Gpc4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpc4
Entrez Gene ID	317322
Full Name	glypican 4
General protein information	Preferred Names glypican 4 Names glypican-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014108.1	NP_001014130.1	glypican-4 precursor
XM_006257580.3	XP_006257642.1	glypican-4 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpc4	NP_001014130.1
Bos taurus (cattle)	GPC4	NP_001192713.1
Mus musculus (house mouse)	Gpc4	NP_032176.2
Gallus gallus (chicken)	GPC4	XP_420222.3
Danio rerio (zebrafish)	gpc4	NP_571935.2
Xenopus tropicalis (tropical clawed frog)	gpc4	XP_002932634.1
Canis lupus familiaris (dog)	GPC4	XP_549265.2
	GPC4	XP_001097252.1
Drosophila melanogaster (fruit fly)	dlp	NP_996075.2
Caenorhabditis elegans (roundworm)	gpn-1	NP_510582.1
Homo sapiens (human)	GPC4	NP_001439.2
Pan troglodytes (chimpanzee)	GPC4	XP_529161.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003559	XP_313306.5

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
Xiong Y, Zhang Y, Zheng F, Yang Y, Xu X, Wang W, Zhu B, Wang X
Biochemical and biophysical research communications478(1)241-246(2016 09)

PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, Chung GY, Condomitti G, Kim HM, Kim H, de Wit J, Park KS, Tabuchi K, Ko J
Proceedings of the National Academy of Sciences of the United States of America112(6)1874-9(2015 Feb)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.
de Wit J, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC, Vennekens KM, Yates JR 3rd, Ghosh A
Neuron79(4)696-711(2013 Aug)

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Allen NJ, Bennett ML, Foo LC, Wang GX, Chakraborty C, Smith SJ, Barres BA
Nature486(7403)410-4(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures.
Title: Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.

GPC-4 showed strong (nanomolar) affinity and heparan sulfate-dependent interaction with the Ig domains of PTPsigma in rat brain synapses.
Title: PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.

data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
Title: Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.

The following Gpc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05002	NM_001014108.1 Latest version!	Rattus norvegicus glypican 4 (Gpc4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa05002	XM_006257580.3 Latest version!	Rattus norvegicus glypican 4 (Gpc4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpc4 ( NM_001014108.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014130.1 Rattus norvegicus glypican 4 (Gpc4), mRNA.

Price & Availability↑

CloneID	ORa05002
Clone ID Related Accession (Same CDS sequence)	NM_001014108.1 , XM_006257580.3
Accession Version	NM_001014108.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	glypican-4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081962.1. On Apr 20, 2005 this sequence version replaced XM_228677.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081962.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG 
CTGGCTGCGG AGCCCAAGTC GAAAAGTTGT TCGGAAGTGC GACGTCTCTA CGTGTCCAAA 
GGCTTCAACA AGAACGATGC CCCCCTCTAT GAGATCAATG GTGACCATTT GAAGATCTGT 
TCCCAGGATT ATACATGCTG TTCTCAAGAG ATGGAGGAGA AGTACAGTCT GCAAAGTAAA 
GATGATTTCC AAACTGTGGT CAGCGAGCAG TGCAACCATT TGCAAGCCAT CTTTGCATCC 
CGTTACAAGA AGTTTGATGA ATTTTTCAAA GAACTTCTTG AAAATGCAGA GAAATCCCTG 
AATGATATGT TCGTGAAGAC ATACGGCCAC TTATACATGC AAAATTCAGA GCTATTTAAA 
GATCTGTTCG TAGAGTTGAA GCGCTACTAT GTGGCGGGAA ACGTGAACCT GGAAGAAATG 
TTAAATGACT TCTGGGCTCG CCTTCTGGAG CGCATGTTCC GCCTGGTGAA CTCCCAGTAC 
CATTTCACAG ATGAGTACCT GGAATGTGTG AGCAAATACA CTGAGCAGCT GAAGCCTTTT 
GGAGACGTCC CTCGGAAACT GAAGCTCCAG GTTACCCGTG CATTCGTTGC AGCCAGGACC 
TTCGCTCAAG GCTTAGCAGT TGCAAGGGAT GTCGTGAACA GAGTCTCTGT GGTGAATCCC 
ACAGCTCAGT GCACCCAAGC ACTGCTGAAG ATGATCTACT GCTCTCACTG CCGGGGCCTG 
GTGACTGTGA AGCCCTGTTA CAACTATTGC TCAAACATCA TGAGAGGCTG TTTGGCCAAC 
CAAGGAGACC TTGATTTAGA GTGGAACAAT TTCATAGATG CCATGCTGAT GGTGGCAGAG 
AGGCTGGAGG GTCCTTTCAA CATTGAGTCC GTTATGGATC CCATCGATGT GAAGATTTCT 
GATGCTATCA TGAACATGCA GGATAATAGT GTTCAGGTGT CTCAGAAGGT TTTCCAAGGC 
TGTGGACCTC CAAAGCCTCT CCCGGCTGGA CGAATTTCTC GTTCCATCTC TGAAAGTGCC 
TTCAGTGCTC GATTCAGACC TTATCATCCA GAGCAACGCC CAACTACAGC AGCTGGCACT 
AGTTTGGACC GACTGGTTAC TGATGTCAAA GAGAAACTGA AGCAAGCTAA GAAGTTCTGG 
TCCTCTCTCC CAAGCACTGT CTGCAATGAT GAGAGGATGG CAGCAGGAAA TGAGAATGAG 
GATGACTGTT GGAACGGGAA GAGCAAAAGC AGGTACCTGT TTGCAGTGAC AGGAAACGGA 
TTAGCCAACC AGGGCAACAA CCCAGAAGTG CAGGTTGACA CCAGCAAGCC GGACATTCTG 
ATCCTTCGTC AAATCATGGC CCTTCGGGTT ATGACCAGTA AAATGAAGAA TGCTTACAAC 
GGAAATGACG TGGACTTCTT TGATATCAGC GATGAGAGTA GTGGAGAGGG AAGCGGAAGC 
GGATGTGAAT ATCAGCAGTG CCCTTCAGAG TTTGAGTACA ACGCCACTGA CCATTCTGGG 
AAGAGTGCCA ACGAGAAAGC TGACAGTGCC GGTGGTGCCC CTGCAGAGGC AAAGCCCTAT 
CTCCTCGCTG CCCTCTGCAT CCTGTTCCTC GCTGTGCAGG GAGAGTGGAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014130.1
CDS	516..2189
Translation	MARLGLLALLCTLAALSASLLAAEPKSKSCSEVRRLYVSKGFNKNDAPLYEINGDHLKICSQDYTCCSQEMEEKYSLQSKDDFQTVVSEQCNHLQAIFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVNRVSVVNPTAQCTQALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDLEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKSKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFEYNATDHSGKSANEKADSAGGAPAEAKPYLLAALCILFLAVQGEWR

Target ORF information:

RefSeq Version	NM_001014108.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glypican 4 (Gpc4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014108.1

ORF Insert Sequence:

ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG 
CTGGCTGCGG AGCCCAAGTC GAAAAGTTGT TCGGAAGTGC GACGTCTCTA CGTGTCCAAA 
GGCTTCAACA AGAACGATGC CCCCCTCTAT GAGATCAATG GTGACCATTT GAAGATCTGT 
TCCCAGGATT ATACATGCTG TTCTCAAGAG ATGGAGGAGA AGTACAGTCT GCAAAGTAAA 
GATGATTTCC AAACTGTGGT CAGCGAGCAG TGCAACCATT TGCAAGCCAT CTTTGCATCC 
CGTTACAAGA AGTTTGATGA ATTTTTCAAA GAACTTCTTG AAAATGCAGA GAAATCCCTG 
AATGATATGT TCGTGAAGAC ATACGGCCAC TTATACATGC AAAATTCAGA GCTATTTAAA 
GATCTGTTCG TAGAGTTGAA GCGCTACTAT GTGGCGGGAA ACGTGAACCT GGAAGAAATG 
TTAAATGACT TCTGGGCTCG CCTTCTGGAG CGCATGTTCC GCCTGGTGAA CTCCCAGTAC 
CATTTCACAG ATGAGTACCT GGAATGTGTG AGCAAATACA CTGAGCAGCT GAAGCCTTTT 
GGAGACGTCC CTCGGAAACT GAAGCTCCAG GTTACCCGTG CATTCGTTGC AGCCAGGACC 
TTCGCTCAAG GCTTAGCAGT TGCAAGGGAT GTCGTGAACA GAGTCTCTGT GGTGAATCCC 
ACAGCTCAGT GCACCCAAGC ACTGCTGAAG ATGATCTACT GCTCTCACTG CCGGGGCCTG 
GTGACTGTGA AGCCCTGTTA CAACTATTGC TCAAACATCA TGAGAGGCTG TTTGGCCAAC 
CAAGGAGACC TTGATTTAGA GTGGAACAAT TTCATAGATG CCATGCTGAT GGTGGCAGAG 
AGGCTGGAGG GTCCTTTCAA CATTGAGTCC GTTATGGATC CCATCGATGT GAAGATTTCT 
GATGCTATCA TGAACATGCA GGATAATAGT GTTCAGGTGT CTCAGAAGGT TTTCCAAGGC 
TGTGGACCTC CAAAGCCTCT CCCGGCTGGA CGAATTTCTC GTTCCATCTC TGAAAGTGCC 
TTCAGTGCTC GATTCAGACC TTATCATCCA GAGCAACGCC CAACTACAGC AGCTGGCACT 
AGTTTGGACC GACTGGTTAC TGATGTCAAA GAGAAACTGA AGCAAGCTAA GAAGTTCTGG 
TCCTCTCTCC CAAGCACTGT CTGCAATGAT GAGAGGATGG CAGCAGGAAA TGAGAATGAG 
GATGACTGTT GGAACGGGAA GAGCAAAAGC AGGTACCTGT TTGCAGTGAC AGGAAACGGA 
TTAGCCAACC AGGGCAACAA CCCAGAAGTG CAGGTTGACA CCAGCAAGCC GGACATTCTG 
ATCCTTCGTC AAATCATGGC CCTTCGGGTT ATGACCAGTA AAATGAAGAA TGCTTACAAC 
GGAAATGACG TGGACTTCTT TGATATCAGC GATGAGAGTA GTGGAGAGGG AAGCGGAAGC 
GGATGTGAAT ATCAGCAGTG CCCTTCAGAG TTTGAGTACA ACGCCACTGA CCATTCTGGG 
AAGAGTGCCA ACGAGAAAGC TGACAGTGCC GGTGGTGCCC CTGCAGAGGC AAAGCCCTAT 
CTCCTCGCTG CCCTCTGCAT CCTGTTCCTC GCTGTGCAGG GAGAGTGGAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpc4 ( XM_006257580.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006257642.1 Rattus norvegicus glypican 4 (Gpc4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa05002
Clone ID Related Accession (Same CDS sequence)	NM_001014108.1 , XM_006257580.3
Accession Version	XM_006257580.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	glypican-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006257580.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG 
CTGGCTGCGG AGCCCAAGTC GAAAAGTTGT TCGGAAGTGC GACGTCTCTA CGTGTCCAAA 
GGCTTCAACA AGAACGATGC CCCCCTCTAT GAGATCAATG GTGACCATTT GAAGATCTGT 
TCCCAGGATT ATACATGCTG TTCTCAAGAG ATGGAGGAGA AGTACAGTCT GCAAAGTAAA 
GATGATTTCC AAACTGTGGT CAGCGAGCAG TGCAACCATT TGCAAGCCAT CTTTGCATCC 
CGTTACAAGA AGTTTGATGA ATTTTTCAAA GAACTTCTTG AAAATGCAGA GAAATCCCTG 
AATGATATGT TCGTGAAGAC ATACGGCCAC TTATACATGC AAAATTCAGA GCTATTTAAA 
GATCTGTTCG TAGAGTTGAA GCGCTACTAT GTGGCGGGAA ACGTGAACCT GGAAGAAATG 
TTAAATGACT TCTGGGCTCG CCTTCTGGAG CGCATGTTCC GCCTGGTGAA CTCCCAGTAC 
CATTTCACAG ATGAGTACCT GGAATGTGTG AGCAAATACA CTGAGCAGCT GAAGCCTTTT 
GGAGACGTCC CTCGGAAACT GAAGCTCCAG GTTACCCGTG CATTCGTTGC AGCCAGGACC 
TTCGCTCAAG GCTTAGCAGT TGCAAGGGAT GTCGTGAACA GAGTCTCTGT GGTGAATCCC 
ACAGCTCAGT GCACCCAAGC ACTGCTGAAG ATGATCTACT GCTCTCACTG CCGGGGCCTG 
GTGACTGTGA AGCCCTGTTA CAACTATTGC TCAAACATCA TGAGAGGCTG TTTGGCCAAC 
CAAGGAGACC TTGATTTAGA GTGGAACAAT TTCATAGATG CCATGCTGAT GGTGGCAGAG 
AGGCTGGAGG GTCCTTTCAA CATTGAGTCC GTTATGGATC CCATCGATGT GAAGATTTCT 
GATGCTATCA TGAACATGCA GGATAATAGT GTTCAGGTGT CTCAGAAGGT TTTCCAAGGC 
TGTGGACCTC CAAAGCCTCT CCCGGCTGGA CGAATTTCTC GTTCCATCTC TGAAAGTGCC 
TTCAGTGCTC GATTCAGACC TTATCATCCA GAGCAACGCC CAACTACAGC AGCTGGCACT 
AGTTTGGACC GACTGGTTAC TGATGTCAAA GAGAAACTGA AGCAAGCTAA GAAGTTCTGG 
TCCTCTCTCC CAAGCACTGT CTGCAATGAT GAGAGGATGG CAGCAGGAAA TGAGAATGAG 
GATGACTGTT GGAACGGGAA GAGCAAAAGC AGGTACCTGT TTGCAGTGAC AGGAAACGGA 
TTAGCCAACC AGGGCAACAA CCCAGAAGTG CAGGTTGACA CCAGCAAGCC GGACATTCTG 
ATCCTTCGTC AAATCATGGC CCTTCGGGTT ATGACCAGTA AAATGAAGAA TGCTTACAAC 
GGAAATGACG TGGACTTCTT TGATATCAGC GATGAGAGTA GTGGAGAGGG AAGCGGAAGC 
GGATGTGAAT ATCAGCAGTG CCCTTCAGAG TTTGAGTACA ACGCCACTGA CCATTCTGGG 
AAGAGTGCCA ACGAGAAAGC TGACAGTGCC GGTGGTGCCC CTGCAGAGGC AAAGCCCTAT 
CTCCTCGCTG CCCTCTGCAT CCTGTTCCTC GCTGTGCAGG GAGAGTGGAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006257642.1
CDS	125..1798
Translation	MARLGLLALLCTLAALSASLLAAEPKSKSCSEVRRLYVSKGFNKNDAPLYEINGDHLKICSQDYTCCSQEMEEKYSLQSKDDFQTVVSEQCNHLQAIFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVNRVSVVNPTAQCTQALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDLEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKSKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFEYNATDHSGKSANEKADSAGGAPAEAKPYLLAALCILFLAVQGEWR

Target ORF information:

RefSeq Version	XM_006257580.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glypican 4 (Gpc4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006257580.3

ORF Insert Sequence:

ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG 
CTGGCTGCGG AGCCCAAGTC GAAAAGTTGT TCGGAAGTGC GACGTCTCTA CGTGTCCAAA 
GGCTTCAACA AGAACGATGC CCCCCTCTAT GAGATCAATG GTGACCATTT GAAGATCTGT 
TCCCAGGATT ATACATGCTG TTCTCAAGAG ATGGAGGAGA AGTACAGTCT GCAAAGTAAA 
GATGATTTCC AAACTGTGGT CAGCGAGCAG TGCAACCATT TGCAAGCCAT CTTTGCATCC 
CGTTACAAGA AGTTTGATGA ATTTTTCAAA GAACTTCTTG AAAATGCAGA GAAATCCCTG 
AATGATATGT TCGTGAAGAC ATACGGCCAC TTATACATGC AAAATTCAGA GCTATTTAAA 
GATCTGTTCG TAGAGTTGAA GCGCTACTAT GTGGCGGGAA ACGTGAACCT GGAAGAAATG 
TTAAATGACT TCTGGGCTCG CCTTCTGGAG CGCATGTTCC GCCTGGTGAA CTCCCAGTAC 
CATTTCACAG ATGAGTACCT GGAATGTGTG AGCAAATACA CTGAGCAGCT GAAGCCTTTT 
GGAGACGTCC CTCGGAAACT GAAGCTCCAG GTTACCCGTG CATTCGTTGC AGCCAGGACC 
TTCGCTCAAG GCTTAGCAGT TGCAAGGGAT GTCGTGAACA GAGTCTCTGT GGTGAATCCC 
ACAGCTCAGT GCACCCAAGC ACTGCTGAAG ATGATCTACT GCTCTCACTG CCGGGGCCTG 
GTGACTGTGA AGCCCTGTTA CAACTATTGC TCAAACATCA TGAGAGGCTG TTTGGCCAAC 
CAAGGAGACC TTGATTTAGA GTGGAACAAT TTCATAGATG CCATGCTGAT GGTGGCAGAG 
AGGCTGGAGG GTCCTTTCAA CATTGAGTCC GTTATGGATC CCATCGATGT GAAGATTTCT 
GATGCTATCA TGAACATGCA GGATAATAGT GTTCAGGTGT CTCAGAAGGT TTTCCAAGGC 
TGTGGACCTC CAAAGCCTCT CCCGGCTGGA CGAATTTCTC GTTCCATCTC TGAAAGTGCC 
TTCAGTGCTC GATTCAGACC TTATCATCCA GAGCAACGCC CAACTACAGC AGCTGGCACT 
AGTTTGGACC GACTGGTTAC TGATGTCAAA GAGAAACTGA AGCAAGCTAA GAAGTTCTGG 
TCCTCTCTCC CAAGCACTGT CTGCAATGAT GAGAGGATGG CAGCAGGAAA TGAGAATGAG 
GATGACTGTT GGAACGGGAA GAGCAAAAGC AGGTACCTGT TTGCAGTGAC AGGAAACGGA 
TTAGCCAACC AGGGCAACAA CCCAGAAGTG CAGGTTGACA CCAGCAAGCC GGACATTCTG 
ATCCTTCGTC AAATCATGGC CCTTCGGGTT ATGACCAGTA AAATGAAGAA TGCTTACAAC 
GGAAATGACG TGGACTTCTT TGATATCAGC GATGAGAGTA GTGGAGAGGG AAGCGGAAGC 
GGATGTGAAT ATCAGCAGTG CCCTTCAGAG TTTGAGTACA ACGCCACTGA CCATTCTGGG 
AAGAGTGCCA ACGAGAAAGC TGACAGTGCC GGTGGTGCCC CTGCAGAGGC AAAGCCCTAT 
CTCCTCGCTG CCCTCTGCAT CCTGTTCCTC GCTGTGCAGG GAGAGTGGAG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
Biochemical and biophysical research communications478(1)241-246(2016 09)
Xiong Y,Zhang Y,Zheng F,Yang Y,Xu X,Wang W,Zhu B,Wang X

PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America112(6)1874-9(2015 Feb)
Ko JS,Pramanik G,Um JW,Shim JS,Lee D,Kim KH,Chung GY,Condomitti G,Kim HM,Kim H,de Wit J,Park KS,Tabuchi K,Ko J

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.
Neuron79(4)696-711(2013 Aug)
de Wit J,O'Sullivan ML,Savas JN,Condomitti G,Caccese MC,Vennekens KM,Yates JR 3rd,Ghosh A

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Nature486(7403)410-4(2012 May)
Allen NJ,Bennett ML,Foo LC,Wang GX,Chakraborty C,Smith SJ,Barres BA

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Gpc4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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