Gene Symbol | POL2 |
Entrez Gene ID | 855459 |
Full Name | DNA polymerase epsilon catalytic subunit |
Synonyms | DUN2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » POL2 cDNA ORF clone
Gene Symbol | POL2 |
Entrez Gene ID | 855459 |
Full Name | DNA polymerase epsilon catalytic subunit |
Synonyms | DUN2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183100.1 | NP_014137.1 | DNA polymerase epsilon catalytic subunit |
Danio rerio (zebrafish) | pole | NP_001121995.1 |
Arabidopsis thaliana (thale cress) | TIL2 | NP_180280.2 |
Arabidopsis thaliana (thale cress) | TIL1 | NP_172303.5 |
Oryza sativa (rice) | Os02g0511900 | NP_001046939.2 |
Caenorhabditis elegans (roundworm) | F33H2.5 | NP_493616.1 |
Canis lupus familiaris (dog) | POLE | XP_543348.3 |
Mus musculus (house mouse) | Pole | NP_035262.2 |
Kluyveromyces lactis | KLLA0C02585g | XP_452312.1 |
Neurospora crassa | NCU04548 | XP_955939.2 |
Xenopus tropicalis (tropical clawed frog) | pole | XP_004910692.1 |
Drosophila melanogaster (fruit fly) | DNApol-epsilon | NP_524462.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004615 | XP_315205.4 |
Saccharomyces cerevisiae (baker's yeast) | POL2 | NP_014137.1 |
Eremothecium gossypii | AGOS_AFR657C | NP_986205.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_03850 | XP_003720041.1 |
Homo sapiens (human) | POLE | NP_006222.2 |
Pan troglodytes (chimpanzee) | POLE | XP_522564.4 |
Bos taurus (cattle) | POLE | NP_001178358.1 |
Rattus norvegicus (Norway rat) | Pole | NP_001100622.2 |
Gallus gallus (chicken) | POLE | XP_004934482.1 |
Schizosaccharomyces pombe (fission yeast) | cdc20 | NP_596354.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.
Philippsen P, Kleine K, P?hlmann R, D?sterh?ft A, Hamberg K, Hegemann JH, Obermaier B, Urrestarazu LA, Aert R, Albermann K, Altmann R, Andr? B, Baladron V, Ballesta JP, B?cam AM, Beinhauer J, Boskovic J, Buitrago MJ, Bussereau F, Coster F, Crouzet M, D'Angelo M, Dal Pero F, De Antoni A, Del Rey F, Doignon F, Domdey H, Dubois E, Fiedler T, Fleig U, Floeth M, Fritz C, Gaillardin C, Garcia-Cantalejo JM, Glansdorff NN, Goffeau A, Gueldener U, Herbert C, Heumann K, Heuss-Neitzel D, Hilbert H, Hinni K, Iraqui Houssaini I, Jacquet M, Jimenez A, Jonniaux JL, Karpfinger L, Lanfranchi G, Lepingle A, Levesque H, Lyck R, Maftahi M, Mallet L, Maurer KC, Messenguy F, Mewes HW, M?sti D, Nasr F, Nicaud JM, Niedenthal RK, Pandolfo D, Pi?rard A, Piravandi E, Planta RJ, Pohl TM, Purnelle B, Rebischung C, Remacha M, Revuelta JL, Rinke M, Saiz JE, Sartorello F, Scherens B, Sen-Gupta M, Soler-Mira A, Urbanus JH, Valle G, Van Dyck L, Verhasselt P, Vierendeels F, Vissers S, Voet M, Volckaert G, Wach A, Wambutt R, Wedler H, Zollner A, Hani J
Nature387(6632 Suppl)93-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants en masse.Our structural genetics approach incorporates structural and phenotypic data for high-resolution dissection of transcription mechanisms and their evolution, and is readily applicable to other essential yeast proteins.
Title: High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop.
By detecting Pol2 and Msh2 dynamics within the same strain, we established that the mismatch recognition complex binds origins and spreads to adjacent regions with the replisome.
Title: The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.
dNTP pool levels correlate with Pol epsilon mutator severity
Title: dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ? variants.
Study finds that wild-type Pol epsilon molecules cannot proofread errors created by proofreading-defective Pol epsilon molecules, whereas Pol delta can not only proofread errors created by proofreading-defective Pol delta molecules, but can also proofread errors created by Pol epsilon-defective molecules.
Title: Replicative DNA polymerase ? but not ? proofreads errors in Cis and in Trans.
Data suggest that DNA-directed DNA polymerase Pols alpha and delta are the primary lagging-strand replicases and Pol epsilon is primarily a leading-strand replicase.
Title: Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.
The following POL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04387 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183100.1 | |
Accession Version | NM_001183100.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 6669bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | DNA polymerase epsilon catalytic subunit | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001146). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGATGTTTG GCAAGAAAAA AAACAACGGA GGATCTTCCA CTGCAAGATA TTCAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_014137.1 |
CDS | 1..6669 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183100.1 |
1 | ATGATGTTTG GCAAGAAAAA AAACAACGGA GGATCTTCCA CTGCAAGATA TTCAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. |
Life with 6000 genes. |