Actn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Actn1
Entrez Gene ID	81634
Full Name	actinin, alpha 1
General protein information	Preferred Names actinin, alpha 1 Names alpha-actinin-1 F-actin cross-linking protein alpha-actinin cytoskeletal isoform non-muscle alpha-actinin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_031005.3	NP_112267.1	alpha-actinin-1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ACTN1	XP_001139826.3
Mus musculus (house mouse)	Actn1	NP_598917.1
Homo sapiens (human)	ACTN1	NP_001123476.1
Canis lupus familiaris (dog)	ACTN1	XP_853103.1
Bos taurus (cattle)	ACTN1	NP_001030428.1
Xenopus tropicalis (tropical clawed frog)	actn1	NP_001072666.1
Rattus norvegicus (Norway rat)	Actn1	NP_112267.1
Gallus gallus (chicken)	ACTN1	NP_989458.1
Danio rerio (zebrafish)	actn1	NP_001161758.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuregulin-1? induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors.
Hao J, Galindo CL, Tran TL, Sawyer DB
The Biochemical journal458(2)335-41(2014 Mar)

Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity.
Ogneva IV, Biryukov NS, Leinsoo TA, Larina IM
PloS one9(4)e96395(2014)

A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family.
Gu?guen P, Rouault K, Chen JM, Ragu?n?s O, Fichou Y, Hardy E, Gobin E, Pan-Petesch B, Kerbiriou M, Trouv? P, Marcorelles P, Abgrall JF, Le Mar?chal C, F?rec C
PloS one8(9)e74728(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

After 6 hours of antiorthostatic suspension alpha-actinin 1 and alpha-actinin 4 levels decreased in the membranous fraction of proteins of cardiomyocytes and soleus muscle fibers.
Title: Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity.

The alpha-actinin-1 form a complex with CLP36 and RIL.
Title: CLP36 and RIL recruit ?-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts.

Desmin and alpha-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
Title: Desmin and ?-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.

Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue, and show intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients.
Title: Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy.

Alpha-Actinin mediates the formation of the template and organization of adhesions associated with actin filaments, suggesting that actin crosslinking has a major role in this process.
Title: Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner.

The following Actn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Actn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07340	NM_031005.3 Latest version!	Rattus norvegicus actinin, alpha 1 (Actn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$524.30 $749.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Actn1 ( NM_031005.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112267.1 Rattus norvegicus actinin, alpha 1 (Actn1), mRNA.

Price & Availability↑

CloneID	ORa07340
Clone ID Related Accession (Same CDS sequence)	NM_031005.3
Accession Version	NM_031005.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2679bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	alpha-actinin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF115386.1. On Aug 12, 2007 this sequence version replaced NM_031005.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF115386.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCATT ATGATTCCCA GCAGACCAAT GACTATATGC AGCCTGAAGA GGACTGGGAC 
CGGGACCTGC TCCTGGATCC GGCCTGGGAG AAGCAGCAGA GAAAGACCTT CACGGCCTGG 
TGCAACTCCC ACCTGCGCAA AGCAGGGACC CAGATTGAGA ACATTGAAGA GGACTTCCGA 
GATGGCCTGA AGCTCATGCT GCTCCTGGAG GTCATCTCAG GTGAGCGTTT GGCCAAGCCA 
GAGAGAGGCA AGATGCGAGT GCACAAGATC TCCAACGTCA ACAAGGCCCT GGATTTCATA 
GCCAGCAAAG GGGTCAAGCT GGTGTCCATT GGAGCTGAAG AAATTGTGGA CGGGAATGTG 
AAGATGACCC TGGGCATGAT CTGGACCATC ATCCTTCGTT TTGCCATCCA AGACATCTCT 
GTGGAAGAGA CATCAGCTAA AGAAGGGTTG CTCCTGTGGT GTCAGAGGAA GACAGCCCCA 
TATAAAAATG TCAACATCCA AAACTTCCAC ATCAGTTGGA AGGATGGTCT TGGTTTCTGT 
GCCTTGATCC ACCGGCACCG GCCCGAGTTG ATTGACTATG GAAAGCTTCG AAAGGATGAT 
CCACTCACAA ACCTGAACAC AGCCTTTGAT GTGGCAGAGA GATACCTGGA CATTCCAAAG 
ATGCTGGATG CAGAAGACAT CGTCGGAACT GCCCGGCCAG ATGAGAAAGC CATTATGACC 
TATGTGTCTA GCTTCTACCA TGCCTTCTCT GGAGCCCAGA AGGCGGAAAC AGCAGCCAAT 
CGCATCTGTA AAGTGTTGGC CGTCAATCAA GAGAATGAAC AGCTTATGGA AGACTATGAG 
AAGCTGGCCA GTGATCTGTT AGAGTGGATC CGCCGCACCA TCCCATGGCT GGAGAATCGG 
GTGCCCGAGA ACACCATGCA GGCCATGCAG CAGAAGCTGG AGGACTTCCG AGACTACCGA 
CGCCTGCACA AGCCGCCCAA GGTGCAGGAG AAGTGCCAGC TGGAGATCAA CTTCAACACA 
CTGCAGACCA AGCTGCGGCT AAGCAACCGG CCTGCCTTCA TGCCCTCCGA GGGCAGGATG 
GTCTCGGATA TCAACAATGC CTGGGGCTGC CTGGAACAGG CAGAGAAGGG CTACGAGGAG 
TGGTTGCTGA ATGAGATCCG GAGGCTAGAG AGGTTGGACC ACCTGGCAGA GAAGTTCCGG 
CAGAAGGCCT CCATCCATGA AGCCTGGACA GACGGCAAAG AAGCCATGCT GCGGCAGAAG 
GATTATGAGA CGGCCACCTT GTCCGAGATC AAGGCCCTAC TCAAGAAGCA CGAGGCCTTT 
GAGAGTGACC TGGCTGCCCA CCAGGACCGC GTGGAGCAGA TCGCGGCCAT TGCCCAGGAG 
CTTAATGAGC TGGACTATTA TGACTCACCA AGTGTCAACG CTCGATGCCA AAAGATCTGT 
GACCAGTGGG ACAATCTAGG GGCCCTGACT CAGAAGCGGA GGGAAGCTTT AGAGCGAACA 
GAGAAGCTGC TGGAGACCAT CGACCAGCTA TACTTGGAGT ACGCCAAGAG GGCTGCACCC 
TTCAACAACT GGATGGAGGG AGCCATGGAG GACCTTCAAG ACACCTTCAT CGTACATACC 
ATTGAGGAGA TCCAGGGACT GACCACAGCC CATGAGCAGT TCAAGGCTAC CCTCCCGGAT 
GCAGACAAGG AGCGCCTGGC CATCCTGGGC ATCCACAATG AAGTGTCCAA GATTGTCCAG 
ACCTATCATG TCAACATGGC AGGCACCAAC CCCTATACAA CCATCACACC TCAGGAGATC 
AATGGCAAAT GGGACCATGT ACGGCAGCTG GTGCCCCGGA GGGACCAGGC TCTAACAGAG 
GAGCACTCGA GGCAGCAGCA CAACGAGAGG TTACGCAAGC AGTTTGGGGC ACAAGCCAAT 
GTCATCGGAC CCTGGATCCA GACCAAGATG GAGGAGATTG GGAGGATCTC CATTGAGATG 
CACGGTACCC TGGAGGACCA ACTCAGCCAC CTGCGGCAGT ATGAAAAGAG CATCGTCAAT 
TATAAGCCAA AGATTGACCA GCTGGAGGGC GACCACCAGC TCATCCAGGA AGCACTTATC 
TTCGACAATA AGCACACCAA CTACACAATG GAGCACATCC GTGTGGGCTG GGAGCAGCTG 
CTCACCACCA TTGCCAGGAC CATCAATGAA GTGGAGAACC AGATCTTGAC CCGGGATGCC 
AAAGGCATCA GCCAGGAACA GATGAACGAA TTCCGGGCCT CCTTCAACCA CTTTGACCGG 
GATCACTCCG GCACGTTGGG TCCCGAAGAG TTCAAAGCCT GCCTCATCAG CTTGGGTTAT 
GATATTGGCA ACGACCCCCA GGGAGAGGCA GAATTTGCCC GGATCATGAG CATTGTAGAC 
CCCAACCGCT TGGGGGTAGT GACATTCCAG GCCTTCATCG ACTTCATGTC CCGAGAGACG 
GCTGACACAG ATACAGCGGA TCAGGTCATG GCTTCCTTCA AGATCCTGGC TGGAGATAAG 
AATTACATCA CCGGGGATGA GCTGCGCCGC GAGCTGCCAC CTGACCAAGC CGAGTACTGC 
ATCGCGAGAA TGGCCCCCTA CGCGGGCCCT GACTCCGTGC CGGGTGCTCT AGACTACATG 
TCCTTCTCCA CGGCGCTGTA CGGCGAGAGT GACCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112267.1
CDS	210..2888
Translation	MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL

Target ORF information:

RefSeq Version	NM_031005.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus actinin, alpha 1 (Actn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031005.3

ORF Insert Sequence:

ATGGACCATT ATGATTCCCA GCAGACCAAT GACTATATGC AGCCTGAAGA GGACTGGGAC 
CGGGACCTGC TCCTGGATCC GGCCTGGGAG AAGCAGCAGA GAAAGACCTT CACGGCCTGG 
TGCAACTCCC ACCTGCGCAA AGCAGGGACC CAGATTGAGA ACATTGAAGA GGACTTCCGA 
GATGGCCTGA AGCTCATGCT GCTCCTGGAG GTCATCTCAG GTGAGCGTTT GGCCAAGCCA 
GAGAGAGGCA AGATGCGAGT GCACAAGATC TCCAACGTCA ACAAGGCCCT GGATTTCATA 
GCCAGCAAAG GGGTCAAGCT GGTGTCCATT GGAGCTGAAG AAATTGTGGA CGGGAATGTG 
AAGATGACCC TGGGCATGAT CTGGACCATC ATCCTTCGTT TTGCCATCCA AGACATCTCT 
GTGGAAGAGA CATCAGCTAA AGAAGGGTTG CTCCTGTGGT GTCAGAGGAA GACAGCCCCA 
TATAAAAATG TCAACATCCA AAACTTCCAC ATCAGTTGGA AGGATGGTCT TGGTTTCTGT 
GCCTTGATCC ACCGGCACCG GCCCGAGTTG ATTGACTATG GAAAGCTTCG AAAGGATGAT 
CCACTCACAA ACCTGAACAC AGCCTTTGAT GTGGCAGAGA GATACCTGGA CATTCCAAAG 
ATGCTGGATG CAGAAGACAT CGTCGGAACT GCCCGGCCAG ATGAGAAAGC CATTATGACC 
TATGTGTCTA GCTTCTACCA TGCCTTCTCT GGAGCCCAGA AGGCGGAAAC AGCAGCCAAT 
CGCATCTGTA AAGTGTTGGC CGTCAATCAA GAGAATGAAC AGCTTATGGA AGACTATGAG 
AAGCTGGCCA GTGATCTGTT AGAGTGGATC CGCCGCACCA TCCCATGGCT GGAGAATCGG 
GTGCCCGAGA ACACCATGCA GGCCATGCAG CAGAAGCTGG AGGACTTCCG AGACTACCGA 
CGCCTGCACA AGCCGCCCAA GGTGCAGGAG AAGTGCCAGC TGGAGATCAA CTTCAACACA 
CTGCAGACCA AGCTGCGGCT AAGCAACCGG CCTGCCTTCA TGCCCTCCGA GGGCAGGATG 
GTCTCGGATA TCAACAATGC CTGGGGCTGC CTGGAACAGG CAGAGAAGGG CTACGAGGAG 
TGGTTGCTGA ATGAGATCCG GAGGCTAGAG AGGTTGGACC ACCTGGCAGA GAAGTTCCGG 
CAGAAGGCCT CCATCCATGA AGCCTGGACA GACGGCAAAG AAGCCATGCT GCGGCAGAAG 
GATTATGAGA CGGCCACCTT GTCCGAGATC AAGGCCCTAC TCAAGAAGCA CGAGGCCTTT 
GAGAGTGACC TGGCTGCCCA CCAGGACCGC GTGGAGCAGA TCGCGGCCAT TGCCCAGGAG 
CTTAATGAGC TGGACTATTA TGACTCACCA AGTGTCAACG CTCGATGCCA AAAGATCTGT 
GACCAGTGGG ACAATCTAGG GGCCCTGACT CAGAAGCGGA GGGAAGCTTT AGAGCGAACA 
GAGAAGCTGC TGGAGACCAT CGACCAGCTA TACTTGGAGT ACGCCAAGAG GGCTGCACCC 
TTCAACAACT GGATGGAGGG AGCCATGGAG GACCTTCAAG ACACCTTCAT CGTACATACC 
ATTGAGGAGA TCCAGGGACT GACCACAGCC CATGAGCAGT TCAAGGCTAC CCTCCCGGAT 
GCAGACAAGG AGCGCCTGGC CATCCTGGGC ATCCACAATG AAGTGTCCAA GATTGTCCAG 
ACCTATCATG TCAACATGGC AGGCACCAAC CCCTATACAA CCATCACACC TCAGGAGATC 
AATGGCAAAT GGGACCATGT ACGGCAGCTG GTGCCCCGGA GGGACCAGGC TCTAACAGAG 
GAGCACTCGA GGCAGCAGCA CAACGAGAGG TTACGCAAGC AGTTTGGGGC ACAAGCCAAT 
GTCATCGGAC CCTGGATCCA GACCAAGATG GAGGAGATTG GGAGGATCTC CATTGAGATG 
CACGGTACCC TGGAGGACCA ACTCAGCCAC CTGCGGCAGT ATGAAAAGAG CATCGTCAAT 
TATAAGCCAA AGATTGACCA GCTGGAGGGC GACCACCAGC TCATCCAGGA AGCACTTATC 
TTCGACAATA AGCACACCAA CTACACAATG GAGCACATCC GTGTGGGCTG GGAGCAGCTG 
CTCACCACCA TTGCCAGGAC CATCAATGAA GTGGAGAACC AGATCTTGAC CCGGGATGCC 
AAAGGCATCA GCCAGGAACA GATGAACGAA TTCCGGGCCT CCTTCAACCA CTTTGACCGG 
GATCACTCCG GCACGTTGGG TCCCGAAGAG TTCAAAGCCT GCCTCATCAG CTTGGGTTAT 
GATATTGGCA ACGACCCCCA GGGAGAGGCA GAATTTGCCC GGATCATGAG CATTGTAGAC 
CCCAACCGCT TGGGGGTAGT GACATTCCAG GCCTTCATCG ACTTCATGTC CCGAGAGACG 
GCTGACACAG ATACAGCGGA TCAGGTCATG GCTTCCTTCA AGATCCTGGC TGGAGATAAG 
AATTACATCA CCGGGGATGA GCTGCGCCGC GAGCTGCCAC CTGACCAAGC CGAGTACTGC 
ATCGCGAGAA TGGCCCCCTA CGCGGGCCCT GACTCCGTGC CGGGTGCTCT AGACTACATG 
TCCTTCTCCA CGGCGCTGTA CGGCGAGAGT GACCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuregulin-1? induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors.
The Biochemical journal458(2)335-41(2014 Mar)
Hao J,Galindo CL,Tran TL,Sawyer DB

Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity.
PloS one9(4)e96395(2014)
Ogneva IV,Biryukov NS,Leinsoo TA,Larina IM

A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family.
PloS one8(9)e74728(2013)
Gu?guen P,Rouault K,Chen JM,Ragu?n?s O,Fichou Y,Hardy E,Gobin E,Pan-Petesch B,Kerbiriou M,Trouv? P,Marcorelles P,Abgrall JF,Le Mar?chal C,F?rec C

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Actn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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