Fkbp1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fkbp1b
Entrez Gene ID	58950
Full Name	FK506 binding protein 1B
General protein information	Preferred Names FK506 binding protein 1B Names peptidyl-prolyl cis-trans isomerase FKBP1B 12.6 kDa FK506-binding protein 12.6 kDa FKBP FKBP-12.6 FKBP-1B PPIase FKBP1B calstabin-2 immunophilin FKBP12.6 rotamase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q14
Summary	associates with the ryanodine receptor 2 (RyR2); binds cyclic ADP-ribose to effect the release of intracellular calcium, may be important for insulin secretion [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017594336.1	XP_017449825.1	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2
XM_017594335.1	XP_017449824.1	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2
XM_006239860.3	XP_006239922.1	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X1
XM_017594334.1	XP_017449823.1	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2
NM_022675.1	NP_073166.1	peptidyl-prolyl cis-trans isomerase FKBP1B

Pathways from BioSystems

Homologies

	FKBP1B	XP_001098297.1
Bos taurus (cattle)	FKBP1B	NP_001091627.1
Xenopus tropicalis (tropical clawed frog)	fkbp1b	NP_001096492.1
Gallus gallus (chicken)	FKBP1B	NP_989898.1
Homo sapiens (human)	FKBP1B	NP_004107.1
Rattus norvegicus (Norway rat)	Fkbp1b	NP_073166.1
Danio rerio (zebrafish)	fkbp1b	NP_957106.1
Pan troglodytes (chimpanzee)	FKBP1B	XP_001144201.2
Canis lupus familiaris (dog)	FKBP1B	XP_853461.1
Mus musculus (house mouse)	Fkbp1b	NP_058559.3

Gene Ontology
Bibliography

Related articles in PubMed

FK506-Binding Protein 12.6/1b, a negative regulator of [Ca
Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW
The Journal of neuroscience : the official journal of the Society for Neuroscience(2017 Dec)

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.
Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW
The Journal of neuroscience : the official journal of the Society for Neuroscience35(30)10878-87(2015 Jul)

Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma.
Du Y, Zhao J, Li X, Jin S, Ma WL, Mu Q, Xu S, Yang J, Rao S, Zhu L, Xin J, Cai PC, Su Y, Ye H
American journal of respiratory cell and molecular biology50(2)398-408(2014 Feb)

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
Galfr? E, Pitt SJ, Venturi E, Sitsapesan M, Zaccai NR, Tsaneva-Atanasova K, O'Neill S, Sitsapesan R
PloS one7(2)e31956(2012)

Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release.
Liu Y, Chen H, Ji G, Li B, Mohler PJ, Zhu Z, Yong W, Chen Z, Xu X, Xin H, Shou W
Assay and drug development technologies9(6)620-7(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

raising FKBP1b reversed calcium dysregulation and memory impairment in aging rats, allowing them to perform a memory task as well as young rats
Title: Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor 2 in bronchial smooth muscle cells is responsible for the increased calcium response contributing to AHR in asthma
Title: Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma.

The effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the gating of single sheep RyR2 channels, were investigated.
Title: FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.

Disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging.
Title: Disrupting function of FK506-binding protein 1b/12.6 induces the Ca?+-dysregulation aging phenotype in hippocampal neurons.

Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling.
Title: Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.

The following Fkbp1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fkbp1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13128	NM_022675.1 Latest version!	Rattus norvegicus FKBP prolyl isomerase 1B (Fkbp1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa29192	XM_006239860.3 Latest version!	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa61736	XM_017594334.1 Latest version!	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa61736	XM_017594335.1 Latest version!	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa61736	XM_017594336.1 Latest version!	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fkbp1b ( NM_022675.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_073166.1 Rattus norvegicus FKBP prolyl isomerase 1B (Fkbp1b), mRNA.

Price & Availability↑

CloneID	ORa13128
Clone ID Related Accession (Same CDS sequence)	NM_022675.1
Accession Version	NM_022675.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase FKBP1B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D86642.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D86642.1, CB556548.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCGTGG AGATCGAGAC CATCTCCCCG GGAGACGGAA GGACATTCCC TAAGAAGGGT 
CAGATATGCG TGGTGCACTA CACAGGGATG CTCCAGAATG GCAAGAAATT CGATTCGTCC 
AGAGACAGAA ACAAACCCTT CAAGTTCAGA ATTGGCAAGC AGGAAGTCAT CAAAGGTTTT 
GAAGAAGGCG CTGCCCAGAT GAGCTTGGGG CAGAGGGCGA AGCTGACCTG CACCCCTGAT 
GTGGCATATG GAGCTACTGG CCACCCCGGT GTCATCCCTC CCAATGCCAC CCTCATCTTT 
GACGTGGAGC TGCTCAACTT AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073166.1
CDS	1..327
Translation	MGVEIETISPGDGRTFPKKGQICVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE

Target ORF information:

RefSeq Version	NM_022675.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FKBP prolyl isomerase 1B (Fkbp1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022675.1

ORF Insert Sequence:

ATGGGCGTGG AGATCGAGAC CATCTCCCCG GGAGACGGAA GGACATTCCC TAAGAAGGGT 
CAGATATGCG TGGTGCACTA CACAGGGATG CTCCAGAATG GCAAGAAATT CGATTCGTCC 
AGAGACAGAA ACAAACCCTT CAAGTTCAGA ATTGGCAAGC AGGAAGTCAT CAAAGGTTTT 
GAAGAAGGCG CTGCCCAGAT GAGCTTGGGG CAGAGGGCGA AGCTGACCTG CACCCCTGAT 
GTGGCATATG GAGCTACTGG CCACCCCGGT GTCATCCCTC CCAATGCCAC CCTCATCTTT 
GACGTGGAGC TGCTCAACTT AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fkbp1b ( XM_006239860.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239922.1 Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29192
Clone ID Related Accession (Same CDS sequence)	XM_006239860.3
Accession Version	XM_006239860.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239860.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCGTGG AGATCGAGAC CATCTCCCCG GGAGACGGGA TGCTCCAGAA TGGCAAGAAA 
TTCGATTCGT CCAGAGACAG AAACAAACCC TTCAAGTTCA GAATTGGCAA GCAGGAAGTC 
ATCAAAGGTT TTGAAGAAGG CGCTGCCCAG ATGAGCTTGG GGCAGAGGGC GAAGCTGACC 
TGCACCCCTG ATGTGGCATA TGGAGCTACT GGCCACCCCG GTGTCATCCC TCCCAATGCC 
ACCCTCATCT TTGACGTGGA GCTGCTCAAC TTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239922.1
CDS	225..503
Translation	MGVEIETISPGDGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE

Target ORF information:

RefSeq Version	XM_006239860.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239860.3

ORF Insert Sequence:

ATGGGCGTGG AGATCGAGAC CATCTCCCCG GGAGACGGGA TGCTCCAGAA TGGCAAGAAA 
TTCGATTCGT CCAGAGACAG AAACAAACCC TTCAAGTTCA GAATTGGCAA GCAGGAAGTC 
ATCAAAGGTT TTGAAGAAGG CGCTGCCCAG ATGAGCTTGG GGCAGAGGGC GAAGCTGACC 
TGCACCCCTG ATGTGGCATA TGGAGCTACT GGCCACCCCG GTGTCATCCC TCCCAATGCC 
ACCCTCATCT TTGACGTGGA GCTGCTCAAC TTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fkbp1b ( XM_017594336.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449825.1 Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa61736
Clone ID Related Accession (Same CDS sequence)	XM_017594336.1 , XM_017594335.1 , XM_017594334.1
Accession Version	XM_017594336.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCAGA ATGGCAAGAA ATTCGATTCG TCCAGAGACA GAAACAAACC CTTCAAGTTC 
AGAATTGGCA AGCAGGAAGT CATCAAAGGT TTTGAAGAAG GCGCTGCCCA GATGAGCTTG 
GGGCAGAGGG CGAAGCTGAC CTGCACCCCT GATGTGGCAT ATGGAGCTAC TGGCCACCCC 
GGTGTCATCC CTCCCAATGC CACCCTCATC TTTGACGTGG AGCTGCTCAA CTTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449825.1
CDS	79..318
Translation	MLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE

Target ORF information:

RefSeq Version	XM_017594336.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594336.1

ORF Insert Sequence:

ATGCTCCAGA ATGGCAAGAA ATTCGATTCG TCCAGAGACA GAAACAAACC CTTCAAGTTC 
AGAATTGGCA AGCAGGAAGT CATCAAAGGT TTTGAAGAAG GCGCTGCCCA GATGAGCTTG 
GGGCAGAGGG CGAAGCTGAC CTGCACCCCT GATGTGGCAT ATGGAGCTAC TGGCCACCCC 
GGTGTCATCC CTCCCAATGC CACCCTCATC TTTGACGTGG AGCTGCTCAA CTTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fkbp1b ( XM_017594335.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449824.1 Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa61736
Clone ID Related Accession (Same CDS sequence)	XM_017594336.1 , XM_017594335.1 , XM_017594334.1
Accession Version	XM_017594335.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCAGA ATGGCAAGAA ATTCGATTCG TCCAGAGACA GAAACAAACC CTTCAAGTTC 
AGAATTGGCA AGCAGGAAGT CATCAAAGGT TTTGAAGAAG GCGCTGCCCA GATGAGCTTG 
GGGCAGAGGG CGAAGCTGAC CTGCACCCCT GATGTGGCAT ATGGAGCTAC TGGCCACCCC 
GGTGTCATCC CTCCCAATGC CACCCTCATC TTTGACGTGG AGCTGCTCAA CTTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449824.1
CDS	108..347
Translation	MLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE

Target ORF information:

RefSeq Version	XM_017594335.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594335.1

ORF Insert Sequence:

ATGCTCCAGA ATGGCAAGAA ATTCGATTCG TCCAGAGACA GAAACAAACC CTTCAAGTTC 
AGAATTGGCA AGCAGGAAGT CATCAAAGGT TTTGAAGAAG GCGCTGCCCA GATGAGCTTG 
GGGCAGAGGG CGAAGCTGAC CTGCACCCCT GATGTGGCAT ATGGAGCTAC TGGCCACCCC 
GGTGTCATCC CTCCCAATGC CACCCTCATC TTTGACGTGG AGCTGCTCAA CTTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fkbp1b ( XM_017594334.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449823.1 Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa61736
Clone ID Related Accession (Same CDS sequence)	XM_017594336.1 , XM_017594335.1 , XM_017594334.1
Accession Version	XM_017594334.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCAGA ATGGCAAGAA ATTCGATTCG TCCAGAGACA GAAACAAACC CTTCAAGTTC 
AGAATTGGCA AGCAGGAAGT CATCAAAGGT TTTGAAGAAG GCGCTGCCCA GATGAGCTTG 
GGGCAGAGGG CGAAGCTGAC CTGCACCCCT GATGTGGCAT ATGGAGCTAC TGGCCACCCC 
GGTGTCATCC CTCCCAATGC CACCCTCATC TTTGACGTGG AGCTGCTCAA CTTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449823.1
CDS	338..577
Translation	MLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE

Target ORF information:

RefSeq Version	XM_017594334.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FK506 binding protein 1B (Fkbp1b), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594334.1

ORF Insert Sequence:

ATGCTCCAGA ATGGCAAGAA ATTCGATTCG TCCAGAGACA GAAACAAACC CTTCAAGTTC 
AGAATTGGCA AGCAGGAAGT CATCAAAGGT TTTGAAGAAG GCGCTGCCCA GATGAGCTTG 
GGGCAGAGGG CGAAGCTGAC CTGCACCCCT GATGTGGCAT ATGGAGCTAC TGGCCACCCC 
GGTGTCATCC CTCCCAATGC CACCCTCATC TTTGACGTGG AGCTGCTCAA CTTAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FK506-Binding Protein 12.6/1b, a negative regulator of [Ca
The Journal of neuroscience : the official journal of the Society for Neuroscience(2017 Dec)
Gant JC,Blalock EM,Chen KC,Kadish I,Thibault O,Porter NM,Landfield PW

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(30)10878-87(2015 Jul)
Gant JC,Chen KC,Kadish I,Blalock EM,Thibault O,Porter NM,Landfield PW

Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma.
American journal of respiratory cell and molecular biology50(2)398-408(2014 Feb)
Du Y,Zhao J,Li X,Jin S,Ma WL,Mu Q,Xu S,Yang J,Rao S,Zhu L,Xin J,Cai PC,Su Y,Ye H

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
PloS one7(2)e31956(2012)
Galfr? E,Pitt SJ,Venturi E,Sitsapesan M,Zaccai NR,Tsaneva-Atanasova K,O'Neill S,Sitsapesan R

Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release.
Assay and drug development technologies9(6)620-7(2011 Dec)
Liu Y,Chen H,Ji G,Li B,Mohler PJ,Zhu Z,Yong W,Chen Z,Xu X,Xin H,Shou W

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Fkbp1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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