Robo4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Robo4
Entrez Gene ID	300518
Full Name	roundabout guidance receptor 4
General protein information	Preferred Names roundabout guidance receptor 4 Names roundabout homolog 4 Magic roundabout roundabout, axon guidance receptor, homolog 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_008766051.2	XP_008764273.1	roundabout homolog 4 isoform X1
NM_181375.1	NP_852040.1	roundabout homolog 4 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ROBO4	XP_508841.3
Rattus norvegicus (Norway rat)	Robo4	NP_852040.1
Homo sapiens (human)	ROBO4	NP_061928.4
Canis lupus familiaris (dog)	ROBO4	XP_005619671.1
	ROBO4	XP_002799918.1
Bos taurus (cattle)	ROBO4	NP_001092661.1
Xenopus tropicalis (tropical clawed frog)	LOC100493397	XP_002937566.2
Mus musculus (house mouse)	Robo4	NP_083059.2
Rattus norvegicus (Norway rat)	LOC100911068	XP_006242881.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.
Jin X, Shin YJ, Riew TR, Choi JH, Lee MY
Neurochemical research41(12)3373-3385(2016 Dec)

Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia.
Park JH, Pak HJ, Riew TR, Shin YJ, Lee MY
Brain research163445-56(2016 Mar)

Robo4 regulates the radial migration of newborn neurons in developing neocortex.
Zheng W, Geng AQ, Li PF, Wang Y, Yuan XB
Cerebral cortex (New York, N.Y. : 1991)22(11)2587-601(2012 Nov)

roundabout4 is essential for angiogenesis in vivo.
Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R
Proceedings of the National Academy of Sciences of the United States of America102(18)6373-8(2005 May)

Robo4 is a vascular-specific receptor that inhibits endothelial migration.
Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY
Developmental biology261(1)251-67(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data revealed a selective and sustained induction of Slit2 and Robo in astrocytes localized throughout the astroglial scar after ischemic stroke, suggesting that Slit2/Robo signaling participates in glial scar formation and brain remodeling following ischemic injury.
Title: Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.

Results suggest that Slit2/Robo signaling may be involved in regulating the astroglial reaction via autocrine or paracrine mechanisms in post-ischemic processes.
Title: Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia.

our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms
Title: Robo4 regulates the radial migration of newborn neurons in developing neocortex.

The following Robo4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Robo4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04288	NM_181375.1 Latest version!	Rattus norvegicus roundabout guidance receptor 4 (Robo4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa45727	XM_008766051.2 Latest version!	Rattus norvegicus roundabout guidance receptor 4 (Robo4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	15-17	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Robo4 ( NM_181375.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_852040.1 Rattus norvegicus roundabout guidance receptor 4 (Robo4), mRNA.

Price & Availability↑

CloneID	ORa04288
Clone ID Related Accession (Same CDS sequence)	NM_181375.1
Accession Version	NM_181375.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	roundabout homolog 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY277635.1. ##Evidence-Data-START## Transcript exon combination :: AY277635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689600, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGGACAAG GAGAGGAGCT GAGAGCAGCC GTTGACTCTG GAGGAATGGG CCTCCTGGGG 
ACTAAGTGTC CTCTGCCTCT ACTGCTTCTT TTCATCATGG GAGGCAAGGC TCTGGATTCT 
CCACCCCAGA TCCTAGTTCA TCCCCAGGAC CAGCTACTTC AGGGCTCCGG GCCGGCCAAG 
ATGAGTTGCA GAGCATCGGG CCAACCACTT CCCACTATCC GCTGGCTGCT GAATGGGCAG 
CCCCTCAGCA TGGCGACCCC AGACCTACAT TACCTCCAAT CAGATGGGAC CCTCCTGCTA 
CATCGGCCCC CTACCCATGG ACGGCCGCAA GACGACCAGA ACATTCTCTC AGCAATCCTG 
GGTGTCTACA CATGTGAGGC CAGCAACCGG CTGGGCACAG CAGTGAGCCG GGGTGCTAGG 
CTGTCTGTGG CTGTCCTCCA GGAGGACTTC CGGATCCAAC CTCGGGACAC AGTGGCCGTG 
GTGGGCGAGA GCTTGGTTCT CGAGTGTGGT CCTCCCTGGG GCTACCCAAA GCCTTCAGTC 
TCCTGGTGGA AAGATGGGAA ACCCCTGGTC CTCCAGCCAG GGAAGCGCAC AGTGTCTGGG 
GATTCTCTGA TGGTGGCAAG AGCAGAGAAG AATGACACGG GGACCTATAT GTGTATGGCC 
ACCAACAATG CCGGACAACG GGAGAGTCGG GCAGCCAGGG TGTCTATCCA GGAGTCACCG 
GACCACAAGG AGCATCTAGA GCTTCTGGCT GTTCGAATTC AGCTGGAAAA TGTGACCCTG 
CTGAACCCAG AACCTGTAAA AGGCCCCAAG CCTGGGCCAG CTGTGTGGCT CAGCTGGAAG 
GTGAGCGGCC CTGCTGCACC TGCCCAGTCA TACACAGCCC TGTTCAGGGC GCAGAGGGAC 
CCCAGGGACC AGGGATCTCC ATGGACAGAG GTGCTGCTGG ATGGCTTGCT GAATGCAAAG 
CTTGGGGGTC TCCGCTGGGG CCAAGACTAC GAATTCAAAG TGAGACCGTC CTCCGGCCGG 
GCTCGAGGCC CTGATAGCAA TGTGTTGCTC CTGAGGCTGC CTGAACAGGT GCCCAGTGCC 
CCACCTCAAG AAGTGACCCT AAGACCTGGC AACGGTAGTG TCTTTGTGAG TTGGGCCCCA 
CCTCCTGCTG AAAACCATAA CGGTTTCATC CGTGGCTACC AGGTCTGGAG CCTGGGCAAT 
GCCTCATTGC CTGCTGCCAA CTGGACCGTA GTGGGTGAAC AGACACAGCT GGAGATTGCC 
GCACGAATGC CAGGCTCCTA TTGTGTGCAG GTGGCTGCAG TCACTGGTGC TGGGGCTGGA 
GAGCCCAGTA TCCCTGTCTG CCTCCTTTTA GAGCAGGCCA TGGAGCAATC AGCACGAGAC 
CCCAGTAAAC ATGTTTCCTG GACCCTGGAA CAGCTGAGGG CCACCTTGAA ACGACCAGAA 
GTCATTGCCA GTGGTGCCGT CCTGCTCTGG TTGCTGCTCC TAGGCATTGC TGTGTGTATC 
TACAGGCGAC GGAAAGCTGG GGTGCACCTG GGCCCAGGTC TCTACAGATA CACCAGTGAG 
GATGCCATTT TAAAACACAG GATGGACCAC AGTGACTCCC CATGGCTGGC AGACACCTGG 
CGCTCCACCT CTGGCTCTAG AGATCTGAGC AGCAGCAGCA GCCTCAGTAG TCGACTAGGA 
GTGGACCCTC GGGACCCACT GGACGGCAGG CGTTCCTTGA TCTCCTGGGA CCCCCGGAGC 
CCCGGTGTAC CCCTGCTTCC AGACACTAGC ACGTTTTACG GCTCCCTCAT TGCAGAGCAG 
ACTTCCAGCC CTCCAGTCCG GCCAAGCCCG CAGACGCCAG CTGCTAGGCG CCTTCCACCC 
AAGCTGACCG GAACCTCCAG CCCCTGGGCT AGCTCAGATA GTCTCTGCAG CCGCAGGGGA 
CTCTGTTCCC CACGCATGTC TCTGGCCCCT GCAGAGGCTT GGAAGGCCAA AAAGAAGCAG 
GAACTGCACC AAGCTAACAG CTCCCCGCTG CTCCAGGGTA GCCACCCCAT GGAAATCTGG 
GCCTGGGAGT TGGGAAGCAG AGCCTCCAAG AACCTTTCTC AAAGCCCGGG CCCAAACACT 
TGTTCCCCAC GAGAAGCTCC CGGAGCAGTG GTAGCCTGGC GTGCCCTGGG ACCACAACTT 
CACCGCAACT CCAGTGAGCT AGCAGCTCGT CCACTCCCTC CGACACCCCT TTCTCTTCGT 
GGAGCCCCCA GTCATGATCC GCAGAGCCAG TGTGTGGAGA AGCTCCAAGC TCCCTCCTCT 
GACCCACTGC CAGCAGCCCC TCTCTCCGTC CTCAACTCTT CCAGGCCTTC CAGCCCCCAG 
GCCTCTTTCC TCTCTGTTCC TAGCCCAGGA TCCAGCAACC TGTCCAGCTC CTCACTGTCA 
TCCTTAGAGG AGGAGGATCA GGACAGTGTA CTCACCCCTG AGGAGGTAGC CCTGTGTCTG 
GAGCTCAGTG ATGGGGAGGA GACACCCACG AACAGTGTAT CTCCTATGCC AAGAGCTCCT 
TCACCCCCAG CAACCTATGG CTATATCAGC ATACCAACCT CCTCAGGACT GGCAGACATG 
GGCAGAGCTG GTGGGGGCGT GGGGTCTGAG GTCGGGAACT TACTGTGCCC ACCTCGGCTC 
TGCCCCACAC CTACACCCAG CGAGGGCTCC CTGGCCAATG GTTGGGGCTC AGCTTCAGAG 
GACAATGTCC CCAGCGCCAG GGCCAGCCTG GTTAGCTCTT CTGATGGCTC CTTCCTTGCT 
GACGCTCACT TTGCTCGTGC CCTGGCAGTG GCTGTGGACA GCTTCGGTTT CAGTCTGGAG 
CCCAGGGAAG CTGACTGTGT CTTTACTGGT ATGTGGGCTC GCCCGCCTCC CTTAGAATGG 
ACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852040.1
CDS	1..2886
Translation	MGQGEELRAAVDSGGMGLLGTKCPLPLLLLFIMGGKALDSPPQILVHPQDQLLQGSGPAKMSCRASGQPLPTIRWLLNGQPLSMATPDLHYLQSDGTLLLHRPPTHGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFRIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGKRTVSGDSLMVARAEKNDTGTYMCMATNNAGQRESRAARVSIQESPDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPAVWLSWKVSGPAAPAQSYTALFRAQRDPRDQGSPWTEVLLDGLLNAKLGGLRWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQEVTLRPGNGSVFVSWAPPPAENHNGFIRGYQVWSLGNASLPAANWTVVGEQTQLEIAARMPGSYCVQVAAVTGAGAGEPSIPVCLLLEQAMEQSARDPSKHVSWTLEQLRATLKRPEVIASGAVLLWLLLLGIAVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGVDPRDPLDGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQTSSPPVRPSPQTPAARRLPPKLTGTSSPWASSDSLCSRRGLCSPRMSLAPAEAWKAKKKQELHQANSSPLLQGSHPMEIWAWELGSRASKNLSQSPGPNTCSPREAPGAVVAWRALGPQLHRNSSELAARPLPPTPLSLRGAPSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSVPSPGSSNLSSSSLSSLEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPATYGYISIPTSSGLADMGRAGGGVGSEVGNLLCPPRLCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADAHFARALAVAVDSFGFSLEPREADCVFTGMWARPPPLEWT

Target ORF information:

RefSeq Version	NM_181375.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus roundabout guidance receptor 4 (Robo4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181375.1

ORF Insert Sequence:

ATGGGACAAG GAGAGGAGCT GAGAGCAGCC GTTGACTCTG GAGGAATGGG CCTCCTGGGG 
ACTAAGTGTC CTCTGCCTCT ACTGCTTCTT TTCATCATGG GAGGCAAGGC TCTGGATTCT 
CCACCCCAGA TCCTAGTTCA TCCCCAGGAC CAGCTACTTC AGGGCTCCGG GCCGGCCAAG 
ATGAGTTGCA GAGCATCGGG CCAACCACTT CCCACTATCC GCTGGCTGCT GAATGGGCAG 
CCCCTCAGCA TGGCGACCCC AGACCTACAT TACCTCCAAT CAGATGGGAC CCTCCTGCTA 
CATCGGCCCC CTACCCATGG ACGGCCGCAA GACGACCAGA ACATTCTCTC AGCAATCCTG 
GGTGTCTACA CATGTGAGGC CAGCAACCGG CTGGGCACAG CAGTGAGCCG GGGTGCTAGG 
CTGTCTGTGG CTGTCCTCCA GGAGGACTTC CGGATCCAAC CTCGGGACAC AGTGGCCGTG 
GTGGGCGAGA GCTTGGTTCT CGAGTGTGGT CCTCCCTGGG GCTACCCAAA GCCTTCAGTC 
TCCTGGTGGA AAGATGGGAA ACCCCTGGTC CTCCAGCCAG GGAAGCGCAC AGTGTCTGGG 
GATTCTCTGA TGGTGGCAAG AGCAGAGAAG AATGACACGG GGACCTATAT GTGTATGGCC 
ACCAACAATG CCGGACAACG GGAGAGTCGG GCAGCCAGGG TGTCTATCCA GGAGTCACCG 
GACCACAAGG AGCATCTAGA GCTTCTGGCT GTTCGAATTC AGCTGGAAAA TGTGACCCTG 
CTGAACCCAG AACCTGTAAA AGGCCCCAAG CCTGGGCCAG CTGTGTGGCT CAGCTGGAAG 
GTGAGCGGCC CTGCTGCACC TGCCCAGTCA TACACAGCCC TGTTCAGGGC GCAGAGGGAC 
CCCAGGGACC AGGGATCTCC ATGGACAGAG GTGCTGCTGG ATGGCTTGCT GAATGCAAAG 
CTTGGGGGTC TCCGCTGGGG CCAAGACTAC GAATTCAAAG TGAGACCGTC CTCCGGCCGG 
GCTCGAGGCC CTGATAGCAA TGTGTTGCTC CTGAGGCTGC CTGAACAGGT GCCCAGTGCC 
CCACCTCAAG AAGTGACCCT AAGACCTGGC AACGGTAGTG TCTTTGTGAG TTGGGCCCCA 
CCTCCTGCTG AAAACCATAA CGGTTTCATC CGTGGCTACC AGGTCTGGAG CCTGGGCAAT 
GCCTCATTGC CTGCTGCCAA CTGGACCGTA GTGGGTGAAC AGACACAGCT GGAGATTGCC 
GCACGAATGC CAGGCTCCTA TTGTGTGCAG GTGGCTGCAG TCACTGGTGC TGGGGCTGGA 
GAGCCCAGTA TCCCTGTCTG CCTCCTTTTA GAGCAGGCCA TGGAGCAATC AGCACGAGAC 
CCCAGTAAAC ATGTTTCCTG GACCCTGGAA CAGCTGAGGG CCACCTTGAA ACGACCAGAA 
GTCATTGCCA GTGGTGCCGT CCTGCTCTGG TTGCTGCTCC TAGGCATTGC TGTGTGTATC 
TACAGGCGAC GGAAAGCTGG GGTGCACCTG GGCCCAGGTC TCTACAGATA CACCAGTGAG 
GATGCCATTT TAAAACACAG GATGGACCAC AGTGACTCCC CATGGCTGGC AGACACCTGG 
CGCTCCACCT CTGGCTCTAG AGATCTGAGC AGCAGCAGCA GCCTCAGTAG TCGACTAGGA 
GTGGACCCTC GGGACCCACT GGACGGCAGG CGTTCCTTGA TCTCCTGGGA CCCCCGGAGC 
CCCGGTGTAC CCCTGCTTCC AGACACTAGC ACGTTTTACG GCTCCCTCAT TGCAGAGCAG 
ACTTCCAGCC CTCCAGTCCG GCCAAGCCCG CAGACGCCAG CTGCTAGGCG CCTTCCACCC 
AAGCTGACCG GAACCTCCAG CCCCTGGGCT AGCTCAGATA GTCTCTGCAG CCGCAGGGGA 
CTCTGTTCCC CACGCATGTC TCTGGCCCCT GCAGAGGCTT GGAAGGCCAA AAAGAAGCAG 
GAACTGCACC AAGCTAACAG CTCCCCGCTG CTCCAGGGTA GCCACCCCAT GGAAATCTGG 
GCCTGGGAGT TGGGAAGCAG AGCCTCCAAG AACCTTTCTC AAAGCCCGGG CCCAAACACT 
TGTTCCCCAC GAGAAGCTCC CGGAGCAGTG GTAGCCTGGC GTGCCCTGGG ACCACAACTT 
CACCGCAACT CCAGTGAGCT AGCAGCTCGT CCACTCCCTC CGACACCCCT TTCTCTTCGT 
GGAGCCCCCA GTCATGATCC GCAGAGCCAG TGTGTGGAGA AGCTCCAAGC TCCCTCCTCT 
GACCCACTGC CAGCAGCCCC TCTCTCCGTC CTCAACTCTT CCAGGCCTTC CAGCCCCCAG 
GCCTCTTTCC TCTCTGTTCC TAGCCCAGGA TCCAGCAACC TGTCCAGCTC CTCACTGTCA 
TCCTTAGAGG AGGAGGATCA GGACAGTGTA CTCACCCCTG AGGAGGTAGC CCTGTGTCTG 
GAGCTCAGTG ATGGGGAGGA GACACCCACG AACAGTGTAT CTCCTATGCC AAGAGCTCCT 
TCACCCCCAG CAACCTATGG CTATATCAGC ATACCAACCT CCTCAGGACT GGCAGACATG 
GGCAGAGCTG GTGGGGGCGT GGGGTCTGAG GTCGGGAACT TACTGTGCCC ACCTCGGCTC 
TGCCCCACAC CTACACCCAG CGAGGGCTCC CTGGCCAATG GTTGGGGCTC AGCTTCAGAG 
GACAATGTCC CCAGCGCCAG GGCCAGCCTG GTTAGCTCTT CTGATGGCTC CTTCCTTGCT 
GACGCTCACT TTGCTCGTGC CCTGGCAGTG GCTGTGGACA GCTTCGGTTT CAGTCTGGAG 
CCCAGGGAAG CTGACTGTGT CTTTACTGGT ATGTGGGCTC GCCCGCCTCC CTTAGAATGG 
ACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Robo4 ( XM_008766051.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008764273.1 Rattus norvegicus roundabout guidance receptor 4 (Robo4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45727
Clone ID Related Accession (Same CDS sequence)	XM_008766051.2
Accession Version	XM_008766051.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3069bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	roundabout homolog 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008766051.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGACAAG GAGAGGAGCT GAGAGCAGCC GTTGACTCTG GAGGAATGGG CCTCCTGGGG 
ACTAAGTGTC CTCTGCCTCT ACTGCTTCTT TTCATCATGG GAGGCAAGGC TCTGGATTCT 
CCACCCCAGA TCCTAGTTCA TCCCCAGGAC CAGCTACTTC AGGGCTCCGG GCCGGCCAAG 
ATGAGTTGCA GAGCATCGGG CCAACCACTT CCCACTATCC GCTGGCTGCT GAATGGGCAG 
CCCCTCAGCA TGGCGACCCC AGACCTACAT TACCTCCAAT CAGATGGGAC CCTCCTGCTA 
CATCGGCCCC CTACCCATGG ACGGCCGCAA GACGACCAGA ACATTCTCTC AGCAATCCTG 
GGTGTCTACA CATGTGAGGC CAGCAACCGG CTGGGCACAG CAGTGAGCCG GGGTGCTAGG 
CTGTCTGTGG CTGTCCTCCA GGAGGACTTC CGGATCCAAC CTCGGGACAC AGTGGCCGTG 
GTGGGCGAGA GCTTGGTTCT CGAGTGTGGT CCTCCCTGGG GCTACCCAAA GCCTTCAGTC 
TCCTGGTGGA AAGATGGGAA ACCCCTGGTC CTCCAGCCAG GGAAGCGCAC AGTGTCTGGG 
GATTCTCTGA TGGTGGCAAG AGCAGAGAAG AATGACACGG GGACCTATAT GTGTATGGCC 
ACCAACAATG CCGGACAACG GGAGAGTCGG GCAGCCAGGG TGTCTATCCA GGAGTCACCG 
GACCACAAGG AGCATCTAGA GCTTCTGGCT GTTCGAATTC AGCTGGAAAA TGTGACCCTG 
CTGAACCCAG AACCTGTAAA AGGCCCCAAG CCTGGGCCAG CTGTGTGGCT CAGCTGGAAG 
GTGAGCGGCC CTGCTGCACC TGCCCAGTCA TACACAGCCC TGTTCAGGGC GCAGAGGGAC 
CCCAGGGACC AGGGATCTCC ATGGACAGAG GTGCTGCTGG ATGGCTTGCT GAATGCAAAG 
CTTGGGGGTC TCCGCTGGGG CCAAGACTAC GAATTCAAAG TGAGACCGTC CTCCGGCCGG 
GCTCGAGGCC CTGATAGCAA TGTGTTGCTC CTGAGGCTGC CTGAACAGGT GCCCAGTGCC 
CCACCTCAAG AAGTGACCCT AAGACCTGGC AACGGTAGTG TCTTTGTGAG TTGGGCCCCA 
CCTCCTGCTG AAAACCATAA CGGTTTCATC CGTGGCTACC AGGTCTGGAG CCTGGGCAAT 
GCCTCATTGC CTGCTGCCAA CTGGACCGTA GTGGGTGAAC AGACACAGCT GGAGATTGCC 
GCACGAATGC CAGGCTCCTA TTGTGTGCAG GTGGCTGCAG TCACTGGTGC TGGGGCTGGA 
GAGCCCAGTA TCCCTGTCTG CCTCCTTTTA GGTGAGGGAA AGGTTTTATC CATATCTTCT 
ACCCCACCCC ATGTTGTCCC TCTGTCTTCC TGTTCCTGTC ATACATTTCC AGCTTCTCTC 
TCTCTCTCTC TCTCTCTCTC TCTCTCTCTC TCTCTTGTCT GTTGGTCCCA CATTGTCCCA 
TTTGCCCTCC CTCTGAGCTC CACATCCCAA ACAGAGCAGG CCATGGAGCA ATCAGCACGA 
GACCCCAGTA AACATGTTTC CTGGACCCTG GAACAGCTGA GGGCTACCTT GAAACGACCA 
GAAGTCATTG CCAGTGGTGC CGTCCTGCTC TGGTTGCTGC TCCTAGGCAT TGCTGTGTGT 
ATCTACAGGC GACGGAAAGC TGGGGTGCAC CTGGGCCCAG GTCTCTACAG ATACACCAGT 
GAGGATGCCA TTTTAAAACA CAGGATGGAC CACAGTGACT CCCCATGGCT GGCAGACACC 
TGGCGCTCCA CCTCTGGCTC TAGAGATCTG AGCAGCAGCA GCAGCCTCAG TAGTCGACTA 
GGAGTGGACC CTCGGGACCC ACTGGACGGC AGGCGTTCCT TGATCTCCTG GGACCCCCGG 
AGCCCCGGTG TACCCCTGCT TCCAGACACT AGCACGTTTT ACGGCTCCCT CATTGCAGAG 
CAGACTTCCA GCCCTCCAGT CCGGCCAAGC CCGCAGACGC CAGCTGCTAG GCGCCTTCCA 
CCCAAGCTGA CCGGAACCTC CAGCCCCTGG GCTAGCTCAG ATAGTCTCTG CAGCCGCAGG 
GGACTCTGTT CCCCACGCAT GTCTCTGGCC CCTGCAGAGG CTTGGAAGGC CAAAAAGAAG 
CAGGAACTGC ACCAAGCTAA CAGCTCCCCG CTGCTCCGGG GTAGCCACCC CATGGAAATC 
TGGGCCTGGG AGTTGGGAAG CAGAGCCTCC AAGAACCTTT CTCAAAGCCC GGGCCCAAAC 
ACTTGTTCCC CACGAGAAGC TCCCGGAGCA GTGGTAGCCT GGCGTGCCCT GGGACCACAA 
CTTCACCGCA ACTCCAGTGA GCTAGCAGCT CGTCCACTCC CTCCGACACC CCTTTCTCTT 
CGTGGAGCCC CCAGTCATGA TCCGCAGAGC CAGTGTGTGG AGAAGCTCCA AGCTCCCTCC 
TCTGACCCAC TGCCAGCAGC CCCTCTCTCC GTCCTCAACT CTTCCAGGCC TTCCAGCCCC 
CAGGCCTCTT TCCTCTCTGT TCCTAGCCCA GGATCCAGCA ACCTGTCCAG CTCCTCACTG 
TCATCCTTAG AGGAGGAGGA TCAGGACAGT GTACTCACCC CTGAGGAGGT AGCCCTGTGT 
CTGGAGCTCA GTGATGGGGA GGAGACACCC ACGAACAGTG TATCTCCTAT GCCAAGAGCT 
CCTTCACCCC CAGCAACCTA TGGCTATATC AGCATACCAA CCTCCTCAGG ACTGGCAGAC 
ATGGGCAGAG CTGGTGGGGG CGTGGGGTCT GAGGTCGGGA ACTTACTGTG CCCACCTCGG 
CTCTGCCCCA CACCTACACC CAGCGAGGGC TCCCTGGCCA ATGGTTGGGG CTCAGCTTCA 
GAGGACAATG TCCCCAGCGC CAGGGCCAGC CTGGTTAGCT CTTCTGATGG CTCCTTCCTT 
GCTGACGCTC ACTTTGCTCG TGCCCTGGCA GTGGCTGTGG ACAGCTTCGG TTTCAGTCTG 
GAGCCCAGGG AAGCTGACTG TGTCTTTACT GGTATGTGGG CTCGCCCACC TCCCTTAGAA 
TGGACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008764273.1
CDS	68..3136
Translation	MGQGEELRAAVDSGGMGLLGTKCPLPLLLLFIMGGKALDSPPQILVHPQDQLLQGSGPAKMSCRASGQPLPTIRWLLNGQPLSMATPDLHYLQSDGTLLLHRPPTHGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFRIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGKRTVSGDSLMVARAEKNDTGTYMCMATNNAGQRESRAARVSIQESPDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPAVWLSWKVSGPAAPAQSYTALFRAQRDPRDQGSPWTEVLLDGLLNAKLGGLRWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQEVTLRPGNGSVFVSWAPPPAENHNGFIRGYQVWSLGNASLPAANWTVVGEQTQLEIAARMPGSYCVQVAAVTGAGAGEPSIPVCLLLGEGKVLSISSTPPHVVPLSSCSCHTFPASLSLSLSLSLSLSLVCWSHIVPFALPLSSTSQTEQAMEQSARDPSKHVSWTLEQLRATLKRPEVIASGAVLLWLLLLGIAVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGVDPRDPLDGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQTSSPPVRPSPQTPAARRLPPKLTGTSSPWASSDSLCSRRGLCSPRMSLAPAEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNTCSPREAPGAVVAWRALGPQLHRNSSELAARPLPPTPLSLRGAPSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSVPSPGSSNLSSSSLSSLEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPATYGYISIPTSSGLADMGRAGGGVGSEVGNLLCPPRLCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADAHFARALAVAVDSFGFSLEPREADCVFTGMWARPPPLEWT

Target ORF information:

RefSeq Version	XM_008766051.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus roundabout guidance receptor 4 (Robo4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008766051.2

ORF Insert Sequence:

ATGGGACAAG GAGAGGAGCT GAGAGCAGCC GTTGACTCTG GAGGAATGGG CCTCCTGGGG 
ACTAAGTGTC CTCTGCCTCT ACTGCTTCTT TTCATCATGG GAGGCAAGGC TCTGGATTCT 
CCACCCCAGA TCCTAGTTCA TCCCCAGGAC CAGCTACTTC AGGGCTCCGG GCCGGCCAAG 
ATGAGTTGCA GAGCATCGGG CCAACCACTT CCCACTATCC GCTGGCTGCT GAATGGGCAG 
CCCCTCAGCA TGGCGACCCC AGACCTACAT TACCTCCAAT CAGATGGGAC CCTCCTGCTA 
CATCGGCCCC CTACCCATGG ACGGCCGCAA GACGACCAGA ACATTCTCTC AGCAATCCTG 
GGTGTCTACA CATGTGAGGC CAGCAACCGG CTGGGCACAG CAGTGAGCCG GGGTGCTAGG 
CTGTCTGTGG CTGTCCTCCA GGAGGACTTC CGGATCCAAC CTCGGGACAC AGTGGCCGTG 
GTGGGCGAGA GCTTGGTTCT CGAGTGTGGT CCTCCCTGGG GCTACCCAAA GCCTTCAGTC 
TCCTGGTGGA AAGATGGGAA ACCCCTGGTC CTCCAGCCAG GGAAGCGCAC AGTGTCTGGG 
GATTCTCTGA TGGTGGCAAG AGCAGAGAAG AATGACACGG GGACCTATAT GTGTATGGCC 
ACCAACAATG CCGGACAACG GGAGAGTCGG GCAGCCAGGG TGTCTATCCA GGAGTCACCG 
GACCACAAGG AGCATCTAGA GCTTCTGGCT GTTCGAATTC AGCTGGAAAA TGTGACCCTG 
CTGAACCCAG AACCTGTAAA AGGCCCCAAG CCTGGGCCAG CTGTGTGGCT CAGCTGGAAG 
GTGAGCGGCC CTGCTGCACC TGCCCAGTCA TACACAGCCC TGTTCAGGGC GCAGAGGGAC 
CCCAGGGACC AGGGATCTCC ATGGACAGAG GTGCTGCTGG ATGGCTTGCT GAATGCAAAG 
CTTGGGGGTC TCCGCTGGGG CCAAGACTAC GAATTCAAAG TGAGACCGTC CTCCGGCCGG 
GCTCGAGGCC CTGATAGCAA TGTGTTGCTC CTGAGGCTGC CTGAACAGGT GCCCAGTGCC 
CCACCTCAAG AAGTGACCCT AAGACCTGGC AACGGTAGTG TCTTTGTGAG TTGGGCCCCA 
CCTCCTGCTG AAAACCATAA CGGTTTCATC CGTGGCTACC AGGTCTGGAG CCTGGGCAAT 
GCCTCATTGC CTGCTGCCAA CTGGACCGTA GTGGGTGAAC AGACACAGCT GGAGATTGCC 
GCACGAATGC CAGGCTCCTA TTGTGTGCAG GTGGCTGCAG TCACTGGTGC TGGGGCTGGA 
GAGCCCAGTA TCCCTGTCTG CCTCCTTTTA GGTGAGGGAA AGGTTTTATC CATATCTTCT 
ACCCCACCCC ATGTTGTCCC TCTGTCTTCC TGTTCCTGTC ATACATTTCC AGCTTCTCTC 
TCTCTCTCTC TCTCTCTCTC TCTCTCTCTC TCTCTTGTCT GTTGGTCCCA CATTGTCCCA 
TTTGCCCTCC CTCTGAGCTC CACATCCCAA ACAGAGCAGG CCATGGAGCA ATCAGCACGA 
GACCCCAGTA AACATGTTTC CTGGACCCTG GAACAGCTGA GGGCTACCTT GAAACGACCA 
GAAGTCATTG CCAGTGGTGC CGTCCTGCTC TGGTTGCTGC TCCTAGGCAT TGCTGTGTGT 
ATCTACAGGC GACGGAAAGC TGGGGTGCAC CTGGGCCCAG GTCTCTACAG ATACACCAGT 
GAGGATGCCA TTTTAAAACA CAGGATGGAC CACAGTGACT CCCCATGGCT GGCAGACACC 
TGGCGCTCCA CCTCTGGCTC TAGAGATCTG AGCAGCAGCA GCAGCCTCAG TAGTCGACTA 
GGAGTGGACC CTCGGGACCC ACTGGACGGC AGGCGTTCCT TGATCTCCTG GGACCCCCGG 
AGCCCCGGTG TACCCCTGCT TCCAGACACT AGCACGTTTT ACGGCTCCCT CATTGCAGAG 
CAGACTTCCA GCCCTCCAGT CCGGCCAAGC CCGCAGACGC CAGCTGCTAG GCGCCTTCCA 
CCCAAGCTGA CCGGAACCTC CAGCCCCTGG GCTAGCTCAG ATAGTCTCTG CAGCCGCAGG 
GGACTCTGTT CCCCACGCAT GTCTCTGGCC CCTGCAGAGG CTTGGAAGGC CAAAAAGAAG 
CAGGAACTGC ACCAAGCTAA CAGCTCCCCG CTGCTCCGGG GTAGCCACCC CATGGAAATC 
TGGGCCTGGG AGTTGGGAAG CAGAGCCTCC AAGAACCTTT CTCAAAGCCC GGGCCCAAAC 
ACTTGTTCCC CACGAGAAGC TCCCGGAGCA GTGGTAGCCT GGCGTGCCCT GGGACCACAA 
CTTCACCGCA ACTCCAGTGA GCTAGCAGCT CGTCCACTCC CTCCGACACC CCTTTCTCTT 
CGTGGAGCCC CCAGTCATGA TCCGCAGAGC CAGTGTGTGG AGAAGCTCCA AGCTCCCTCC 
TCTGACCCAC TGCCAGCAGC CCCTCTCTCC GTCCTCAACT CTTCCAGGCC TTCCAGCCCC 
CAGGCCTCTT TCCTCTCTGT TCCTAGCCCA GGATCCAGCA ACCTGTCCAG CTCCTCACTG 
TCATCCTTAG AGGAGGAGGA TCAGGACAGT GTACTCACCC CTGAGGAGGT AGCCCTGTGT 
CTGGAGCTCA GTGATGGGGA GGAGACACCC ACGAACAGTG TATCTCCTAT GCCAAGAGCT 
CCTTCACCCC CAGCAACCTA TGGCTATATC AGCATACCAA CCTCCTCAGG ACTGGCAGAC 
ATGGGCAGAG CTGGTGGGGG CGTGGGGTCT GAGGTCGGGA ACTTACTGTG CCCACCTCGG 
CTCTGCCCCA CACCTACACC CAGCGAGGGC TCCCTGGCCA ATGGTTGGGG CTCAGCTTCA 
GAGGACAATG TCCCCAGCGC CAGGGCCAGC CTGGTTAGCT CTTCTGATGG CTCCTTCCTT 
GCTGACGCTC ACTTTGCTCG TGCCCTGGCA GTGGCTGTGG ACAGCTTCGG TTTCAGTCTG 
GAGCCCAGGG AAGCTGACTG TGTCTTTACT GGTATGTGGG CTCGCCCACC TCCCTTAGAA 
TGGACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.
Neurochemical research41(12)3373-3385(2016 Dec)
Jin X,Shin YJ,Riew TR,Choi JH,Lee MY

Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia.
Brain research163445-56(2016 Mar)
Park JH,Pak HJ,Riew TR,Shin YJ,Lee MY

Robo4 regulates the radial migration of newborn neurons in developing neocortex.
Cerebral cortex (New York, N.Y. : 1991)22(11)2587-601(2012 Nov)
Zheng W,Geng AQ,Li PF,Wang Y,Yuan XB

roundabout4 is essential for angiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America102(18)6373-8(2005 May)
Bedell VM,Yeo SY,Park KW,Chung J,Seth P,Shivalingappa V,Zhao J,Obara T,Sukhatme VP,Drummond IA,Li DY,Ramchandran R

Robo4 is a vascular-specific receptor that inhibits endothelial migration.
Developmental biology261(1)251-67(2003 Sep)
Park KW,Morrison CM,Sorensen LK,Jones CA,Rao Y,Chien CB,Wu JY,Urness LD,Li DY

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Robo4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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