAT TGAGAAACTG 
GCAACACTTT ACTGGTTTAC AGTGGAGTTT GGACTCTGCA GACAGAATGG GATAGTCAAA 
GCCTATGGGG CAGGGCTCCT GTCTTCCTAT GGGGAGCTCA TACACTCCTT GTCAGATGAA 
CCAGAGGTAC GAGACTTTGA TCCTGATGCT GCTGCAGTTC AGCCCTACCA GGACCAGAAC 
TACCAGCCTG TGTATTTTGT GTCTGAGAGC TTCAGTGATG CCAAAAACAA GCTGAGGAAC 
TACGCAGCAC ATATCAAGAG GCCCTTCTCA GTGAAATACG AGCCCTACAC CCACAGCATC 
GAGCTCCTGG ACAGCCCCCA GACCATCTGC CACTCCCTGG AGAGTGTAAG GGACGAGCTT 
CATTCGCTGA TTAACGCGCT CAATGTGATC AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypothalamic vasotocin and tyrosine hydroxylase levels following maternal care and selection for low mortality in laying hens.
BMC veterinary research10167(2014 Jul)
Hewlett SE,Zeinstra EC,van Eerdenburg FJ,Rodenburg T,van Kooten PJ,van der Staay F,Nordquist RE

Effects of maternal care and selection for low mortality on tyrosine hydroxylase concentrations and cell soma size in hippocampus and nidopallium caudolaterale in adult laying hen.
Journal of animal science91(1)137-46(2013 Jan)
Nordquist RE,Zeinstra EC,Rodenburg TB,van der Staay FJ

Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation.
Cardiovascular research88(1)111-20(2010 Oct)
L?pez-S?nchez C,B?rtulos O,Mart?nez-Campos E,Ga??n C,Valenciano AI,Garc?a-Mart?nez V,De Pablo F,Hern?ndez-S?nchez C

The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells.
Mechanisms of development52(1)125-36(1995 Jul)
Ernsberger U,Patzke H,Tissier-Seta JP,Reh T,Goridis C,Rohrer H

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TH cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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