Th cDNA ORF clone, Rattus norvegicus(Norway rat)

Activation of the HMGB1-RAGE axis upregulates TH expression in dopaminergic neurons via JNK phosphorylation.
Kim SJ, Ryu MJ, Han J, Jang Y, Kim J, Lee MJ, Ryu I, Ju X, Oh E, Chung W, Kweon GR, Heo JY
Biochemical and biophysical research communications493(1)358-364(2017 11)

Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity.
Janenaite E, Vengeliene V, Bespalov A, Behl B
Behavioural brain research334105-108(2017 09)

Reduced TH expression and ?-synuclein accumulation contribute towards nigrostriatal dysfunction in experimental hepatic encephalopathy.
Su?rez I, Bodega G, Rubio M, Fern?ndez B
Restorative neurology and neuroscience35(5)469-481(2017)

Our results suggest that HMGB1 upregulates TH expression to maintain dopaminergic neuronal function via activating RAGE, which is dependent on JNK phosphorylation.
Title: Activation of the HMGB1-RAGE axis upregulates TH expression in dopaminergic neurons via JNK phosphorylation.

Objective of the present study was to determine whether the lack of activity-stimulating effects of amphetamine in hyperactive rats is associated with changes in tyrosine hydroxylase (TH) activity. Study confirmed that changes in TH activity may be causally involved in the loss of amphetamine's locomotor-stimulating effects under conditions of impaired DAT activity.
Title: Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity.

Data suggest that TH phosphorylated at Ser-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
Title: Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.

tyrosine hydroxylase and dopamine beta-hydroxylase-was evaluated in the organ of Zuckerkandl of rats in the critical period of morphogenesis
Title: Gene expression and content of enzymes of noradrenaline synthesis in the rat organ of Zuckerkandl at the critical period of morphogenesis.

Study compared showing a clear-cut profile of either gambling proneness or aversion, found a selective down-regulation of i) serotonin transporter in prefrontal cortex, ii) tyrosine hydroxylase in ventral striatum, iii) dopamine transporter in lymphocytes was evidenced in "gambler" vs "non-gambler" rats.
Title: Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms.