Anti-Rituximab Antibody (6C1), MAb, Mouse

ELISA binding of Anti-Rituximab Antibody (6C1) (GenScript, A01969-40) with Rituximab. While the antibody does not recognize the human IgG (data not shown).Coating antigen: Rituximab, 1 µg/ml.
Anti-Rituximab Antibody (6C1) (GenScript, A01969-40) dilutions start from 2,000 ng/ml.
EC₅₀= 7.819 ng/ml.

Standard curve of Rituximab Sandwich ELISA. The Rituximab Sandwich ELISA assay is developed by using Anti-Rituximab Antibody (6C1), mAb, Mouse (GenScript, A01969-40) and Anti-Rituximab Antibody (17B6), mAb, Mouse (GenScript, A01970-40) as the capture and detection antibodies, respectively.
In this ELISA assay, Anti-Rituximab Antibody (17B6), mAb, Mouse (GenScript, A01970-40) was labeled with Biotin. GenScript can provide customized conjugation services for this product per customer's request.
The sensitivity is less than 1 ng/ml.

Anti-Rituximab Antibody (6C1), mAb, Mouse

The product is specific for Rituximab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01970-40, Anti-Rituximab Antibody (17B6), mAb, Mouse.

Cat. No.	A01969
Size	40 μg Customized Size
Quantity
Price	¥25,548.00


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Overview

Specificity	The product is specific for Rituximab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01970-40, Anti-Rituximab Antibody (17B6), mAb, Mouse.
Host Species	Mouse
Immunogen	Rituximab
Conjugate	Unconjugated

Applications

Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

Application	Recommended Usage
ELISA	0.01-0.1 µg/ml

Properties

Form	Lyophilized
Storage Buffer	lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/mL.
Storage Instructions	The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
Purification	Protein A affinity column
Isotype	Mouse IgG1
Clonality	Monoclonal
Clone ID	6C1
Note	GenScript can customize this product per customer's request including product size, buffer components, etc.

Examples

Background

Target Background

Rituximab (Rituxan) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of hematological cancers and autoimmune diseases. When Rituximab binds to CD20 on the surface of normal and malignant B cells, natural killer (NK) cells is activated to destroy these B cells. It is therefore used to treat diseases with too many B cells, overactive B cells, or dysfunctional B cells. Anti-Rituximab Antibody (6C1), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Rituximab.

Synonyms

Mouse monoclonal to Rituxan

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

Anti-Rituximab Antibody (6C1), mAb, Mouse

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