TH cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	TH
Entrez Gene ID	403444
Full Name	tyrosine hydroxylase
General protein information	Preferred Names tyrosine hydroxylase Names tyrosine 3-monooxygenase tyrosine 3-hydroxylase
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002966.1	NP_001002966.1	tyrosine 3-monooxygenase

Pathways from BioSystems

Homologies

Homo sapiens (human)	TH	NP_954987.2
Mus musculus (house mouse)	Th	NP_033403.1
Drosophila melanogaster (fruit fly)	ple	NP_476897.1
Bos taurus (cattle)	TH	NP_776309.1
Rattus norvegicus (Norway rat)	Th	NP_036872.1
	TH	XP_002799487.1
Canis lupus familiaris (dog)	TH	NP_001002966.1
Pan troglodytes (chimpanzee)	TH	XP_003312902.2
Gallus gallus (chicken)	TH	NP_990136.1
Danio rerio (zebrafish)	th	NP_571224.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006023	XP_316061.3
Xenopus tropicalis (tropical clawed frog)	LOC100488900	XP_002938944.2
Caenorhabditis elegans (roundworm)	cat-2	NP_001254009.1

Gene Ontology
Bibliography

Related articles in PubMed

DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.
Wan M, Hejjas K, Ronai Z, Elek Z, Sasvari-Szekely M, Champagne FA, Mikl?si A, Kubinyi E
Animal genetics44(6)717-27(2013 Dec)

Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
Kubinyi E, Vas J, Hejjas K, Ronai Z, Br?der I, Turcs?n B, Sasvari-Szekely M, Mikl?si A
PloS one7(1)e30271(2012)

Immunoreactivity and protein levels of olfactory marker protein and tyrosine hydroxylase are not changed in the dog main olfactory bulb during normal ageing.
Choi JH, Lee CH, Yoo KY, Kwon SH, Her S, Shin HC, Lee YL, Hwang IK, Lee IS, Won MH
Journal of comparative pathology142(2-3)147-56(2010 Feb-Apr)

Canine tyrosine hydroxylase (TH) gene and dopamine beta -hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds.
Takeuchi Y, Hashizume C, Chon EM, Momozawa Y, Masuda K, Kikusui T, Mori Y
The Journal of veterinary medical science67(9)861-7(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.
Title: DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.

Results indicate that the tyrosine hydroxylase intron 4 repeat polymorphism was related to the behavioural test scale.
Title: Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.

There was no significant age-related loss of TH immunoreactivity in the olfactory bulbs of dogs of different ages.
Title: Immunoreactivity and protein levels of olfactory marker protein and tyrosine hydroxylase are not changed in the dog main olfactory bulb during normal ageing.

The following TH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe33963	NM_001002966.1 Latest version!	Canis lupus familiaris tyrosine hydroxylase (TH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TH ( NM_001002966.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001002966.1 Canis lupus familiaris tyrosine hydroxylase (TH), mRNA.

Price & Availability↑

CloneID	OCe33963
Clone ID Related Accession (Same CDS sequence)	NM_001002966.1
Accession Version	NM_001002966.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Canis lupus familiaris(dog)
Product	tyrosine 3-monooxygenase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB097058.1. On Jan 12, 2005 this sequence version replaced XM_533203.1. ##Evidence-Data-START## Transcript exon combination :: AB097058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2240903 [ECO:0000348] ##Evidence-Data-END##

ATGCCCACTC CCAACACCGC CTCGCCGCAG GCCAAGGGCT TCCGCAGGGC TGTCTCGGAG 
CTGGACGCCA AGCAGGCCGA AGCCATCATG TCCCCGCGCT TCATCGGGCG GCGCCAGAGC 
CTCATTGAGG ACGCACGCAA GGAGCGAGAG AAAGCAGAGG CCGCGTCGGC TGCCTCCTCG 
GAGCCCGGAG ACCTCCTGGA GGCCGCGGTG TCCAAGGAGA AGGACGGGAA GGCCATGCTG 
AACTTGCTCT TCACCCTGCG GGGCGCCAAG ACCTCTTCGC TGTCCCGAGC CGTGAAGGCA 
TTTGAGACGT TTGAAGCCCA AATCCACCAT CTGGAGACCC GGCCCGTCCA GAGGCCACGG 
GCAGGGGGCC CCCACCTGGA GTACTTTGTG CGCTGTGAGG TGCCCAGTGC TGACCTGCCC 
GCCCTGCTCA GCTCCGTGCG CCGGGTGGCG GAGGATGTGC GTGGTGCCGG GGAGAACAAG 
GTCCTCTGGT TCCCAAGGAA AGTTTCTGAG CTGGACAAGT GCCACCATCT AGTCACCAAG 
TTTGACCCTG ACCTGGACTT GGATCACCCG GGCTTCTCGG ACCAGGTGTA CCGCCAGCGC 
AGGAAGCTGA TTGCAGAGAT CGCATTCCAA TACAAGCATG GTGACCCCAT TCCCCGAGTG 
GAGTACACGG CCGAGGAGAT TGCCACCTGG AAGGAGGTCT ACACCACCCT GAAAAGCCTG 
TATGTGACCC ATGCCTGCCG GGAGCACCTG GAGGCCTTCC AGCTGCTGGA GCGCTTCAGC 
GGGTACCGTG AGGACAGCAT CCCCCAGCTG GAGGACGTGT CCCGCTTCCT GAAGGAGCGG 
ACAGGCTTCC AGCTGCGGCC CGTGGCCGGT CTGCTGTCCG CAAGGGACTT CCTGGCCAGC 
CTGGCCTTCC GAGTGTTCCA GTGCACGCAG TACATCCGGC ACGCGTCCTC ACCCATGCAC 
TCCCCCGAGC CGGACTGCTG TCATGAGCTG CTGGGGCACG TGCCCATGCT GGCTGACCGG 
ACCTTCGCTC AGTTTTCCCA GGACATTGGG CTCGCGTCCT TGGGGGCTTC TGATGAGGAA 
ATTGAGAAGC TGTCCACGCT GTACTGGTTC ACAGTGGAGT TCGGGCTGTG CAAGCAGAAT 
GGTGAGGTGA AGGCCTATGG CGCTGGGCTG CTGTCCTCCT ACGGGGAGCT CCTGCACTCC 
CTGTCTGAGG AGCCCGAGAT CCGGGCCTTC GACCCAGACG CTGCGGCCGT GCAGCCTTAC 
CAGGACCAGA CCTACCAGTC GGTCTACTTT GTGTCTGAAA GCTTCAGCGA TGCCAAGGAC 
AAGCTCAGGA ACTACGCTTC CCGCATCCAA CGCCCCTTCT CCGTGAAGTT CGACCCATAT 
ACGCTGGCCA TCGACGTGCT GGACAGTCCC CACGCCATCC GGCGCTCGCT GGAGGGGGTC 
CAGGACGAGC TGCACACCCT CGCCCATGCG CTCAGCGCCA TCGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002966.1
CDS	1..1488
Translation	MPTPNTASPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAASAASSEPGDLLEAAVSKEKDGKAMLNLLFTLRGAKTSSLSRAVKAFETFEAQIHHLETRPVQRPRAGGPHLEYFVRCEVPSADLPALLSSVRRVAEDVRGAGENKVLWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYTTLKSLYVTHACREHLEAFQLLERFSGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQPYQDQTYQSVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRSLEGVQDELHTLAHALSAIG

Target ORF information:

RefSeq Version	NM_001002966.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris tyrosine hydroxylase (TH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002966.1

ORF Insert Sequence:

ATGCCCACTC CCAACACCGC CTCGCCGCAG GCCAAGGGCT TCCGCAGGGC TGTCTCGGAG 
CTGGACGCCA AGCAGGCCGA AGCCATCATG TCCCCGCGCT TCATCGGGCG GCGCCAGAGC 
CTCATTGAGG ACGCACGCAA GGAGCGAGAG AAAGCAGAGG CCGCGTCGGC TGCCTCCTCG 
GAGCCCGGAG ACCTCCTGGA GGCCGCGGTG TCCAAGGAGA AGGACGGGAA GGCCATGCTG 
AACTTGCTCT TCACCCTGCG GGGCGCCAAG ACCTCTTCGC TGTCCCGAGC CGTGAAGGCA 
TTTGAGACGT TTGAAGCCCA AATCCACCAT CTGGAGACCC GGCCCGTCCA GAGGCCACGG 
GCAGGGGGCC CCCACCTGGA GTACTTTGTG CGCTGTGAGG TGCCCAGTGC TGACCTGCCC 
GCCCTGCTCA GCTCCGTGCG CCGGGTGGCG GAGGATGTGC GTGGTGCCGG GGAGAACAAG 
GTCCTCTGGT TCCCAAGGAA AGTTTCTGAG CTGGACAAGT GCCACCATCT AGTCACCAAG 
TTTGACCCTG ACCTGGACTT GGATCACCCG GGCTTCTCGG ACCAGGTGTA CCGCCAGCGC 
AGGAAGCTGA TTGCAGAGAT CGCATTCCAA TACAAGCATG GTGACCCCAT TCCCCGAGTG 
GAGTACACGG CCGAGGAGAT TGCCACCTGG AAGGAGGTCT ACACCACCCT GAAAAGCCTG 
TATGTGACCC ATGCCTGCCG GGAGCACCTG GAGGCCTTCC AGCTGCTGGA GCGCTTCAGC 
GGGTACCGTG AGGACAGCAT CCCCCAGCTG GAGGACGTGT CCCGCTTCCT GAAGGAGCGG 
ACAGGCTTCC AGCTGCGGCC CGTGGCCGGT CTGCTGTCCG CAAGGGACTT CCTGGCCAGC 
CTGGCCTTCC GAGTGTTCCA GTGCACGCAG TACATCCGGC ACGCGTCCTC ACCCATGCAC 
TCCCCCGAGC CGGACTGCTG TCATGAGCTG CTGGGGCACG TGCCCATGCT GGCTGACCGG 
ACCTTCGCTC AGTTTTCCCA GGACATTGGG CTCGCGTCCT TGGGGGCTTC TGATGAGGAA 
ATTGAGAAGC TGTCCACGCT GTACTGGTTC ACAGTGGAGT TCGGGCTGTG CAAGCAGAAT 
GGTGAGGTGA AGGCCTATGG CGCTGGGCTG CTGTCCTCCT ACGGGGAGCT CCTGCACTCC 
CTGTCTGAGG AGCCCGAGAT CCGGGCCTTC GACCCAGACG CTGCGGCCGT GCAGCCTTAC 
CAGGACCAGA CCTACCAGTC GGTCTACTTT GTGTCTGAAA GCTTCAGCGA TGCCAAGGAC 
AAGCTCAGGA ACTACGCTTC CCGCATCCAA CGCCCCTTCT CCGTGAAGTT CGACCCATAT 
ACGCTGGCCA TCGACGTGCT GGACAGTCCC CACGCCATCC GGCGCTCGCT GGAGGGGGTC 
CAGGACGAGC TGCACACCCT CGCCCATGCG CTCAGCGCCA TCGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.
Animal genetics44(6)717-27(2013 Dec)
Wan M,Hejjas K,Ronai Z,Elek Z,Sasvari-Szekely M,Champagne FA,Mikl?si A,Kubinyi E

Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
PloS one7(1)e30271(2012)
Kubinyi E,Vas J,Hejjas K,Ronai Z,Br?der I,Turcs?n B,Sasvari-Szekely M,Mikl?si A

Immunoreactivity and protein levels of olfactory marker protein and tyrosine hydroxylase are not changed in the dog main olfactory bulb during normal ageing.
Journal of comparative pathology142(2-3)147-56(2010 Feb-Apr)
Choi JH,Lee CH,Yoo KY,Kwon SH,Her S,Shin HC,Lee YL,Hwang IK,Lee IS,Won MH

Canine tyrosine hydroxylase (TH) gene and dopamine beta -hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds.
The Journal of veterinary medical science67(9)861-7(2005 Sep)
Takeuchi Y,Hashizume C,Chon EM,Momozawa Y,Masuda K,Kikusui T,Mori Y

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TH cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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