Rtn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rtn2
Entrez Gene ID	308410
Full Name	reticulon 2
Synonyms	RTN2-B
General protein information	Preferred Names reticulon 2 Names reticulon-2 NSP-like 1 formerly RTN2w reticulon 2 (Z-band associated protein)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589116.1	XP_017444605.1	reticulon-2 isoform X1
NM_201562.3	NP_963856.1	reticulon-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RTN2	NP_005610.1
Canis lupus familiaris (dog)	RTN2	XP_852420.4
Mus musculus (house mouse)	Rtn2	NP_038676.1
Rattus norvegicus (Norway rat)	Rtn2	NP_963856.1
Bos taurus (cattle)	RTN2	NP_001106731.1
Xenopus tropicalis (tropical clawed frog)	rtn2	NP_001107739.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.
Montenegro G, Rebelo AP, Connell J, Allison R, Babalini C, D'Aloia M, Montieri P, Sch?le R, Ishiura H, Price J, Strickland A, Gonzalez MA, Baumbach-Reardon L, Deconinck T, Huang J, Bernardi G, Vance JM, Rogers MT, Tsuji S, De Jonghe P, Pericak-Vance MA, Sch?ls L, Orlacchio A, Reid E, Z?chner S
The Journal of clinical investigation122(2)538-44(2012 Feb)

Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.
Ikemoto T, Hosoya T, Takata K, Aoyama H, Hiramatsu T, Onoe H, Suzuki M, Endo M
Diabetes58(12)2802-12(2009 Dec)

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.
Liu Y, Vidensky S, Ruggiero AM, Maier S, Sitte HH, Rothstein JD
The Journal of biological chemistry283(10)6561-71(2008 Mar)

A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family.
Oertle T, Klinger M, Stuermer CA, Schwab ME
FASEB journal : official publication of the Federation of American Societies for Experimental Biology17(10)1238-47(2003 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RTN2B functions as a positive regulator in the delivery of EAAC1 from the ER to the cell surface.
Title: Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.

The following Rtn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rtn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05474	NM_201562.3 Latest version!	Rattus norvegicus reticulon 2 (Rtn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa56569	XM_017589116.1 Latest version!	Rattus norvegicus reticulon 2 (Rtn2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rtn2 ( NM_201562.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_963856.1 Rattus norvegicus reticulon 2 (Rtn2), mRNA.

Price & Availability↑

CloneID	ORa05474
Clone ID Related Accession (Same CDS sequence)	NM_201562.3
Accession Version	NM_201562.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	reticulon-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY279211.1. On Jun 3, 2007 this sequence version replaced NM_201562.2. ##Evidence-Data-START## Transcript exon combination :: AY279211.1, BK001788.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCATCTAC AGCCTCTTCT 
ACCCCCGATT CCACGGAAGG AGGGAATGAC GACTCGGATT TTCGGGAGCT GCACACAGCC 
CGGGAATTCT CGGAGGACGA AGAGGAGGAG ACTACATCGC AGGACTGGGG CACCCCCAGG 
GAGCTGACCT TTTCCTACAT TGCCTTCGAC GGCGTGGTGG GCTCTGGGGG CCGTAGGGAT 
TCAGTTGTTC GTCGTCCCAG GCCCCAGGGA CGTTCAGTCT CAGAACCAAG GGACCCACCC 
CCACAGCCCA GCCTGGGTGA CAGCTTGGAG AGTATCCCTA GTCTGAGCCA GTCCCCAGAG 
CCGGGGCGTC GCGGTGACCC AGACACTGTA CCTCCAGCTG AGCGCCCGCT GGAGGAACTG 
AGGCTTCGGC TGGACCAGCT TGGCTGGGCT GTCCGGAGTG CGGGATCTGG GGAGGATTCG 
GCCACCAGCA GCTCTACCCC GCTGGAAAAT GAGGAGCCGG ATGGATTGGA GGCCAGCGAG 
GCTGGAGAGA CGAATCTGGA ACTCCGACTT GCTCAGCCTC TACATTTGCA ATTTGAGGGC 
TTGACTCCTC AGCTTAGCCC GAGCTCCGGG ATTCCCCAGG CGCATACCCC ATCCCCACAG 
AGATCTCAAG ATTTGAACAC CGGTCCTGAT GAGCCGCTGC CGAATGGGGA AGGAGAACAT 
TGGCGGCTGC TGGAGCAGGA GCCAATCACG GCCCAGTGCC TCAATAGCAC AGACCAATCA 
GAATTCACGT TGGAGCCGCT CCTTCTAGTG GCAGACCTGT TGTACTGGAA GGACACCAGG 
ACGTCGGGAG CCATCTTCAC GGGCCTCATG GCCTCTCTCC TCTGCCTCCT GCACTTTAGC 
ATCGTGTCCG TGGCTGCGCA CCTGGCCCTG CTGGGTCTCT GCGCCACCAT CTCTCTCAGG 
GTTTACCGCA AAGTGCTGCA GGCCGTGCAC CGGGGCGACG GCACCAACCC TTTCCAGGCT 
TACCTGGACA TGGACCTGAC CCTGACTCGG GAGCAGACAG AACGTTTGTC CCAGCAGATT 
GCCTCCCACG TGGTCTCCAC GGCCACACAG CTGCGGCATT TCTTCCTCGT AGAAGACCTG 
GTGGATTCTC TCAAGCTGGC TCTTCTCTTC TACATCTTGA CCTTCGTGGG AGCCATCTTT 
AACGGCTTGA CTCTTGTCAT CTTGGGAGTG GTTGCTTTGT TCACCGTCCC CCTTCTGTAC 
AGACAACATC AGGCCCAGAT TGACCAGTAT GTGGGGTTGG TGACCAGCCA GTTGAGCCAC 
ATCAAAGCTA AGATCCGAGC TAAGATCCCG GGGACCGGAA CCCTTGCCCC AGCAGCATCA 
GTCTCCGGAT CCAAAGCCAA AGCCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_963856.1
CDS	1..1410
Translation	MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDEEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPPQPSLGDSLESIPSLSQSPEPGRRGDPDTVPPAERPLEELRLRLDQLGWAVRSAGSGEDSATSSSTPLENEEPDGLEASEAGETNLELRLAQPLHLQFEGLTPQLSPSSGIPQAHTPSPQRSQDLNTGPDEPLPNGEGEHWRLLEQEPITAQCLNSTDQSEFTLEPLLLVADLLYWKDTRTSGAIFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTSQLSHIKAKIRAKIPGTGTLAPAASVSGSKAKAE

Target ORF information:

RefSeq Version	NM_201562.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus reticulon 2 (Rtn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201562.3

ORF Insert Sequence:

ATGGGGCAGG TCCTGCCGGT CTTCGCCCAC TGCAAAGAAG CTCCATCTAC AGCCTCTTCT 
ACCCCCGATT CCACGGAAGG AGGGAATGAC GACTCGGATT TTCGGGAGCT GCACACAGCC 
CGGGAATTCT CGGAGGACGA AGAGGAGGAG ACTACATCGC AGGACTGGGG CACCCCCAGG 
GAGCTGACCT TTTCCTACAT TGCCTTCGAC GGCGTGGTGG GCTCTGGGGG CCGTAGGGAT 
TCAGTTGTTC GTCGTCCCAG GCCCCAGGGA CGTTCAGTCT CAGAACCAAG GGACCCACCC 
CCACAGCCCA GCCTGGGTGA CAGCTTGGAG AGTATCCCTA GTCTGAGCCA GTCCCCAGAG 
CCGGGGCGTC GCGGTGACCC AGACACTGTA CCTCCAGCTG AGCGCCCGCT GGAGGAACTG 
AGGCTTCGGC TGGACCAGCT TGGCTGGGCT GTCCGGAGTG CGGGATCTGG GGAGGATTCG 
GCCACCAGCA GCTCTACCCC GCTGGAAAAT GAGGAGCCGG ATGGATTGGA GGCCAGCGAG 
GCTGGAGAGA CGAATCTGGA ACTCCGACTT GCTCAGCCTC TACATTTGCA ATTTGAGGGC 
TTGACTCCTC AGCTTAGCCC GAGCTCCGGG ATTCCCCAGG CGCATACCCC ATCCCCACAG 
AGATCTCAAG ATTTGAACAC CGGTCCTGAT GAGCCGCTGC CGAATGGGGA AGGAGAACAT 
TGGCGGCTGC TGGAGCAGGA GCCAATCACG GCCCAGTGCC TCAATAGCAC AGACCAATCA 
GAATTCACGT TGGAGCCGCT CCTTCTAGTG GCAGACCTGT TGTACTGGAA GGACACCAGG 
ACGTCGGGAG CCATCTTCAC GGGCCTCATG GCCTCTCTCC TCTGCCTCCT GCACTTTAGC 
ATCGTGTCCG TGGCTGCGCA CCTGGCCCTG CTGGGTCTCT GCGCCACCAT CTCTCTCAGG 
GTTTACCGCA AAGTGCTGCA GGCCGTGCAC CGGGGCGACG GCACCAACCC TTTCCAGGCT 
TACCTGGACA TGGACCTGAC CCTGACTCGG GAGCAGACAG AACGTTTGTC CCAGCAGATT 
GCCTCCCACG TGGTCTCCAC GGCCACACAG CTGCGGCATT TCTTCCTCGT AGAAGACCTG 
GTGGATTCTC TCAAGCTGGC TCTTCTCTTC TACATCTTGA CCTTCGTGGG AGCCATCTTT 
AACGGCTTGA CTCTTGTCAT CTTGGGAGTG GTTGCTTTGT TCACCGTCCC CCTTCTGTAC 
AGACAACATC AGGCCCAGAT TGACCAGTAT GTGGGGTTGG TGACCAGCCA GTTGAGCCAC 
ATCAAAGCTA AGATCCGAGC TAAGATCCCG GGGACCGGAA CCCTTGCCCC AGCAGCATCA 
GTCTCCGGAT CCAAAGCCAA AGCCGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rtn2 ( XM_017589116.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444605.1 Rattus norvegicus reticulon 2 (Rtn2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56569
Clone ID Related Accession (Same CDS sequence)	XM_017589116.1
Accession Version	XM_017589116.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	reticulon-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAGTA AAGTGGCAGA CCTGTTGTAC TGGAAGGACA CCAGGACGTC GGGAGCCATC 
TTCACGGGCC TCATGGCCTC TCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCT 
GCGCACCTGG CCCTGCTGGG TCTCTGCGCC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG CGACGGCACC AACCCTTTCC AGGCTTACCT GGACATGGAC 
CTGACCCTGA CTCGGGAGCA GACAGAACGT TTGTCCCAGC AGATTGCCTC CCACGTGGTC 
TCCACGGCCA CACAGCTGCG GCATTTCTTC CTCGTAGAAG ACCTGGTGGA TTCTCTCAAG 
CTGGCTCTTC TCTTCTACAT CTTGACCTTC GTGGGAGCCA TCTTTAACGG CTTGACTCTT 
GTCATCTTGG GAGTGGTTGC TTTGTTCACC GTCCCCCTTC TGTACAGACA ACATCAGGCC 
CAGATTGACC AGTATGTGGG GTTGGTGACC AGCCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAGA TCCCGGGGAC CGGAACCCTT GCCCCAGCAG CATCAGTCTC CGGATCCAAA 
GCCAAAGCCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444605.1
CDS	114..728
Translation	MGSKVADLLYWKDTRTSGAIFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTSQLSHIKAKIRAKIPGTGTLAPAASVSGSKAKAE

Target ORF information:

RefSeq Version	XM_017589116.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus reticulon 2 (Rtn2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589116.1

ORF Insert Sequence:

ATGGGGAGTA AAGTGGCAGA CCTGTTGTAC TGGAAGGACA CCAGGACGTC GGGAGCCATC 
TTCACGGGCC TCATGGCCTC TCTCCTCTGC CTCCTGCACT TTAGCATCGT GTCCGTGGCT 
GCGCACCTGG CCCTGCTGGG TCTCTGCGCC ACCATCTCTC TCAGGGTTTA CCGCAAAGTG 
CTGCAGGCCG TGCACCGGGG CGACGGCACC AACCCTTTCC AGGCTTACCT GGACATGGAC 
CTGACCCTGA CTCGGGAGCA GACAGAACGT TTGTCCCAGC AGATTGCCTC CCACGTGGTC 
TCCACGGCCA CACAGCTGCG GCATTTCTTC CTCGTAGAAG ACCTGGTGGA TTCTCTCAAG 
CTGGCTCTTC TCTTCTACAT CTTGACCTTC GTGGGAGCCA TCTTTAACGG CTTGACTCTT 
GTCATCTTGG GAGTGGTTGC TTTGTTCACC GTCCCCCTTC TGTACAGACA ACATCAGGCC 
CAGATTGACC AGTATGTGGG GTTGGTGACC AGCCAGTTGA GCCACATCAA AGCTAAGATC 
CGAGCTAAGA TCCCGGGGAC CGGAACCCTT GCCCCAGCAG CATCAGTCTC CGGATCCAAA 
GCCAAAGCCG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.
The Journal of clinical investigation122(2)538-44(2012 Feb)
Montenegro G,Rebelo AP,Connell J,Allison R,Babalini C,D'Aloia M,Montieri P,Sch?le R,Ishiura H,Price J,Strickland A,Gonzalez MA,Baumbach-Reardon L,Deconinck T,Huang J,Bernardi G,Vance JM,Rogers MT,Tsuji S,De Jonghe P,Pericak-Vance MA,Sch?ls L,Orlacchio A,Reid E,Z?chner S

Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.
Diabetes58(12)2802-12(2009 Dec)
Ikemoto T,Hosoya T,Takata K,Aoyama H,Hiramatsu T,Onoe H,Suzuki M,Endo M

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.
The Journal of biological chemistry283(10)6561-71(2008 Mar)
Liu Y,Vidensky S,Ruggiero AM,Maier S,Sitte HH,Rothstein JD

A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology17(10)1238-47(2003 Jul)
Oertle T,Klinger M,Stuermer CA,Schwab ME

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Rtn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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